Rehovot, Israel
Rehovot, Israel

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PubMed | Erasmus Medical Center, Academic Colorectal Center, Peking University and Elfi Tech
Type: Journal Article | Journal: Surgical innovation | Year: 2016

Perioperative bowel perfusion (local hemodynamic index [LHI]) was measured with a miniaturized dynamic light scattering (mDLS) device, aiming to determine whether anastomotic perfusion correlates with the anastomotic healing process and whether LHI measurement assists in the detection of anastomotic leakage (AL) in colorectal surgery.A partial colectomy was performed in 21 male Wistar rats. Colonic and anastomotic LHIs were recorded during operation. On postoperative day (POD) 3, the rats were examined for AL manifestations. Anastomotic LHI was recorded before determining the anastomotic bursting pressure (ABP). The postoperative LHI measurements were repeated in 15 other rats with experimental colitis. Clinical manifestations and anastomotic LHI were also determined on POD3. Diagnostic value of LHI measurement was analyzed with the combined data from both experiments.Intraoperative LHI measurement showed no correlation with the ABP on POD3. Postoperative anastomotic LHI on POD3 was significantly correlated with ABP in the normal rats (R(2) = 0.52; P < .001) and in the rats with colitis (R(2) = 0.63; P = .0012). Anastomotic LHI on POD3 had high accuracy for identifying ABP <50 mm Hg (Area under the curve = 0.86; standard error = 0.065; P < .001). A cutoff point of 1236 yielded a sensitivity of 100% and a specificity of 65%. On POD3, rats with LHIs <1236 had significantly higher dehiscence rates (40% vs 0%), more weight loss, higher abscess severity, and lower ABPs (P < .05); worse anastomotic inflammation and collagen deposition were also found in the histological examination.Our data suggest that postoperative evaluation of anastomotic microcirculation with the mDLS device assists in the detection of AL in colorectal surgery.


Kuznik B.I.,Chita State Medical Academy | Fine I.W.,Elfi Tech | Kaminsky A.V.,Elfi Tech
Bulletin of Experimental Biology and Medicine | Year: 2011

We propose a noninvasive method of in vivo examination the hemostasis system based on speckle pattern analysis of coherent light scattering from the skin. We compared the results of measuring basic blood coagulation parameters by conventional invasive and noninvasive methods. A strict correlation was found between the results of measurement of soluble fibrin monomer complexes, international normalized ratio (INR), prothrombin index, and protein C content. The noninvasive method of examination of the hemostatic system enable rough evaluation of the intensity of the intravascular coagulation and correction of the dose of indirect anticoagulants maintaining desired values of INR or prothrombin index. © 2011 Springer Science+Business Media, Inc.


Doronin A.,University of Otago | Fine I.,Elfi Tech | Meglinski I.,University of Otago
Laser Physics | Year: 2011

Optical/laser modalities provide a broad variety of practical solutions for clinical diagnostics and therapy in a range from imaging of single cells and molecules to non-invasive biopsy of specific biological tissues and organs tomography. Near-infrared transmittance pulse oximetry with laser diodes is the accepted standard in current clinical practice and widely used for noninvasive monitoring of oxygen saturation in arterial blood hemoglobin. Conceptual design of practical pulse oximetry systems requires careful selection of various technical parameters, including intensity, wavelength, beam size and profile of incident laser radiation, size, numerical aperture of the detector, as well as a clear understanding of how the spatial and temporal structural alterations in biological tissues can be linked with and can be distinguished by variations of these parameters. In current letter utilizing state-of-the-art NVIDEA CUDA technology, a new object oriented programming paradigm and on-line solutions we introduce a computational tool applied for human finger transmittance spectra simulation and assessment of calibration curve for near-infrared transmitted pulseoximetry. © Pleiades Publishing, Ltd., 2011.


Fine I.,Elfi Tech
Progress in Biomedical Optics and Imaging - Proceedings of SPIE | Year: 2014

PPG volumetric model is frequently adopted to explain the pulsatile nature of optical response for arterial pulsation. In this article we show that the pulsatile fluctuation of optical response can be explained in terms of the light scattering related changes. According to this assumption, these fluctuations are driven by the modulation the scattering coefficient associated with the blood flow hemodynamic effects. There was shown that the proposed model yields a good correspondence with the pulse-oximetry related parameters. Moreover, it was found that the experimental relationship between the red blood concentration in the blood (hematocrit) and the parameters being derived from the in vivo measured optical signals can be described in terms of this scattering driven model. There was demonstrated that the commonly used volumetric assumption fails to provide a reasonable description of the experimental results. The last fact can be used as a decisive argument in favor of the scattering driven model. This model can be used for better understanding of the pulse oximetry as well as for the guidance for the algorithmic development of the blood hemoglobin/ hematocrit in vivo. © 2014 SPIE.


Fine I.,Elfi Tech | Kaminsky A.,Elfi Tech
Progress in Biomedical Optics and Imaging - Proceedings of SPIE | Year: 2011

Optical spectroscopy approach, using non-coherent light sources, has become an important tool for non-invasive analysis in vivo. It is based on the assumption that biochemical characteristics of biological system can be determined through the optical coefficients of blood and tissue particles. Thus, in the framework of this approach, the major concern is to express the obtained optical signals in terms the optical coefficients of the single particle of blood or tissue. However, since the light propagation in tissue is dominated by the multiple-scattering component, a direct measurement of single scattering characteristics turns to be a very difficult task. Practically, only the relative changes of absorption and scattering coefficients are measured. We suggested to adopt the dynamic light scattering (DLS) or speckle technique for the determination of the light scattering coefficients of the red blood cells under stasis conditions in vivo. We assumed that under zero flow conditions the RBC movement is driven mostly by the Brownian motion. It was shown, that under appropriate measurement geometry, the measured optical signal can be decomposed into a few major components. The most dominant components are ascribed to the single backscattering and forward scattering coefficients of the red blood cells. In-vitro and in vivo experimental tests have shown a good correspondence between the theoretically estimated and experientially measured results. The obtained results indicate that the DLS technique can be adopted for the determination of blood particles scattering characteristics in addition to the movement and effective viscosity parameters measurement in vivo.


Fine I.,Elfi Tech | Kaminsky A.V.,Elfi Tech | Shenkman L.,Elfi Tech
Progress in Biomedical Optics and Imaging - Proceedings of SPIE | Year: 2016

It is widely recognized that effective stress management could have a dramatic impact on health care and preventive medicine. In order to meet this need, efficient and seamless sensing and analytic tools for the non-invasive stress monitoring during daily life are required. The existing sensors still do not meet the needs in terms of specificity and robustness. We utilized a miniaturized dynamic light scattering sensor (mDLS) which is specially adjusted to measure skin blood flow fluctuations and provides multi- parametric capabilities. Based on the measured dynamic light scattering signal from the red blood cells flowing in skin, a new concept of hemodynamic indexes (HI) and oscillatory hemodynamic indexes (OHI) have been developed. This approach was utilized for stress level assessment for a few usecase scenario. The new stress index was generated through the HI and OHI parameters. In order to validate this new non-invasive stress index, a group of 19 healthy volunteers was studied by measuring the mDLS sensor located on the wrist. Mental stress was induced by using the cognitive dissonance test of Stroop. We found that OHIs indexes have high sensitivity to the mental stress response for most of the tested subjects. In addition, we examined the capability of using this new stress index for the individual monitoring of the diurnal stress level. We found that the new stress index exhibits similar trends as reported for to the well-known diurnal behavior of cortisol levels. Finally, we demonstrated that this new marker provides good sensitivity and specificity to the stress response to sound and musical emotional arousal. © 2016 SPIE.


Fine I.,Elfi Tech | Kaminsky A.,Elfi Tech | Kuznik B.,Chita State Medical Academy | Shenkman L.,Tel Aviv University
Laser Physics | Year: 2012

We present a new non-invasive method for assessing hemostasis in vivo. This method is based on the analysis of the movement characteristics of red blood cells (RBCs) during blood stasis condition. Stasis is intermittently induced by occlusion of arterial blood flow at the finger root. We assumed that under zero flow conditions, RBC movement is driven mostly by Brownian motion, and we characterized the RBC movement by utilizing the dynamic light scattering (DLS) technique in vivo. We found that during the stasis the RBCs diffusion coefficient in plasma decreases. We speculate that the RBC diffusion coefficient is most strongly related to endothelial and hemostatic activity. This assumption is supported by our findings that RBC movement, being expressed through the characteristics of the measured DLS signal, is correlative to the biological age and also is related to the coagulation factors. This new method can serve as a new diagnostic and research tool for the assessment of hemostasis and vascular function. © Pleiades Publishing, Ltd., 2012.


A method and apparatus are presented for non-invasive determination of blood clotting related and blood circulation related parameters of a mammal. At least one stimulus ST is non-invasively induced in a blood containing medium in the mammal for a preset period of time t_(ST). This at least one stimulus is selected to cause at least one of the following to occur: (a) inducing at least two of three Virchows triad elements including abnormalities of blood flow; abnormalities of blood constituents and abnormalities of the blood vessel wall, and (b) inducing a change in red blood cell (RBC) aggregation or local blood viscosity. Measurements are non-invasively performed at a measurement location in the mammal by applying an external field thereto for a preset time period t_(m), a response of the measurement location to the applied field is detected, and measured data indicative thereof generated. At least a portion of the measured data and stimulus related data are processed so as to determine a relation between a time function of the at least one stimulus ST(t) and a time function of the measured data OR(t). This relation is indicative of at least one blood circulation and blood coagulation related parameter of the mammal.


A system, method and medical tool are presented for use in non-invasive in vivo determination of at least one desired parameter or condition of a subject having a scattering medium in a target region. The measurement system comprises an illuminating system, a detection system, and a control system. The illumination system comprises at least one light source configured for generating partially or entirely coherent light to be applied to the target region to cause a light response signal from the illuminated region. The detection system comprises at least one light detection unit configured for detecting time-dependent fluctuations of the intensity of the light response and generating data indicative of a dynamic light scattering (DLS) measurement. The control system is configured and operable to receive and analyze the data indicative of the DLS measurement to determine the at least one desired parameter or condition, and generate output data indicative thereof.


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