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Campinas, Brazil

Bacchetti R.,Eldorado Research Institute
Communications in Computer and Information Science

The Internet of Things is transforming the way we interact with our houses and cities. The advance of technology granted a wide range of possibilities to connect virtually any device and collect data on its use; however, it seems that we are not considering the human that will interact with it. In this paper, I will present how a Human-Centered Design approach was adopted in the development of a Smart Building office. © Springer International Publishing Switzerland 2016. Source

Santos P.S.,Federal University of Uberlandia | Sena A.A.S.,Federal University of Uberlandia | Nascimento R.,Federal University of Uberlandia | Araujo T.G.,Federal University of Uberlandia | And 6 more authors.

Bovine anaplasmosis is a hemoparasitic disease that causes considerable economic loss to the dairy and beef industries. Cattle immunized with the Anaplasma marginale MSP1 outer membrane protein complex presents a protective humoral immune response; however, its efficacy is variable. Immunodominant epitopes seem to be a key-limiting factor for the adaptive immunity. We have successfully demonstrated that critical motifs of the MSP1a functional epitope are essential for antibody recognition of infected animal sera, but its protective immunity is yet to be tested. We have evaluated two synthetic vaccine formulations against A. marginale, using epitope-based approach in mice. Mice infection with bovine anaplasmosis was demonstrated by qPCR analysis of erythrocytes after 15-day exposure. A proof-of-concept was obtained in this murine model, in which peptides conjugated to bovine serum albumin were used for immunization in three 15-day intervals by intraperitoneal injections before challenging with live bacteria. Blood samples were analyzed for the presence of specific IgG2a and IgG1 antibodies, as well as for the rickettsemia analysis. A panel containing the cytokines' transcriptional profile for innate and adaptive immune responses was carried out through qPCR. Immunized BALB/c mice challenged with A. marginale presented stable body weight, reduced number of infected erythrocytes, and no mortality; and among control groups mortality rates ranged from 15% to 29%. Additionally, vaccines have significantly induced higher IgG2a than IgG1 response, followed by increased expression of pro-inflammatory cytokines. This is a successful demonstration of epitope-based vaccines, and protection against anaplasmosis may be associated with elicitation of effector functions of humoral and cellular immune responses in murine model. © 2013 Santos et al. Source

Garcia C.K.Z.,Eldorado Research Institute
Communications in Computer and Information Science

This paper will demonstrate what the main benefits of applying Human Centered Design Techniques in a Scrum Project are, especially when they are used by the Product Owner. These techniques, like user observation, prototyping, user evaluation tests can be used in order to connect people to build the best solution and, when they are applied throughout the project sprints they can became a powerful tool to guarantees product success and outstanding results. © Springer International Publishing Switzerland 2015. Source

Almeida A.P.,University of Sao Paulo | Marcili A.,University of Sao Paulo | Leite R.C.,Federal University of Minas Gerais | Nieri-Bastos F.A.,University of Sao Paulo | And 3 more authors.
Ticks and Tick-borne Diseases

In the present study, the presence of tick-associated bacteria and protozoa in Ornithodoros rostratus ticks (adults, nymphs, and eggs) from the Pantanal region of Brazil were determined by molecular detection. In these ticks, DNA from protozoa in the genera Babesia and Hepatozoon, and bacteria from the genera Rickettsia, Borrelia, Anaplasma, and Ehrlichia were not detected. Conversely, all tested ticks (100%) yielded PCR products for 3 Coxiella genes (16S rRNA, pyrG, cap). PCR and phylogenetic analysis of 3 amplified genes (16S rRNA, pyrG, cap) demonstrated that the agent infecting O. rostratus ticks was a member of the genus Coxiella. This organism grouped with Coxiella symbionts of other soft tick species (Argasidae), having different isolates of C. burnetii as a sister group, and these 2 groups formed a clade that grouped with another clade containing Coxiella symbionts of hard tick species (Ixodidae). Analysis of tick mitochondrial 16S rRNA gene database composed mostly of tick species previously shown to harbor Coxiella symbionts suggests a phylogenetic congruence of ticks and their Coxiella symbionts. Furthermore, these results suggest a very long period of coevolution between ticks and Coxiella symbionts and indicates that the original infection may have occurred in an ancestor common to the 2 main tick families, Argasidae (soft ticks) and Ixodidae (hard ticks). However, this evolutionary relationship must be confirmed by more extensive testing of additional tick species and expanded populations. © 2012 Elsevier GmbH. Source

Domingues L.R.,Eldorado Research Institute | Domingues L.R.,University of Campinas | Pedrini H.,University of Campinas
Proceedings - High Performance Graphics 2015

In this paper, we present a new method for building high-quality bounding volume hierarchies (BVHs) on manycore systems. Our method is an extension of the current state-of-the-art on GPU BVH construction, Treelet Restructuring Bounding Volume Hierarchy (TRBVH), and consists of optimizing an already existing tree by rearranging subsets of its nodes using a bottom-up agglomerative clustering approach. We implemented our solution for the NVIDIA Kepler architecture using CUDA and tested it on 16 distinct scenes, most of which are commonly used to evaluate the performance of acceleration structures. We show that our implementation is capable of producing trees whose quality is on par with the ones generated by TRBVH for those scenes, while being about 30% faster to do so. © 2015 ACM. Source

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