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PubMed | First Peoples Hospital of Foshan, Eighth Peoples Hospital of Guangzhou and Central Hospital of Panyu District
Type: | Journal: Neuroscience | Year: 2016

The mechanism underlying neuropathic pain (NP) is complex and has not been fully elucidated. The TWIK-related spinal cord K


Liu Y.,U.S. Center for Disease Control and Prevention | Liu Y.,Sun Yat Sen University | Tam Y.H.,University of Hong Kong | Yuan J.,U.S. Center for Disease Control and Prevention | And 13 more authors.
PLoS ONE | Year: 2015

Foodborne outbreaks caused by a mixed infection of Vibrio parahaemolyticus and norovirus have rarely been described. We reported a mixed outbreak of Vibrio parahaemolyticus and norovirus causing acute gastroenteritis in 99 staff members of a company in Guangdong, China, in May 2013, following consumption of roasted duck, an uncommon non-seafood vehicle for such mixed infection, in one meal served in the company's catering service. Epidemiological and laboratory findings indicated that a single asymptomatic food handler was the source of both pathogens, and the high rate of infection of both pathogens was exacerbated by the setting's suboptimal food hygiene practice. © 2015 Liu et al.


Cai H.-X.,Sun Yat Sen University | Cheng H.-L.,Sun Yat Sen University | Song J.-W.,Eighth Peoples Hospital of Guangzhou | Chen S.-Y.,Sun Yat Sen University
Experimental and Therapeutic Medicine | Year: 2014

The aim of the present study was to compare the root canal preparation ability of rotary nickel-titanium (NiTi) Hero 642 and K3 files in curved mandibular or maxillary molars. A total of 40 extracted mandibular molars with two separate mesial canals, an apical width of approximately size ≤15 and a root canal curvature of 15-30 ° were randomly divided into two groups and instrumented using Hero 642 (n=20) or K3 files (n=20). Canal straightening, working length, transportation, cross-sectional area, minimum dentin thickness and the canal angle curvature degree were examined, and a systematic review of the literature was conducted. No statistically significant differences were observed between the two groups with regard to the mean degree of straightening, mean change in working length, mean transportation, amount of dentin removed or remaining minimum dentin thickness (P>0.05). The canal angle curvature decreased in the two groups postoperatively. The systematic review identified six studies, and overall the two files performed similarly in the majority of categories examined. Therefore, the rotary NiTi Hero 642 and K3 files demonstrated comparable shaping abilities and maintenance of working length.


PubMed | Eighth Peoples Hospital of Guangzhou, Zhongshan Second Peoples Hospital, Sun Yat Sen University and Panyu Peoples Hospital
Type: Clinical Trial, Phase III | Journal: PloS one | Year: 2015

The optimal treatment of hepatitis C virus (HCV) genotype 6 is unclear owing to its limited geographic distribution. Because of a high predictive value of rapid virological response (RVR) for sustained virological response (SVR), we conducted an open-label randomized controlled trial to compare 24- and 48-week peginterferon/ribavirin combination therapy for patients with HCV genotype 6 in Southern China who achieved an RVR.Treatment-naive, non-cirrhotic patients with chronic hepatitis C genotype 6 were treated with pegylated interferon -2a (180 g/week) and ribavirin (800-1,200 mg, according to weight) for 4 weeks. Patients who achieved an RVR, which was defined as HCV RNA negativity at week 4 (<50 IU), were randomized to receive either an additional 20 or 44 weeks of treatment (24- and 48-week treatment groups, respectively). The primary outcome measure was SVR. From January 2011 to June 2014, 152(152/210, 72.4%) patients with HCV genotype 6a and RVR were randomized 1:1 to the 24- or 48-week treatment group. The SVR rates in the 24- and 48-week groups in the intention-to-treat analysis were 90.8% (69/76) and 88.2% (67/76), respectively; those in the per-protocol analysis were 95.7% (67/70) and 97.0% (64/66), respectively. More patients in the 48-week group had anemia (46.1% vs. 28.9%, P = 0.03), but other adverse events were comparable between the groups. The limitation of the present study was that only patients from Southern China were enrolled which may inhibit the extensive application of the findings.Twenty-four weeks of peginterferon/ribavirin combination therapy was non-inferior to 48 weeks in patients with HCV genotype 6a in Southern China who achieved an RVR.ClinicalTrials.gov NCT01263860.


PubMed | Eighth Peoples Hospital of Guangzhou and Sun Yat Sen University
Type: Journal Article | Journal: Experimental and therapeutic medicine | Year: 2014

The aim of the present study was to compare the root canal preparation ability of rotary nickel-titanium (NiTi) Hero 642 and K3 files in curved mandibular or maxillary molars. A total of 40 extracted mandibular molars with two separate mesial canals, an apical width of approximately size 15 and a root canal curvature of 15-30 were randomly divided into two groups and instrumented using Hero 642 (n=20) or K3 files (n=20). Canal straightening, working length, transportation, cross-sectional area, minimum dentin thickness and the canal angle curvature degree were examined, and a systematic review of the literature was conducted. No statistically significant differences were observed between the two groups with regard to the mean degree of straightening, mean change in working length, mean transportation, amount of dentin removed or remaining minimum dentin thickness (P>0.05). The canal angle curvature decreased in the two groups postoperatively. The systematic review identified six studies, and overall the two files performed similarly in the majority of categories examined. Therefore, the rotary NiTi Hero 642 and K3 files demonstrated comparable shaping abilities and maintenance of working length.


Liang X.-J.,Jinan University | Huang S.-M.,Jinan University | Li J.-P.,Eighth Peoples Hospital of Guangzhou | Zhu X.-N.,Second Peoples Hospital of Yuebei | And 4 more authors.
Clinical Laboratory | Year: 2014

Background: Scrub typhus is a potentially fatal infectious disease caused by Orientia tsutsugamushi. There is little attention given to hepatic impairment in the adults with scrub typhus. This study investigated the incidence and the prognostic implications of hepatic impairment in patients with scrub typhus. Methods: We retrospectively reviewed a total of 143 adult patients with scrub typhus who were admitted between January 1999 and December 2010 in Guangdong province, China. The patients were divided into three groups, e.g., normal, mild, and moderate to severe groups based on the elevated serum ALT and/or total bilirubin levels. Furthermore, clinical characteristics and prognosis of the patient groups were compared. Results: 109 patients (76.2%) had abnormal liver function. Among the patients with hepatic impairment 45 cases (31.4%), 54 cases (37.8%), and 10 cases (7.0%) had mild, moderate, and severe hepatic damage, respectively. The moderate to severe hepatic impairment group had higher levels of serum creatinine compared with that of normal hepatic function. The incidence of new onset of renal dysfunction - defined as peak serum creatinine ≥ 176 μmol/L during hospital stay with no evidence of renal disease prior hospitalization - was 0% in the mild hepatic impairment group, 8.9% in the moderate hepatic impairment group, and 21.9% in the severe hepatic impairment group, (p = 0.005 for trend). Additionally, the patients with hepatic impairment (n = 109) had higher incidences of episodes of thrombocytopenia (45.9% vs. 8.82%, p < 0.001), hypoalbuminemia (50.5% vs. 11.8%, p < 0.001), new onset of renal dysfunction (16.5% vs. 0.0%, p = 0.011), and electrocardiogram abnormality (28.4% vs. 8.82%, p = 0.019) than the patients without hepatic impairment. Conclusions: The degree of hepatic impairment induced by scrub typhus is associated with new onset of renal dysfunction.


Xiao Y.-H.,Central South University | Xiao Y.-H.,Eighth Peoples Hospital of Guangzhou | Li X.-H.,Central South University | Tan T.,Central South University | And 11 more authors.
Journal of Cancer Research and Clinical Oncology | Year: 2011

Purpose: To identify methylation-silenced genes in acute myeloid leukemia (AML). Methods: Microarray analyses were performed in AML cell line HL-60 cells exposed to the demethylating agent 5-aza-2dC. The methylation status and expression of glioma pathogenesis-related protein 1 (GLIPR1), one of highly induced genes by demethylation, were further detected in six hematopoietic malignancy cell lines and 260 bone marrow samples from leukemia patients and nonmalignant diseases as control, as well as pre-treated and post-treated bone marrow samples from 24 complete remission AML patients received chemotherapy using MS-PCR, bisulfite DNA sequencing, RT-PCR, and Western blotting. Results: One hundred and nine genes were significantly induced by demethylation in HL-60 cells, 12 genes of which were confirmed by RT-PCR. GLIPR1, a tumor suppressor gene, was frequently methylation-silenced in AML cell lines and AML patients, but not in the other hematopoietic malignancy cell lines and patients. The frequencies of methylation-silenced GLIPR1 in the pre-treatment were significantly higher than those in the post-treatment in complete remission AML patients. Conclusion: We identify 109 genes induced by demethylation in HL-60 cells, and demonstrate that GLIPR1 is a methylation-silenced gene in the AML patients, and may serve as a marker for monitoring disease activity during therapy in the AML patients. The data provide the important information for studying the pathogenesis of AML and discovering the target genes of methylating agents. © 2011 Springer-Verlag.


Li Z.,Eighth Peoples Hospital of Guangzhou
Nan fang yi ke da xue xue bao = Journal of Southern Medical University | Year: 2011

To investigate the optimal perioperative management of HIV infection/AIDS in surgical patients in the department of gynecology and obstetrics. Fifty-seven surgical patients with HIV infection or AIDS were studies. Before the operations, the patients were treated with highly active anti-retroviral therapy (HAART), and the surgical approach was determined according to the level of CD4(+) T lymphocytes. The operations were performed strictly following the standard procedures with careful operation to reduce surgical injuries. Routine antibiotics were administered to prevent postoperative infections. The white blood cell count, hemoglobin and CD4(+) T lymphocytes recorded pre- and postoperatively were analyzed for evaluation of the perioperative management and therapeutic effects. With these perioperative managements, the white blood cells and CD4(+) T lymphocytes showed no significant changes after the operation (P>0.05) and no wound infections or opportunistic infections were found in these cases. Appropriate perioperative management can ensure surgical success in patients with HIV infection or AIDS in the department of gynecology and obstetrics.


Guan W.,Eighth Peoples Hospital of Guangzhou | Liu J.,Eighth Peoples Hospital of Guangzhou | Zhang L.,Eighth Peoples Hospital of Guangzhou | Chen B.,Eighth Peoples Hospital of Guangzhou | And 5 more authors.
Chinese Journal of Radiology (China) | Year: 2015

Objective: To study the chest imaging manifestations of mycobacterium avium-intracellulare complex (MAC) infection in patients with acquired immunodeficiency syndrome (AIDS). Methods: Thirty-one cases of proven AIDS and MAC infection were included in the study. Imaging findings and clinical data of the patients were retrospectively analyzed. Results: All 31 patients underwent chest X-ray and/or chest CT examination, three patients were normal, 28 patients showed findings of lung infection. The chest CT imaging findings of MAC lung infection in AIDS patients were similar with pulmonary TB, including air space consolidation (21 cases) with three cases of large consolidation, bronchiectasis (18 cases), nodules (18 cases), miliary nodules (10 cases), cavities (10 cases), pleural effusion (10 cases), predominantly moderately enlarged mediastinal lymph nodes (15 cases), and enlarged hilus lymph nodes (7 cases). Conclusions: The imaging manifestations of MAC infection in AIDS patients were varied and atypical. Air space consolidation, small nodules and bronchiectasis were the main CT manifestations of MAC pulmonary disease. Copyright © 2015 by the Chinese Medical Association


PubMed | Eighth Peoples Hospital of Guangzhou
Type: Journal Article | Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University | Year: 2011

To investigate the optimal perioperative management of HIV infection/AIDS in surgical patients in the department of gynecology and obstetrics.Fifty-seven surgical patients with HIV infection or AIDS were studies. Before the operations, the patients were treated with highly active anti-retroviral therapy (HAART), and the surgical approach was determined according to the level of CD4(+) T lymphocytes. The operations were performed strictly following the standard procedures with careful operation to reduce surgical injuries. Routine antibiotics were administered to prevent postoperative infections. The white blood cell count, hemoglobin and CD4(+) T lymphocytes recorded pre- and postoperatively were analyzed for evaluation of the perioperative management and therapeutic effects.With these perioperative managements, the white blood cells and CD4(+) T lymphocytes showed no significant changes after the operation (P>0.05) and no wound infections or opportunistic infections were found in these cases.Appropriate perioperative management can ensure surgical success in patients with HIV infection or AIDS in the department of gynecology and obstetrics.

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