Angels Camp, MI, United States
Angels Camp, MI, United States
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Alvarez-Estevez D.,Sleep Center | van Velzen I.,Sleep Center | Ottolini-Capellen T.,Sleep Center | Kemp B.,Emeritus
Biomedical Signal Processing and Control | Year: 2017

This work presents a method for the derivation of two new features characterizing the occurrence of both, saccadic and slow eye movements (SEM), in electrooculographic (EOG) sleep recordings. Analysis of EOG activity is of fundamental importance for the clinical interpretation of a subject's sleep pattern. The features here presented are derived from purely horizontal EOG recordings, and have been built to be patient-adaptive and relatively robust against a variety of artifacts. Using the two derived features, performance analysis of two derived Bayes classifiers (respectively for the automatic detection of saccades and of SEM) was validated. Experiments were carried out using a database of 21 whole-night recordings. Automatic and human detections were obtained on a 30-s time grid. Two clinical experts were used as the standard reference. Average kappa indexes were obtained to characterize the agreement between this reference and the automatic detector. Automatic-reference and human–human REM agreements were 0.80 and 0.87, respectively, for the detection of saccades. Corresponding SEM agreements were 0.59 and 0.64, respectively. Our results closely match the expected inter-rater agreement and therefore support the robustness of the method and the validity of the implemented features for the automatic analysis of sleep EOG recordings. © 2017 Elsevier Ltd

Ginter E.,Emeritus | Kajaba I.,CarnoMed
Lekarsky Obzor | Year: 2014

The brown adipose tissue has a unique chemical structure and a specific metabolic role. It has the ability to dissipate energy by producing heat, rather than storing energy as triglycerides. The cells of the white adipose tissue contain one large globule of triglycerides. Brown adipose tissue contains numerous smaller droplets of triglycerides, much higher number of mitochondria and a specific uncoupling protein thermogenin. This specialized protein uncouples ATP production from mitochondrial respiration and converts energy into heat. Exercise has been shown to activate the peroxisome proliferator-activated receptor γ-coactivator-1α which is a transcriptional coactivator that regulates the genes involved in energy metabolism. The discovery of irisin provides more insight into exercise-induced browning of adipose tissue. These substances act as a regulator of mitochondrial biogenesis and function. Very recently it was revealed that the mediator of this metabolic process is a low molecular myokine, the β-aminoisobutyric acid. This compound with a simple molecular structure has a key metabolic role: it converts the cells of white adipose tissue into brown fat. The discovery of irisin provides more insight into exercise-induced browning of adipose tissue. We await further advanced studies to document possible metabolic and pharmacologic interventions, using brown adipose tisue, irisin and β-aminoisobutyric acid as a primary target to prevent and manage obesity.

Rogers J.R.,Emeritus
World Environmental and Water Resources Congress 2017: International Perspectives, History and Heritage, Emerging Technologies, and Student Papers - Selected Papers from the World Environmental and Water Resources Congress 2017 | Year: 2017

Harvey Orem Banks, Honorary Member ASCE and AWWA, Diplomate EE, received his BSCE (magna cum laude) from Syracuse University in 1930, an MS in hydraulic and sanitary engineering from Stanford in 1935, and a Ph.D. in agricultural economics from University of California-Berkeley in 1964. Harvey worked for the City of Palo Alto and joined the Soil Conservation Service in 1935. Banks joined the California Division of Water Resources in 1938, but left in 1942-1945 to serve the U.S. Army Corps of Engineers: 382 Combat Engineers on Guadacanal as a major. From 1945-1950 Harvey worked for Harold Conkling Consulting Engineers. In 1950, Banks re-joined the state of California, moving to principal hydraulic engineer, and then state engineer in 1955-1956. With the new California Department of Water Resources, Harvey Banks was the first director, working on the California State Water Project to transport stored water from northern CA to central and southern California. In 1961, Banks joined Leeds, Hill, Jewett as President and Board Chairman until 1969. In 1977, Harvey merged his consulting firm with Camp Dresser McKee, serving as president of the Water Resources Division. Banks later worked on a long-range Texas water plan and on a High Plains Aquifer Study. Harvey served with the World Bank, U.N., U.S.A.I.D., and published for ASCE, AWWA, WPCF, ICE in U.K., and the California Law Review. In 1973, Banks was elected to the National Academy of Engineering and received the ASCE Julian Hinds and Royce J. Tipton Awards. © ASCE.

Bulloch W.P.,Utility Revenue Management | Rogers J.R.,Emeritus | Fairman A.,City of Los Altos
World Environmental and Water Resources Congress 2017: International Perspectives, History and Heritage, Emerging Technologies, and Student Papers - Selected Papers from the World Environmental and Water Resources Congress 2017 | Year: 2017

Michael Maurice O'Shaughnessy (May 28, 1864-October 12, 1934) was an Irish civil engineer who worked on two railroads near San Francisco, laying out the towns of Mill Valley and Sausalito. O'Shaughnessy started a San Francisco office for an International Exposition, designed the Copper Mountain Company railroad, and worked for Spring Valley Water (San Mateo) and water projects in Hawaii in 1889, including four aqueducts. Michael then worked on Morena Dam outside San Diego and on the Merced River Dam as well as a water supply for Port Costa. O'Shaughnessy became city engineer for the city of San Francisco, supervised the construction of the Twin Peaks Reservoir, Twin Peaks and Stockton Tunnels, the Municipal Railway System-completing the San Francisco streetcar system, street planning, a high-pressure fire system and new sewers. Additionally, the prominent U.S. hydraulic engineer O'Shaughnessy started the Hetch Hetchy Dam (renamed O'Shaughnessy Dam on July 7, 1923), 150 miles of tunnels, pumping stations, hydroelectricity, a 68-mile-long railroad, several smaller dams, and 156 miles of aqueduct and pipelines to San Francisco. Water diverted from O'Shaughnessy Dam flows by gravity into the Hetch Hetchy Aqueduct, which supplies 85 percent of the municipal water for 2.5 million people in the San Francisco Bay Area. © ASCE.

Bulloch W.P.,Utility Revenue Management | Rogers J.R.,Emeritus | Bulloch K.J.,Houston Public Works and Engineering
World Environmental and Water Resources Congress 2017: International Perspectives, History and Heritage, Emerging Technologies, and Student Papers - Selected Papers from the World Environmental and Water Resources Congress 2017 | Year: 2017

The Liverpool and Manchester Railway was dedicated 14 September 2016 at the Rainhill Library as an International Historic Civil and Mechanical Engineering Landmark by ASCE, ASME, ICE, and IMechE. Highlights of the railway plaque dedication and unique railway innovations will be featured. The plaque states: "Opened on 16 September 1830, this railway proved to be one of the most significant developments in transportation history. It was the first public railway for the scheduled transportation of passengers and freight between remote cities. A team led by George Stephenson (1781-1848) designed the 35-mile, double-tracked line. Overcoming numerous engineering challenges, including Olive Mount, the Sankey Valley and Chat Moss, the railway established the historic reputations of many engineers assigned to its various sections. The first ever locomotive trials at Rainhill during 6-14 October 1829 had five entries. Rocket, designed and built by Robert Stephenson (1803-1859) and Henry Booth, outperformed the others and proved that locomotive propulsion was practical. Still operating on its original alignment with many original structures, this railway established the basic format for almost all subsequent railways and rolling stock world-wide." The largest water crossing required the design and construction of the nine-arch Sankey Viaduct. Near Manchester, the River Irwell Bridge was completed in August of 1830. A canal crossing required the Bridgewater Canal Bridge. Much peat moss bog at Chat Moss required special timber footings and embankment fill and drainage. © ASCE.

Ellingson R.A.,University of California at Los Angeles | Swift C.C.,Emeritus | Jacobs D.K.,University of California at Los Angeles
Molecular Phylogenetics and Evolution | Year: 2014

North Pacific Bay gobies (Teleostei: Gobioidei: Gobionellidae) inhabit bays, beaches, coastal lagoons, and estuaries of temperate Asia and North America, but are absent from the boreal northernmost Pacific. Previously, morphological characters conventionally subdivided the clade into two groups - an elongate-bodied, infaunal-inhabiting "Astrabe" group, and a deeper-bodied, non-infaunal "Chasmichthys" group - each with a disjunct East-West (amphi-) Pacific distribution. Here we use mitochondrial and multi-locus nuclear DNA sequence data to show that several morphological characters previously used to delimit these two groups have in fact arisen independently on both sides of the Pacific, revealing convergence of ecologically adaptive characters within a geographically divided clade. Basal divergence of the resultant tree coincides with a dramatic global cooling event at the Eocene/Oligocene transition, without evidence of subsequent trans-Pacific migration. A novel approach to partitioning sequence data by relative rate, as opposed to traditional gene/codon position partitioning, was used to help distinguish phylogenetic signal from noise on a per-site basis. Resulting improvements in topology and nodal support, along with decreased computational effort, suggest that this partitioning strategy may be useful for future studies in phylogenetics and phylogenomics. © 2013 Elsevier Inc.

Nalamachu S.,International Clinical Research Institute | Nalamachu S.,University of Kansas | Wortmann R.,Emeritus
Postgraduate Medicine | Year: 2014

Nonsteroidal anti-inflammatory drugs are a class of analgesics that includes traditional nonselective and selective cyclooxygenase-2 inhibitors that block the biosynthesis of prostaglandins and thromboxane. Indomethacin is a nonsteroidal anti-inflammatory drug with potent antipyretic, analgesic, and anti-inflammatory activity that has been effectively used in the management of mild-to-moderate pain since the mid-1960s. It is commonly prescribed for the relief of acute gouty arthritis pain, but has demonstrated efficacy in the treatment of various other painful conditions. Numerous comparative studies have affirmed the clinical utility of indomethacin relative to other widely used analgesics. This review provides an historic overview of indomethacin and its efficacy compared with other commonly used analgesics, and discusses new indomethacin drug products. © 2014, Postgraduate Medicine.

Wazwaz A.-M.,Saint Xavier University | Rach R.,Emeritus | Duan J.-S.,Shanghai Institute of Technology
Mathematical Methods in the Applied Sciences | Year: 2014

In this paper, we introduce systems of Volterra integral forms of the Lane-Emden equations. We use the systematic Adomian decomposition method to handle these systems of integral forms. The Volterra integral forms overcome the singular behavior at the origin x = 0. The Adomian decomposition method gives reliable algorithm for analytic approximate solutions of these systems. Our results are supported by investigating several numerical examples. Copyright © 2013 John Wiley & Sons, Ltd.

Schiva T.,Emeritus
Acta Horticulturae | Year: 2013

Bamboo has a long story linked to mankind's civilisation. About 1200 species are scattered worldwide, chiefly in the southern hemisphere in tropical, subtropical and temperate climatic areas. Erratic sexual reproduction prevents conventional breeding, but the large genetic variability of natural populations allow to select elite genotypes through the application of micropropagation procedures. Recently, besides the classical ornamental purposes, other utilisations are developed for bamboo, especially for industrial application: textile, paper, medicine, environmental, bio-remediation, etc. Because the large inter- and intra-specific variability, botanical exploration may produce again innovative results, so as the set up agronomical procedures aiming to increase the production in cultivation. Advanced technologies will produce an added value in this unexploited and not completely known germplasm. The growing mass of scientific literature emerging is the best proof of the profitable perspectives of the basic and applied research on the bamboo.

Beckers J.M.,Emeritus
AO for ELT 2011 - 2nd International Conference on Adaptive Optics for Extremely Large Telescopes | Year: 2011

Using Magneto-Optical Filters (MOFs) it is possible to see Sodium Laser Guide Stars in the daytime sky. This makes it possible to use ELT Adaptive Optics systems for diffraction limited observations 24 hours/day. Because of the bright daytime sky this LGS-AO application is only of interest in the mid-infrared wavelength region (3.5-25 μm) where the thermal radiation of the atmospheretelescope system dominates the atmospheric scattering of sunlight. Incorporating MOFs in the LGS wavefront sensors substantially increases the amount of ELT observing time. The gain with respect to the JWST lies in the 5-6 times better linear angular resolution. The contrast gain in brightness at near-IR wavelengths is sufficient to give enough natural guide stars for tip-tilt control. The main complication associated with incorporating MOFs in ELT AO systems for daytime observations is likely the requirement to make the telescope and its enclosure robust in the daytime environment. Poorer daytime seeing conditions may also be detrimental. The use of Mica etalons and narrow band interference filters is also briefly examined. The TMT is used as a good option for the implementation of this technique.

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