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Matsuyama, Japan

Ehime University is a Japanese national university in Matsuyama, Ehime, Japan. The university has one of the largest student populations in the Shikoku region.After Japan's defeat in World War II, Aidai was established in May 1949 among many other national universities by the Japanese government during the reformation of the education system. The university originally had three Faculties : Humanities and Science, Education, and Engineering; which were consolidated from Matsuyama National High School , Ehime Prefectural Teachers School , Ehime Prefectural Youth Teachers School , and Ehime Prefectural Niihama Technical School .Today, the university has six faculties and five graduate schools. Wikipedia.


Riboswitches are RNA elements in mRNA that control gene expression in cis in response to their specific ligands. Because artificial riboswitches make it possible to regulate any gene with an arbitrary molecule, they are expected to function as biosensors, in which the output is easily detectable protein expression. I report herein a fully rational design strategy for artificially constructing novel riboswitches that work in a eukaryotic cell-free translation system (wheat germ extract). In these riboswitches, translation mediated by an internal ribosome entry site (IRES) is promoted only in the presence of a specific ligand (ON), while it is inhibited in the absence of the ligand (OFF). The first rationally designed riboswitch, which is regulated by theophylline, showed a high switching efficiency and dependency on theophylline. In addition, based on the design of the theophylline-dependent riboswitch, other three kinds of riboswitches controlled by FMN, tetracycline, and sulforhodamine B, were constructed only by calculating the ΔG value of one stem - loop structure. The rational design strategy described herein is therefore useful for easily producing various ligand-dependent riboswitches, which are available as biosensors for detecting their ligands. Published by Cold Spring Harbor Laboratory Press. Copyright © 2011 RNA Society. Source


Patent
Ehime University and Otsuka Pharmaceutical Factory Inc. | Date: 2014-12-16

The present invention provides an easy and rapid method for detecting/identifying the presence or absence of specific


The purpose of the present invention is to provide a method for treating autoimmune diseases. Disclosed is a method or the like for the treatment of autoimmune diseases, which utilizes an antigen-specific tolerogenic antigen presenting cell. Specifically disclosed are: a method for producing an antigen-specific tolerogenic antigen presenting cell, which is characterized by using carbonic anhydrase I; an immunogenic antigen presenting cell which is specific to carbonic anhydrase I; and a method or the like for the treatment of autoimmune diseases (especially inflammatory bowel diseases), which is characterized by using a tolerogenic antigen presenting cell which is specific to carbonic anhydrase I.


Patent
Otsuka Pharmaceutical Factory Inc. and Ehime University | Date: 2014-12-16

The present invention provides an easy and rapid method for detecting/identifying the presence or absence of specific


Patent
Ehime University and ABIES Co. | Date: 2015-02-27

Due to the recent problems of higher fuel costs and exhaustion of marine resources, fish meal-free feeds have been developed. However, these feeds are insufficient from the standpoints of feed-intake and growth of fishes. Also, there has been required a feed which can economically and easily prevent or treat fish diseases and, even in the case of given in a reduced amount, ensures efficacious fish growth without disturbing the growth of fishes. Disclosed is a feed containing fly pupae and/or fly larvae. This feed can be taken at a high feeding rate by fishes, promotes the growth of the fishes having taken the same and exerts an effect of activating the immunity of the fishes.

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