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San Francisco, CA, United States

Rudewicz P.J.,Elan Pharmaceuticals Inc.
Bioanalysis | Year: 2011

Turbulent flow chromatography (TFC) as an analytical technique was introduced in the mid-1990s for online sample processing in bioanalysis. Turbulent flow columns are packed with large particles permitting the use of high mobile phase linear velocities. Solute molecules travel in a uniform concentrated band in which large matrix biomolecules are effectively separated from lower molecular weight analytes by differential mass transfer effects. In addition, the use of various bonded stationary phases enhances selectivity in TFC separations. Originally, the turbulent flow column was used for both online sample processing and the analytical separation. This mode of operation has largely been replaced with a dual column arrangement, in which sample processing is done online with the turbulent flow column and a second analytical column is employed for separation. Within the pharmaceutical industry, certain laboratories now use TFC routinely for bioanalytical support of in vivo drug discovery pharmacokinetic studies. Validated TFC methods are also used to support GLP-compliant preclinical toxicokinetic studies and clinical trials. TFC has been shown to simplify bioanalytical sample preparation and reduce sample processing costs when compared with offline techniques such as SPE. TFC may be combined with multiplexing up to four HPLC systems to a single mass spectrometer to increase analytical throughput. © 2011 Future Science Ltd. Source


Compounds are provided having a structure according to Formula (I): wherein A


Patent
Elan Pharmaceuticals Inc. | Date: 2014-03-12

The present invention provides compounds having a structure according to Formula I. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinsons disease.


Patent
Elan Pharmaceuticals Inc. | Date: 2013-04-17

The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, X, R


Patent
Elan Pharmaceuticals Inc. | Date: 2015-01-14

The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, X, R

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