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Burcea M.,Emergency Eye Hospital Ophthalmology | Burcea M.,University of Bucharest | Tataru C.P.,Emergency Eye Hospital Ophthalmology | Mihai C.,ALCOR Clinic Ophthalmology | And 2 more authors.
Acta Endocrinologica | Year: 2015

Objective. The extremely negative effects of diabetic neuropathy over the entire human organism make the detection of modifications in early stages very important. Introduction. The purpose of this study is to establishacorrelation between early modifications appeared at the level of corneal nerves fibers and the glycemic values ol patients with type 2 diabetes. The affection of corneal nerves fibers has been emphasized with the help of corneal confocal microscopy (CCM). Method. A total number of 70 subjects have been evaluated of which 55 suffered from type 2 diabetes (group A) and 15 have been subject to control (group B). The ophthalmologic control also contained a confocal microscopy that has highlighted the decrease of the number of nerves filets °f the sub-basal plexus, modifications associated with type 2 diabetes. Results. The density of nerves fibers (12.11 ± 1.064 n/inni2 compared to 28.33 ± 2.101 n/mnr, P= 0.001); the density of nerves branches (29.94 ± 3.980 n/mnr compared to 43.75 ± 4.605 n/mnT. P<0.001); the length of nerves fibers (11.77 ± 0.638 mm/mnr compared to 17.82 ± 0.479 mm/mnr, P=0.002), the total density of nerves fibers (23.25 ± 3.213 n/nini2 compared to 63.75 ± 8.278 n/mnr\ P=0.042) and thearca of corneal nerves fibers (0.0044 ± 0.000247 nmr /mm-compared to 0.007893 ± 0.00054 nmr /nmr. P=0.014) have been significantly smaller in patients with diabetes compared *° healthy subjects. Conclusions. Being a non invasive technique, corneal confocal microscopy represents a technique that can be easily Used in the detection of early modifications of libers ol sub- hasal corneal nerves stratum, in the case ol patients sullering from type 2 diabetes. © 2015, Editura Academiei Romane. All rights reserved. Source

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