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Ceylan C.,Elazig Research and Training Hospital | Ceylan G.G.,Firat University | Serel T.A.,Suleyman Demirel University of Turkey
Genetics and Molecular Research | Year: 2010

We looked for a possible association between Klinefelter syndrome (KFS) and microdeletions in the Y chromosome in Turkish KFS patients. We examined the frequency of KFS in male patients with proven non-obstructive azoospermia and the types of Y chromosome microdeletions in these KFS patients. Fifty azoospermic patients and 50 fertile men were included in this study. KFS was found in 14 azoospermic patients. Y chromosome microdeletions were found in eight KFS patients. Azoospermia factor locus c (AZFc) was the most commonly deleted interval in KFS patients. All KFS patients had elevated plasma follicle-stimulating hormone and luteinizing hormone concentrations, but they had normal plasma testosterone concentrations. Testis biopsy of five samples with Y microdeletions revealed Sertoli cell-only syndrome. No Y microdeletions were found in the fertile group. We concluded that there could be an association between the AZFc region and KFS. Screening for this should be part of diagnostic work-up, particularly in those considering assisted reproduction. © FUNPEC-RP.

Dostbil Z.,Dicle University | Polat C.,Elazig Research and Training Hospital | Karakus A.,Dicle University | Bakir S.,Dicle University | Yuce S.,Sivas State Hospital
Toxicology and Industrial Health | Year: 2011

Marble workers are occupationally exposed to intense environmental marble dust in their workplace. We aimed to investigate the effect of occupational marble dust exposure on nasal mucociliary transport rate (NMTR). Seventeen marble workers and 18 healthy controls were studied. In all subjects, NMTRs were measured by 99mTc-MAA rhinoscintigraphy. NMTRs of workers and control groups were compared by statistically. Mean NMTR was found as 9 ± 1.8 mm/min in marble workers whereas mean NMTR of healthy controls was 9.6 ± 2.2 mm/min. There was no statistically significant difference between NMTRs of workers and control groups (p > 0.05). This study has shown that occupationally exposured marble dusts may not cause functional impairment on NMTR in marble workshop workers. © The Author(s) 2011.

Bakar-Dertlioglu S.,Harran University | Ucak H.,Elazig Research and Training Hospital | Cicek D.,Firat University | Bitiren M.,Harran University
Turkish Journal of Pediatrics | Year: 2012

Vitiligo and psoriasis are both common diseases. However, coexistence of these two diseases is rare. The pathogenesis of the coexistence of vitiligo and psoriasis is still unknown. Herein, we report three children (11-year-old, 8-year-old, and 7-year-old females) who attended our Department of Dermatology with coexisting vitiligo and psoriasis.

Polat C.,Elazig Research and Training Hospital | Dostbil Z.,Dicle University
European Archives of Oto-Rhino-Laryngology | Year: 2010

In this study, we have investigated the effect of nasal septal deviation (NSD) on nasal mucociliary activity and how does a septoplasty operation affecs the nasal mucociliary transport rate in the first and third months during the post-operative period. Twenty-two patients who were diagnosed with NSD and 22 healthy controls were studied using rhinoscintigraphy with Tc-99m- macroaggregated albumin (Tc-99m-MAA). On each case, the nasal mucociliary transport rate (NMTR) was measured pre-operatively only on five cases, on the first and third months of post-operative period. The NMTRs of patients with a deviated septum were significantly lower than the NMTRs of the healthy controls on both the convex and concave sides. Significant improvement was observed in the first post-operative month. On the concave and convex sides, the average postop third month post-operative NMTR value was higher than the first month post-operative NMTR values. It was concluded that the septoplasty operation improves reduced NMTRs after surgery. The effect of nasal surgery on nasal mucociliary activity may be more accurately evaluated in the third month than the first month of post-operative period. © 2009 The Author(s).

Aydin S.,Firat University | Aydin S.,Elazig Research and Training Hospital | Eren M.N.,Dicle University | Sahin I.,Erzincan University | Sahin I.,Firat University
Protein and Peptide Letters | Year: 2014

Apelins are a peptide hormone known as the ligand for the G protein-coupled APJ receptor. There are many different forms of apelin in the circulation. Apelins and their receptors are expressed in the central nervous system, including the hypothalamus, and in numerous other peripheral tissues. These peptides are also synthesized in and secreted from the adipose tissues. Additionally, apelins were immunohistochemically shown to be synthesized in smooth muscle cells in the media of the left internal mammary artery (LIMA) and the saphenous vein, fibroblast cells in the media of the aorta and endothelial cells of the intima. Similarly, it was recently reported that the enzyme linked immunoassay (ELISA) measurements of apelins were similar to its immunohistochemical data in the tissues of the aorta and left internal mammary artery. Apelins which are rapidly eliminated from the circulation have a half life of less than eight minutes. The normal concentration of apelins in the human plasma ranges between 1.3 ng/mL and 246±0.045 ng/mL. Apelins serve important functions in food intake, vasopressin (anti-diuretic hormone: ADH) and histamine release, gastric acid, bicarbonate secretion and insulin secretion, diuresis, cell proliferation, angiogenesis, glucose-fluid balance and regulation of gastrointestinal motility and cardiovascular system. Therefore, this review aims to focus on the potential role of the apelin system in the balance of the cardiovascular system. © 2014 Bentham Science Publishers.

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