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Serafinceanu C.,Carol Davila University of Medicine and Pharmacy | Serafinceanu C.,Prof Nc Paulescu National Institute Of Diabetes | Timar R.,County Emergency Hospital Timisoara | Timar R.,Victor Babes University of Medicine and Pharmacy Timisoara | And 2 more authors.
Acta Endocrinologica | Year: 2016

Metformin, a biguanide, remains the most widely used first-line type 2 diabetes drug. It is generally considered weight-neutral with chronic use and does not increase the risk of hypoglycaemia. Most patients eventually require more than one antihyperglycemic agent to achieve target blood glucose levels. The primary objective of this non-interventional study was to describe and compare the main criteria used by physicians from regular outpatient setting in selecting the add-on therapy in patients with inadequately metformincontrolled type 2 diabetes in 2 time points at 1-year distance by assessment of patient, and/or agent characteristics and/or physician decision. At the end of phase one of the study, the mean duration of type 2 diabetes was 6.8 years. The majority of patients included in the study were overweight (32%) and obese (62%), and presented diabetes complications (59.6%). In 50% of the cases, the major reason for selecting the second-line therapy was related to patient characteristics, while agent characteristics and physician decision were the main categories in 38% and 12%, respectively. Importance to achieve glycemic control and estimated treatment efficacy were selected in 73.9% and 82.4% of patients, calculated as percentage in the respective categories. © 2016, Acta Endocrinologica Foundation. All rights reserved.

Banica D.,County Emergency Hospital Timisoara | Fratila R.,City Hospital Timisoara | Sima A.,Victor Babes University of Medicine and Pharmacy Timisoara | Sima A.,County Emergency Hospital Timisoara | And 4 more authors.
Romanian Journal of Diabetes, Nutrition and Metabolic Diseases | Year: 2014

Autoimmune polyglandular syndromes are characterized by the association of two or more autoimmune diseases. They are classified into two major subtypes, each having its own characteristics. The autoimmune polyglandular syndrome type 2 is defined by the presence of at least two of the following diseases: Addison's disease, type 1 diabetes mellitus and thyroid autoimmune disease. Other autoimmune diseases belonging to the autoimmune polyglandular syndrome type 2 are: primary hypogonadism, myasthenia gravis, celiac disease, pernicious anemia, alopecia, vitiligo. We are going to present the case of a patient, aged 40, with diabetes mellitus (probably latent autoimmune diabetes of the adult), chronic autoimmune thyroiditis and celiac disease. © 2014 ILEX PUBLISHING HOUSE, Bucharest, Roumania.

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