Ecole Polytechnique Federale de Lausanne

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Lausanne, Switzerland
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Patent
Ecole Polytechnique Federale de Lausanne | Date: 2017-08-09

The invention relates to a method for quantitative measurement of a biomarker by in situ immunofluorescence and uses thereof. In particular, the invention relates to a method which is a useful tool for use in the field of diagnosis, prevention and/or treatment of disease or disorders, in particular in the field of cancer management and therapy.


The invention concerns a method of manufacturing objects by selective laser melting (SLM) in which between the forming of subsequent layers of the object a plastic deformation and residual stresses are induced into the solidified material of at least one of said layers to improve the mechanical properties and the fatigue life of the object. This step is carried out with a laser, as a LSP or WLSP step. The invention also concerns a system to carry out the method.


Patent
Ecole Polytechnique Federale de Lausanne | Date: 2017-08-09

Heparin binding peptides derived from a Tenascin (TNC) III1-5 domain or a fibrinogen 15-66 domain have been found that bind certain cytokines with high affinity. Materials and methods for making compositions and devices using these peptides are disclosed.


A method for manufacturing an object including the steps of forming layers by adding successive layers of material to form the object by selective laser melting (SLM), and inducing plastic deformation and residual stress into solidified material of at least one of the successive layers of material to improve mechanical properties and a fatigue resistance of the object, wherein the plastic deformation and the residual stress are induced by a laser.


Patent
Ecole Polytechnique Federale de Lausanne | Date: 2016-12-05

Described herein are microelectrode array devices, and methods of fabrication, assembly and use of the same, to provide highly localized neural recording and/or neural stimulation to a neurological target. The device includes multiple microelectrode elements arranged protruding shafts. The protruding shafts are enclosed within an elongated probe shaft, and can be expanded from their enclosure. The microelectrode elements, and elongated probe shafts, are dimensioned in order to target small volumes of neurons located within the nervous system, such as in the deep brain region. Beneficially, the probe can be used to quickly identify the location of a neurological target, and remain implanted for long-term monitoring and/or stimulation.


Patent
Ecole Polytechnique Federale de Lausanne | Date: 2016-07-27

A drop delivery system comprising a light source; an optical waveguide bringing light from the light source; and a liquid supplying means configured to bring a liquid at a tip of the optical waveguide, wherein the light source and the optical waveguide are configured to enable the light to eject a drop of the liquid.


Patent
Ecole Polytechnique Federale de Lausanne | Date: 2017-05-10

The invention relates to a scaffold material comprising a carrier and embedded microbeads for use in tissue engineering applications such as soft tissues therapeutic treatment. The scaffold provides a short-term bulking effect coupled with a long-term functional activity. Both the carrier and the microbeads are substantially composed of natural or extracellular matrix-derived polymers, and the beads can comprise homogeneously distributed active agents, providing a regulated agent release along time. An aspect of the invention relates to a method for producing the microbeads of the invention by using an expressly designed microfluidic chip.


Patent
Ecole Polytechnique Federale de Lausanne | Date: 2017-09-20

The invention provides ionic polymers (IP) consisting of anions and a polymeric backbone containing cations. The invention also provides the ionic polymers incorporated in membranes or attached to solid supports and use of the ionic polymers in processing of biomass.


Gonczy P.,Ecole Polytechnique Federale de Lausanne
Nature Reviews Molecular Cell Biology | Year: 2012

The centriole is an evolutionarily conserved macromolecular structure that is crucial for the formation of flagella, cilia and centrosomes. The ultrastructure of the centriole was first characterized decades ago with the advent of electron microscopy, revealing a striking ninefold radial arrangement of microtubules. However, it is only recently that the molecular mechanisms governing centriole assembly have begun to emerge, including the elucidation of the crucial role of spindle assembly abnormal 6 (SAS-6) proteins in imparting the ninefold symmetry. These advances have brought the field to an exciting era in which architecture meets function. © 2012 Macmillan Publishers Limited. All rights reserved.


Brisken C.,Ecole Polytechnique Federale de Lausanne
Nature Reviews Cancer | Year: 2013

Understanding the biology of the breast and how ovarian hormones impinge on it is key to rational new approaches in breast cancer prevention and therapy. Because of the success of selective oestrogen receptor modulators (SERMs), such as tamoxifen, and aromatase inhibitors in breast cancer treatment, oestrogens have long received the most attention. Early progesterone receptor (PR) antagonists, however, were dismissed because of severe side effects, but awareness is now increasing that progesterone is an important hormone in breast cancer. Oestrogen receptor-α (ERα) signalling and PR signalling have distinct roles in normal mammary gland biology in mice; both ERα and PR delegate many of their biological functions to distinct paracrine mediators. If the findings in the mouse model translate to humans, new preventive and therapeutic perspectives might open up. © 2013 Macmillan Publishers Limited. All rights reserved.

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