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Shahbunder H.,Ain Shams University | Shahbunder H.,University of the Humanities | Hafez N.,Egyptian Russian University
Progress in Nuclear Energy | Year: 2017

Minor actinide recycling and transmutation are important stages in the advanced nuclear systems design such as Generation IV reactors that offers a high level of safety, waste reduction, and minimizes its environmental and radiological impacts. In the present work, two preliminary model configurations are used to examine the effects of adding two long-lived isotopes of minor actinides (243Am and 247Cm) in MINERVE reactor reference core (R1-UO2) that represents a LWR loaded with UO2 fuel rods. The effects are studied in two models of uniform and nonuniform minor actinides distributions, and include the numerical evaluation of neutronic parameters such as neutron spectrum, flux distribution and fission rate, using MCNPX transport code. The analysis of and comparison between the uniform and nonuniform models have been discussed to evaluate which of either is expected to be favored for minor actinide transmutation and energy production. © 2017 Elsevier Ltd.


Nassar E.,Ain Shams University | Abdel-Aziz H.A.,King Saud University | Ibrahim H.S.,Egyptian Russian University | Mansour A.M.,Al - Azhar University of Egypt
Scientia Pharmaceutica | Year: 2011

A series of chalcone-based diarylpyrazoles containing a phenylsulphone or carbonitrile moiety was synthesized. Thus, 3-acetylpyrazoles 6a-c and 10a-c were used as useful substrates in facile synthesis of functional pyrazoles 7a-f and 11a-f, respectively. The anti-inflammatory activity and ulcerogenic effect were evaluated and some of the obtained products possessed a significant anti-inflammatory activity. 1-[1-(3-Methylphenyl)-5-phenyl-4-(phenylsulfonyl)-1H-pyrazol-3-yl]ethanone (6b) showed a high activity when compared with indomethacin as reference drug with lower gastrointestinal (GI) profile. Furthermore, molecular docking studies were performed in order to rationalize the obtained biological results. © Nassar et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria.


Saeed N.M.,Egyptian Russian University | El-Demerdash E.,Ain Shams University | Abdel-Rahman H.M.,Egyptian Russian University | Algandaby M.M.,King Abdulaziz University | And 2 more authors.
Toxicology and Applied Pharmacology | Year: 2012

Methyl palmitate (MP) and ethyl palmitate (EP) are naturally occurring fatty acid esters reported as inflammatory cell inhibitors. In the current study, the potential anti-inflammatory activity of MP and EP was evaluated in different experimental rat models. Results showed that MP and EP caused reduction of carrageenan-induced rat paw edema in addition to diminishing prostaglandin E2 (PGE2) level in the inflammatory exudates. In lipopolysaccharide (LPS)-induced endotoxemia in rats, MP and EP reduced plasma levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). MP and EP decreased NF-κB expression in liver and lung tissues and ameliorated histopathological changes caused by LPS. Topical application of MP and EP reduced ear edema induced by croton oil in rats. In the same animal model, MP and EP reduced neutrophil infiltration, as indicated by decreased myeloperoxidase (MPO) activity. In conclusion, this study demonstrates the effectiveness of MP and EP in combating inflammation in several experimental models. © 2012 Elsevier Inc..


Eissa M.S.,Egyptian Russian University
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2017

In this work, various sensitive and selective spectrophotometric methods were first introduced for the simultaneous determination of sofosbuvir and ledipasvir in their binary mixture without preliminary separation. Ledipasvir was determined simply by zero-order spectrophotometric method at its λmax = 333.0 nm in a linear range of 2.5–30.0 μg/ml without any interference of sofosbuvir even in low or high concentrations and with mean percentage recovery of 100.05 ± 0.632. Sofosbuvir can be quantitatively estimated by one of the following smart spectrophotometric methods based on ratio spectra developed for the resolution of the overlapped spectra of their binary mixture; ratio difference spectrophotometric method (RD) by computing the difference between the amplitudes of sofosbuvir ratio spectra at 228 nm and 270 nm, first derivative (DD1) of ratio spectra by measuring the sum of amplitude of trough and peak at 265 nm and 277 nm, respectively, ratio subtraction (RS) spectrophotometric method in which sofosbuvir can be successfully determined at its λmax = 261.0 nm and mean centering (MC) of ratio spectra by measuring the mean centering values at 270 nm. All of the above mentioned spectrophotometric methods can estimate sofosbuvir in a linear range of 7.5–90.0 μg/ml with mean percentage recoveries of 100.57 ± 0.810, 99.92 ± 0.759, 99.51 ± 0.475 and 100.75 ± 0.672, respectively. These methods were successfully applied to the analysis of their combined dosage form and bulk powder. The adopted methods were also validated as per ICH guidelines and statistically compared to an in-house HPLC method. © 2017 Elsevier B.V.


Ellakwa E.T.,Egyptian Russian University
American Journal of Drug Discovery and Development | Year: 2014

The effect of nutrition on different host plants (cabbage, castor bean and cotton) on midgut redox potentional (Eh), midgut pH and digestive enzymes of the fourth larval instar of Agrotis ipsilon was studied. The results showed that all larvae had strongly alkaline midguts pH ranging from 9-9.75. There were no significant differences between midgut pH of larvae fed for 24 h or that fed for 7 days, effect different host plants, reflecting the rapidity by which the larvae adjust their midgut pH. On the contrary, plant species had a significant effect on mid gut Eh. Conditions in all guts were oxidizing ranging from +171 to +250 mV i.e., all tested midguts Eh were positive. The results also revealed that continuous feeding on host, plants for 7 days significantly lowered the oxidizing state of gut, except cabbage, as compared to those larvae fed for 24 h. Each host plant had own specific effect on protease, lipase and invertase. However lipase was the least enzyme that affected. The study clarifies the effect of host plants on midgut physicochemistry which mid gut affect digestion and gut physiology, ultimately affecting the normal growth of the pest. © 2014 Academic Journal.


Barakat E.M.F.,Ain Shams University | El Wakeel L.M.,Ain Shams University | Hagag R.S.,Egyptian Russian University
World Journal of Gastroenterology | Year: 2013

AIM: To evaluate the safety, efficacy and tolerability of Nigella sativa (N. sativa) in patients with hepatitis C not eligible for interferon (IFN)-α. METHODS: Thirty patients with hepatitis C virus (HCV) infection, who were not eligible for IFN/ribavirin therapy, were included in the present study. Inclusion criteria included: patients with HCV with or without cirrhosis, who had a contraindication to IFN-α therapy, or had refused or had a financial constraint to IFN-α therapy. Exclusion criteria included: patients on IFN-α therapy, infection with hepatitis B or hepatitis I virus, hepatocellular carcinoma, other malignancies, major severe illness, or treatment non-compliance. Various parameters, including clinical parameters, complete blood count, liver function, renal function, plasma glucose, total antioxidant capacity (TAC), and polymerase chain reaction, were all assessed at baseline and at the end of the study. Clinical assessment included: hepato and/ or splenomegaly, jaundice, palmar erythema, flapping tremors, spider naevi, lower-limb edema, and ascites. N. sativa was administered for three successive months at a dose of (450 mg three times daily). Clinical response and incidence of adverse drug reactions were assessed initially, periodically, and at the end of the study. RESULTS: N. sativa administration significantly improved HCV viral load (380808.7 ± 610937 vs 147028.2 ± 475225.6, P = 0.001) and TAC (1.35 ± 0.5 vs 1.612 ± 0.56, P = 0.001). After N. sativa administration, the following laboratory parameters improved: total protein (7.1 ± 0.7 vs 7.5 ± 0.8, P = 0.001), albumin (3.5 ± 0.87 vs 3.69 ± 0.91, P = 0.008), red blood cell count (4.13 ± 0.9 vs 4.3 ± 0.9, P = 0.001), and platelet count (167.7 ± 91.2 vs 198.5 ± 103, P = 0.004). Fasting blood glucose (104.03 ± 43.42 vs 92.1 ± 31.34, P = 0.001) and postprandial blood glucose (143.67 ± 72.56 vs 112.1 ± 42.9, P = 0.001) were significantly decreased in both diabetic and non-diabetic HCV patients. Patients with lower-limb edema decreased significantly from baseline compared with after treatment [16 (53.30%) vs 7 (23.30%), P = 0.004]. Adverse drug reactions were unremarkable except for a few cases of epigastric pain and hypoglycemia that did not affect patient compliance. CONCLUSION: N. sativa administration in patients with HCV was tolerable, safe, decreased viral load, and improved oxidative stress, clinical condition and glycemic control in diabetic patients. © 2013 Baishideng. All rights reserved.


El-Mesallamy H.O.,Ain Shams University | Hamdy N.M.,Ain Shams University | Ezzat O.A.,Egyptian Russian University | Reda A.M.,Egyptian Russian University
Journal of Investigative Medicine | Year: 2011

Objective: Advanced glycation end products (AGEs) and the interaction with their receptors (RAGE) play an important role in the pathogenesis of diabetic foot (DF) associated with diabetic neuropathy. Our study examined the association between asymmetric dimethyl arginine (ADMA), fructosamine, nitric oxide (NO), and soluble (s) RAGE levels in serum of diabetic patients with and without neuropathy. Methods: Circulating levels of ADMA, fructosamine, NO, and sRAGE, estimated either chemically or by enzyme-linked immunosorbent assay, were examined in 60 type 2 diabetes mellitus (T2DM) overweight/obese (body mass index, 30.5 ± 1.5 kg/m 2) male patients and 20 age-matched (55 T 3 years) obese healthy subjects as control group. The T2DM subjects were categorized as patients without DF (n = 30), and the remaining were patients with DF associated with neuropathy. Results: First sRAGE levels were significantly increased in T2DM patients without DF in comparison to healthy controls (1656.6 [1198.8-2065.4] vs 1111.7 [909-1605.3] pg/mL, respectively; P < 0.05). However, in the DF group (1049.6 [783.7-1221.8] pg/mL), its level decreased significantly in comparison to both groups (P G 0.05). However, ADMA and fructosamine were significantly higher in diabetic patients with DF than both T2DM without DF and healthy controls. Moreover, NO was significantly lower in DF than in diabetic patients without DF and controls (5 T 0.4 and 8 T 0.4 vs 42 T 2.5 Kmol/L, respectively; P G 0.05). Finally, sRAGE levels were significantly correlated with ADMA, fructosamine, and NO. Conclusions: Soluble forms of the receptor for advanced glycation end product could be an endogenous protection factor against occurrence of DF, hence may be of therapeutic value in the treatment of DF. © 2011 by The American Federation for Medical Research.


Saeed A.,Egyptian Russian University | Elbashar Y.H.,Aswan University | El Kameesy S.U.,Ain Shams University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Experimental studies of the optical band passes filter behavior of a new series of copper phosphate glasses have been carried out. The amorphous nature of the prepared samples was examined using XRD analysis. The effect of different contents of CuO on the thermal transition temperature (Tg) was investigated using differential thermal analysis (DTA). Density and its derivative parameters such as molar volume, copper ion concentration, and interionic distance have explored the effect of copper ions behave. The EPR spectra of copper phosphate glasses were measured at room temperature in order to examine the valance state of copper in the glass network. Finally, the optical filtering behavior of the prepared glasses was carried out using UV-Visible measurements. Optical band gap, Urbach energy, and refractive index, were studied to check the effect of Cu ion on the present glasses.


Haggag S.,Egyptian Russian University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2016

The Senovilla family for a subclass of Petrov type-D stationary axisymmetric differentially rotating perfect fluids is considered. A scheme is presented to construct from a solution an interior of a rotating compact body satisfying dominant energy conditions and with a boundary of vanishing pressure. The equatorial disk of the body is a surface layer due to a jump in the second fundamental form. However, unlike previous results, the body is free from curvature singularities. © 2016 American Physical Society.


Dweedar H.E.,Sadat City University | Mahrous H.,Sadat City University | Ibrahim H.S.,Egyptian Russian University | Abdel-Aziz H.A.,King Saud University | Abdel-Aziz H.A.,National Research Center of Egypt
European Journal of Medicinal Chemistry | Year: 2014

The docking studies on CDK2 and GSK-3β inspired us to synthesis a series of indoline-2,3-dione hydrazones 10a-l. Treatment of indoline-2,3-dione derivatives 7a-d with hydrazine gave 3-hydrazonoindolin-2-ones 8a-d which were reacted with the appropriate aldehydes 9a-c to yield 3-substituted- (methylenehydrazono)indolin-2-ones 10a-l. Compounds 10a-l showed a significant anticancer activity against human breast cell line MCF-7. Compounds 10c, f, i exhibited the highest activity almost the same of doxorubicin (IC50 = 6.10 μM) with IC50 = 7.75, 6.75, 6.25 μM, respectively. © 2014 Elsevier Masson SAS. All rights reserved.

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