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The invention concerns a method of manufacturing objects by selective laser melting (SLM) in which between the forming of subsequent layers of the object a plastic deformation and residual stresses are induced into the solidified material of at least one of said layers to improve the mechanical properties and the fatigue life of the object. This step is carried out with a laser, as a LSP or WLSP step. The invention also concerns a system to carry out the method.


Patent
Ecole Polytechnique Federale de Lausanne | Date: 2017-05-10

The invention relates to a scaffold material comprising a carrier and embedded microbeads for use in tissue engineering applications such as soft tissues therapeutic treatment. The scaffold provides a short-term bulking effect coupled with a long-term functional activity. Both the carrier and the microbeads are substantially composed of natural or extracellular matrix-derived polymers, and the beads can comprise homogeneously distributed active agents, providing a regulated agent release along time. An aspect of the invention relates to a method for producing the microbeads of the invention by using an expressly designed microfluidic chip.


Patent
Ecole Polytechnique Federale de Lausanne | Date: 2015-10-19

The present invention concerns a method of sampling a test signal. The method comprises: acquiring (21) training signals sampled at a plurality of sampling locations; running (23) an optimization procedure for determining an index set of n indices, representing a subset of the sampling locations, that maximize a function, over the training signals, of a quality parameter representing how well a given training signal is represented by the n indices; and sampling (25) the test signal at the sampling locations represented by the n indices.


Patent
Ecole Polytechnique Federale de Lausanne | Date: 2015-05-22

An organic-inorganic perovskite CH_(3)NH_(3)PbI_(3 )nanowire showing a length-width aspect ratio from 5-400 up to 10^(9 )and a width-height ratio of 1-100 up to 1-10000. Further, the invention is embodied as a process for making the nanowire wherein at least a polar aprotic solvents is used, the polar aprotic solvent being at least one from the list comprising DMF, DMSO, and DMAc solvents.


Patent
Quartet Medicine and Ecole Polytechnique Federale de Lausanne | Date: 2016-09-30

Inhibitors of sepiapterin reductase and uses of sepiapterin reductase inhibitors in analgesia, treatment of acute and chronic pain, anti-inflammation, and immune cell regulation are disclosed.


Patent
Ecole Polytechnique Federale de Lausanne | Date: 2015-11-20

Method for processing a circular light field comprising the step of receiving or storing a circular light field matrix, wherein the circular light field matrix comprises pixel data for different circumferential angles and for different incidence angles, wherein each circumferential angle represents one intersection point of a light ray with a circle, and each incidence angle represents an angle of incidence of the light ray in the plane of the circle at the one intersection point; and the step of determining a sub set of pixel data of the circular light field matrix relating to a location by determining for each different circumferential angle an incidence angle related to said location.


Patent
Ecole Polytechnique Federale de Lausanne | Date: 2016-10-14

The present invention provides methods of treating various disorders associated with mitochondrial dysfunction, including but not limited to metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, and diseases of aging.


Patent
Ecole Polytechnique Federale de Lausanne | Date: 2016-12-21

The present invention relates to a reflective optical objective (1) comprising: a first reflecting element (3) including a front surface (3a) and a hack surface (3b), the front surface (3a) including a convex reflecting surface (11); and a second reflecting element (5) including a concave reflecting surface (13) facing the convex reflecting surface (11) of the first reflecting element (3), the second reflecting element (5) including a transmissive section (7) permitting electromagnetic radiation to pass through the concave reflecting surface (13) of the second reflecting element (5) to the first reflecting element (3). The reflective optical objective (1) is characterised in that the reflective optical objective (1) includes a carrier material (9) embedding at least the front surface (3a) of the first reflecting element (3) and defining the distance (d) between the first (3) and second (5) reflecting elements.


Gonczy P.,Ecole Polytechnique Federale de Lausanne
Nature Reviews Molecular Cell Biology | Year: 2012

The centriole is an evolutionarily conserved macromolecular structure that is crucial for the formation of flagella, cilia and centrosomes. The ultrastructure of the centriole was first characterized decades ago with the advent of electron microscopy, revealing a striking ninefold radial arrangement of microtubules. However, it is only recently that the molecular mechanisms governing centriole assembly have begun to emerge, including the elucidation of the crucial role of spindle assembly abnormal 6 (SAS-6) proteins in imparting the ninefold symmetry. These advances have brought the field to an exciting era in which architecture meets function. © 2012 Macmillan Publishers Limited. All rights reserved.


Brisken C.,Ecole Polytechnique Federale de Lausanne
Nature Reviews Cancer | Year: 2013

Understanding the biology of the breast and how ovarian hormones impinge on it is key to rational new approaches in breast cancer prevention and therapy. Because of the success of selective oestrogen receptor modulators (SERMs), such as tamoxifen, and aromatase inhibitors in breast cancer treatment, oestrogens have long received the most attention. Early progesterone receptor (PR) antagonists, however, were dismissed because of severe side effects, but awareness is now increasing that progesterone is an important hormone in breast cancer. Oestrogen receptor-α (ERα) signalling and PR signalling have distinct roles in normal mammary gland biology in mice; both ERα and PR delegate many of their biological functions to distinct paracrine mediators. If the findings in the mouse model translate to humans, new preventive and therapeutic perspectives might open up. © 2013 Macmillan Publishers Limited. All rights reserved.

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