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Kyriazis M.,ELPIs Foundation for Indefinite Lifespans
Rejuvenation Research | Year: 2014

Editor's Note: A response to this article from Aubrey de Grey, Editor-in-Chief, can be found on pages 397-400 in this issue. The notion that it is possible to eradicate age-related degeneration and live a life with a negligible rate of senescence solely by using a physical "repair- oriented" approach is flawed on a number of fronts. Here, I will argue that there are so many unknown variables embedded in this line of thinking that make the final result impossible to predict. Two relatively easy-to-research areas are the search for successful cross-link breakers and an effective lysosomal degradation therapy. A more complex and speculative strategy is whole-body interdiction of lengthening of telomeres (WILT). Highlighting these as examples, I argue that it is unlikely that such rejuvenation biotechnologies will be used meaningfully by the general public. The discussion assumes that although such therapies may in theory one day be developed in the laboratory, and even possibly be formulated as physical clinical therapies, these will be unusable in practical terms when applied upon humans at large. Due to inherent characteristics of our biological, evolutionary, and psychological heritage, it is implausible that curing aging will occur by using physical interventions alone. © 2014 Mary Ann Liebert, Inc. Source

Kyriazis M.,ELPIs Foundation for Indefinite Lifespans
Current Aging Science | Year: 2014

We live within an increasingly technological, information-laden environment for the first time in human evolution. This subjects us (and will continue to subject us in an accelerating fashion) to an unremitting exposure to 'meaningful information that requires action'. Directly dependent upon this new environment are novel evolutionary pressures, which can modify existing resource allocation mechanisms and may eventually favour the survival of somatic cells (particularly neurons) at the expense of germ line cells. In this theoretical paper I argue that persistent, structured information-sharing in both virtual and real domains, leads to increased biological complexity and functionality, which reflects upon human survival characteristics. Certain biological immortalisation mechanisms currently employed by germ cells may thus need to be downgraded in order to enable somatic cells to manage these new energy demands placed by our modern environment. Relevant concepts from a variety of disciplines such as the evolution of complex adaptive systems, information theory, digital hyper-connectivity, and cell immortalisation will be reviewed. Using logical, though sometimes speculative arguments, I will attempt to describe a new biology. A biology not driven by sex and reproduction but by information and somatic longevity. © 2014 Bentham Science Publishers. Source

Kyriazis M.,ELPIs Foundation for Indefinite Lifespans
Current Aging Science | Year: 2016

There is no doubt that the world is divided and unequal, mostly with respect to wealth. However, the true obstacle preventing the progress of humanity is not the divide between the rich and the poor. It is the divide between the cognitive and the physical. Apart from the social and ethical issues associated with this, there are also medical ones. The implications of this divide have direct relevance to aging, both in research and in the clinical sense. We cannot simply apply the same ‘healthy aging’ guidelines to everybody, but we need to establish if our approach is specifically suited to the individual. Our research endeavours need to have this division in focus. In this Opinion paper I describe three separate groups of humanity, which are divided, not by economic criteria, but by a worldview of intellectual creativity. Each arbitrary group has its own health priorities. If we overlook these priorities we may, at best, give the wrong advice to our patients, or at worst waste resources and exacerbate the rate of age-related degeneration in many individuals. As our society becomes more reliant on technology, what is now considered ‘healthy’ may not be so, for many millions of people. © 2016 Bentham Science Publishers. Source

Kyriazis M.,ELPIs Foundation for Indefinite Lifespans | Apostolides A.,ELPIs Foundation for Indefinite Lifespans
Current Aging Science | Year: 2015

The process of aging is a continuum of degeneration which eventually leads to loss of function and clinically manifest disease. Yet, in the purely therapeutic sense, there is a distinct clinical and practical separation between age-related degenerative diseases and the background process of aging itself. It is quite possible that biomedical technologies will prove invaluable in treating or alleviating the impact of distinct age-related degenerative diseases such as cardiovascular disease, arthritis or dementia. However, when it comes to addressing the fundamental, background stochastic nature of aging, it is unlikely that regenerative biotechnologies will have any appreciable impact in continually counteracting the process. In this paper we discuss some essential conceptual obstacles, both functional and translational, which will prove overwhelming and which preclude the notion that aging can be eliminated by using physical therapies. Our reasoning is two-fold: 1. Disruptive regenerative biotechnologies interfere with the complex, dynamic topological architecture of the human organism, in a manner that will render them unsuitable for clinical use against all age-related degeneration. 2. Even if some regenerative biotechnological treatments are developed in the laboratory, the translational issues will be insurmountable, and the treatments will thus be practically unusable by the general public at large. Predictions about the near or mid-term development of rejuvenating biotechnologies are not sufficiently grounded, and do not provide a framework for effective practical achievement of negligible senescence. Instead, the answer must lie in more global and abstract methods which align well with evolutionary mechanisms based on techno-cultural societal necessities. These are likely to operate in a way which ultimately may downgrade the importance of human aging and make it an evolutionarily unnecessary process. © 2015 Bentham Science Publishers Source

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