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Hagiya H.,Emergency Unit and Critical Care Center | Kajioka H.,Tsuyama Central Hospital
Internal Medicine | Year: 2013

We herein report the case of an 85-year-old woman presenting with right internal jugular vein candidal thrombophlebitis associated with central venous catheters (CTCVC). The infecting agent was Candida albicans, which caused recurrent candidemia five times in total. Micafungin (MCFG) alone was ineffective; however, the combination of MCFG with fosfluconazole (F-FLCZ) successfully treated the patient without a need for any anticoagulant or surgical therapies. To the extent of our knowledge, this is the first report of CTCVC being successfully treated with a combination of F-FLCZ and MCFG. These new antifungal agents have better efficacy, tolerability and bioavailability; therefore, they can be useful alternatives to classical combination therapies such as amphotericin-B and 5-fluorocytosine. © 2013 The Japanese Society of Internal Medicine. Source


Hagiya H.,Okayama University of Science | Hagiya H.,Emergency Unit and Critical Care Center | Matsumoto M.,Tsuyama Central Hospital | Yamasawa T.,Tsuyama Central Hospital | And 2 more authors.
Acta Medica Okayama | Year: 2014

A 79-year-old man who had undergone a right femoropopliteal (FP) bypass operation 6 weeks previously was diagnosed with vascular graft infection caused by Staphylococcus lugdunensis. Another FP bypass operation was performed, with long-term administration of antibiotics, and the patient eventually recovered well without any recurrences for over 2 years. Although S. lugdunens is classified as coagulase-negative Staphylococcus, its pathogenicity has been reported to be equal to that of S. aureus. Based on the literature review, the organism characteristically colonizes the inguinal area of human skin; thus, operations such as FP bypass grafting may place patients at a relatively high risk for infection by S. lugdunensis, a potentially high-pathogenicity organism. © 2014 by Okayama University Medical School. Source


Hagiya H.,Okayama University of Science | Hagiya H.,Emergency Unit and Critical Care Center | Kimura M.,Tsuyama Central Hospital | Miyamoto T.,Tsuyama Central Hospital | And 2 more authors.
Internal Medicine | Year: 2014

Acute generalized exanthematous pustulosis (AGEP) is a self-limiting type of drug eruption that frequently occurs as a reaction to antibiotics, particularly penicillins or macrolides. Daptomycin (DAP) is a newly developed antibiotic that specifically targets methicillin-resistant Staphylococcus aureus infection. We herein present the case of a 77-year-old severe burn victim who was diagnosed with DAP-induced AGEP while receiving treatment in an intensive care unit. Although rare, physicians should be aware that the administration of DAP can cause AGEP, which may complicate the clinical course of patients with a high fever and inflammation. © 2014 The Japanese Society of Internal Medicine. Source


Hagiya H.,Okayama University of Science | Hagiya H.,Emergency Unit and Critical Care Center | Hagioka S.,Emergency Unit and Critical Care Center | Otsuka F.,Okayama University of Science
Internal Medicine | Year: 2013

A 73-year-old man with long-term food deprivation and total parenteral nutrition was diagnosed with septic pulmonary emboli (SPE) and a persistent bacteremia caused by central line-associated blood stream methicillin-resistant Staphylococcus aureus (MRSA) infection. Although daptomycin (DAP) failed to treat the persistent bacteremia, linezolid successfully controlled it. DAP is inactivated by lung surfactant, and therefore, it should not be administered for lower respiratory infections. However, SPE caused by MRSA has been reported to be treatable with DAP since it is an infection of the lung parenchyma. We herein report the lack of effect of daptomycin in SPE treatment. © 2013 The Japanese Society of Internal Medicine. Source


Hagiya H.,Emergency Unit and Critical Care Center | Ohnishi K.,Kochi University
Journal of Clinical Microbiology | Year: 2013

The clinical picture of Ochrobactrum anthropi infection is not well described because the infection is rare in humans and identification of the pathogen is difficult. We present a case of O. anthropi bacteremia that was initially misidentified as Ralstonia paucula and later identified by 16S rRNA sequencing and recA analysis. Copyright © 2013. Source

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