EgeUniversity

Bornova, Turkey

EgeUniversity

Bornova, Turkey

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Istanbullu H.,EgeUniversity | Zencir S.,Pamukkale University | Berenyi A.,University of Szeged | Canturk Kilickaya P.,Cumhuriyet University | And 3 more authors.
Marmara Pharmaceutical Journal | Year: 2015

Majority of anti-cancer drugs were shown to exert their activities by interfering with DNA topoisomerase reactions. Since the identification of Camptothecin as the topoisomerase I targeting compound, these enzymes are widely utilized in biological assays to assess the pharmaceutical significance of the synthetic and natural agents. Because a considerable number of compounds were shown to have cytostatic activities via blocking topoisomerase reactions, we aimed to identify if the previously-reported physiological activities of acetonapthones involves the interference with topoisomerase reactions. We covered topoisomerase activity and cytostatic activity evaluation of piperidinopropionaphthone hydrochloride type Mannich base (MB) to compare its bioactivities to the starting propionaphtone in order to assess the contribution of aminomethyl moiety of the compound on its bioactivity. MB was synthesized and characterized in our laboratory. Supercoiled plasmid relaxation and decatenation assays were carried out to evaluate their biological activities in mammalian DNA topoisomerases. We also assayed the cytostatic activities using HeLa, MCF7 and A431 cell lines. Our data showed a considerable inhibition of MB on type I and type II DNA topoisomerases without a correlation to cytostatic assays. MB exerted a modest activity against the proliferation of MCF7 cells with an IC50 value of 27.62 μM. The presence of MB inhibited topo II decatenation activity as well. Results offer no direct explanation for the contradictory effects on the DNA topoisomerases and the proliferation of cancer cells in vitro. Our results are discussed in relation to potential significance of aminomethyl group of Mannich base in the course of drug-development studies. © 2015, Marmara University. All rights reserved.


Mert E.,Empa - Swiss Federal Laboratories for Materials Science and Technology | Mert E.,EgeUniversity | Oglakcioglu N.,EgeUniversity | Bal S.,YUNSA Yunlu San. Ve Tic. A.S. | Marmarali A.,EgeUniversity
Tekstil ve Konfeksiyon | Year: 2014

The term of clothing comfort can be defined as a pleasant state including physiological, psychological and physical harmony between a human body and its environment. It is commonly classified into four broad categories: thermal, body movement, aesthetic and sensorial (tactile) comfort. One of the important components that affecting clothing comfort is the fabric that provides thermal balance between body and environment and achieves good tactile properties. Clothing comfort properties of fabrics are affected by fabric structure, type and ratio of fiber, yarn structure and finishing treatments. Within this study, the effects of calendering and milling process on thermal comfort and surface properties of suit fabrics were investigated. The results indicate that air permeability, thickness and thermal resistance values were decreased, while thermal absorptivity values were increased after calendering process. However, calendering had no significant effect on surface properties. Besides, milling process increased air permeability, thickness, thermal resistance and surface friction coefficient values and decreased thermal absorptivity values.


Yildiz Turp G.,Ege University | Icier F.,Ege University | Kor G.,EgeUniversity
Meat Science | Year: 2016

The objective of the current study was to improve the quality characteristics of ohmically pre-cooked beef meatballs via infrared cooking as a final stage. Samples were pre-cooked in a specially designed-continuous type ohmic cooker at a voltage gradient of 15.26 V/cm for 92 s. Infrared cooking was then applied to the pre-cooked samples at different combinations of heat fluxes (3.706, 5.678, and 8.475 kW/m2), application distances (10.5, 13.5, and 16.5 cm) and application durations (4, 8, and 12 min). Effects of these parameters on color, texture and cooking characteristics of ohmically pre-cooked beef meatballs were investigated. The appearance of ohmically pre-cooked meatball samples was improved via infrared heating. A dark brown layer desired in cooked meatballs formed on the surface of the meatballs with lowest application distance (10.5 cm) and longest application duration (12 min). The texture of the samples was also improved with these parameters. However the cooking yield of the samples decreased at the longest application duration of infrared heating. © 2015 Elsevier Ltd.


PubMed | EgeUniversity and Ege University
Type: | Journal: Meat science | Year: 2016

The objective of the current study was to improve the quality characteristics of ohmically pre-cooked beef meatballs via infrared cooking as a final stage. Samples were pre-cooked in a specially designed-continuous type ohmic cooker at a voltage gradient of 15.26 V/cm for 92 s. Infrared cooking was then applied to the pre-cooked samples at different combinations of heat fluxes (3.706, 5.678, and 8.475 kW/m(2)), application distances (10.5, 13.5, and 16.5 cm) and application durations (4, 8, and 12min). Effects of these parameters on color, texture and cooking characteristics of ohmically pre-cooked beef meatballs were investigated. The appearance of ohmically pre-cooked meatball samples was improved via infrared heating. A dark brown layer desired in cooked meatballs formed on the surface of the meatballs with lowest application distance (10.5 cm) and longest application duration (12 min). The texture of the samples was also improved with these parameters. However the cooking yield of the samples decreased at the longest application duration of infrared heating.


Tarakci M.,Dokuz Eylül University | Harmansah C.,EgeUniversity | Sac M.M.,EgeUniversity | Ichedef M.,EgeUniversity
Applied Radiation and Isotopes | Year: 2014

The distribution of radon activity is determined from pre-earthquake data. Analysis using Normal, Gamma, Weibull and Rayleigh distributions indicates that the variation of radon levels in seismically active regions is best described by a normal distribution. It was observed that radon levels would change in compressive fault lines prior to earthquake. Besides that it tended to increase before the earthquake and then decrease towards the time of earthquake occurrences. © 2013 Elsevier Ltd.

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