Emcure Pharmaceutical Ltd.
Emcure Pharmaceutical Ltd.
Raskar V.,Emcure Pharmaceutical Ltd.
Asian Journal of Pharmaceutics | Year: 2015
Aim: The present investigation was carried out with an aim to formulate and evaluate praziquantel (PZQ) tablets using solid dispersion approach. Methodology: The solid dispersion was prepared by solvent evaporation method using carriers such as mannitol, urea and PEG 6000 with drug: Carrier ratio of 1:1, 1:2 and 1:3. The solid dispersion was evaluated for physical parameters such as angle of repose, bulk density, Carr′s index, Hausner ratio, drug content and in vitro drug release studies. PZQ tablets (100 mg drug) were prepared further from solid dispersions using direct compression technique. Results: The results of individual assays of solid dispersions with different ratios revealed that the 1:2 ratio of PZQ with PEG 6000 showed higher dissolution rates when compared to others. Tablets compressed were evaluated for their physical parameters such as weight variation, thickness, hardness, friability, dissolution, and disintegration tests and compared with plain drug and marketed formulation (Biltricide 600 mg Bayer HealthCare Pharmaceuticals). In vitro dissolution profile of optimized batch (F8) showed better release. The highest solubility was shown by tablet prepared from solid dispersion with 1:2 ratio of PZQ: PEG 6000, which was found to be more than plain drug. Infrared spectra showed that the functional groups of PZQ and PEG 6000 were preserved. Results of 2 3 factorial designs affect the dependent variables such as hardness, disintegration time and % friability. Conclusion: It was concluded that by adopting a systematic formulation approach one can reach to an optimum level. Hence, solid dispersion formulation using PEG 6000 carriers was found to be a good alternative approach for increasing the dissolution rate of PZQ tablets in distilled water.
Gharge V.,Emcure Pharmaceutical Ltd |
Gunjal P.,Zuventus Healthcare Ltd |
Shinde M.,Zuventus Healthcare Ltd |
Gadhe A.,Emcure Pharmaceutical Ltd |
And 2 more authors.
Pharma Times | Year: 2016
Modified release dosage forms are designed by altering drug absorption or the site of drug release in order to accomplish predetermined clinical objectives. Possible therapeutic benefits of a modified release product include improved efficacy and reduced adverse effects, increased convenience and patient compliance, optimized performance, a greater selectivity of activity. Polymers are becoming increasingly important in design and development of modified drug delivery systems to provide modulation of drug release. The pharmaceutical applications of polymers range from their use as binders, solubility modifier, filler, coating agent in tablets to viscosity, flow controlling agents in liquids, suspensions and emulsions. The choice of a specific material and control mechanism for active pharmaceutical has become a critical aspects. The selection of polymeric material mainly is based on drug properties, target site, desired release environment, duration of action and desired release rate. This review assembles the current knowledge on the structure and chemistry of polymers, different commercial grades of polymers and their application in modified drug delivery systems. The review also elaborates the mechanism and kinetic of drug release from these polymeric system. © 2016, Indian Pharmaceutical Association. All rights reserved.
Karna N.,B Pharmacy College Rampura |
Biswal B.,B Pharmacy College Rampura |
Bhavsar B.,Emcure Pharmaceutical Ltd
International Journal of PharmTech Research | Year: 2014
Levetiracetam is an antiepileptic drug with good bioavailability, rapid achievement of steady state concentration after oral administration. Besides it also has relatively short elimination half-life (6 hours). A drug with a short half-life requires frequent dosing and this makes Levetiracetam an ideal candidate for a extended-release formulation. Hydrophilic and swellable polymer matrix such as HPMC K-15M and PEO are widely used in extended-release delivery because of their flexibility to obtain a desirable drug release profile. To provide a extended-release composition which releases Levetiracetam over a time period of at least about 12 hours when exposed to gastrointestinal milieu thus facilitating a reduction in frequency of drug administration through extended-drug delivery system. Optimization was done using 32 full factorial design at 3 levels and 2 factors. From the polynomial equation, both the two independent factors showed significant effect on dependent variables.
Srikant P.,Emcure Pharmaceutical Ltd |
Akash J.,Emcure Pharmaceutical Ltd |
Mahesh D.,Emcure Pharmaceutical Ltd |
Astik S.,Emcure Pharmaceutical Ltd
International Journal of PharmTech Research | Year: 2015
Roller compaction is a dry granulation technology in which powder is densified between two counter rotating rolls by the application of mechanical pressure as powder passes through the rolls.Dry granulation process powders consist of the active pharmaceutical ingredient and excipients, e.g., diluents, disintegrants, and lubricants, are mixed in suitable blender. The powder mixtures are then roller compacted and size reduced to form granules. Rollercompaction is usually prefer to overcome unfavorable physical properties of powders and APIs, such as poor flow, low bulk density, blend uniformity, segregation of powder blends by optimizing process parameter and selection of excipients. Roller compaction process has significant effect on particles size distribution, flowability, homogeneity,compressibility, compactability of active pharmaceutical ingredients and excipients and thus can affect consequently dissolution profile, disintegration time, hardness and other post compression parameter of tablet. Roller compaction processoffers advantageous as compared with wet granulation process such as simple manufacturing procedure, easier scale up,high volume production output, and relatively low operational costs. Roller compaction process excludes liquid solvent or binder solution. This process is also energy efficient and suitable for processing pharmaceutical agents that are sensitive to moisture and heat.Good quality granules can be obtained byoptimizing roller compaction process parameter such as compression force, rollerspeed, screw feeder speed, roll gap andmilling. © 2014, International Journal of PharmTech Research. All rights reserved.
Gunjal P.T.,Zuventus Healthcare Ltd |
Shinde M.B.,Zuventus Healthcare Ltd |
Gharge V.S.,Emcure Pharmaceutical Ltd |
Pimple S.V.,Emcure Pharmaceutical Ltd |
And 2 more authors.
Indian Journal of Pharmaceutical Sciences | Year: 2015
The objective of this present investigation was to develop and formulate floating sustained release matrix tablets of s (-) atenolol, by using different polymer combinations and filler, to optimize by using surface response methodology for different drug release variables and to evaluate the drug release pattern of the optimized product. Floating sustained release matrix tablets of various combinations were prepared with cellulose-based polymers: Hydroxypropyl methylcellulose, sodium bicarbonate as a gas generating agent, polyvinyl pyrrolidone as a binder and lactose monohydrate as filler. The 32 full factorial design was employed to investigate the effect of formulation variables on different properties of tablets applicable to floating lag time, buoyancy time, % drug release in 1 and 6 h (D1 h,D6 h) and time required to 90% drug release (t90%). Significance of result was analyzed using analysis of non variance and P<0.05 was considered statistically significant. S (-) atenolol floating sustained release matrix tablets followed the Higuchi drug release kinetics that indicates the release of drug follows anomalous (non-Fickian) diffusion mechanism. The developed floating sustained release matrix tablet of improved efficacy can perform therapeutically better than a conventional tablet. © 2015 Indian Journal of Pharmaceutical Sciences | Published by Wolters Kluwer - Medknow.
Krishna V.,Emcure Pharmaceutical Ltd. |
Singh P.,University of Rajasthan
Journal of the Indian Chemical Society | Year: 2013
The chemistry of eight isocedrenolides and an α-isocedrenedial from the aerial parts of Moscharia pinnatifida, trixiparadoxin, its isovalerate and 2-methyi butyrate from the aerial parts of Trixis inula, five trixikingolides alongwith trixiparadoxin esters from the roots and the aerial parts of Trixis paradoxa, four trixikingolides from the aerial parts, 14β-methoxytrixic acid methyl ester and trixiparadoxin isovalerate from the roots of Trixis vautheri and further five trixikingolides in addition to trixiparadoxin isovalerate from the roots and the aerial parts of Trixis antimenorrhoea have been reviewed.
Krishna V.,Emcure Pharmaceutical Ltd |
Khandelwal P.,Mohanlal Sukhadia University |
Koolwal N.,University of Rajasthan |
Sharma M.C.,University of Rajasthan |
Singh P.,University of Rajasthan
Journal of the Indian Chemical Society | Year: 2012
The present brief review focus on isolation of a large number of naphthoquinones, anthraquinones and naphthoquinone dimers from more than 33 plant species of 16 genera of family Bignoniaccae. The following sixteen genera viz. Catalpa, Crescentia, Heterophragma (syn : Haplophragma), Kigelia, Lundia, Mansoa, Markhamia (syn : Dolichandrone), Newbouldia, Oroxylum, Paratecoma, Phyllarthron, Radermachera, Stereospermum, Tabebuia, Tecomella (syn : Tecoma) and Zeyhera have so far chemically investigated for more than sixty quinonoid constituents. Ten plant species belonging to seven genera namely Heterophragma, Kigelia, Markhamia, Phyllarthron, Stereospermum, Tabebuia and Tecomella have chemically been examined by our group during last three decades which have resulted in the isolation of two dozen of quinonoid compounds including some new naphthoquinones and their dimers. The structures of these compounds were unambiguously established from chemical and spectral evidences. Their taxonomic and biogenetic significance were discussed.
Biswal B.,Bpharmacy College Rampura |
Karna N.,Bpharmacy College Rampura |
Bhavsar B.,Emcure Pharmaceutical Ltd
Journal of Applied Pharmaceutical Science | Year: 2014
The present work was performed to develop and evaluate buccal tablet containing antidiabetic drug (Repaglinide). Ethyl cellulose was used as backing membrane and Carbopol 934p, Polyox wsr N-80 NF, HEC and HPC was used as bucco adhesive polymer. Aspartame was used as sweetener. Thickness, Hardness, weight variation and drug uniformity were investigated. The tablet formulations were also subjected to drug release in 250ml 6.8 phosphate buffer. Ex vivo bioadhesion, retention time and permeation through porcine buccal mucosa membrane. Effects of different bucco adhesive polymer were evaluated on release and bioadhesion, retention time and permeation of drugs. F5 formulations showed maximum amounts of drugs release (87.18%) at the end of 10 h dissolution study. F5 also showed maximum bioadheion (0.0754N) and the resident time of F5 formulation was 9.2 h. It shows 41.52% drug release after 10 h permeation study through porcine buccal mucosa mounted in Franz cell. The tablet also found stable in human saliva after 10hr. The tablet was not showed any type of physical changes after the completion of 10 h. The results of the study suggested that new buccal tablet formulations of combined bucco adhesive polymers can be suitably developed as an alternate to conventional dosage forms. © 2014 Biswajit Biswal et al.
Neelakandan K.,Emcure Pharmaceutical Ltd |
Neelakandan K.,Annamalai University |
Manikandan H.,Annamalai University |
Santosha N.,Emcure Pharmaceutical Ltd |
Prabhakaran B.,Emcure Pharmaceutical Ltd
Organic Process Research and Development | Year: 2013
An improved process for the preparation of trimethobenzamide hydrochloride conforming to regulatory specification is reported. Specifically, a process for the preparation of trimethobenzamide hydrochloride, which is free from the associated impurities that are normally encountered during coupling of 4-(2-dimethylaminoethoxy)benzyl amine with 3,4,5-trimethoxy benzoic acid is described. © 2013 American Chemical Society.
PubMed | Zuventus Healthcare Ltd and Emcure Pharmaceutical Ltd
Type: Journal Article | Journal: Indian journal of pharmaceutical sciences | Year: 2016
The objective of this present investigation was to develop and formulate floating sustained release matrix tablets of s (-) atenolol, by using different polymer combinations and filler, to optimize by using surface response methodology for different drug release variables and to evaluate the drug release pattern of the optimized product. Floating sustained release matrix tablets of various combinations were prepared with cellulose-based polymers: Hydroxypropyl methylcellulose, sodium bicarbonate as a gas generating agent, polyvinyl pyrrolidone as a binder and lactose monohydrate as filler. The 3(2) full factorial design was employed to investigate the effect of formulation variables on different properties of tablets applicable to floating lag time, buoyancy time, % drug release in 1 and 6 h (D1 h,D6 h) and time required to 90% drug release (t90%). Significance of result was analyzed using analysis of non variance and P < 0.05 was considered statistically significant. S (-) atenolol floating sustained release matrix tablets followed the Higuchi drug release kinetics that indicates the release of drug follows anomalous (non-Fickian) diffusion mechanism. The developed floating sustained release matrix tablet of improved efficacy can perform therapeutically better than a conventional tablet.