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Krishna V.,Emcure Pharmaceutical Ltd. | Khandelwal P.,Mohanlal Sukhadia University | Koolwal N.,University of Rajasthan | Sharma M.C.,University of Rajasthan | Singh P.,University of Rajasthan
Journal of the Indian Chemical Society

The present brief review focus on isolation of a large number of naphthoquinones, anthraquinones and naphthoquinone dimers from more than 33 plant species of 16 genera of family Bignoniaccae. The following sixteen genera viz. Catalpa, Crescentia, Heterophragma (syn : Haplophragma), Kigelia, Lundia, Mansoa, Markhamia (syn : Dolichandrone), Newbouldia, Oroxylum, Paratecoma, Phyllarthron, Radermachera, Stereospermum, Tabebuia, Tecomella (syn : Tecoma) and Zeyhera have so far chemically investigated for more than sixty quinonoid constituents. Ten plant species belonging to seven genera namely Heterophragma, Kigelia, Markhamia, Phyllarthron, Stereospermum, Tabebuia and Tecomella have chemically been examined by our group during last three decades which have resulted in the isolation of two dozen of quinonoid compounds including some new naphthoquinones and their dimers. The structures of these compounds were unambiguously established from chemical and spectral evidences. Their taxonomic and biogenetic significance were discussed. Source

Biswal B.,Bpharmacy College Rampura | Karna N.,Bpharmacy College Rampura | Bhavsar B.,Emcure Pharmaceutical Ltd.
Journal of Applied Pharmaceutical Science

The present work was performed to develop and evaluate buccal tablet containing antidiabetic drug (Repaglinide). Ethyl cellulose was used as backing membrane and Carbopol 934p, Polyox wsr N-80 NF, HEC and HPC was used as bucco adhesive polymer. Aspartame was used as sweetener. Thickness, Hardness, weight variation and drug uniformity were investigated. The tablet formulations were also subjected to drug release in 250ml 6.8 phosphate buffer. Ex vivo bioadhesion, retention time and permeation through porcine buccal mucosa membrane. Effects of different bucco adhesive polymer were evaluated on release and bioadhesion, retention time and permeation of drugs. F5 formulations showed maximum amounts of drugs release (87.18%) at the end of 10 h dissolution study. F5 also showed maximum bioadheion (0.0754N) and the resident time of F5 formulation was 9.2 h. It shows 41.52% drug release after 10 h permeation study through porcine buccal mucosa mounted in Franz cell. The tablet also found stable in human saliva after 10hr. The tablet was not showed any type of physical changes after the completion of 10 h. The results of the study suggested that new buccal tablet formulations of combined bucco adhesive polymers can be suitably developed as an alternate to conventional dosage forms. © 2014 Biswajit Biswal et al. Source

Krishna V.,Emcure Pharmaceutical Ltd. | Singh P.,University of Rajasthan
Journal of the Indian Chemical Society

The chemistry of eight isocedrenolides and an α-isocedrenedial from the aerial parts of Moscharia pinnatifida, trixiparadoxin, its isovalerate and 2-methyi butyrate from the aerial parts of Trixis inula, five trixikingolides alongwith trixiparadoxin esters from the roots and the aerial parts of Trixis paradoxa, four trixikingolides from the aerial parts, 14β-methoxytrixic acid methyl ester and trixiparadoxin isovalerate from the roots of Trixis vautheri and further five trixikingolides in addition to trixiparadoxin isovalerate from the roots and the aerial parts of Trixis antimenorrhoea have been reviewed. Source

Neelakandan K.,Emcure Pharmaceutical Ltd. | Neelakandan K.,Annamalai University | Manikandan H.,Annamalai University | Santosha N.,Emcure Pharmaceutical Ltd. | Prabhakaran B.,Emcure Pharmaceutical Ltd.
Organic Process Research and Development

An improved process for the preparation of trimethobenzamide hydrochloride conforming to regulatory specification is reported. Specifically, a process for the preparation of trimethobenzamide hydrochloride, which is free from the associated impurities that are normally encountered during coupling of 4-(2-dimethylaminoethoxy)benzyl amine with 3,4,5-trimethoxy benzoic acid is described. © 2013 American Chemical Society. Source

Shinde M.,Zuventus Healthcare Ltd | Gharge V.,Zuventus Healthcare Ltd | Pimple S.,Emcure Pharmaceutical Ltd. | Gurjar M.,Emcure Pharmaceutical Ltd. | Shah M.,Emcure Pharmaceutical Ltd.
Asian Journal of Pharmaceutical and Clinical Research

Objective: The objective of this study was to compare and evaluate in vitro ex vivo transdermal potential of the diclofenac sodium (DS) gel by different permeation enhancers using Franz-type diffusion cells.Methods: DS gel was prepared with carbapol, dimethyl sulfoxide, oleic acid (OA), and menthol with 1% w/w concentration each as the penetration enhancer. The in vitro, ex vivo permeability were determined using cellophane membrane and abdominal rat skin. Steady-state flux, permeability coefficient (kp), diffusion coefficient, and lag time were calculated.Results: Menthol, at the concentration of 1% w/w, shows maximum kp, diffusion coefficient permeation enhancement effect with an enhancement ratio 40%, as compared to dimethyl sulfoxide and OA.Conclusion: This finding predicts that DS gel 1% w/w containing menthol 1% w/w can possibly deliver therapeutically relevant dose of DS. © 2014, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved. Source

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