Time filter

Source Type

Boston, MA, United States

Emmanuel College is a constituent college of the University of Cambridge. The college was founded in 1584 by Sir Walter Mildmay, Chancellor of the Exchequer to Elizabeth I.Since 1998, Emmanuel has been among the top five colleges in the Tompkins Table, which ranks colleges according to end-of-year examination results. Emmanuel has topped the table five times since then and placed second six times .Emmanuel is one of the wealthier colleges at Cambridge with a financial endowment of approximately £105m and net assets of £150m . Wikipedia.

Alfonso J.,Emmanuel College at Boston
Journal of Child and Adolescent Substance Abuse

This study compared two Web-based alcohol programs in a sample of incoming freshmen on the reduction of drinking and related risks (N = 122). Participants were randomized to either a standard personalized normative feedback (PNF) intervention with descriptive social norms, or to a version of the program with personalized feedback only (PFO). At 3-month follow-up results indicated that both programs reduced drinking and related risks significantly, and that PFO resulted in greater reductions on all alcohol use outcomes, with comparable reductions on alcohol-related risk. Findings suggest that the use of PFO may be preferable to use with first-year college students. © 2015 Taylor & Francis Group, LLC. Source

Allen B.,Emmanuel College at Boston | Allen B.,Harvard University | Nowak M.A.,Harvard University
PLoS Biology

Microorganisms have been cooperating with each other for billions of years: by sharing resources, communicating with each other, and joining together to form biofilms and other large structures. These cooperative behaviors benefit the colony as a whole; however, they may be costly to the individuals performing them. This raises the question of how such cooperation can arise from natural selection. Mathematical modeling is one important avenue for exploring this question. Evolutionary experiments are another, providing us with an opportunity to see evolutionary dynamics in action and allowing us to test predictions arising from mathematical models. A new study in this issue of PLOS Biology investigates the evolution of a cooperative resource-sharing behavior in yeast. Examining the competition between cooperating and "cheating" strains of yeast, the authors find that, depending on the initial mix of strains, this yeast society either evolves toward a stable coexistence or collapses for lack of cooperation. Using a simple mathematical model, they show how these dynamics arise from eco-evolutionary feedback, where changes in the frequencies of strains are coupled with changes in population size. This study and others illustrate the combined power of modeling and experiment to elucidate the origins of cooperation and other fundamental questions in evolutionary biology. © 2013 Allen and Nowak. Source

Benenson J.F.,Emmanuel College at Boston
Philosophical Transactions of the Royal Society B: Biological Sciences

Throughout their lives, women provide for their own and their children's and grandchildren's needs and thus must minimize their risk of incurring physical harm. Alliances with individuals who will assist them in attaining these goals increase their probability of survival and reproductive success. High status in the community enhances access to physical resources and valuable allies. Kin, a mate, and affines share a mother's genetic interests, whereas unrelated women constitute primary competitors. From early childhood onwards, girls compete using strategies that minimize the risk of retaliation and reduce the strength of other girls. Girls' competitive strategies include avoiding direct interference with another girl's goals, disguising competition, competing overtly only from a position of high status in the community, enforcing equality within the female community and socially excluding other girls. © 2013 The Author(s) Published by the Royal Society. All rights reserved. Source

Alfonso J.,Emmanuel College at Boston | Hall T.V.,University of Central Florida | Dunn M.E.,University of Central Florida
Clinical Psychology and Psychotherapy

The present study used a randomized clinical trial design to examine the effectiveness of personalized alcohol feedback delivered individually, in a group and via computer on alcohol use and related negative consequences in a sample of 173 college students referred for alcohol-related violations. Findings revealed statistically significant reductions in alcohol use and related harms for the individually delivered intervention, with significant reductions in alcohol-related harms for the electronically delivered intervention. No statistically significant results were found for the group-delivered intervention or between groups, and a main effect of time was noted for all outcome variables. This study adds to the literature by being the first randomized clinical trial to include analyses of an empirically supported individually delivered personalized alcohol feedback intervention with more cost-effective group-delivered and electronically delivered feedback formats within a single research design, by expanding the range of participant drinking habits reported at baseline to include all drinking levels and not solely those classified as 'heavy drinking' and by providing anonymity pre-intervention and post-intervention given the potential demand characteristics to underreport illegal and/or illicit behaviours in this vulnerable population. © 2012 John Wiley & Sons, Ltd. Source

McCullagh E.,University of California at San Francisco | Seshan A.,University of California at San Francisco | Seshan A.,Emmanuel College at Boston | El-Samad H.,University of California at San Francisco | Madhani H.D.,University of California at San Francisco
Nature Cell Biology

In the Saccharomyces cerevisiae pheromone-response pathway, the transcription factor Ste12 is inhibited by two mitogen-activated protein (MAP)-kinase-responsive regulators, Dig1 and Dig2. These two related proteins bind to distinct regions of Ste12 but are redundant in their inhibition of Ste12-dependent gene expression. Here we describe three functions for Dig1 that are non-redundant with those of Dig2. First, the removal of Dig1 results in a specific increase in intrinsic and extrinsic noise in the transcriptional outputs of the mating pathway. Second, in dig1 " cells, Ste12 relocalizes from the nucleoplasmic distribution seen in wild-type cells into discrete subnuclear foci. Third, genome-wide insertional chromatin immunoprecipitation studies revealed that Ste12-dependent genes have increased interchromosomal interactions in dig1 " cells. These findings suggest that the regulation of gene expression through long-range gene interactions, a widely observed phenomenon, comes at the cost of increased noise. Consequently, cells may have evolved mechanisms to suppress noise by controlling these interactions. © 2010 Macmillan Publishers Limited. All rights reserved. Source

Discover hidden collaborations