ECOMINE Co.

Busan, South Korea

ECOMINE Co.

Busan, South Korea

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Choi J.-S.,Silla University | Cheon E.J.,Silla University | Kim T.-U.,Silla University | Moon W.-S.,ECOMINE Co. | And 2 more authors.
Food Science and Biotechnology | Year: 2015

The present study was carried out to evaluate the dermal toxicity of topically administered rice bran supercritical CO2 extract (RB-SCE; 500, 1,000, and 2,000 mg/kg) in male and female rats when given as a single dose and a 4-week repeated dose. In all rats that underwent the single-dose toxicity test, there were no abnormal changes in clinical signs or body weight and no deaths or abnormal gross necropsy findings related to RB-SCE. Based on the above results, the LD50 is >2,000 mg/kg in both sexes. In all rats that underwent the 4-week repeated dermal toxicity test, there were no abnormal RB-SCEassociated changes with respect to external signs, urine and blood, or organs. The no-observed-adverse-effect level (NOAEL) of RB-SCE was thus considered to be 2,000 mg/kg/day for both sexes and the target organ. RB-SCE can be regarded as a very safe agent for topical dermal administration at a moderate dose. © 2015, The Korean Society of Food Science and Technology and Springer Science+Business Media Dordrecht.


Choi J.-S.,Silla University | Choi J.-S.,ECOMINE Co. | Choi J.-S.,Kyungpook National University | Moon J.-N.,Silla University | And 14 more authors.
Toxicology and Environmental Health Sciences | Year: 2015

This study was conducted to investigate the acute dermal and ocular irritation potential of rice bran supercritical CO2 extract (RB-SCE) and a 0.5% RB-SCE essence product in rabbits and guinea pigs. No abnormal clinical signs attributable to RB-SCE were detected. In the dermal irritation test, erythema, eschar, and edema formation was observed at 24 h of RB-SCE treatment, and the skin returned to normal after 72 h. The dermal primary irritation index (PII) of RB-SCE was 2.71; thus it was classified as a moderate irritant. In the ocular irritation test, there were no clinical signs related to the application of the RB-SCE; thus it was classified as a non-irritant according to the Draize scoring system. In a skin sensitivity test in rabbits, no abnormal clinical signs attributable to RB-SCE essence were observed and the PII was 0 because there was no evidence of erythema, eschar, or edema. In the guinea pig skin sensitivity test, no abnormal body weight changes or increased mortality was detected. Sensitization to the RB-SCE essence was 0%; thus it was classified as a very weak irritant. © 2015, Korean Society of Environmental Risk Assessment and Health Science and Springer Science+Business Media Dordrecht.


Choi J.-S.,Silla University | Cheon E.J.,Silla University | Kim T.-U.,Silla University | Moon W.-S.,ECOMINE Co. | And 2 more authors.
Biological and Pharmaceutical Bulletin | Year: 2014

Rice bran oil extracted by supercritical CO2 extraction (RB-SCE) reportedly exhibits pharmacological activities such as antioxidant and in vivo hair growth-inducing effects. Such activities raise the possibility of the development of novel hair growth-inducing agents using RB-SCE. The aim of this study was to investigate the potential genotoxic effects of RB-SCE in three short-term mutagenicity assays (bacterial reverse mutation assay, in vitro mammalian chromosomal aberration test, and in vivo micronucleus assay). RB-SCE showed no genotoxicity in the bacterial reverse mutation assay up to 5000 mg/plate and in the in vivo micronucleus test up to 600 mg/kg body weight. However, at 120 μg/mL with S9 mix and 200 μg/mL without S9 mix RB-SCE showed significantly different genotoxicity than the negative control in the in vitro chromosome aberration test. The induction of chromosomal aberrations under the present conditions may have no biological significance. We have herein demonstrated that RB-SCE can be regarded as a non-genotoxic material based on the available in vivo and in vitro results. © 2014 The Pharmaceutical Society of Japan.


Choi J.-S.,Silla University | Moon W.-S.,ECOMINE Co. | Moon J.-N.,ECOMINE Co. | Cheon E.J.,Silla University | And 3 more authors.
Toxicology and Environmental Health Sciences | Year: 2013

The aim of this study was to evaluate the toxicity of rice bran supercritical CO2 extract (RB-SCE) in vitro and in vivo. A cytotoxicity assay revealed no inhibitory effects on cell viability in a mouse leukemic monocyte macrophage cell line (RAW 264.7) after 24-h incubation with 0.16 or 0.32 μg/mL of RB-SCE. RB-SCE was administered to male and female Sprague-Dawley rats at 2,500, 5,000, or 10,000 mg/kg to evaluate acute oral toxicity. Mortality, clinical symptoms, and body weight changes were monitored for two weeks. Animals were then euthanized and necropsies performed. Clinical symptoms included soft stool, diarrhea, and soiled perineal region. No significant changes in body weight were observed in treatment groups compared to the control. In addition, necropsy revealed no abnormal finding at any dosage. The approximate lethal dose (ALD) of RB-SCE was estimated at >10,000 mg/kg for both sexes and orally administered RBSCE was deemed safe. © 2013 Korean Society of Environmental Risk Assessment and Health Science and Springer Science+Business Media Dordrecht.


Choi J.-S.,Silla University | Roh M.-K.,ECOMINE Co. | Kim T.-U.,Silla University | Cheon E.J.,Silla University | And 2 more authors.
Journal of Environmental Biology | Year: 2015

In the present study, esterified rice bran oil (ERBO) was characterized using enzymatic esterification to improve stability, prevent acidification, enhance health-promoting biological activity and generate ω-3 PUFA-rich rice bran oil (RBO). Esterification reactions using RBO and ethanol were performed at 50°C under 200 bar with 3% lipozyme TL-IM (Thermomuces lanuginosa immobilized on silica gel) or RM-IM (Rft/zomucorm/efte/immobilized on ion exchange resin) for 3 hr under supercritical CO2. The molar ratios of ethanol to RBO were 3,6,9 and 12, respectively. Total lipid contents and acid values decreased (maximum 83.75%), buty-oryzanol content increased (maximum 41.33%) in esterified RBO (ERBO) prepared using TL-IM or RM-IM. In addition, DPPH radical scavenging activity of ERBO prepared by RM-IM atan ethanol to RBO molar ratio of 3 was 0.02 μg μl-1, which was 63-fold higher than that of α-tocopherol (IC50=1.25 μg μl-1). The anti-inflammatory effect of RM-IM 1:3 hydrolysate of RBO was verified showing its suppressive effect towards iNOS and Cox-2mRNA expression in a dose-dependent manner. Therefore, ERBO is a promising source of functional food, cosmetics and pharmaceuticals. © 2015 Triveni Enterprise, Lucknow (India).


Roh M.-K.,Ecomine Co. | Jeon M.-H.,Ecomine Co. | Moon J.-N.,Ecomine Co. | Moon W.-S.,Ecomine Co. | And 2 more authors.
Botanical Sciences | Year: 2013

The purpose of this study was to develop a simple and effective method using conventional solvent extraction and antisolvent precipitation for the isolation of lycopene from Lycopersicon esculentum. A total of 100 grams of freeze-dried L. esculentum powder was weighed into a glass tube with a glass filter at the bottom. The material was extracted for 1 hour using 1 L of the following solvents: hexane, ethyl acetate, and ethanol. The extraction yields were 3.58, 4.39, and 1.25 mg/g, respectively, indicating that ethyl acetate was the most effective of the studied extraction solvents. Next, all carotenoids, except lycopene, were removed from the crude extract using an anti-solvent (methanol) salting-out method. The precipitated and isolated lycopene totaled 3.50 mg/g, indicating a 77.43% lycopene recovery rate. The lycopene isolation method developed in this study was more effective than the previous reported methods for the large-scale preparative isolation of lycopene.


Patent
Ecomine Co. | Date: 2012-04-26

Provided is an optical treatment device for a scalp and a hair. According to the optical treatment device for the scalp and the hair, LEDs are mounted on a device to irradiate an ultraviolet light and visible light to the scalp and the hair, so that the metabolism of cells is activated. Iontophoresis equipment is mounted at the upper portion of the device or the lateral side portion of the device to apply the potential difference to the skin, thereby changing an electric environment of the skin, so that the transmittance of ionized medicine through the skin is increased. The optical treatment device includes a body, an MTS cartridge detachably provided at one side of the body, and an LED lamp interposed between the body and the MTS cartridge.


Trademark
Ecomine Co. | Date: 2014-09-11

Cosmetics for hair and scalp; Dandruff creams not fot medical treatment; Depilatories; Hair care lotions; Hair tonics; Hair Shampoos; Nutritional creams for scalp; Hair conditioners; Nutritional supplements for hair; Nutritional supplements for scalp. Electric massage apparatus for household use; Electric massage apparatus for skin care for household use; Electric massage appliances, namely, electric vibrating massager; Electric aesthetic massage apparatus for household use; Electric massage apparatus for scalp care for household use; Electric massage apparatus for scalp care for medical purposes.


Trademark
ECOMINE Co. | Date: 2015-09-01

Cosmetics; cosmetics for hair and scalp; non-medicated treatment for hair and scalp; dandruff creams not for medical treatment; depilatories; hair lotion; hair tonic for cosmetic use; hair shampoos. Nutritional supplements for hair; nutritional supplements for scalp.

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