Research and Education Hospital

Van, Turkey

Research and Education Hospital

Van, Turkey
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Aydin M.D.,Atatürk University | Kanat A.,Recep Tayyip Erdoğan University | Yilmaz A.,Sisli Research and Education Hospital | Cakir M.,Research and Education Hospital | And 5 more authors.
Experimental Neurology | Year: 2011

Background: The heart is innervated by several systems that contribute to the control of the heart's rhythm. The cardiac fibers of the vagus nerve have an important role in the regulation of heart rhythm under many emotional and physical conditions. Severe electrocardiographic disturbances have been reported following subarachnoid hemorrhage (SAH), but ischemic neuronal degeneration of the nodose ganglion of the vagus nerve has not been previously investigated. We examined if there is a relationship between ischemic injury of the nodose ganglion of the vagus nerve and the severity of heart rhythm disorders after subarachnoid hemorrhage. Methods: This study was conducted on 20 rabbits. Four rabbits were used as a baseline group. Experimental subarachnoid hemorrhage was applied to half of the remaining animals (n=8) by injecting homologous blood into the cisterna magna, and the others (SHAM group, n=8) were injected with isotonic saline solution in the same manner. For 20. days after the injection, heart rhythm changes were observed daily. After the experiment, normal and ischemic neuron densities in the nodose ganglia of the vagus nerves were examined stereologically. The number of heart rhythm irregularities and the number of degenerated neurons in the nodose ganglia were compared statistically. Results: The normal heart rhythm rate was 280 ± 45/min. At the beginning of the SAH, the average heart rate was 220 ± 30/min; about 10. hours later, it decreased to 189 ± 30/min, indicating severe bradycardia. However, after 7. days, the average heart rate had increased to 350 ± 30/min. Six animals died due to irregularities in cardiac function and respiration. Histopathological examinations showed that the average density of normal neurons in the nodose ganglion was 10,500 ± 2500 in the baseline animals and the SHAM group, but the normal neuron density was 8250 ± 1500 in survivors and 6450 ± 1330 in dead animals. The ischemic neuronal degeneration in the nodose ganglia was more severe in the dead animals than in the survivors (p<0.0001). Conclusion: Afferent vagus nerves originating from the nodose ganglia have an important role in regulating heart rhythm via their afferent fibers and efferent connections. If neurons of the nodose ganglia are lesioned due to ischemic insult during subarachnoid hemorrhage, heart rhythm regulation by vagus afferent reflexes is disturbed. Vagus pathway paralysis may result in indirect sympathetic overactivity. The development of tachycardia causes depletion of the heart's reserves, and cardiac arrest may be inevitable following extensive subarachnoid hemorrhage. © 2010 Elsevier Inc.


Seyfeli E.,Acibadem University | Sarli B.,Research and Education Hospital | Saglam H.,Research and Education Hospital | Karatas C.Y.,Research and Education Hospital | And 2 more authors.
Journal of Clinical Hypertension | Year: 2016

The authors aimed to evaluate the relationship between high-sensitivity C-reactive protein (hs-CRP) and presence of left ventricular hypertrophy and diastolic dysfunction in patients with hypertension. A total of 95 newly diagnosed hypertensive patients (mean age, 54±10 years) and 20 controls were included in this study. Patients were divided into four groups according to relative wall thickness as normal, concentric remodeling, concentric, and eccentric hypertrophy. hs-CRP was measured in all patients and serum hs-CRP level was shown to be increased in patients with hypertension compared with controls (0.57 mg/dL vs 0.25 mg/dL, respectively; P<.001). The hs-CRP level was highest in patients with concentric hypertrophy. When compared with controls, serum hs-CRP level was significantly higher in patients with concentric remodeling (0.61±0.3 mg/dL vs 0.43±0.5 mg/dL, P<.030) and concentric hypertrophy (0.69±0.3 mg/dL vs 0.43±0.5 mg/dL, P<.032). The present study shows that serum hs-CRP is significantly associated with left ventricular diastolic function and concentric hypertrophy in patients with hypertension. © 2015 Wiley Periodicals, Inc.


PubMed | Research and Education Hospital and Acibadem University
Type: Journal Article | Journal: Journal of clinical hypertension (Greenwich, Conn.) | Year: 2016

The authors aimed to evaluate the relationship between high-sensitivity C-reactive protein (hs-CRP) and presence of left ventricular hypertrophy and diastolic dysfunction in patients with hypertension. A total of 95 newly diagnosed hypertensive patients (mean age, 5410 years) and 20 controls were included in this study. Patients were divided into four groups according to relative wall thickness as normal, concentric remodeling, concentric, and eccentric hypertrophy. hs-CRP was measured in all patients and serum hs-CRP level was shown to be increased in patients with hypertension compared with controls (0.57 mg/dL vs 0.25 mg/dL, respectively; P<.001). The hs-CRP level was highest in patients with concentric hypertrophy. When compared with controls, serum hs-CRP level was significantly higher in patients with concentric remodeling (0.610.3 mg/dL vs 0.430.5 mg/dL, P<.030) and concentric hypertrophy (0.690.3 mg/dL vs 0.430.5 mg/dL, P<.032). The present study shows that serum hs-CRP is significantly associated with left ventricular diastolic function and concentric hypertrophy in patients with hypertension.


Turan M.,Yuzuncu Yil University | Ucler R.,Yuzuncu Yil University | Aslan M.,Yuzuncu Yil University | Kalkan F.,Research and Education Hospital | And 3 more authors.
Redox Report | Year: 2015

Objectives: Paraoxonase-1 (PON1) prevents oxidative stress by inhibiting the oxidation of cell membrane lipids by the reactive oxygen species that form during acute and chronic inflammation. The aim of this study was to investigate serum PON1 activity and oxidative stress in patients with chronic otitis media (COM). Methods: Fifty consecutive patients with COM and 55 controls were enrolled in the present study. The patients were divided into two groups according to the presence of cholesteatoma. The serum PON1 arylesterase activities and lipid hydroperoxide (LOOH) levels were determined. Results: Serum paraoxonase and arylesterase activities were significantly lower in the COM patients than in the controls (P < 0.001 for all comparisons), whereas the LOOH levels were significantly higher (P < 0.001). Discussion: These results indicated that a lower level of PON1 activity was associated with an oxidant–antioxidant imbalance. In addition, decreased PON1 activity may play an important role in the pathophysiology of COM. © Mahfuz Turan 2015.


Ozar M.,Istanbul University | Ozar E.,Research and Education Hospital | Koylu S.,Istanbul University | Taskin M.,Research and Education Hospital
Journal of Neurosurgical Sciences | Year: 2014

Aim. Prediction of chromosomal disorders causing to severe pathological conditions can provide big benefits in early diagnosis and treatment. Adding a predeterminable feature to the cancer risk is very important in enlightening of the mechanisms inducing the disease, in elongation of survival times of the patients due to early diagnosis of the disease and in reducing mortality and morbidity by developing effective and economical treatment protocols. Studies using chromosomal aberrations as biological markers indicate that increasing aberration levels are important indicators in predisposition to the cancer. Aim of this study was to determine it this is feasible. One or several types of cancers were used in these studies reported in the literature. The increases in frequency of chromosome aberrations in Italy and Norwegian societies have been associated to some types of cancers. Methods. This study was performed on 10 untreated brain cancer patients and 10 controls. Peripheral blood specimen taken from each of the patients and healthy individuals and one of these specimens were subjected to in-vitro 2 Gy irradiation dose. Mitosis was induced in cultured peripheral blood lymphocytes via the activation of mitogen (phytohemaglutinin) activated pathways. Cell division was blocked in metaphase by the addition of colchemid and the chromosomal damages in the preparations were scored with asymmetrical chromosomal aberrations. Results. The ratio of dicentric chromosome was found to be higher in the glioblastoma multiforme patients. Conclusion. To reach judicial conclusions, case-controlled trials including more patients should be performed.


Sanh A.M.,Research and Education Hospital | Turkoglu E.,Research and Education Hospital | Kahveci R.,Research and Education Hospital | Sekerci Z.,Research and Education Hospital
Child's Nervous System | Year: 2010

Introduction Intradural spinal lipoma is rare and seen about 1% of all tumors of the spinal cord. Lipomas of the cervical location with intracranial extension are extremely rare and are described as intramedullary or subpial location. Case A 12-year-old female with lipoma of the cervicothoracic spinal cord demonstrated progressive quadriparesis. The patient underwent surgery with decompression of the affected craniocervical location. Discussion In the reported case, we describe a rare intradural lipoma of the cervicothoracic spinal cord with posterior fossa extension in the child, and the relevant English medical literature is reviewed. © Springer-Verlag 2010.


Akar E.,Istanbul University | Tural D.,Akdeniz University | Arslan D.,Research and Education Hospital | Bassorgun C.,Akdeniz University | Yildiz O.,Istanbul University
Journal of Cancer Research and Therapeutics | Year: 2015

Late relapse of testicular cancer, defined as >2 years interval between initial treatment and recurrence, is a rare disease with the incidence rate of 2.6%. Due to its chemoresistant features, treatment options of late relapses are controversial while surgical approach and cisplatin-based chemotherapies can be considered. We report here a patient with nonseminomatous germ cell tumor who experienced relapse 24 years after his first diagnosis. After detecting left supraclavicular lymphadenopathy and absence of any other malignant lesion in positron emission tomography-computerized tomography, patient was treated with three cycles of VeIP regimen (vinblastine/ifosfamide/cisplatin). Second complete response to this treatment was achieved with chemotherapy alone.


Yucel O.E.,Research and Education Hospital | Ariturk N.,Ondokuz Mayis University
Ondokuz Mayis Universitesi Tip Dergisi | Year: 2012

The aim of this study was to compare the efficacy and safety of latanoprost, travoprost and bimatoprost monotherapies in previously untreated patients with open angle glaucoma and ocular hypertension. This study included thirty-six eyes of 18 patients diagnosed with primary open angle glaucoma (POAG) and ocular hypertension (OHT) at Ondokuz Mayis University, Medical Faculty, Department of Ophthalmology. All patients were underwent complete ophthalmic examination. Patients were randomized into 3 groups with six patients; group 1 received latanoprost 0.005% (Xalatan, Pharmacia), group 2 received travoprost 0.004% (Travatan, Alcon) and group 3 received bimatoprost 0.03% (Lumigan, Allergan) monotherapies. First examination was performed at the beginning of the study. Control examinations were performed at the 2, 4, 12 and 24th weeks of the therapy. Efficacy and side effects of these drugs were evaluated on each control visits. There were no significant differences in demographic characteristics among treatment groups. Baseline mean intra ocular pressure (IOP) levels were 26.50±3.14 mmHg in group 1, 25.58±3.62 mmHg in group 2 and 24.66±3.62 mmHg in group 3. Mean IOP levels were similar at end of the study between groups and 14.83±2.24 mmHg in group 1, 16.41±4.16 mmHg in group 2 and 16.16±3.53 mmHg in group 3. The most frequent side-effect was conjunctival hyperemia, which was determined in none of the patients in group 1, in 2 eyes in group 2 (16.7%) and 6 eyes in group 3 (50%). There was no statistically significant difference of IOP between latanoprost, travoprost and bimatoprost monotherapies. The side-effects were fewest in the latanoprost group and the most frequent in the bimatoprost group. © 2012 OMU.


PubMed | Research and Education Hospital
Type: | Journal: Journal of the Chinese Medical Association : JCMA | Year: 2016

We aimed to evaluate the efficacy and safety of dinoprostone for cervical ripening and labor induction in patients with term oligohydramnios and Bishop score5.This was a prospective case-control study, which included 104 consecutive women with a Bishop score5. Participants were divided into two groups. Women with term isolated oligohydramnios and Bishop score5 underwent induction of labor with a vaginal insert containing 10-mg timed-release dinoprostone (prostaglandin E2; Group A, n=40). The control group, Group B, consisted of 64 cases of pregnancy with normal amniotic fluid volume (amniotic fluid index5cm) and Bishop score5, and was matched for patients age and parity. The primary outcome was time from induction to delivery; the secondary outcomes were the caesarean section (CS) rate, uterine hyperstimulation, rate of failed induction, and neonatal complications.The mean time interval from induction to delivery was not different between the two groups (p=0.849), but there was a statistically significant difference between the groups in terms of the CS rate (p=0.005). There were no differences between the groups in neonatal outcome or perinatal morbidity or mortality.Dinoprostone appears to be a safe alternative for induction of labor in pregnancies with oligohydramnios. Induction of labor with dinoprostone in term pregnancies with isolated oligohydramnios is associated with increased rate of CS but there is no higher risk of perinatal complications.


PubMed | Research and Education Hospital
Type: Journal Article | Journal: Taiwanese journal of obstetrics & gynecology | Year: 2016

To compare fetal fibronectin (fFN) assessment, ultrasound parameters, and Bishop score in the prediction of successful induction of labor at term when cervix is unfavorable.Seventy-three nulliparous women undergoing labor induction at term with Bishop score less than 5 were enrolled in this study. Successful labor induction was defined as vaginal delivery occurring within 24 hours of initiation of induction. fFN obtained from vaginal secretion was measured by immunoassay.Patients who delivered within 24 hours (n = 33) differed significantly from the remaining patients by a positive fFN (84.8% vs. 15.2%, p = 0.002). The mean cervical length or Bishop scores were not statistically different between women who delivered vaginally before 24 hours of induction and those who did not (28.9 mm vs. 27.9 mm, p = 0.468 and 3.3 vs. 3.2, p = 0.928, respectively). Binary logistic regression analysis showed only the fFN immunoassay to be an independent statistically significant predictor of vaginal delivery within 24 hours of induction (odds ratio 6.168; 95% confidence interval 1.897-20.059; p = 0.002). A positive fibronectin assay had a sensitivity and specificity of 84.9% and 50%, respectively.In cases with unfavorable cervix, presence of vaginal fFN predicts the success of labor induction.

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