Current Opinion in Nephrology and Hypertension | Year: 2015
Purpose of review To examine the putative measures of arterial stiffness and the mechanisms of adverse effects of stiffness on blood pressure and target organ damage using data from comprehensive hemodynamic profiles obtained in the Framingham Heart Study and the Age, Gene/Environment Susceptibility-Reykjavik Study. Recent findings Once thought to be a consequence of longstanding hypertension, recent evidence suggests that aortic stiffness antedates and contributes to the pathogenesis of hypertension and target organ damage in the heart, brain, and kidneys. Carotid-femoral pulse-wave velocity (CFPWV) has emerged as the reference standard measure of aortic stiffness and a powerful predictor of cardiovascular disease risk. Augmentation index, a putative measure of arterial stiffness and wave reflection, has complex relations with stiffness and risk. Recent evidence suggests that wave reflection, which is a normal consequence of impedance mismatch between compliant aorta and stiff muscular arteries, is protective and limits the exposure of target organs to potentially harmful pulsatile energy. Aortic stiffening produces impedance matching that reduces wave reflection and exposes the microcirculation to excessive pulsatile stress, resulting in microvascular target organ damage and dysfunction. Summary CFPWV provides a powerful new tool for risk stratification and elucidation of the pathogenesis of target organ damage in hypertension. © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Edgewater | Date: 2013-03-12
A magnetically assisted coupling comprises at least two shaft segments. Each shaft segment has opposed ends and a hollow core. Adjacent segment ends are configured in a probe/socket configuration such that one segment end is configured to receive the adjacent segment end. Magnets of opposite polarity are mounted within said hollow core of adjacent segment ends, such that the magnet in the socket is positioned at a bottom of the socket, while the magnet in the probe defines a probe end. When adjacent segment ends are brought into close proximity the magnets attract each other and draw the probe end into the socket until the magnets are in contact.
Edgewater | Date: 2014-11-12
A magnetically assisted coupling comprises at least two shaft segments. Each shaft segment (18) has opposed ends and a hollow core (20). Adjacent segment ends(22,24) are configured in a probe/socket configuration such that one segment end is configured to receive the adjacent segment end. Magnets (26) of opposite polarity are mounted within said hollow core of adjacent segment ends, such that the magnet in the socket is positioned at a bottom of the socket, while the magnet in the probe defines a probe end. When adjacent segment ends are brought into close proximity the magnets attract each other and draw the probe end into the socket until the magnets are in contact.
Edgewater | Date: 2016-03-30
The disclosed line guides combine a wear resistant ring with a superelastic, shape memory alloy frame and support to provide a lightweight and durable assembly. The wear resistant ring is constructed of hard material such as ceramic. The wear resistant ring includes a groove or annular depression on the outside surface where the ring and frame meet. The elastic frame is configured to grip the ring, which provides an enhanced mechanical connection between the wear resistant ring and the superelastic frame. The groove also provides a location for the application of adhesive. The frame is exposed around the wear resistant ring and protects the ring from damage during storage, transportation and use. The superelastic alloy frame and support flex to absorb shock and when deformed rebound to their original shape.
Edgewater | Date: 2013-11-15
Techniques for distributing computation and storage tasks between customer premises equipment and a remote vendor computer are disclosed. The techniques include receiving, at a customer premises computer equipment, a TCP-based data flow from a client, rewriting the IP header of the TCP-based data flow, and forwarding the TCP-based data flow to a defined TCP port. The techniques also include a transient termination server process operating in user space of the customer premises equipment to read an application payload sent by the client and sending data to a deep packet inspection engine for classification. The techniques may include identifying, from the client data flow, a protocol associated with the data flow, looking up a handling policy from a policy cache stored in the customer premises equipment, and handling the data flow according to the handling policy.
Edgewater | Date: 2015-03-09
Techniques for providing remote transcoding of call media data on a communications network are disclosed. The techniques include a communication module receiving a call request from a first communication device, transmitting a call invite to a second communication device, receiving a response from the second communication device, determining a first media encoding requirement for media transmitted to the first communication device and a second media encoding requirement for media transmitted to the second communication device, and transmitting information regarding the first communication device, the second communication device, the first media encoding requirement, and the second media encoding requirement to a transcoding module operating on a computer server. The techniques include the transcoding module receiving first call media data from the first communication device, transcoding the first call media data, and transmitting the transcoded first call media data to the second communication device.
Edgewater | Date: 2015-09-14
Automatic Gain Control (AGC) system for multi-channel signals attenuates an incoming multi-channel signal by providing a gain. The system further adjusts each individual channel, of the multi-channel signal, by supplying a second gain if needed. The AGC system is designed to ensure a received signal power is at an optimal level for analog to digital conversion or any other form of signal processing. The system also enables elimination of mid-packet gain adjustments.
Edgewater | Date: 2015-01-27
Techniques for maintaining configuration data for software components deployed on a computer network are disclosed. The techniques include a server on the computer network receiving configuration data values associated with the software components, committing the configuration data values to a data store, creating, from configuration data stored in the data store, configuration files for the software components with the configuration data value, and providing the configuration files to the software components.
Edgewater | Date: 2015-01-13
A 1553 data communication system having a primary data bus, a redundant data bus and a non-1553 data communication overlay system is provided. The non-1553 data communication overlay system comprises a non-1553 bus controller terminal and a non-1553 remote terminal. Each non-1553 terminal includes a non-1553 transmitter block connected to the primary bus and the redundant bus for sending non-1553 signals, a non-1553 receiver block for receiving non-1553 signals and a non-1553 receive path selection block. The non-1553 receive path selection block selectively establishes a receive path between the primary data bus or the redundant data bus and the non-1553 receiver block according to predefined receive path selection criteria. A 1553 data communication method is also provided.
Edgewater | Date: 2016-05-06
Gain variations during a packet can lead to significant performance degradation in communications systems that use high order quadrature amplitude modulation (QAM). A method and the associated apparatus track such variations in an OFDM system and completely eliminate any performance degradation. Gain estimation and compensation is employed with the use of pilot subcarriers in the payload of an OFDM data packet. Estimated pilot magnitude ratios are averaged, throughout the processing life of a packet, to yield accurate gain estimations. A gain compensation factor is used to adjust data carriers. An exclusion method is also employed to eliminate pilot carriers which contribute to noise.