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Padova, Italy

Ross M.A.,EMG Laboratory
Neurologic Clinics | Year: 2012

Electrodiagnostic studies are an important component of the evaluation of patients with suspected peripheral nerve disorders. The pattern of findings and the features that are seen on the motor and sensory nerve conduction studies and needle electromyography can help to identify the type of neuropathy, define the underlying pathophysiology (axonal or demyelinating), and ultimately help to narrow the list of possible causes. This article reviews the electrodiagnostic approach to and interpretation of findings in patients with peripheral neuropathies. © 2012 Elsevier Inc. Source

Novotna R.,University of Hradec Kralove | Vysata O.,University of Hradec Kralove | Ehler E.,University of Pardubice | Kanta M.,University of Hradec Kralove | And 4 more authors.
Acta Neurochirurgica | Year: 2015

Background: According to some studies, peripheral nerve injury healing is prolonged in elderly patients. Compressive ulnar neuropathy in the elbow (UNE) is the second most common compressive mononeuropathy. To our knowledge, no study has investigated the effect of age on the postoperative ulnar nerve injury repair rate. Our aim was to evaluate age-related differences in the electrophysiological parameters before and approximately 100 days after operations for cubital tunnel syndrome. Methods: This retrospective study included 103 patients who underwent in situ ulnar nerve decompressions in the elbow. The included patients suffered from paraesthesia and hypoesthesia in their ulnar nerve distribution, hypertrophy, and weakening of the hand muscles, which were innervated by the ulnar nerve. Concurrently, these patients met the EGM diagnostic criteria for UNE. The age dependency on the differences between the preoperative and postoperative parameter values that were measured during the conductive studies was estimated using a regression analysis. Results: A statistically significant deceleration of the monitored parameter adaptation, which included segmental conduction velocity in the elbow area and CMAP amplitude during the above-elbow stimulation of the ulnar nerve, was found. Conclusions: Ulnar nerve injury repair in the cubital tunnel area after a UNE operation proceeds significantly slower in elderly patients. © 2015, Springer-Verlag Wien. Source

Brown D.L.,Sleep Disorders Center | Chervin R.D.,EMG Laboratory | Wolfe J.,University of Michigan | Hughes R.,Sleep Disorders Center | And 4 more authors.
Neurology | Year: 2014

Objective: This cross-sectional study of acute ischemic stroke patients examined relationships between hypoglossal nerve conduction, sleep-disordered breathing (SDB), and its severity. Methods: Patients within 7 days of stroke underwent nocturnal respiratory monitoring with the ApneaLink device and hypoglossal nerve conduction studies. Results: Eighteen of 52 subjects (35% [95% confidence interval: 22%, 49%]) had an abnormal hypoglossal amplitude and 23 (44%[95%confidence interval: 30%, 59%]) had an abnormal hypoglossal latency. No differences were identified in hypoglossal nerve latency or amplitude between those with (n 5 26) and without (n 5 26) significant SDB, defined by an apnea-hypopnea index 15. However, hypoglossal nerve conduction latency was associated (linear regression p , 0.05) with SDB severity as reflected by the apnea-hypopnea index. Conclusions: Acute ischemic stroke patients have a high prevalence of hypoglossal nerve dysfunction. Further studies are needed to explore whether hypoglossal nerve dysfunctionmay be a cause or consequence of SDB in stroke patients and whether this association can provide further insight into the pathophysiology of SDB in this population. Source

Gasparotti R.,University of Brescia | Lucchetta M.,University of Padua | Cacciavillani M.,EMG Laboratory | Neri W.,Institute of Neurology | And 5 more authors.
Journal of Neurology | Year: 2015

Neuroimaging is increasingly used in the study of peripheral nerve diseases, and sometimes may have a pivotal role in the diagnostic process. We report on three patients with atypical chronic inflammatory polyradiculoneuropathy (CIDP) in whom magnetic resonance imaging (MRI) and nerve Ultrasound (US) were crucial for a correct diagnostic work-out. A literature review on MRI and US in acquired demyelinating polyneuropathies is also provided. Awareness of the imaging features of CIDP will assist in confirmation of the diagnosis, institution of the appropriate therapy, and prevention of inadequate or delayed treatment in atypical CIDP. © 2015, Springer-Verlag Berlin Heidelberg. Source

Brozkova D.,Charles University | Mazanec R.,Charles University | Rychly Z.,Central Military Hospital | Haberlova J.,Charles University | And 7 more authors.
Muscle and Nerve | Year: 2011

We report four novel point mutations in the PMP22 gene with two different phenotypes: mutation p.Ser79Thr arose de novo in a patient with the Dejerine-Sottas neuropathy (DSN) phenotype; and mutations c.78+5 G>A, c.320-1 G>C, and p.Trp140Stop segregated with HNPP in 5 families. Our findings show that point mutations in PMP22 may be more likely in HNPP patients than in CMT1 patients after exclusion of CMT1A/HNPP. © 2011 Wiley Periodicals, Inc. Source

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