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Hamerschlak N.,Bone Marrow Transplant Unit | Rodrigues M.,Bone Marrow Transplant Unit | Moraes D.A.,University of Sao Paulo | Oliveira M.C.,University of Sao Paulo | And 19 more authors.
Bone Marrow Transplantation | Year: 2010

Studies have shown that autologous hematopoietic SCT (HSCT) can be used as an intensive immunosuppressive therapy to treat refractory patients and to prevent the progression of multiple sclerosis (MS). This is a prospective multicentric Brazilian MS trial comparing two conditioning regimens: BEAM/horse ATG and CY/rabbit ATG. Most (80.4%) of the 41 subjects in the study had the secondary progressive MS subtype and the mean age was 42 years. The baseline EDSS score in 58.5% of the subjects was 6.5 and 78% had a score of 6.0 or higher, respectively. The complication rate during the intra-transplantation period was 56% for all patients: 71.4% of the patients in the BEAM/hATG group and 40% in the CY/rATG group (P=0.04). Three subjects (7.5%) died of cardiac toxicity, sepsis and alveolar hemorrhage, all of them in the BEAM/ATG group. EFS was 58.54% for all patients: 47% in the BEAM/hATG group and 70% in the CY/rATG group (P=0.288). In conclusion, the CY/rATG regimen seems to be associated with similar outcome results, but presented less toxicity when compared with the BEAM/hATG regimen. Long-term follow-up would be required to fully assess the differences in therapeutic effectiveness between the two regimens. © 2010 Macmillan Publishers Limited All rights reserved.


Iyer V.G.,Educational and Research Institute | Mastorakis N.E.,Technical University of Sofia
Proceedings of the International Conference on Energy and Environment Technologies and EquipmProceedings of the International Conference on Energy and Environment Technologies and Equipment, EEETE '10 | Year: 2010

Orissa accounts for 95 percent of the chromium ore reserves of India. It increases the economic status, but adversely reduces the ecological cover. Chromite mines generate considerable quantity of pollutants containing toxic hexavalent chromium, a known carcinogen, which contaminates 10 to 4000 mg/kg (ppm) of total chromium in air, water and soil environment. Surface water and ground water in Sukinda region contain hexavent chromium Cr(VI), well above the permissible limits of 0.05 mg/l (ppm). There are clusters of chromite mines release considerable quantity of effluents and slurries, as well as the over burden stockpiles as hazardous wastes. These are discharged into various tributaries of the Brahmani river. Suspended and respirable particulate matter were found well above the prescribed limit of 100 μg/m3. Chromium based diseases among the workers have been found which could be a result of the intake of excessive Cr(VI). Chromite mine workers, who were constantly exposed to contaminated dust and water, report gastrointestinal bleeding, tuberculosis and asthma besides incidence of infertility, birth defects and still births. They suffer from chromium based diseases such as chromium poisoning, ulcer, allergic dermatitis, lung cancer, lever necrosis, brain damage, premature death, lever and kidney problems. It is important that these mines have to initiate regulatory measures to control this unsafe chromium pollution. It is required to get treated this mine water using chromium effluent treatment plants (CETP) as well as to get evolved preventive and control strategies at the planning stages itself as prevention is better than cure, very little or nothing can be done if the toxic chromium reaches the air, water and soil environment. It has been observed that the management of chromite mines have not implemented the worker's compensation law and occupational diseases law. As per the present research work conducted, it has been proved that approximately 80 percent of mining disasters are preventable provided that these laws get enforced efficiently. It is necessary that the mine workers must follow adequate safety compliances. The present study has been done to present the research investigations pertaining to environmental health effects of Orissa chromite mines.


Esakkiappan C.,Educational and Research Institute | Thyagarajan T.,Anna University | Sharmila G.V.,Anna University
European Journal of Scientific Research | Year: 2012

Since the introduction of relay feedback test by Astrom and Hagglund, autotuning of PID controller has received much attention. Without the knowledge of the model structure, most of the relay feedback autotuners uses Zeigler-Nichols type tuning rules to set controller parameters. This can lead to poor performance in some cases, because no single tuning rule can work well for all model structures. Lyben pointed out that additional information can be obtained from the relay feedback tests, namely, the shape of the response. Literature says that shape of the relay response depends on its model structure. After several simulations, it is found that for many processes the shape of the relay response remains unique irrespective of changes in gain, dead time and time constant. However, identification of model structure from the shape of relay response by naked eye is difficult. Hence, in this work, identification of model structure from the shape of the relay response using Pattern Recognition Techniques (PRT) is proposed. Relay test is conducted for various benchmark processes namely: Pure Dead Time (PDT) process, Integrator Plus Dead Time (IPDT) process, First Order Plus Dead Time (FOPDT) stable process, FOPDT unstable process, Over damped Second Order Plus Dead Time (SOPDT) process Higher order (HO) process, First Order Lag with Integrator Plus Dead Time (FOLIPD) process and Inverse Response Plus Time Delay (IRPTD) process. The PRT is implemented to automate the identification of model structure from the shape of the relay response. This automation is carried out by extracting Fourier Descriptors as features from the relay response and classifying it using Euclidean distance and Neural Network (NN) classifiers. © EuroJournals Publishing, Inc. 2012.


Boopathi M.,Pachaiyappas College for Men | Boopathi M.,Educational and Research Institute | Udhayakala P.,Educational and Research Institute | Rajendiran T.V.,Pachaiyappas College | Gunasekaran S.,St Peters Institute Of Higher Education And Research
Journal of Applied Spectroscopy | Year: 2016

In the present investigation, a vibration spectral analysis was carried out using FT-Raman and FT-IR spectroscopy in the range 100–4000 and 400–4000 cm−1 respectively, for 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazoline sulfonamide (metolazone). The molecular structure, fundamental vibration frequencies, and intensity of the vibration bands are interpreted with the help of structure optimizations by density functional theory (DFT) types of the electronic structure method in the B3LYP/6-311++G(d,p) basis set. The results of the calculations were applied to simulated spectra of the title compound, which showed good agreement with observed spectra. The overestimations of the calculated harmonic wave numbers were efficiently corrected with the aid of a specific scaling procedure. A molecular electrostatic potential (MEP) map of the titled compound has been plotted in order to predict the electron rich and poor centers. © 2016 Springer Science+Business Media New York

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