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Liang X.-J.,Jinan University | Huang S.-M.,Jinan University | Li J.-P.,Eighth Peoples Hospital of Guangzhou | Zhu X.-N.,Second Peoples Hospital of Yuebei | And 4 more authors.
Clinical Laboratory | Year: 2014

Background: Scrub typhus is a potentially fatal infectious disease caused by Orientia tsutsugamushi. There is little attention given to hepatic impairment in the adults with scrub typhus. This study investigated the incidence and the prognostic implications of hepatic impairment in patients with scrub typhus. Methods: We retrospectively reviewed a total of 143 adult patients with scrub typhus who were admitted between January 1999 and December 2010 in Guangdong province, China. The patients were divided into three groups, e.g., normal, mild, and moderate to severe groups based on the elevated serum ALT and/or total bilirubin levels. Furthermore, clinical characteristics and prognosis of the patient groups were compared. Results: 109 patients (76.2%) had abnormal liver function. Among the patients with hepatic impairment 45 cases (31.4%), 54 cases (37.8%), and 10 cases (7.0%) had mild, moderate, and severe hepatic damage, respectively. The moderate to severe hepatic impairment group had higher levels of serum creatinine compared with that of normal hepatic function. The incidence of new onset of renal dysfunction - defined as peak serum creatinine ≥ 176 μmol/L during hospital stay with no evidence of renal disease prior hospitalization - was 0% in the mild hepatic impairment group, 8.9% in the moderate hepatic impairment group, and 21.9% in the severe hepatic impairment group, (p = 0.005 for trend). Additionally, the patients with hepatic impairment (n = 109) had higher incidences of episodes of thrombocytopenia (45.9% vs. 8.82%, p < 0.001), hypoalbuminemia (50.5% vs. 11.8%, p < 0.001), new onset of renal dysfunction (16.5% vs. 0.0%, p = 0.011), and electrocardiogram abnormality (28.4% vs. 8.82%, p = 0.019) than the patients without hepatic impairment. Conclusions: The degree of hepatic impairment induced by scrub typhus is associated with new onset of renal dysfunction. Source


Cai H.-X.,Sun Yat Sen University | Cheng H.-L.,Sun Yat Sen University | Song J.-W.,Eighth Peoples Hospital of Guangzhou | Chen S.-Y.,Sun Yat Sen University
Experimental and Therapeutic Medicine | Year: 2014

The aim of the present study was to compare the root canal preparation ability of rotary nickel-titanium (NiTi) Hero 642 and K3 files in curved mandibular or maxillary molars. A total of 40 extracted mandibular molars with two separate mesial canals, an apical width of approximately size ≤15 and a root canal curvature of 15-30 ° were randomly divided into two groups and instrumented using Hero 642 (n=20) or K3 files (n=20). Canal straightening, working length, transportation, cross-sectional area, minimum dentin thickness and the canal angle curvature degree were examined, and a systematic review of the literature was conducted. No statistically significant differences were observed between the two groups with regard to the mean degree of straightening, mean change in working length, mean transportation, amount of dentin removed or remaining minimum dentin thickness (P>0.05). The canal angle curvature decreased in the two groups postoperatively. The systematic review identified six studies, and overall the two files performed similarly in the majority of categories examined. Therefore, the rotary NiTi Hero 642 and K3 files demonstrated comparable shaping abilities and maintenance of working length. Source


Liu Y.,U.S. Center for Disease Control and Prevention | Liu Y.,Sun Yat Sen University | Tam Y.H.,University of Hong Kong | Yuan J.,U.S. Center for Disease Control and Prevention | And 13 more authors.
PLoS ONE | Year: 2015

Foodborne outbreaks caused by a mixed infection of Vibrio parahaemolyticus and norovirus have rarely been described. We reported a mixed outbreak of Vibrio parahaemolyticus and norovirus causing acute gastroenteritis in 99 staff members of a company in Guangdong, China, in May 2013, following consumption of roasted duck, an uncommon non-seafood vehicle for such mixed infection, in one meal served in the company's catering service. Epidemiological and laboratory findings indicated that a single asymptomatic food handler was the source of both pathogens, and the high rate of infection of both pathogens was exacerbated by the setting's suboptimal food hygiene practice. © 2015 Liu et al. Source


Li Z.,Eighth Peoples Hospital of Guangzhou
Nan fang yi ke da xue xue bao = Journal of Southern Medical University | Year: 2011

To investigate the optimal perioperative management of HIV infection/AIDS in surgical patients in the department of gynecology and obstetrics. Fifty-seven surgical patients with HIV infection or AIDS were studies. Before the operations, the patients were treated with highly active anti-retroviral therapy (HAART), and the surgical approach was determined according to the level of CD4(+) T lymphocytes. The operations were performed strictly following the standard procedures with careful operation to reduce surgical injuries. Routine antibiotics were administered to prevent postoperative infections. The white blood cell count, hemoglobin and CD4(+) T lymphocytes recorded pre- and postoperatively were analyzed for evaluation of the perioperative management and therapeutic effects. With these perioperative managements, the white blood cells and CD4(+) T lymphocytes showed no significant changes after the operation (P>0.05) and no wound infections or opportunistic infections were found in these cases. Appropriate perioperative management can ensure surgical success in patients with HIV infection or AIDS in the department of gynecology and obstetrics. Source


Liao Q.,University of Hong Kong | Yuan J.,U.S. Center for Disease Control and Prevention | Lau E.H.Y.,University of Hong Kong | Chen G.Y.,U.S. Center for Disease Control and Prevention | And 13 more authors.
PLoS ONE | Year: 2015

Background A novel avian-origin influenza A(H7N9) caused a major outbreak in Mainland China in early 2013. Exposure to live poultry was believed to be the major route of infection. There are limited data on how the general public changes their practices regarding live poultry exposure in response to the early outbreak of this novel influenza and the frequency of population exposure to live poultry in different areas of China. Methodology This study investigated population exposures to live birds from various sources during the outbreak of H7N9 in Guangzhou city, China in 2013 and compared them with those observed during the 2006 influenza A(H5N1) outbreak. Adults were telephone-interviewed using two-stage sampling, stratified by three residential areas of Guangzhou: urban areas and two semi-rural areas in one of which (Zengcheng) A(H7N9) virus was detected in a chicken from wet markets. Logistic regression models were built to describe practices protecting against avian influenza, weighted by age and gender, and then compare these practices across residential areas in 2013 with those from a comparable 2006 survey. Principal Findings Of 1196 respondents, 45% visited wet markets at least daily and 22.0% reported buying live birds from wet markets at least weekly in April-May, 2013, after the H7N9 epidemic was officially declared in late March 2013. Of those buying live birds, 32.3%reported touching birds when buying and 13.7%would slaughter the poultry at home. Although only 10.1% of the respondents reported raising backyard birds, 92.1% of those who did so had physical contact with the birds they raised. Zengcheng respondents were less likely to report buying live birds from wet markets, but more likely to buy from other sources when compared to urban respondents. Compared with the 2006 survey, the prevalence of buying live birds from wet markets, touching when buying and slaughtering birds at home had substantially declined in the 2013 survey. Conclusion/Significance Although population exposures to live poultry were substantially fewer in 2013 compared to 2006, wet markets and backyard poultry remained the two major sources of live bird exposures for the public in Guangzhou in 2013. Zengcheng residents seemed to have reduced buying live birds from wet markets but not from other sources in response to the detection of H7N9 virus in wet markets. © 2015 Liao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Source

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