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Baykara M.,Elazig Training and Research Hospital | Kara G.,Elazig Training and Research Hospital
European Review for Medical and Pharmacological Sciences | Year: 2014

OBJECTIVE: The goal of this study was to analyze magnetic resonance imaging findings of gamma-amino butyric acid and gamma deuteroxy sodium butyrate and to evaluate possible "in vitro" and "in vivo" areas of use. MATERIALS AND METHODS: Materials used included gamma-amino butyric acid and gamma deuteroxy sodium butyrate which is formed by the replacement of the deuteroxy group. An amino group in the gamma position of gamma-amino butyric acid was evaluated with a standard magnetic resonance device with the power of 1.5Tesla and a brain coil. These findings have been compared. RESULTS: Gamma deuteroxy sodium butyrate has shown to have statistically different signals than gamma-amino butyric acid, 0.09 NaCl, distilled water and gadolinium chelates. CONCLUSIONS: Findings suggest that "in vivo" studies should be conducted in addition to phantom studies; Deuterium imaging may be used with or without proton imaging with technical support. Other agents may be studied for "in vivo" use following the labeling with Deuterium.

Sakallioglu O.,Elazig Training and Research Hospital
Kulak burun boǧaz ihtisas dergisi : KBB = Journal of ear, nose, and throat | Year: 2012

Basal cell adenocarcinoma (BCA) is an uncommon salivary gland neoplasm. The majority of salivary gland tumors are located in the parotid gland, while only a few involves the minor salivary gland of the oral cavity. Pathological diagnosis is important to differentiate BCA from other neoplasms, as the prognosis of the diseases is significantly different. In this article, we present a 41-year-old-male with BCA involving the upper labial mucosa.

Aykut V.,Elazig Training and Research Hospital | Oner V.,Recep Tayyip Erdoğan University | Tas M.,Malatya State Hospital | Iscan Y.,Batman State Hospital | Agachan A.,Bakirkoy Training and Research Hospital
Current Eye Research | Year: 2013

Purpose: To evaluate the influence of axial length on peripapillary retinal nerve fiber layer (RNFL) thickness in myopic, hyperopic and emmetropic children eyes by RTVue optical coherence tomography (OCT). Methods: One hundred twenty eyes of 120 children including 40 myopic, 40 emmetropic and 40 hyperopic eyes were enrolled in the study. Peripapillary RNFL thickness measurements were performed using spectral-domain RTVue OCT (Optovue, Fremont, CA). RNFL thickness parameters were obtained from all octametric sections: upper temporal (TU), superotemporal (ST), superonasal (SN), upper nasal (NU), lower nasal (NL), inferonasal (IN), inferotemporal (IT) and lower temporal (TL). Spherical equivalent refractive error was determined via cycloplegic auto-refraction (Topcon, Tokyo, Japan). The axial length was measured using IOLMaster (Carl Zeiss MEDITEC). Littmann formula was used for correction of axial length-related ocular magnification effect. Results: Peripapillary RNFL thicknesses were significantly different among the three groups in all sectors except for NU and IT sectors. RNFL thicknesses in all sectors except for TU and TL sectors had significant negative correlations with axial length. However, these differences (excluding TU and TL sectors) and correlations disappeared after correction of magnification effect. Conclusion: In conclusion, axial length influences peripapillary RNFL thickness as measured by RTVue OCT. However, this appears to be due to the ocular magnification effects associated with axial length and can be corrected for with the application of the Littman formula. © Informa Healthcare USA, Inc.

Mutlu M.F.,Gazi University | Erdem M.,Gazi University | Erdem A.,Gazi University | Yildiz S.,Gazi University | And 3 more authors.
Journal of Assisted Reproduction and Genetics | Year: 2013

Purpose: To determine the predictive value of serum anti-müllerian hormone (AMH) concentrations and antral follicle counts (AFC), on ovarian response and live birth rates after IVF and compare with age and basal FSH. Methods: Basal levels of AMH, FSH and antral follicle count were measured in 192 patients prior to IVF treatment. The predictive value of these parameters were evaluated in terms of retrieved oocyte number and live birth rates. Results: Poor responders in IVF were older, had lower AFC and AMH but higher basal FSH levels. In multivariate analysis AFC was the best and only independent parameter among other parameters and AMH was better than age and basal FSH to predict poor response to ovarian stimulation. Addition of AMH, basal FSH, age and total gonadotropin dose to AFC did not improve its prognostic reliability. Area under curve (AUC) for each parameter according to ROC analysis also revealed that AFC performed better in poor response prediction compared with AMH, basal FSH and age. The cut-off point for mean AMH and AFC in discriminating the best between poor and normal ovarian response cycles was 0.94 ng/mL (with a sensitivity of 70 % and a specificity of 86 %) and 5.5 (with a sensitivity of 91 % and a specificity of 91 %), respectively. However, age was the only independent predictor of live birth in IVF as compared to hormonal and ultrasound indices of ovarian reserve. Conclusion: AFC is better than AMH to predict poor ovarian response. Although AMH and AFC could be used to predict ovarian response they had limited value in live birth prediction. The only significant predictor of the probability of achieving a live birth was age. © 2013 Springer Science+Business Media New York.

Oner V.,Recep Tayyip Erdoğan University | Aykut V.,Elazig Training and Research Hospital | Tas M.,Batman State Hospital | Alakus M.F.,Batman State Hospital | Iscan Y.,Batman State Hospital
British Journal of Ophthalmology | Year: 2013

Aim: To evaluate the in fluence of axial length on retinal nerve fibre layer (RNFL) thickness in myopic, hyperopic and emmetropic eyes by spectral domain optical coherence tomography (OCT). Methods: Subjects were divided into three groups: myopic (n=35), emmetropic (n=30) and hyperopic eyes (n=33). RNFL thickness was obtained from all octametric section parameters by RTVue OCT. Axial length and spherical equivalent values were determined for all patients. Results: RNFL thickness values, except for lower and upper nasal sectors, were thinner in the myopic eyes than in the hyperopic eyes. Average RNFL thickness and the RNFL thicknesses of the superotemporal, superonasal, inferotemporal and lower temporal sectors were significantly different between the myopic and emmetropic eyes, and average RNFL thickness and the RNFL thicknesses of the upper temporal and inferonasal sectors were signifi cantly different between the hyperopic and emmetropic eyes. The average peripapillary RNFL thickness had a negative correlation with axial length (r= -0.741, p<0.001). However, after correction of the magnification effect, the significant differences disappeared. Conclusions: We have shown that axial length/ refractive status affected the peripapillary RNFL thickness pro file measured by RTVue OCT. To make a correct diagnosis for glaucoma, either the axial length-induced magnification effect should corrected by ophthalmologists or the RTVue OCT database should be improved by taking axial length into account.

Sakallioglu O.,Elazig Training and Research Hospital
Kulak burun boǧaz ihtisas dergisi : KBB = Journal of ear, nose, and throat | Year: 2012

Respiratory epithelial adenomatoid hamartoma (REAH) is an uncommon benign lesion of the nasal cavity and paranasal sinuses. The etiology is unclear, however it is considered to be secondary to chronic sinonasal inflammation. Although it is rare, REAH should be taken into consideration in differential diagnosis of the nasal lesions. Complete surgical excision of the lesion is generally enough for the cure. A detailed pathological examination is necessary to prevent unnecessary surgical interventions. In this article, we present a 60-year-old female patient with REAH in the left nasal cavity associated with inflammatory polyp in the right nasal cavity.

Girgin M.,Firat University | Kanat B.H.,Elazig Training and Research Hospital
Indian Journal of Surgery | Year: 2014

The aim of this study was to investigate the cure rate after a one-time phenol application for pilonidal sinus disease. Forty-eight patients diagnosed with pilonidal sinus from May 2006 to September 2009 were retrospectively reviewed. They were all managed under the same polyclinic conditions in different hospitals by the same surgeon under local anesthesia. Crystallized phenol was applied a total of 97 times on 48 patients. The median follow-up was 22 months (range, six to 38 months). Two patients (4 %) could not participate in the follow-up. One of these patients had 12 sinuses and didn't continue treatment after eight applications of phenol, and the other had nine sinuses and didn't continue treatment after five applications of phenol. The one-time application cure rate was 64.5 %, and the rate of success was 95 % with two or more applications. Recurrence did not occur during this period. A one-time phenol application is an effective treatment for pilonidal sinus disease. Hence, it can be an alternative to surgical treatment. © 2012 Association of Surgeons of India.

Ceylan C.,Clinic of Turkiye Yuksek Ihtisas Training and Research Hospital | Doluoglu O.G.,Ankara Nuclear Research And Training Center | Aglamis E.,Elazig Training and Research Hospital | Baytok O.,Clinic of Turkiye Yuksek Ihtisas Training and Research Hospital
Journal of the Canadian Urological Association | Year: 2014

Introduction: In this study, we evaluate the relationship between increasing core numbers and cancer detection rate. Methods: We included 1120 patients with prostate-specific antigen levels ≤20 ng/mL and/or suspicious digital rectal examination findings in this study. All patients had a first-time prostate biopsy and 8, 10, 12, 16, and 20 core biopsies were taken and examined in different groups during the study. Multiple logistic regression analysis was made to reach the factor affecting the cancer detection rate between the patients with and without cancer. A p < 0.05 was considered statistically significant. Results: Out of 1120 patients, 221 (19.7%) had prostate cancer. Again of the total 1120 patients, 8 core biopsies were taken from 229 (20.4%); 10 core biopsies from 473 (42.2%); 12 core biopsies from 100 (8.9%); 16 core biopsies from 140 (12.5%); and 20 core biopsies from 178 (15.9%) patients. The increase in the core number increased the cancer detection rate by 1.06 times (p = 0.008). Conclusions: As long as prostate volume increases, increasing the core number elevates the cancer detection rate. Thus, the rate of missed cancer will be reduced and the rates of unnecessary repetitive biopsy decreases. © 2014 Canadian Urological Association.

Mutlu I.,Elazig Training and Research Hospital | Demir A.,Elazig Training and Research Hospital | Mutlu M.F.,HRS Women Hospital
European Journal of Contraception and Reproductive Health Care | Year: 2014

Objectives To evaluate the predictive value of uterine artery Doppler characteristics in predicting copper intrauterine device (IUD)-induced side effects such as dysmenorrhoea and menorrhagia, and worsening of dyspareunia. Methods One hundred and twenty regularly menstruating women were enrolled in the study. All underwent transvaginal uterine artery Doppler analysis in the early follicular phase, on two occasions: before insertion of the IUD, and six months after insertion. Pre- and post-insertion resistance (RI) and pulsatility (PI) indices of the uterine arteries were measured. Doppler parameters were compared between subjects experiencing an increase in IUD-mediated side effects and those reporting no change. Results RI and PI of all participants before and after IUD insertion were not significantly different (0.75 ± 0.06 vs. 0.74 ± 0.09, p = 0.49; 1.81 ± 0.55 vs. 1.83 ± 0.70, p = 0.7, respectively). No significant difference was found in the comparison of pre- and post-insertion PI and RI values of women who had increased- and those who experienced no change in dysmenorrhoea, dyspareunia and duration/amount of menstruation. Conclusions No major changes in uterine blood flow were observed in women experiencing increased menstrual bleeding, dyspareunia or dysmenorrhoea after insertion of a copper IUD. The occurrence of these effects cannot be predicted by prior Doppler flow analysis. © 2014 The European Society of Contraception and Reproductive Health.

Elbuken F.,Elazig Training and Research Hospital | Baykara M.,Elazig Training and Research Hospital | Ozturk C.,Elazig Training and Research Hospital
Singapore Medical Journal | Year: 2012

Introduction The morphology of the proximal femur has often been investigated in the literature, but the normal population ranges and standard deviations have still not been determined for this area. This study aimed to determine the age-, gender- and body mass index (BMI)-related changes in the femoral neck, especially on the neck-shaft angle, by using dual-energy X-ray absorptiometry (DXA) measurements. Method s Retrospective analyses of DXA images of the proximal femur from 18,943 individuals aged 20-108 years were performed. The age, gender, weight and height of each individual were obtained at the time of bone measurement. Data on theta angle were obtained from DXA measurements. Simple linear regression analysis and Pearson's correlation coefficients were used to investigate the relationships between theta and age, gender and BMI. Results There was a significant correlation between theta and age (p < 0.001). We also found a significant difference between the various age groups using analysis of variance (p < 0.001), but there was no meaningful correlation between theta and BMI (p = 0.377) and the BMI groups (p = 0.180). There were small but statistically significant differences in the neck-shaft angle between males and females (p < 0.05). Conclusion In this study, DXA-based measurements were used and many parameters of proximal femur geometry were calculated with limited radiation exposure. We have demonstrated that the mean neck-shaft angle is greater in males than in females, and that theta increases with age. We also found a significant difference between different age groups, but no meaningful correlation between theta and BMI.

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