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Patent
EMCURE PHARMACEUTICALS Ltd | Date: 2012-08-27

The present invention provides a convenient and industrially viable process for preparation of Zolmitriptan (I) having desired purity. The invention specifically relates to a method for isolating (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one hydrochloride (IIIa) of desired purity by separating the undesired inorganic side products such as stannous hydroxide by manipulation of pH at different stages and finally treating with N,N-dimethylamino butyraldehyde diethyl acetal in an acidic medium to provide Zolmitriptan (I) conforming to regulatory specifications.


Patent
EMCURE PHARMACEUTICALS Ltd | Date: 2012-09-05

Controlled release oral dosage formulations containing calcium channel blocker and processes for preparation thereof, are provided for once a day treatment. The active agent is preferably a dihydropyridine calcium channel blocker, such as nisoldipine. In one embodiment, the formulation provides controlled release of micronized nisoldipine with one or more pH independent release controlling polymers. The controlled release matrix formulation is advantageous and can be prepared by a simple, economically viable process as compared to complex core-coat prior-art versions.


Patent
Emcure Pharmaceuticals Ltd | Date: 2012-12-21

The present invention relates to a novel synthetic route for the preparation of raltegravir and pharmaceutically acceptable salts, starting from 2-amino-2-methylpropanenitrile and oxadiazole carbonyl chloride, through the formation of a pyrimidinone intermediate of formula (V).


Patent
Emcure Pharmaceuticals Ltd | Date: 2011-06-08

The present invention provides a simple method for synthesis of taxane derivatives such as paclitaxel docetaxel or cabazitaxel. Taxane derivative obtained by present process posses significant stability and formation of 7-epimer, which is a principal degradation product, is significantly reduced. The taxane derivatives obtained by present process are highly useful for preparing the pharmaceutical compositions.


The present invention relates to the preparation of stable pyridone disulphide derivatives having general formula (I) and its stereoisomers, which are useful in the treatment of gastrointestinal disorders. Pyridone disulphide derivatives (I) wherein, R_(1), R_(2 )and R_(3 )are independently alkyl, alkoxy, halogen, halogenated alkoxy, halogenated alkyl, hydrogen and could be the same or different and X is CH or N. R_(1 )is methyl, methoxy, fluorine, trifluoromethyl, difluoromethoxy and hydrogen, R_(2 )is methyl, methoxy and hydrogen, and R_(3 )is methyl and hydrogen.


Patent
Emcure Pharmaceuticals Ltd | Date: 2010-08-18

The present invention provides a simple method for preparation of benzphetamine and its acid addition salt comprising reaction of methamphetamine hydrochloride of formula (III) with benzyl chloride and treating the isolated benzphetamine of formula (II) with an acid dissolved in an organic solvent to provide benzphetamine acid addition salt, more specifically, benzphetamine hydrochloride of formula (I).


Patent
Emcure Pharmaceuticals Ltd | Date: 2012-04-09

Disclosed is process for the preparation of a key Rilpivirine intermediate namely, (E)-4-(2-cyanoethenyl)-2,6-dimethylphenylamine hydrochloride (II) by a process comprising reaction of the tetrafluoroborate salt of the diazonium ion of 2,6-dimethyl-4-amino-1-carboxybenzyl phenylamine (VI) with acrylonitrile in presence of palladium acetate, followed by treatment with an acid and its subsequent conversion to the hydrochloride salt (II), wherein the undesired Z isomer is less than 0.5% and provides Rilpivirine hydrochloride having Z isomer less than 0.1%.


Patent
EMCURE PHARMACEUTICALS Ltd | Date: 2014-11-14

A process for preparation of diethyl 2-aetamido-2-(4-octyl phenyl)ethyl malonate (III), a key intermediate of fingolimod hydrochloride comprising reaction of 2-(4-octylphenyl)ethyl iodide (IV) with diethyl acetamido malonate in presence of a base and an iodinating agent and in an organic solvent. The compound of formula (III) thus obtained provided fingolimod hydrochloride (Ia) having associated impurities below the regulatory limits.


The present invention relates to the preparation of stable pyridone disulphide derivatives having general formula (I) and its stereoisomers, which are useful in the treatment of gastrointestinal disorders. Pyridone disulphide derivatives (I) wherein, R_(1), R_(2 )and R_(3 )are independently alkyl, alkoxy, halogen, halogenated alkoxy, halogenated alkyl, hydrogen and could be the same or different and X is CH or N. R_(1 )is methyl, methoxy, fluorine, trifluoromethyl, difluoromethoxy and hydrogen, R_(2 )is methyl, methoxy and hydrogen, and R_(3 )is methyl and hydrogen.


Patent
Emcure Pharmaceuticals Ltd | Date: 2016-06-28

The present invention relates to a novel synthetic route for the preparation of raltegravir and pharmaceutically acceptable salts, starting from 2-amino-2-methylpropanenitrile and oxadiazole carbonyl chloride, through the formation of a pyrimidinone intermediate of formula (V).

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