Egyptian Russian University
Cairo, Egypt

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Shahbunder H.,Ain Shams University | Shahbunder H.,University of the Humanities | Hafez N.,Egyptian Russian University
Progress in Nuclear Energy | Year: 2017

Minor actinide recycling and transmutation are important stages in the advanced nuclear systems design such as Generation IV reactors that offers a high level of safety, waste reduction, and minimizes its environmental and radiological impacts. In the present work, two preliminary model configurations are used to examine the effects of adding two long-lived isotopes of minor actinides (243Am and 247Cm) in MINERVE reactor reference core (R1-UO2) that represents a LWR loaded with UO2 fuel rods. The effects are studied in two models of uniform and nonuniform minor actinides distributions, and include the numerical evaluation of neutronic parameters such as neutron spectrum, flux distribution and fission rate, using MCNPX transport code. The analysis of and comparison between the uniform and nonuniform models have been discussed to evaluate which of either is expected to be favored for minor actinide transmutation and energy production. © 2017 Elsevier Ltd.

Zainud-Deen S.H.,Menoufia University | Malhat H.A.,Menoufia University | Gaber S.M.,Egyptian Russian University | Ibrahim M.,MUST University | Awadalla K.H.,Menoufia University
Plasmonics | Year: 2013

This paper investigates the design of four different configurations of plasma reflectarrays. The results provide insight into different radiation characteristics of plasma reflectarrays. The proposed unit cell consists of a cubic glass box filled with argon gas energized with applied AC voltage. The reflectarray reflection coefficient phase variation is achieved by varying the plasma frequency of the energized gas. Four plasma reflectarrays for satellite applications at 12 GHz are proposed (centre feed centre beam, centre feed offset beam, offset feed centre beam, and finally, offset feed offset beam). The finite integration technique is used to analyse the plasma reflectarray. © 2013 Springer Science+Business Media New York.

Barakat E.M.F.,Ain Shams University | El Wakeel L.M.,Ain Shams University | Hagag R.S.,Egyptian Russian University
World Journal of Gastroenterology | Year: 2013

AIM: To evaluate the safety, efficacy and tolerability of Nigella sativa (N. sativa) in patients with hepatitis C not eligible for interferon (IFN)-α. METHODS: Thirty patients with hepatitis C virus (HCV) infection, who were not eligible for IFN/ribavirin therapy, were included in the present study. Inclusion criteria included: patients with HCV with or without cirrhosis, who had a contraindication to IFN-α therapy, or had refused or had a financial constraint to IFN-α therapy. Exclusion criteria included: patients on IFN-α therapy, infection with hepatitis B or hepatitis I virus, hepatocellular carcinoma, other malignancies, major severe illness, or treatment non-compliance. Various parameters, including clinical parameters, complete blood count, liver function, renal function, plasma glucose, total antioxidant capacity (TAC), and polymerase chain reaction, were all assessed at baseline and at the end of the study. Clinical assessment included: hepato and/ or splenomegaly, jaundice, palmar erythema, flapping tremors, spider naevi, lower-limb edema, and ascites. N. sativa was administered for three successive months at a dose of (450 mg three times daily). Clinical response and incidence of adverse drug reactions were assessed initially, periodically, and at the end of the study. RESULTS: N. sativa administration significantly improved HCV viral load (380808.7 ± 610937 vs 147028.2 ± 475225.6, P = 0.001) and TAC (1.35 ± 0.5 vs 1.612 ± 0.56, P = 0.001). After N. sativa administration, the following laboratory parameters improved: total protein (7.1 ± 0.7 vs 7.5 ± 0.8, P = 0.001), albumin (3.5 ± 0.87 vs 3.69 ± 0.91, P = 0.008), red blood cell count (4.13 ± 0.9 vs 4.3 ± 0.9, P = 0.001), and platelet count (167.7 ± 91.2 vs 198.5 ± 103, P = 0.004). Fasting blood glucose (104.03 ± 43.42 vs 92.1 ± 31.34, P = 0.001) and postprandial blood glucose (143.67 ± 72.56 vs 112.1 ± 42.9, P = 0.001) were significantly decreased in both diabetic and non-diabetic HCV patients. Patients with lower-limb edema decreased significantly from baseline compared with after treatment [16 (53.30%) vs 7 (23.30%), P = 0.004]. Adverse drug reactions were unremarkable except for a few cases of epigastric pain and hypoglycemia that did not affect patient compliance. CONCLUSION: N. sativa administration in patients with HCV was tolerable, safe, decreased viral load, and improved oxidative stress, clinical condition and glycemic control in diabetic patients. © 2013 Baishideng. All rights reserved.

Zainud-Deen S.H.,Menoufia University | Malhat H.A.,Menoufia University | Gaber S.M.,Egyptian Russian University | Awadalla K.H.,Menoufia University
Plasmonics | Year: 2014

The aim of this paper is to design and analyze plasma reflectarray/transmitarray antennas which include investigation of performance parameters for these antennas in free space. The unit cell element for both arrays consists of a cubic glass box with fixed dimensions filled by argon gas. The plasma frequency of the argon gas is varied by changing the applied voltage at both ends of the glass box. This allows steering the reflected/transmitted wave to a certain direction. Full-wave simulations using the finite element method (FEM) and finite integral technique (FIT) are used to optimize and analyze different plasma reflectarray and plasma transmitarray antennas. The plasma reflectarray antenna is composed of 13×13 elements and covered an area of 208×208 mm2. A circular horn is used to feed the antenna at a distance of 20.8 cm (focal-to-diameter ratio (F/D)=1). The reflectarray is designed at f=12 GHz. The radiation patterns of the plasma reflectarray for scanning angles of 10° to 70° angles are illustrated. For larger scanning angles, significant sidelobe levels are produced. The maximum value of beam scanning gain patterns is reduced. The half-power beamwidth (HPBW) is increased. The plasma transmitarray is composed of 9×9 cell elements and covered an area of 72×72 mm2. The feed is a linearly polarized circular horn. The F/D ratio is set to 1. The transmitarray is operating at f=15 GHz. The radiation patterns of the plasma transmitarray for scanning angles of -40° to + 40° are demonstrated. Significant sidelobe levels are produced at large scanning angles. © Springer Science+Business Media New York 2013.

El-Mesallamy H.O.,Ain Shams University | Hamdy N.M.,Ain Shams University | Ezzat O.A.,Egyptian Russian University | Reda A.M.,Egyptian Russian University
Journal of Investigative Medicine | Year: 2011

Objective: Advanced glycation end products (AGEs) and the interaction with their receptors (RAGE) play an important role in the pathogenesis of diabetic foot (DF) associated with diabetic neuropathy. Our study examined the association between asymmetric dimethyl arginine (ADMA), fructosamine, nitric oxide (NO), and soluble (s) RAGE levels in serum of diabetic patients with and without neuropathy. Methods: Circulating levels of ADMA, fructosamine, NO, and sRAGE, estimated either chemically or by enzyme-linked immunosorbent assay, were examined in 60 type 2 diabetes mellitus (T2DM) overweight/obese (body mass index, 30.5 ± 1.5 kg/m 2) male patients and 20 age-matched (55 T 3 years) obese healthy subjects as control group. The T2DM subjects were categorized as patients without DF (n = 30), and the remaining were patients with DF associated with neuropathy. Results: First sRAGE levels were significantly increased in T2DM patients without DF in comparison to healthy controls (1656.6 [1198.8-2065.4] vs 1111.7 [909-1605.3] pg/mL, respectively; P < 0.05). However, in the DF group (1049.6 [783.7-1221.8] pg/mL), its level decreased significantly in comparison to both groups (P G 0.05). However, ADMA and fructosamine were significantly higher in diabetic patients with DF than both T2DM without DF and healthy controls. Moreover, NO was significantly lower in DF than in diabetic patients without DF and controls (5 T 0.4 and 8 T 0.4 vs 42 T 2.5 Kmol/L, respectively; P G 0.05). Finally, sRAGE levels were significantly correlated with ADMA, fructosamine, and NO. Conclusions: Soluble forms of the receptor for advanced glycation end product could be an endogenous protection factor against occurrence of DF, hence may be of therapeutic value in the treatment of DF. © 2011 by The American Federation for Medical Research.

Saeed A.,Egyptian Russian University | Elbashar Y.H.,Aswan University | El Kameesy S.U.,Ain Shams University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Experimental studies of the optical band passes filter behavior of a new series of copper phosphate glasses have been carried out. The amorphous nature of the prepared samples was examined using XRD analysis. The effect of different contents of CuO on the thermal transition temperature (Tg) was investigated using differential thermal analysis (DTA). Density and its derivative parameters such as molar volume, copper ion concentration, and interionic distance have explored the effect of copper ions behave. The EPR spectra of copper phosphate glasses were measured at room temperature in order to examine the valance state of copper in the glass network. Finally, the optical filtering behavior of the prepared glasses was carried out using UV-Visible measurements. Optical band gap, Urbach energy, and refractive index, were studied to check the effect of Cu ion on the present glasses.

Saeed N.M.,Egyptian Russian University | El-Naga R.N.,Ain Shams University | El-Bakly W.M.,Ain Shams University | Abdel-Rahman H.M.,Egyptian Russian University | And 2 more authors.
Biochemical Pharmacology | Year: 2015

Doxorubicin (DOX) is a widely used chemotherapeutic agent however its clinical use is limited by cumulative cardiotoxicity. Epigallocatechin-3-gallate (EGCG), a main catechin in green tea, possesses a potent antioxidant, anti-apoptotic and anticancer properties. The current study aimed to investigate the potential protective effect of EGCG against DOX-induced cardiotoxicity. Firstly the potential cardioprotective dose of EGCG was screened at different doses (10, 20 and 40 mg/kg/day) against a single dose of DOX (15 mg/kg; i.p.). EGCG protected against DOX-induced ECG changes, leakage of cardiac enzymes (creatine kinase isoenzyme-MB, and lactate dehydrogenase) and histopathological changes. The dose of 40 mg/kg EGCG was selected for further assessment to address the EGCG cardioprotective mechanisms. EGCG was given orally 3 times/week for 4 consecutive weeks and DOX (2.5 mg/kg; i.p.) 3 times/week on the last 2 weeks. EGCG significantly ameliorated oxidative stress injury evoked by DOX as evidenced by inhibition of reduced glutathione depletion and lipid peroxidation as well as elevation of antioxidant enzyme activities. DOX caused down-regulation of ErbB2 expression while EGCG pretreatment significantly increased ErbB2 expression indicating its effect on pro-survival pathway. Furthermore, DOX provoked apoptotic responses evidenced by increasing the expression of nuclear factor kappa-B, tumor suppressor protein p53, calpain 2, caspases 3 and 12. Additionally basal level of Hsp70 was reduced in DOX-intoxicated group. EGCG pretreatment significantly ameliorated these apoptotic signals indicating its anti-inflammatory and anti-apoptotic actions. In conclusion, EGCG possesses cardioprotective action against DOX-induced cardiotoxicity by suppressing oxidative stress, inflammation and apoptotic signals as well as activation of pro-survival pathways. © 2015 Elsevier Inc. All rights reserved.

Haggag S.,Egyptian Russian University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2016

The Senovilla family for a subclass of Petrov type-D stationary axisymmetric differentially rotating perfect fluids is considered. A scheme is presented to construct from a solution an interior of a rotating compact body satisfying dominant energy conditions and with a boundary of vanishing pressure. The equatorial disk of the body is a surface layer due to a jump in the second fundamental form. However, unlike previous results, the body is free from curvature singularities. © 2016 American Physical Society.

Hassan M.H.,Taibah University | Hassan M.H.,Al Azahr University | Edfawy M.,Egyptian Russian University | Mansour A.,Al Azahr University | Hamed A.-A.,Al Azahr University
Toxicology and Industrial Health | Year: 2012

The aim of the study was to evaluate the potential hepatoprotective utility of capsaicin against carbon tetrachloride (CCl4)-induced liver injury and to explore the possible mechanisms whereby this agent mediated its beneficial effects. We randomized 40 rats into four groups for treatment with corn oil, CCl4, capsaicin and both CCl4 and capsaicin, respectively, for 8 weeks. At the end of the experiment, blood samples were collected and used for determination of aspartylaminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin, while the liver tissues were subjected to hematoxylin and eosin examination; evaluation of malondialdehyde (MDA), reduced glutathione (GSH) and active caspase-3 contents; and evaluation of superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST) activities. Animals treated with CCl4 exhibited significant elevation in AST, ALT, total bilirubin and caspase-3 and exhibited significant decrease in activities of SOD, CAT, GST and GSH contents. The combination (both capsaicin and CCl4) group has preserved the liver histology, liver enzymes and bilirubin close to normal, exhibited significant induction in the activities of CAT, SOD and GST, increased the liver content of GSH and active caspase-3 and conversely showed significant decrease in liver MDA content compared to CCl4 challenged rats. Capsaicin confers an appealing hepatoprotective effect which might be explained partially via diminishing the generation of MDA, induction of antioxidant systems and inhibition of active caspase-3. © The Author(s) 2011.

Dweedar H.E.,Sadat City University | Mahrous H.,Sadat City University | Ibrahim H.S.,Egyptian Russian University | Abdel-Aziz H.A.,King Saud University | Abdel-Aziz H.A.,National Research Center of Egypt
European Journal of Medicinal Chemistry | Year: 2014

The docking studies on CDK2 and GSK-3β inspired us to synthesis a series of indoline-2,3-dione hydrazones 10a-l. Treatment of indoline-2,3-dione derivatives 7a-d with hydrazine gave 3-hydrazonoindolin-2-ones 8a-d which were reacted with the appropriate aldehydes 9a-c to yield 3-substituted- (methylenehydrazono)indolin-2-ones 10a-l. Compounds 10a-l showed a significant anticancer activity against human breast cell line MCF-7. Compounds 10c, f, i exhibited the highest activity almost the same of doxorubicin (IC50 = 6.10 μM) with IC50 = 7.75, 6.75, 6.25 μM, respectively. © 2014 Elsevier Masson SAS. All rights reserved.

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