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Mexico City, Mexico

Hellaby M.D.,Education and Research Division
Simulation in Healthcare | Year: 2011

Introduction: Massive anaphylactic reactions are rare but potentially life-threatening events. It is recognized that there are concerns in both the immediate management and recognition of the condition. The report describes an innovative approach to develop a simple, low-cost device to simulate a rash on a mannequin as part of an education session. Methods: A system was developed to allow a plastic sheet with surface-mounted light-emitting diodes to be placed under the mannequin's chest skin. The lightemitting diodes presence and intensity could be controlled remotely via a potentiometer. Results: Staff were initially surprised by the presence of a rash on the mannequin but very quickly used the presence of the rash to support a diagnosis of severe anaphylaxis. Participants appeared to have responded positively to these simulationreinforced courses on acute anaphylaxis. Conclusions: The development of a method to visually demonstrate a rash on a mannequin facilitated some of the educational goals of the course: the importance of skin changes in aiding the diagnosis of acute anaphylaxis and the importance of exposure of the skin of the patient. © 2011 Society for Simulation in Healthcare.

Sabin E.A.,Education and Research Division | DeHaven W.R.,American Veterinary Medical Association
OIE Revue Scientifique et Technique | Year: 2012

Veterinary education serves as the foundation on which a country can build effective Veterinary Services (VS). In addition, an appropriately well-educated animal health workforce will be better poised to actively participate in and advance good governance practices. Good governance, in turn, will lead to improved animal and veterinary public heath infrastructures and help advance economic development across the globe. A crucial first step in establishing a strong educational foundation is to define minimum competencies for both public-and private-practice veterinarians to perform veterinary service tasks. Defining minimum competencies will also assist veterinary education establishments (VEEs) in developing and implementing curricula to allow graduates to achieve those competencies. Incorporating veterinary educational prerequisites and requirements into governance documents that regulate VS will help to ensure that those who deliver VS have an adequate knowledge and skills base to do so. Public-private partnerships may be particularly effective in designing and implementing curricula that address defined minimum competencies and assure the quality of VEEs. Through these partnerships, a system of continuous quality improvement is established that embodies the qualities essential to good governance practices. Such practices will ultimately strengthen national VS, better protect animal and public health, and ensure food security.

Mancilla-Herrera I.,Graduate Program on Immunology | Mancilla-Herrera I.,Specialties Hospital of the National Medical Center Siglo Mexican Social Security Institute | Alvarado-Moreno J.A.,Medical Research Unit in Thrombosis | Cerbulo-Vazquez A.,Education and Research Division | And 6 more authors.
Cell Biology International | Year: 2015

Inflammation is the normal immune response of vascularized tissues to damage and bacterial products, for which leukocyte transendothelial migration (TEM) is critical. The effects of cell-to-cell contact seen in both leukocyte and endothelial cells include cytoskeleton rearrangement, and dynamic expression of adhesion molecules and metalloproteinases. TEM induces expression of anti-apoptotic molecules, costimulatory molecules associated with antigen presentation, and pattern recognition receptors (PRR), such as TLR-4, in monocytes. However, little is known about how TLR-4 increment operates in monocytes during an inflammatory response. To understand it better, we used an in vitro model in which monocytes crossed a layer of IL-1β stimulated Human Umbilical Vein Endothelial Cells (HUVEC). After TEM, monocytes were tested for the secretion of inflammatory cytokines and chemokines, their phenotype (CD14, CD16, TLR-4 expression), and TLR-4 canonical [Nuclear Factor kappa B, (NF-κB) pathway] and non-canonical [p38, extracellular signal-regulated kinases (ERK) 1/2 pathway] signal transduction induced by lipopolysaccharide (LPS). Phagocytosis and bacterial clearance were also measured. There was diminished secretion of LPS-induced inflammatory cytokines (IL-1β, IL-6, and TNF-α) and higher secretion of chemokines (CXCL8/IL-8 and CCL2/MCP-1) in supernatant of TEM monocytes. These changes were accompanied by increases in TLR-4, CD14 (surfaces expression), p38, and ERK1/2 phosphorylated cytoplasmic forms, without affecting NF-κB activation. It also increased bacterial clearance after TEM by an O2-independent mechanism. The data suggest that interaction between endothelial cells and monocytes fine-tunes the inflammatory response and promotes bacterial elimination. © 2015 International Federation for Cell Biology.

Johnson R.,Education and Research Division | Jalleh G.,Curtin University Australia | Pratt I.S.,Education and Research Division | Pratt I.S.,Curtin University Australia | And 5 more authors.
Breast | Year: 2013

Mammography is widely acknowledged to be the most cost-effective technique for population screening for breast cancer. Recently in Australia, imaging modalities other than mammography, including thermography, electrical impedance, and computerised breast imaging, have been increasingly promoted as alternative methods of breast cancer screening. This study assessed the impact of three commercial breast imaging companies' promotional material upon consumers' beliefs about the effectiveness of the companies' technology in detecting breast cancer, and consumers' intentions to seek more information or consider having their breasts imaged by these modalities. Results showed 90% of respondents agreed that the companies' promotional material promoted the message that the advertised breast imaging method was effective in detecting breast cancer, and 80% agreed that the material promoted the message that the imaging method was equally or more effective than a mammogram. These findings have implications for women's preference for and uptake of alternative breast imaging services over mammography. © 2013 Elsevier Ltd.

Pratt I.S.,Education and Research Division | Pratt I.S.,Curtin University Australia | Croager E.J.,Education and Research Division | Rosenberg M.,University of Western Australia
Appetite | Year: 2012

Portion size has increased considerably over the past few decades and one influencing factor is dishware size. Using mathematical models we investigated how dish size affects the potential energy available in a meal. Two types of plate filling - flat and conical - were modelled for a range of plate sizes and energy densities, then compared to recommended daily energy requirements from Australian guidelines. Bowl filling was also modelled. Results indicate that a small increase in dishware size can lead to a substantial increase in energy available to be consumed, particularly if food is energy dense. This reinforces the need to consider dishware size when developing strategies to prevent over-consumption. © 2011 Elsevier Ltd.

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