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Patent
Ecole Polytechnique Federale de Lausanne | Date: 2015-04-22

A system for measuring blood pressure of a user that comprises an ElectroCardioGram (ECG) circuit with at least two ECG electrodes configured to obtain an electrical activity of a heart of the user by measuring the electrical signals detected at the at least two ECG electrodes as an electrocardiogram waveform, and a pulse oximeter circuit configured to obtain a pulse waveform corresponding to a blood flow on users vessels. The system further comprises a processor that is in electrical contact with the electrocardiogram circuit and the pulse oximeter circuit. The processor is configured to simultaneously analyze the electrocardiogram waveform and the pulse waveform. The processor is further configured to identify a Zero Voltage Crossing point on the electrocardiogram waveform and to determine time delays from this point to respective different determined points of the pulse waveform; and to use the time delays to compute the blood pressure values


Patent
Ecole Polytechnique Federale de Lausanne | Date: 2016-12-05

Described herein are microelectrode array devices, and methods of fabrication, assembly and use of the same, to provide highly localized neural recording and/or neural stimulation to a neurological target. The device includes multiple microelectrode elements arranged protruding shafts. The protruding shafts are enclosed within an elongated probe shaft, and can be expanded from their enclosure. The microelectrode elements, and elongated probe shafts, are dimensioned in order to target small volumes of neurons located within the nervous system, such as in the deep brain region. Beneficially, the probe can be used to quickly identify the location of a neurological target, and remain implanted for long-term monitoring and/or stimulation.


Patent
Ecole Polytechnique Federale de Lausanne | Date: 2015-03-05

The invention provides for a bioactive composition comprising solid particles, such as e.g. calcium phosphate particles, loaded with an active agent, preferably an osteoconductive/osteoinductive agent or an anti-resorptive agent like a bisphosphonate. The drug-loaded particles are included into a carrier that is preferably composed of a polymeric matrix, such as for instance a hyaluronic acid-based hydrogel. The composition is particularly useful for the treatment of bone defects, including dental-related pathological conditions, and particularly for bone regeneration/healing. The composition can be applied and/or injected directly in situ to perform its action on the bone defect. A pharmaceutical composition comprising the bioactive composition is also disclosed herein.


Patent
Ecole Polytechnique Federale de Lausanne | Date: 2016-07-27

A drop delivery system comprising a light source; an optical waveguide bringing light from the light source; and a liquid supplying means configured to bring a liquid at a tip of the optical waveguide, wherein the light source and the optical waveguide are configured to enable the light to eject a drop of the liquid.


A method produces a conductive paste comprising 15-20% by weight of PDMS and 80-85% by weight of metallic micro-nano particles, wherein the conductive paste is obtained by repeated addition of singular doses of PDMS to a heptane diluted PDMS low viscosity liquid containing the metallic micro-nano particles, wherein the heptane fraction is allowed to evaporate after addition of each of the singular doses of PDMS. A method forms a conductive path on a support layer, wherein the conductive path is encapsulated by an encapsulation layer comprising at least one via through which at least one portion of the conductive path is exposed, the method comprising filling the at least one via with the conductive paste.


Patent
Ecole Polytechnique Federale de Lausanne | Date: 2015-07-29

A wireless validation method between an first apparatus and a second apparatus comprising the following steps of communicating between the first apparatus and the second apparatus for agreeing in a protected way on a common symmetric key and performing a symmetric distance bounding validation between the first apparatus and the second apparatus over a wireless communication link on the basis of the agreed common symmetric key.


A method for manufacturing an object including the steps of forming layers by adding successive layers of material to form the object by selective laser melting (SLM), and inducing plastic deformation and residual stress into solidified material of at least one of the successive layers of material to improve mechanical properties and a fatigue resistance of the object, wherein the plastic deformation and the residual stress are induced by a laser.


Patent
Ecole Polytechnique Federale de Lausanne | Date: 2015-09-06

The invention provides a method for coping with an unintentional islanding of an electrical distribution grid within a Commelec-type framework for the real-time control of micro-grids, of Resource Agents (RA) controlled by Grid Agents (GA), comprising at least maintain at any time before the unintentional islanding occurs a rating of all resource agents controlled by a same grid agent in view of their ability to be a slack resource, by computing the rating based on a power availability and on a state-of-energy of each resource, the state-of-energy quantifying an amount of energy that may be withdrawn from a potential slack irrespectively of a PQ profile, whereby the PQ profile describes bounds for active and reactive power that a resource can inject or absorb; and a shedding list of all the resources that have to be shed if a current best candidate slack resource is selected, the current best candidate slack resource being the slack resource having the best rating of all resources as determined in the step of rating all resource agents, the shedding list being obtained by computing from an uncertainty of the resources and a predetermined order of shedding priority. The method further comprises continuously monitor islanding conditions via an available real-time state estimation process, and when an islanding condition is detected, causing the grid agent to shed all resources in the shedding list and choose an initial slack based on the rating obtained before the islanding occurrence from the step of rating of all resource agents.


Patent
Ecole Polytechnique Federale de Lausanne | Date: 2016-07-26

A system for subpixel resolution imaging of an amplitude and quantitative phase image, the system including a waveguide having a top plane, a bottom plane, and two sides, an array of light sources emitting first befit beams from one side of the two sides of a waveguide, a holographic photopolymer film positioned on the top plane or the bottom plane of the waveguide and arranged to be illuminated by the first light beams from the array of light sources via the waveguide and to produce second light beams by diffraction, and an imaging device for capturing interference pattern light beams that passed through a sample, the sample arranged to be illuminated by the second light beams.


Patent
Ecole Polytechnique Federale de Lausanne | Date: 2015-09-30

A system and method of coupling a Branch Target Buffer (BTB) content of a BTB with an instruction cache content of an instruction cache. The method includes: tagging a plurality of target buffer entries that belong to branches within a same instruction block with a corresponding instruction block address and a branch bitmap to indicate individual branches in the block; coupling an overflow buffer with the BTB to accommodate further target buffer entries of instruction blocks, distinct from the plurality of target buffer entries, which have more branches than the bundle is configured to accommodate in the corresponding instructions bundle in the BTB; and predicting the instructions or the instruction blocks that are likely to be fetched by the core in the future and fetch those instructions from the lower levels of the memory hierarchy proactively by means of a prefetcher.


Patent
Ecole Polytechnique Federale de Lausanne | Date: 2015-02-13

Molecular sensing system including: a sensing device (5) comprising at least one support layer (10), and an active layer (6) mounted on said support layer and having at least one nano-pore (12) configured for translocation of a molecular analyte (18) therethrough; an electrically conducting liquid (4) in contact with the active layer in a region around said nano-pore; and a signal processing circuit (7) comprising an ionic current circuit (8) configured to generate and measure an ionic current (Ii) in the electrically conducting liquid influenced by the translocation of the molecular analyte through the nano-pore. The molecular sensing device of the invention allows for single-nucleotide discrimination and detection of the specific sequence within ssDNA.


Patent
Ecole Polytechnique Federale de Lausanne | Date: 2016-09-26

System comprising at least one sensor configured to take a set of images from different viewpoints of a scene; a processor configured to identifying a point source represented in the images of a set of images; computing for each image of the set of images the subspace of potential locations of the point source in the scene on the basis of the viewpoint or a viewpoint region of the image and on the basis of the subregion of the image representing the point source; and computing a point intersection region of the subspaces of potential locations of the point source of the images of the set of images.


Patent
Ecole Polytechnique Federale de Lausanne | Date: 2015-04-14

The present invention relates to a method and device for measuring m/z ratios of ions in ion cyclotron resonance (ICR) mass spectrometry. The described ion traps for ICR mass spectrometry are distinct from the previous configurations by having one or many narrow aperture (flat) detection electrodes that could be moved radially inward the ICR trap, for example on the plane where radiofrequency excitation potential is minimal, closer to the post-excitation ion trajectories.


Patent
Ecole Polytechnique Federale de Lausanne | Date: 2015-07-31

The present invention concerns a method of encoding a media bitstream of a media content. The media bitstream comprises a payload portion for the media content, and an overhead portion, different from the payload portion. The method comprises the steps of: modifying a part of the payload portion of the media bitstream, the modified part representing a region of the media content; and inserting the said part, as unmodified, into the overhead portion of the modified media bitstream for later reconstruction of the unmodified payload portion, such that the modified part in the media bitstream can be decoded without decoding the part as unmodified from the overhead portion. The invention also relates to a method of decoding, to an encoder and to a decoder.


Oosterveer M.H.,University of Groningen | Schoonjans K.,Ecole Polytechnique Federale de Lausanne
Cellular and Molecular Life Sciences | Year: 2014

The hepatic glucose-sensing system is a functional network of enzymes and transcription factors that is critical for the maintenance of energy homeostasis and systemic glycemia. Here we review the recent literature on its components and metabolic actions. Glucokinase (GCK) is generally considered as the initial postprandial glucose-sensing component, which acts as the gatekeeper for hepatic glucose metabolism and provides metabolites that activate the transcription factor carbohydrate response element binding protein (ChREBP). Recently, liver receptor homolog 1 (LRH-1) has emerged as an upstream regulator of the central GCK-ChREBP axis, with a critical role in the integration of hepatic intermediary metabolism in response to glucose. Evidence is also accumulating that O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) and acetylation can act as glucose-sensitive modifications that may contribute to hepatic glucose sensing by targeting regulatory proteins and the epigenome. Further elucidation of the components and functional roles of the hepatic glucose-sensing system may contribute to the future treatment of liver diseases associated with deregulated glucose sensors. © 2013 Springer.


Belanger M.,Ecole Polytechnique Federale de Lausanne | Allaman I.,Ecole Polytechnique Federale de Lausanne | Magistretti P.J.,Ecole Polytechnique Federale de Lausanne
Cell Metabolism | Year: 2011

The energy requirements of the brain are very high, and tight regulatory mechanisms operate to ensure adequate spatial and temporal delivery of energy substrates in register with neuronal activity. Astrocytes - a type of glial cell - have emerged as active players in brain energy delivery, production, utilization, and storage. Our understanding of neuroenergetics is rapidly evolving from a "neurocentric" view to a more integrated picture involving an intense cooperativity between astrocytes and neurons. This review focuses on the cellular aspects of brain energy metabolism, with a particular emphasis on the metabolic interactions between neurons and astrocytes. © 2011 Elsevier Inc.


Dagousset G.,CNRS Natural Product Chemistry Institute | Zhu J.,Ecole Polytechnique Federale de Lausanne | Masson G.,CNRS Natural Product Chemistry Institute
Journal of the American Chemical Society | Year: 2011

A chiral phosphoric acid (5)-catalyzed three-component Povarov reaction of aldehydes 2, anilines 3, and enecarbamates 4 afforded cis-4-amino-2-aryl(alkyl)- 1,2,3,4-tetrahydroquinolines 1 in high yields with excellent diastereoselectivities (>95%) and almost complete enantioselectivities (up to >99% ee). The reaction was applicable to a wide range of anilines bearing electron-donating (OMe) and electron-withdrawing groups (e.g., Cl, CF 3, NO 2) and allowed, for the first time, aliphatic aldehydes to be employed in the enantioselective Povarov reaction. With β-substituted acyclic enecarbamates, 2,3,4-trisubstituted 1,2,3,4-tetrahydroquinolines with three contiguous stereogenic centers were produced in excellent diastereo- and enantioselectivities (87 to >99% ee). A detailed study of the active catalytic species allowed us to reduce the catalyst loading from 10% to 0.5% with no deterioration of enantiomeric excess. In addition, mechanistic studies allowed us to conclude unequivocally that the Povarov reaction involving enecarbamate as dienophile proceeded via a stepwise mechanism. The key role of the free NH function of the enecarbamate in the success of this transformation was demonstrated. NMR experiments indicating the catalyst-substrate interaction as well as a linear correlation between catalyst and product ee's were also documented. © 2011 American Chemical Society.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: FoF.NMP.2012-4 | Award Amount: 18.22M | Year: 2013

The overarching goal of AMAZE is to rapidly produce large defect-free additively-manufactured (AM) metallic components up to 2 metres in size, ideally with close to zero waste, for use in the following high-tech sectors namely: aeronautics, space, automotive, nuclear fusion and tooling. Four pilot-scale industrial AM factories will be established and enhanced, thereby giving EU manufacturers and end-users a world-dominant position with respect to AM production of high-value metallic parts, by 2016. A further aim is to achieve 50% cost reduction for finished parts, compared to traditional processing. The project will design, demonstrate and deliver a modular streamlined work-flow at factory level, offering maximum processing flexibility during AM, a major reduction in non-added-value delays, as well as a 50% reduction in shop-floor space compared with conventional factories. AMAZE will dramatically increase the commercial use of adaptronics, in-situ sensing, process feedback, novel post-processing and clean-rooms in AM, so that (i) overall quality levels are improved, (ii) dimensional accuracy is increased by 25% (iii) build rates are increased by a factor of 10, and (iv) industrial scrap rates are slashed to <5%. Scientifically, the critical links between alloy composition, powder/wire production, additive processing, microstructural evolution, defect formation and the final properties of metallic AM parts will be examined and understood. This knowledge will be used to validate multi-level process models that can predict AM processes, part quality and performance. In order to turn additive manufacturing into a mainstream industrial process, a sharp focus will also be drawn on pre-normative work, standardisation and certification, in collaboration with ISO, ASTM and ECSS. The team comprises 31 partners: 21 from industry, 8 from academia and 2 from intergovernmental agencies. This represent the largest and most ambitious team ever assembled on this topic.


Grant
Agency: Cordis | Branch: H2020 | Program: IA | Phase: LCE-09-2015 | Award Amount: 27.97M | Year: 2016

This proposal is an application to the EU programme Horizon 2020 and its topic Large scale energy storage (LCE-09-2015). The presented project STORE&GO will demonstrate three innovative Power to Gas storage concepts at locations in Germany, Switzerland and Italy in order to overcome technical, economic, social and legal barriers. The demonstration will pave the way for an integration of PtG storage into flexible energy supply and distribution systems with a high share of renewable energy. Using methanation processes as bridging technologies, it will demonstrate and investigate in which way these innovative PtG concepts will be able to solve the main problems of renewable energies: fluctuating production of renewable energies; consideration of renewables as suboptimal power grid infrastructure; expensive; missing storage solutions for renewable power at the local, national and European level. At the same time PtG concepts will contribute in maintaining natural gas or SNG with an existing huge European infrastructure and an already advantageous and continuously improving environmental footprint as an important primary/secondary energy carrier, which is nowadays in doubt due to geo-political reasons/conflicts. So, STORE&GO will show that new PtG concepts can bridge the gaps associated with renewable energies and security of energy supply. STORE&GO will rise the acceptance in the public for renewable energy technologies in the demonstration of bridging technologies at three living best practice locations in Europe.


Grant
Agency: Cordis | Branch: H2020 | Program: SGA-RIA | Phase: FETFLAGSHIP | Award Amount: 89.00M | Year: 2016

This project is the second in the series of EC-financed parts of the Graphene Flagship. The Graphene Flagship is a 10 year research and innovation endeavour with a total project cost of 1,000,000,000 euros, funded jointly by the European Commission and member states and associated countries. The first part of the Flagship was a 30-month Collaborative Project, Coordination and Support Action (CP-CSA) under the 7th framework program (2013-2016), while this and the following parts are implemented as Core Projects under the Horizon 2020 framework. The mission of the Graphene Flagship is to take graphene and related layered materials from a state of raw potential to a point where they can revolutionise multiple industries. This will bring a new dimension to future technology a faster, thinner, stronger, flexible, and broadband revolution. Our program will put Europe firmly at the heart of the process, with a manifold return on the EU investment, both in terms of technological innovation and economic growth. To realise this vision, we have brought together a larger European consortium with about 150 partners in 23 countries. The partners represent academia, research institutes and industries, which work closely together in 15 technical work packages and five supporting work packages covering the entire value chain from materials to components and systems. As time progresses, the centre of gravity of the Flagship moves towards applications, which is reflected in the increasing importance of the higher - system - levels of the value chain. In this first core project the main focus is on components and initial system level tasks. The first core project is divided into 4 divisions, which in turn comprise 3 to 5 work packages on related topics. A fifth, external division acts as a link to the parts of the Flagship that are funded by the member states and associated countries, or by other funding sources. This creates a collaborative framework for the entire Flagship.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-EID | Phase: MSCA-ITN-2015-EID | Award Amount: 3.86M | Year: 2016

The target of this project is to prepare and train future engineers for the design challenges and opportunities provided by modern optics technology. Such challenges include lossless photon management, modelling at the system, components and feature level, and the link between design and technology. Today all optical designs are often perceived following different approaches, namely geometrical optics, physical optics and nano-photonics. Traditionally these approaches are linked to the different lengths-scale that are important to the system. Starting from the entire system that is macroscopic and uses geometrical optics, over the miniaturized unit that is based on micro-optics and needs physical optics design, down to the active nano-photonics entity that allows steering light truly at the nano-scale but which requires to be designed with rigorous methods that provide full wave solutions to the governing Maxwells equations. A design for manufacture of next generation optical applications necessarily requires to bridge the gap between the different length scales and to consider the design at a holistic level. At the core are optical simulation models developed and used in the academic research and the one used for optical designs in industry. Up to now, only the academic partners apply an integral approach to include micro- and nano-photonics in their simulations. Together with the industrial partners projects will be launched to promote the academic developments in optical design and simulation over different length scales towards the industry. The industry will use the know-how to consolidate their expertise, expand their businesses, and occupy new fields of activities. For each research subject, may it be nano-photonics, micro-optics or system engineering, a channel can be provided to access particular knowledge and/or stimulate collaborations.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.95M | Year: 2015

TERRE aims to develop novel geo-technologies to address the competitiveness challenge of the European construction industry in a low carbon agenda. It will be delivered through an inter-sectoral and intra-European coordinated PhD programme focused on carbon-efficient design of geotechnical infrastructure. Industry and Research in the construction sector have been investing significantly in recent years to produce innovative low-carbon technologies. However, little innovation has been created in the geo-infrastructure industry, which is lagging behind other construction industry sectors. TERRE aims to close this gap through a network-wide training programme carried out by a close collaboration of eleven Universities and Research Centres and three SMEs. It is structured to provide a balanced combination of fundamental and applied research and will eventually develop operational tools such as software for low-carbon geotechnical design and a Decision Support System for infrastructure project appraisal. The research fellows will be involved in inter-sectoral and intra-European projects via enrolment in 8 Joint-Awards and 7 Industrial PhDs. The research fellows will be trained in low-carbon design by developing novel design concepts including eco-reinforced geomaterials, engineered vegetation, engineered soil-atmosphere interfaces, biofilms, shallow geothermal energy and soil carbon sequestration. Distinctive features of TERRE are the supervision by an inter-sectoral team and the orientation of the research towards technological applications. Training at the Network level includes the development of entrepreneurial skills via a special programme on Pathways to Research Enterprise to support the research fellows in establishing and leading spin-out companies after the end of the project.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP-2008-3.2-1 | Award Amount: 16.82M | Year: 2009

The ultimate ambition of COPIRIDE is to develop a new modular production and factory concept for the chemical industry using adaptable plants with flexible output. This concept will be superior, intellectual property (IP) protected, and enable a much wider spread of know-how and education of this skill-intensive technology. Key functional enabling units are new production-scale, mass-manufactured microstructured reactors as well as other integrated process intensification (PI) reactors realising integrated processes. This will lead to a substantial reduction in costs, resources & energy and notably improves the eco-efficiency. To ensure the competitiveness of European (EU) manufacturing businesses, PI technology / know-how is transferred from leaders to countries (and respective medium & small industries) with no exposure in PI so far, but with a track record in sustainability, and to the explorative markets food and biofuels. A deeply rooted base will be created for IP rights (Copyright, = COPIRIDE) by generic modular reactor & plant design and new generic processes via Novel Process Windows, facilitating patent filing. Due to the entire modular plant concept comprising all utilities far beyond the reaction & processual parts - a holistic PI concept is provided, covering the whole development cycle with, e.g., safety & process control & plant approval. Features, inter alia, are fast plant start-up and shut-down for multipurpose functionality (flexibility in products), sustainable & safe production, and fast transfer from lab to production & business (time-to-market). Industrial demonstration activities up to production scale with five field trials present a good cross-section of reactions relevant to the EU chemical industry. The economic impact in COPIRIDE is 10 Mio /a (cautiously optimistic) to 30 Mio /a (optimistic) by direct exploitation. Indirect exploitation might sum up to 800 Mio /a (very optimistic) by other companies via technology transfer.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.5.1 | Award Amount: 3.52M | Year: 2011

REWIRE develops, integrates and field tests an innovative virtual reality based rehabilitation platform, which allows patients, discharged from the hospital, to continue intensive rehabilitation at home under remote monitoring by the hospital itself. The main idea is to assemble off the shelf components in a robust and reliable way to get a platform system that can be to be deployed massively at the patients homes. The platform is constituted of three hierarchical components: a patient station (PS), deployed installed at home, a hospital station (HS) and a networking station (NS) at a the health provider site. The PS is based on video-based tracking (through a mix of 2D and 3D cameras) and virtual reality. The patient sees on the display himself or an avatar moving and interacting in real-time with a virtual game with his movements tracked in real-time. Game variety of scenarios, balanced scoring system, quantitative exercise evaluation, audio-visual feed-back aims at maximum patients motivation. A robust and reliable auto-calibration and spatial synchronization with the graphics is developed. Patients daily activity is monitored by a Body Sensor Networks and his activity is profiled through eigenbehaviors. Environmental, physiological and motion data are combined to tune the rehabilitation exercise level, to assess potential risks and advice clinicians on the therapy. The HS main role is the definition and monitoring of the treatment. Data mining in the NS discovers common features and trends of rehabilitation treatment among hospitals and regions. A virtual community is setup to educate and motivate patients. A pilot is designed both for the clinical evaluation of effectiveness and suitability of REWIRE, and the study of the most appropriate model to seamlessly connect long-term at home rehabilitation to that at hospital, appropriate service settings and adequate business models. Using advanced DTI imaging it is tested whether REWIRE meets the rationale of rehabilitation, that it triggers brain adaptations that mediate recovery.


Grant
Agency: Cordis | Branch: FP7 | Program: NOE | Phase: ICT-2009.4.3 | Award Amount: 3.69M | Year: 2010

PlanetData aims to establish a sustainable European community of researchers that supports organizations in exposing their data in new and useful ways. The ability to effectively and efficiently make sense out of the enormous amounts of data continuously published online, including data streams, (micro)blog posts, digital archives, eScience resources, public sector data sets, and the Linked Open Data Cloud, is a crucial ingredient for Europes transition to a knowledge society. It allows businesses, governments, communities and individuals to take decisions in an informed manner, ensuring competitive advantages, and general welfare. Research will concentrate on three key challenges that need to be addressed for effective data exposure in a usable form at global scale. We will provide representations for stream-like data, and scalable techniques to publish, access and integrate such data sources on the Web. We will establish mechanisms to assess, record, and, where possible, improve the quality of data through repair. To further enhance the usefulness of data - in particular when it comes to the effectiveness of data processing and retrieval - we will define means to capture the context in which data is produced and understood - including space, time and social aspects. Finally, we will develop access control mechanisms - in order to attract exposure of certain types of valuable data sets, it is necessary to take proper account of its owners concerns to maintain control and respect for privacy and provenance, while not hampering non-contentious use. We will test all of the above on a highly scalable data infrastructure, supporting relational, RDF, and stream processing, and on novel data sets exposed through the network, and derive best practices for data owners. By providing these key precursors, complemented by a comprehensive training, dissemination, standardization and networking program, we will enable and promote effective exposure of data at planetary scale.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP-2008-2.4-1 | Award Amount: 9.75M | Year: 2009

ORION puts together a multidisciplinary consortium of leading European universities, research institutes and industries with the overall goal of advancing the fabrication of inorganic-organic hybrid materials using ionic liquids. Maximum research efforts within ORION will be addressed to achieve inorganic-organic hybrids with an ordered nanostructure and to understand and characterize the new generation of inorganic-organic hybrids. ORION aims to take advantage of the properties of Ionic Liquids as templating supramolecular solvents in the synthesis of novel hybrid materials. Additionally, the use of ILs will bring innovative properties to the hybrid materials due to their intrinsic wide electrochemical window and high ionic conductivity and hence this method will generate radically new materials. The new ordered inorganic-organic hybrids will be morphologically and electrochemically characterized with emphasis on their potential application in batteries, innovative solar cells and gas sensors. By reaching this ambitious goal, ORION will pave the way towards inorganic-organic hybrid products for chemical, materials, energy and sensor industries.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP-SICA | Phase: KBBE-2009-1-1-03 | Award Amount: 3.76M | Year: 2010

NEXTGEN proposes the bold step of using whole genome data to develop and optimise conservation genetic management of livestock diversity for the foreseeable future. The rationale for choosing whole genome data is to future-proof DNA-based analysis in livestock conservation against upcoming changes in technology and analysis. Thus, in the context of whole genome data availability, our global objective is to develop cost-effective optimized methodologies for preserving farm-animal biodiversity, using cattle, sheep, and goats as model species. More specifically, NEXTGEN will: - produce whole genome data in selected populations; - develop the necessary bioinformatics approaches, taking advantage of the 1000 human genomes project, and focusing on the identification of genomic regions under recent selection (adaptive / neutral variation); - develop the methods for optimizing breeding and biobanking, taking into account both neutral and adaptive variations; - develop innovative biobanking methods based on freeze-dried nuclei; - provide guidelines for studying disease resistance and genome/environment relationships in a spatial context; - assess the value of wild ancestors and breeds from domestication centres as genetic resources; - assess the performance of a surrogate marker system compared with whole genome sequence data for preserving biodiversity; - provide efficient training and a wide dissemination of the improved methodologies. The consortium has been designed to specifically reach these objectives, and encompasses skills in conservation genetics, bioinformatics, biobanking and breeding technologies, GIScience. The work plan has been established with great care. The sequencing task has been postponed to year 3 to take advantage of cost dynamics, while the two first years are dedicated to bioinformatics and to an innovative sampling strategy that fully integrates the spatial aspect and that offers more value at the data analysis stage.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY.2010.2.1-1 | Award Amount: 7.02M | Year: 2010

The overall objective of the current project is a significant contribution to the dissemination of PV in order to improve the sustainability of the European energy supply and to strengthen the situation of the European PV industry. The approach to reach this overall objective is the development of solar cells which are substantially thinner than todays common practice. We will reduce the current solar cell thickness of typically 180 m down to a minimum of 50 m. At the same time we target to produce solar cells with high efficiencies in the range of 20% light conversion rate into power. The processes will be optimized and transferred into a pilot production line aiming at an efficiency of 19.5% on wafers of 100 m thickness at a yield that is comparable to the one in standard production lines. This shall help to drive down production costs significantly and save Si resources from todays 8 grams per watt to 3 grams per watt. In more detail the following topics are addressed: Wafering from Si ingots, surface passivation, light trapping, solar cell and module processing and handling of the thin wafers The partners of this project form an outstanding consortium to reach the project goals, including four leading European R&D institutes as well as four companies with recorded and published expertise in the field of thin solar cells and modules and handling of such. The project is structured in 10 work packages covering the process chain from wafer to module and the transfer into pilot production already at mid term as well as integral eco-assessment and management tasks.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2009-1.4-1 | Award Amount: 15.92M | Year: 2010

Type 1 diabetes is a serious chronic disease with major health risks and heavy burden on patients and society. It is caused by massive immune-mediated loss of insulin-producing beta cells in the pancreas that can so far not be locally corrected. A cellular allotransplant in the liver can install a new beta cell mass but the size is insufficient and the procedure faces limitations of donor shortage, inaccessibility of the implants, risks of associated immunosuppression. Our consortium of research, clinical and bioindustry teams is focused on overcoming these obstacles and implementing a roadmap for translation to preclinical models and clinical trials. We will pursue three interacting tracks. First, our ability to induce beta cell progenitors and stimulate beta cell proliferation in vivo should lead us to cells and compounds that activate this process in a diabetic pancreas, thus activating endogenous beta cell regeneration. Second, we will produce human beta (progenitor) cells in vitro by derivation from stem cells as well as from reprogrammed autologous cells; their therapeutic potential will be compared to that of primary human beta cells following implantation in rodents using a site that is accessible to modulation and monitoring. Third, we will design an antibody-based therapy for inducing immune tolerance to regenerated beta cells and to a beta cell implant. Efficacy, safety and regulatory criteria will be determined for clinical implementation. Clinical protocols will be prepared by adjusting associated therapy and by adopting an accessible and controlled implant site. Clinical trials will benefit from state-of-the art biologic markers for comparative analysis of the developed forms of beta cell therapy. This program should provide proof of principle for strategies that make beta cell transplantation and beta cell regeneration realistic for large numbers of type 1 diabetic patients, and probably also for some categories of type 2 diabetes.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.5.2 | Award Amount: 5.00M | Year: 2010

This proposal addresses the development of technologies for patient safety in robotic surgery. We define patient safety metrics for surgical procedures and then develop methods that abide by safety requirements, formulated in terms of our metrics. We aim at demonstrating that a properly controlled robotic surgery carried out in accordance to our safety criteria can improve the level of patient safety currently achievable by traditional surgery. The main innovative aspects of this project are: 1-\tResearch driven by patient-safety requirements 2-\tEmphasis on methodological rigor: development of a methodology founded in evidence-based medicine 3-\tScope: the entire surgical workflow is considered for development and validation. SAFROS focuses on innovative development of methods for the following technologies: \tSoft organ modeling and calibration, considering patient pathologies and anatomical variants \t Simulation planning in deformable environments\tIntra-operative registration and workflow monitoring\t Robot modeling and performance monitoring\tSurgeon training\tOperator interface with integrated stereovision and haptics New methods are integrated and validated on two distinct surgical robots (MIRO and RAMS), with respect to two inherently different contexts (pancreatic and vascular surgery). We quantitatively validate the adherence of our methods to the safety criteria, using surgical phantoms and animals. By comparing across robots and surgical contexts we draw conclusions about the generality of our approach. The SAFROS consortium comprises:\tHospitals with worldwide reputation, which provide medical knowledge and can validate our approach\tEuropes leading research groups in telerobotics and surgical robotics \tInnovative companies, to develop new technologies for surgical simulators\tWorld Health Organization, with global expertise in patient safety surgical safety guidelines\tRenowned educational organizations, to innovate surgeon training


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.81M | Year: 2015

Mathematical, computational models are central in biomedical and biological systems engineering; models enable (i) mechanistically justifying experimental results via current knowledge and (ii) generating new testable hypotheses or novel intervention methods. SyMBioSys is a joint academic/industrial training initiative supporting the convergence of engineering, biological and computational sciences. The consortiums mutual goal is developing a new generation of innovative and entrepreneurial early-stage researchers (ESRs) to develop and exploit cutting-edge dynamic (kinetic) mathematical models for biomedical and biotechnological applications. SyMBioSys integrates: (i) six academic beneficiaries with a strong record in biomedical and biological systems engineering research, these include four universities and two research centres; (ii) four industrial beneficiaries including key players in developing simulation software for process systems engineering, metabolic engineering and industrial biotechnology; (iii) three partner organisations from pharmaceutical, biotechnological and entrepreneurial sectors. SyMBioSys is committed to supporting the establishment of a Biological Systems Engineering research community by stimulating programme coordination via joint activities. The main objectives of this initiative are: * Developing new algorithms and methods for reverse engineering and identifying dynamic models of biosystems and bioprocesses * Developing new model-based optimization algorithms for exploiting dynamic models of biological systems (e.g. predicting behavior in biological networks, identifying design principles and selecting optimal treatment intervention) * Developing software tools, implementing the preceding novel algorithms, using state-of-the-art software engineering practices to ensure usability in biological systems engineering research and practice * Applying the new algorithms and software tools to biomedical and biological test cases.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: FoF.NMP.2010-3 | Award Amount: 3.39M | Year: 2010

FEMTOPRINT is to develop a printer for microsystems with nano-scale features fabricated out of glass. Our ultimate goal is to provide a large pool of users from industry, research and universities with the capability of producing their own micro-systems, in a rapid-manner without the need for expensive infrastructures and specific expertise. Recent researches have shown that one can form three-dimensional patterns in glass material using low-power femtosecond laser beam. This simple process opens interesting new opportunities for a broad variety of microsystems with feature sizes down to the nano-scale. These patterns can be used to form integrated optics components or be developed by chemically etching to form three-dimensional structures like fluidic channels and micro-mechanical components. Worth noticing, sub-micron resolution can be achieved and sub-pattern smaller than the laser wavelength can be formed. Thanks to the low-energy required to pattern the glass, femtosecond laser consisting simply of an oscillator are sufficient to produce such micro- and nano- systems. These systems are nowadays table-top and cost a fraction of conventional clean-room equipments. It is highly foreseeable that within 3 to 5 years such laser systems will fit in a shoe-box. The proposal specific objectives are: 1/ Develop a femtosecond laser suitable for glass micro-/nano- manufacturing that fits in a shoe-box 2/ Integrate the laser in a machine similar to a printer that can position and manipulate glass sheets of various thicknesses 3/ Demonstrate the use of the printer to fabricate a variety of micro-/nano-systems with optical, mechanical and fluid-handling capabilities. A clear and measurable outcome of Femtoprint will be to be in a situation to commercialize the femtoprinter through the setting-up of a consortium spin-off. The potential economical impact is large and is expected in various industrial sectors.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SC5-16-2014 | Award Amount: 15.99M | Year: 2015

Terrestrial and marine ecosystems provide essential services to human societies. Anthropogenic pressures, however, cause serious threat to ecosystems, leading to habitat degradation, increased risk of collapse and loss of ecosystem services. Knowledge-based conservation, management and restoration policies are needed to improve ecosystem benefits in face of increasing pressures. ECOPOTENTIAL makes significant progress beyond the state-of-the-art and creates a unified framework for ecosystem studies and management of protected areas (PA). ECOPOTENTIAL focuses on internationally recognized PAs in Europe and beyond in a wide range of biogeographic regions, and it includes UNESCO, Natura2000 and LTER sites and Large Marine Ecosystems. Best use of Earth Observation (EO) and monitoring data is enabled by new EO open-access ecosystem data services (ECOPERNICUS). Modelling approaches including information from EO data are devised, ecosystem services in current and future conditions are assessed and the requirements of future protected areas are defined. Conceptual approaches based on Essential Variables, Macrosystem Ecology and cross-scale interactions allow for a deeper understanding of the Earths Critical Zone. Open and interoperable access to data and knowledge is assured by a GEO Ecosystem Virtual Laboratory Platform, fully integrated in GEOSS. Support to transparent and knowledge-based conservation and management policies, able to include information from EO data, is developed. Knowledge gained in the PAs is upscaled to pan-European conditions and used for planning and management of future PAs. A permanent stakeholder consultancy group (GEO Ecosystem Community of Practice) will be created. Capacity building is pursued at all levels. SMEs are involved to create expertise leading to new job opportunities, ensuring long-term continuation of services. In summary, ECOPOTENTIAL uses the most advanced technologies to improve future ecosystem benefits for humankind.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA | Phase: ICT-2013.9.8 | Award Amount: 1.21M | Year: 2013

The goal of this proposal is to create a coordination activity among consortia involved in the ICT-ENERGY subject with specific reference to bringing together the existing Toward Zero-Power ICT community organized within the ZEROPOWER C.A. and the novel MINECC (Minimising energy consumption of computing to the limit) community recently funded under the FET Proactive Call 8 (FP7-ICT-2011-8) Objective 9.8. The coordination activity is aimed at assessing the impact of the research efforts developed in the groups involved in the different consortia and proposing measures to increase the visibility of ICT-Energy related initiatives to the scientific community, targeted industries and to the public at large through exchange of information, dedicated networking events and media campaigns. The activities of our C.A. will inspire more research projects in this emerging area by generating broader acceptance for the developed technology and the benefits of its applications. ICT-Energy C.A. will facilitate broader interaction and feedback among the consortia members and stakeholders, thereby, consolidating progress in the field. Positive benefits to the European Community are foreseen in all great challenges of energy, security, environment and health by developing a strategic research agenda in low power, energy efficient ICT and making it happen.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.3.5 | Award Amount: 4.05M | Year: 2011

Advances in the fields of molecular and cell biology are strongly coupled to the implementation of photonic tools that allow highly-sensitive measurements in living cells at high molecular concentrations and at the nanometre scale. The goal of NANO-VISTA is to exploit novel concepts of photonic antennas to develop a new generation of bionanophotonic tools for ultrasensitive detection, nanoimaging and nanospectroscopy of biomolecules, both in-vitro and in living cells. By taking advantage of the extraordinary field enhancement, directionality and nanofocusing of photonic antennas, our approach will allow single biomolecule detection in ultra-reduced detection volumes, including living cells. The project focuses on three main objectives: a) to pioneer the development of novel photonic antennas for ultrasensitive detection in fluids and simultaneous spatio-temporal superresolution in living cells; b) to develop high-throughput large-scale nanofabrication of photonic antennas fully compatible with life science applications; c) to demonstrate the functionality of the technology for biosensing and transferability into potential market products, and for nanoimaging and nanospectroscopy on living cells. Thus, NANO-VISTA is fully targeted to the development of disruptive photonic technologies fundamental in strategic applications such as medicine and biology. To maximise the chances of success we have chosen for an interdisciplinary, trans-national and multi-institutional partnership (including a SME and a Medical Centre). True European specialists, with long standing expertise in the fields of nanophotonics, photonic antennas, large-scale nanofabrication approaches and nanoimmunologists are concentrated in this proposal strengthening European research cohesion. In the mid-long term we expect that both, cell biologists as well as industrial sectors (biophotonic, microscopy and biotechnology enterprises) will benefit from this new technology


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: BIOTEC-2-2015 | Award Amount: 7.09M | Year: 2016

Omics data is not leveraged effectively in the biotechnology industry due to lack of tools to rapidly access public and private data and to design cellular manipulations or interventions based on the data. With this project we aim to make a broad spectrum of omics data useful to the biotechnology industry covering application areas ranging from industrial biotechnology to human health. We will develop novel approaches for integrative model-based omics data analysis to enable 1) Identification of novel enzymes and pathways by mining metagenomic data, 2) Data-driven design of cell factories for the production of chemicals and proteins, and 3) Analysis and design of microbial communities relevant to human health, industrial biotechnology and agriculture. All research efforts will be integrated in an interactive web-based platform that will be available for the industrial and academic research and development communities, in particular enhancing the competitiveness of biotech SMEs by economizing resources and reducing time-to-market within their respective focus areas. The platform will be composed of standardized and interoperable components that service-oriented bioinformatics SMEs involved in the project can reuse in their own products. An important aspect of the platform will be implementation of different access levels to data and software tools allowing controlling access to proprietary data and analysis tools. Two end-user companies will be involved in practical testing of the platform built within the project using proprietary omics data generated at the companies.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.3.6 | Award Amount: 5.17M | Year: 2010

Cloud Computing refers to the emerging environment providing software and hardware services over the Internet or Cloud on demand. These services are provided to millions of Cloud users, in particular Mobile users, by thousands of servers in the data centres. Server power consumption and costs are becoming a great concern in the data centres in which the servers are built with high end, expensive and power-hungry CPUs. We are now reaching the limit of voltage scaling preventing further power reductions. In the absence of voltage scaling, chips in the future may have hundreds of cores, but to maintain a power envelope, these cores have to be embedded cores having orders of magnitude lower power consumption.\nServer applications are rich with client-request and memory-level parallelism. Each client is primarily served by a simple core with high-bandwidth/low-latency access to memory. 3D-stacking of on-chip DRAM on many embedded cores will provide high memory bandwidth with less power consumption while enabling scalability for green future servers.\nWe propose EuroCloud - 3D Server-on-Chip built using many ARM cores and integrating 3D DRAM to provide a very dense low power server, and targeting the Cloud workloads. EuroCloud targets 10x improvement in cost- and energy-efficiency compared to current state-of-the-art servers. This will scale to hundreds of cores in a single server, and make a 1M core data centre feasible in the future. Thus, designing the 3D Server-on-Chip will provide us with capabilities to build super-efficient, environmentally clean and compact data centres in Europe aiming at green Cloud services. Thus, pioneering the green data centres will further strengthen the European leadership and excellence in green computing.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2007.4.3 | Award Amount: 8.50M | Year: 2009

ROLEs cross-disciplinary innovations will deliver and test prototypes of highly responsive TEL environments, offering breakthrough levels of effectiveness, flexibility, user-control and mass-individualisation. Our work also advances the state-of-the-art in human resource management; self-regulated and social learning; psycho-pedagogical theories of adaptive education and educational psychology; service composition and orchestration; and the use of ICT in lifelong learning. Significant benefits arise for learners, their communities, employers, TEL developers and society.\nROLE offers adaptivity and personalization in terms of (1) content and navigation and (2) the entire learning environment and its functionalities. This approach permits individualization of the components, tools, and functionalities of a learning environment, and their adjustment or replacement by existing web-based software tools. Learning environment elements can be combined to generate (to mashup) new components and functionalities, which can be adapted by lone learners or collaborating learners to meet their own needs and to enhance the effectiveness of their learning. This empowers each user to generate new tools and functions according to their needs, and can help them to establish a livelier and personally more meaningful learning context and learning experience.\nROLEs generic framework uses an open source approach, interoperable across software systems and technology. Hence any tool created by an individual is available from a pool of services and tools to all learners via the internet, no matter which learning environment, operating system, or device they use, and which subject matter they learn.\nThe consortium consists of well-renown experts covering all required pedagogical and technical competencies. Respective activities have been defined to bring the results of ROLE to the targeted international markets in higher education and corporate training.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.8.6 | Award Amount: 3.09M | Year: 2010

The aim of the SiNAPS project is to develop standalone dust-sized chemical sensing platforms that harvest energy from ambient electromagnetic radiation (light) and will enable miniaturisation below the current mm^3 barrier. Current solutions in nanoelectronics are enabled by new materials at the nanoscale. It is proposed to use high-density semiconductor nanowire arrays, such as Si and Ge, as efficient photovoltaic units and low-power chemical sensing elements on small volume modules to be integrated, via 3D system in a chip, in a miniaturised platform that transmits the acquired information wirelessly for further processing. To demonstrate the proof-of-concept without committing huge resources in optimization the SiNAPS project has set a pragmatic but ambitious, miniaturisation target ~10^8 m^3, beyond the state-of-the-art. With further development of the energy harvesting and sensing technology, 10^6 m^3 and below can be possible.\nSiNAPS brings together a consortium to address the two topics of the ICT-Proactive call, namely: (a) fundamentals of ambient energy harvesting at the nanoscale and (b) development of self powered autonomous sensor devices, with target dimensions of 1 mm^3. These topics are of great interest in the areas of energy supply, energy use in ICT, smart(er) buildings, medical diagnostics, e-health and integrated smart systems.\nSiNAPS involves the development of the capacity of nanowires for use as a nanoscale energy harvester and a (bio-)chemical sensor for the prototype biotin-streptavidin system via fundamental studies. Miniaturised CMOS electronics will be developed for efficient power management and sensor interface. Existing IP for wireless communication will be used to avoid costly development. The integrated modules will be used to demonstrate the SiNAPS mote concept. Concluding SiNAPS, a set of new technologies for self powered autonomous devices and beyond will be available for further development towards commercialisation.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: SPA.2010.2.1-04 | Award Amount: 2.84M | Year: 2010

Our MicroThrust proposal addresses the FP7 target for advanced in-space propulsion technologies for solar system exploration. This research provides a key component in facilitating exploration missions: a technology that can substantially reduce the cost of undertaking particular types of robotic exploration. Building on the framework of a successful ESA study, our team of leading academics, research institutions and space companies has developed a conceptual design of a very small, yet highly performant electrical propulsion system. The conceptual design is based upon experimental data already obtained by team members. As a result we are confident that this system can provide the transportation element for taking nano/micro satellites to any location in the Earth-Moon system and will even allow missions to nearby planets and asteroids. The propulsion system will thus permit new exploration mission concepts. These missions due to their size will be developed within a fraction of the time for conventional missions. Their simplicity, perhaps even single instrument spacecraft, will reduce risk for carrying out the mission. Overall this will dramatically reduce cost of individual missions, thus providing more flight opportunities for planetary scientists and planetary exploration. To achieve these goals the propulsion technology has high performance at low mass and low power demand. The propulsion system is a microfabricated colloid thruster having a high degree of subsystem integration. Our work so far has demonstrated the capability of this concept to have a radically reduced part set making substantial progress towards a thruster-on-a-chip. Our experienced team will take the technology through to the significant position of having tested and fully characterized a breadboard model. The design approach is that this is also a proto-flight model such that gaining the final step of a flight test for the hardware is low risk and low development cost.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA | Phase: ICT-2011.9.5 | Award Amount: 1.71M | Year: 2011

Guardian Angels (GA) are future zero-power, intelligent, autonomous systems-of-systems featuring sensing, computation, and communication beyond human aptitudes. GA will assist humans from their infancy to old age in complex life situations and environments. Zero-power reflects system-of-systems ability to scavenge energy in dynamic environments by disruptive harvesting techniques. The project prepares zero-power technologies based on future energy-efficient technologies, heterogeneous design, and disruptive energy scavengers.\nThree zero-power generations of GAs are foreseen: Physical Guardian Angels are zero-power, on-body networks or implantable devices that monitor vital health signals and take appropriate actions to preserve human health. Environmental Guardian Angels extend monitoring to dynamic environments, using disruptive scavengers, personalized data communication, and first thinking algorithms. They are personal assistants that protect their wearers from environment dangers. Emotional Guardian Angels are intelligent personal companions with disruptive zero-power, manmachine interfaces deployed at large scale. They sense and communicate using non-verbal languages playing an important role in health, education, and security worldwide. This project addresses the following scientific challenges for energy-efficient visionary Guardian Angel autonomous systems: (i) energy-efficient computing (down to E=10-100kT), (ii) and communication (approaching the limit of 1pJ/bit), (iii) low-power sensing, (iv) disruptive scavenging (bio-inspired, thermoelectric, etc, targeting energy densities of tens of mW/cm2), and (v) zero-power man-machine interfaces. A selection of emerging technologies based on energy efficiency is proposed. We will also develop design tools that integrate electrical, mechanical, optical, thermal, and chemical simulation tools over length and time scales currently not achievable.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SEC-2011.2.2-2 | Award Amount: 4.80M | Year: 2012

Security and quality of life in industrialized countries depend on continuous and coordinate performance of a set of infrastructures (energy systems, ICT systems, transportation etc) which can be therefore defined critical infrastructures (CI). STRUCTURES - Strategies for The impRovement of critical infrastrUCTUre Resilience to Electromagnetic attackS aims at analyzing possible effects of electromagnetic (e.m.) attacks, and in particular of intentional e.m. interference (IEMI), on such CIs, at assessing their impact for our defense and economic security, at identifying innovative awareness and protection strategies and at providing a picture for the policy makers on the possible consequences of an electromagnetic attack. The work is organized into four main tasks, namely: - Scenario assessment (IEMI threat analysis; CIs analysis; modelling and experimental methodologies for investigation) - Investigation (assessment of susceptibility levels of critical systems/units; analysis and testing; innovative protection strategy identification) - IEMI sensors for real-time awareness of threats and implementation of active protection strategies - Delivery of pre-regulatory guidelines to support people in the understanding of IEMI related risk and in planning/application of proper protection strategies. Existing standards such as the Business Continuity Management approach (BS25999 standard) and other standardized CIIP (Critical Information Infrastructures Protection) polices will be considered in order to properly identify critical items and to set criteria for risk acceptance. Already existing results relevant to EMC (ElectroMagnetic Compatibility), LEMP/NEMP/HEMP (Lightning/Nuclear/High altitude ElectroMagnetic Pulse) will be considered as possible starting points leading to find effective solution to IEMI problem. Topological approach, Risk Analysis and 3D modelling tools will be mainly applied for the analysis to a comprehensive set of reference configurations. P


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: EINFRA-5-2015 | Award Amount: 4.84M | Year: 2015

E-CAM will create, develop and sustain a European infrastructure for computational science applied to simulation and modelling of materials and of biological processes of industrial and societal importance. Building on the already significant network of 15 CECAM centres across Europe and the PRACE initiative, it will create a distributed, sustainable centre for simulation and modelling at and across the atomic, molecular and continuum scales. The ambitious goals of E-CAM will be achieved through three complementary instruments: 1. development, testing, maintenance, and dissemination of robust software modules targeted at end-user needs; 2. advanced training of current and future academic and industrial researchers able to exploit these capabilities; 3. multidisciplinary, coordinated, top-level applied consultancy to industrial end-users (both large multinationals and SMEs). The creation and development of this infrastructure will also impact academic research by creating a training opportunity for over 300 researchers in computational science as applied to their domain expertise. It will also provide a structure for the optimisation and long-term maintenance of important codes and provide a route for their exploitation. Based on the requests from its industrial end-users, E-CAM will deliver new software in a broad field by creating over 200 new, robust software modules. The modules will be written to run with maximum efficiency on hardware with different architectures, available at four PRACE centres and at the Hartree Centre for HPC in Industry. The modules will form the core of a software library (the E-CAM library) that will continue to grow and provide benefit well beyond the funding period of the project. E-CAM has a 60 month duration, involves 48 staff years of effort, has a total budget of 5,836,897 and is requesting funding from the EC of 4,836,897, commensurate with achieving its ambitious goals.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SPIRE-06-2015 | Award Amount: 5.19M | Year: 2015

Out of the community created by SPIRE covering industrial and research actors throughout Europe, the EPOS project brings together 6 global process industries from 6 key relevant sectors: steel, cement, minerals, chemicals, bio-based/life science products and engineering. Together they represent 166 bn in sales with 75% of their production located in Europe. The 6 industries joined forces with 2 excellent science institutes and 4 highly R&I minded SMEs, building the EPOS consortium with Ghent University as coordinator. With the aim of reinforcing competitiveness of the EU industry, it is the ambition of the EPOS partners to gain cross-sectorial knowledge and investigate cluster opportunities using an innovative Industrial Symbiosis (IS) platform to be developed and validated during the project. The main objective is to enable cross-sectorial IS and provide a wide range of technological and organisational options for making business and operations more efficient, more cost-effective, more competitive and more sustainable across process sectors. The expected impact is clearly in line with the SPIRE roadmap - and sector associations, city councils (in the districts where EPOS is deployed), the SPIRE PPP as well as standardisation bodies are committed to participate in the EPOS transdisciplinary advisory board. The EPOS project spans 48 months and its structure builds on activities that ensure the project challenge is addressed in an optimal way, including cross-sectorial key performance indicators, sector profiles and cross-sector markets, IS toolbox development, training and validation of the (simple and single) IS management tool in 5 clusters strategically located throughout EU (i.e. France, Poland, Switzerland and UK). Entire work packages are dedicated to dissemination and to define realistic business scenarios for the exploitation of the EPOS tool and the proven, overall cost-reducing IS cluster activities, in view of a wide uptake and a broad EPOS outreach.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: WATER-5c-2015 | Award Amount: 3.57M | Year: 2016

The WHO estimates that in 2015 in Africa ~156 million people relied on untreated sources for their drinking water. WATERSPOUTT will design, develop, pilot and field-test a range of, sustainable point-of-use solar disinfection (SODIS) technologies that will provide affordable access to safe water to remote and vulnerable communities in Africa and elsewhere. These novel large-volume water treatment SODIS technologies will be developed in collaboration and consultation with the end-users, and include: 1. HARVESTED RAINWATER SODIS SYSTEMS for domestic and community use. (South Africa, Uganda). 2. TRANSPARENT 20L SODIS JERRYCANS. (Ethiopia) 3. COMBINED 20L SODIS/CERAMIC POT FILTRATION SYSTEMS. (Malawi) These are novel technologies that will create employment and economic benefits for citizens in both the EU and resource-poor nations. WATERSPOUTT will use social science strategies to: a. Build integrated understanding of the social, political & economic context of water use & needs of specific communities. b. Examine the effect of gender relations on uptake of SODIS technologies. c. Explore the relevant governance practices and decision-making capacity at local, national and international level that impact upon the use of integrated solar technologies for point-of-use drinking water treatment. d. Determine the feasibility & challenges faced at household, community, regional and national level for the adoption of integrated solar technologies for point-of-use drinking water treatment. WATERSPOUTT will transform access to safe drinking water through integrated social sciences, education & solar technologies, thus improving health, survival, societal well-being & economic growth in African developing countries. These goals will be achieved by completing health impact studies of these technologies among end-user communities in Africa. Many of the consortium team have worked for more than 15 years on SODIS research in collaboration with African partners.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: EINFRA-9-2015 | Award Amount: 8.22M | Year: 2016

The overall objective of READ is to implement a Virtual Research Environment where archivists, humanities scholars, computer scientists and volunteers are collaborating with the ultimate goal of boosting research, innovation, development and usage of cutting edge technology for the automated recognition, transcription, indexing and enrichment of handwritten archival documents. This Virtual Research Environment will not be built from the ground up, but will benefit from research, tools, data and resources generated in multiple national and EU funded research and development projects and provide a basis for sustaining the network and the technology in the future. This ICT based e-infrastructure will address the Societal Challenge mentioned in Europe in a Changing World namely the transmission of European cultural heritage and the uses of the past as one of the core requirements of a reflective society. Based on research and innovation enabled by the READ Virtual Research Environment we will be able to explore and access hundreds of kilometres of archival documents via full-text search and therefore be able to open up one of the last hidden treasures of Europes rich cultural hertitage.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.16M | Year: 2016

INFRASTAR aims to develop knowledge, expertise and skill for optimal and reliable management of structures. The generic methodology will be applied to bridges and wind turbines in relation to fatigue offering the opportunity to deal with complementary notions (such as old and new asset management, unique and similar structures, wind and traffic actions) while addressing 3 major challenges: 1/advanced modelling of concrete fatigue behaviour, 2/new non destructive testing methods for early aged damage detection and 3/probabilistic approach of structure reliability under fatigue. Benefit of cross-experience and inter-disciplinary synergies will create new knowledge. INFRASTAR proposes innovative solutions for civil infrastructure asset management so that young scientists will acquire a high employment profile in close dialogue between industry and academic partners. Modern engineering methods, including probabilistic approaches, risk and reliability assessment tools, will take into account the effective structural behaviour of existing bridges and wind turbines by exploiting monitored data. Existing methods and current state-of -the art is based on excessive conservatism which produces high costs and hinders sustainability. INFRASTAR will improve knowledge for optimising the design of new structures, for more realistic verification of structural safety and more accurate prediction of future lifetime of the existing structures. That is a challenge for a sustainable development because it reduces building material and energy consumption as well as CO2 production. Within the global framework of optimal infrastructure asset management, INFRASTAR will result in a multi-disciplinary body of knowledge covering generic problems from the design stage process of the new civil infrastructures up to recycling after dismantlement. This approach and the proposed methods and tools are new and will allow a step forward for innovative and effective process.


Grant
Agency: Cordis | Branch: H2020 | Program: IA | Phase: ICT-19-2015 | Award Amount: 3.84M | Year: 2016

The arrival of immersive head-mounted displays to the consumer market will create a demand for immersive content of over 2 Billion euros in 2016. However, current audiovisual content is ill-suited for Immersive displays. For example, cuts between shots, which constitute the very basic fabric of traditional cinematic language, do not work well in immersive displays. ImmersiaTV will create a novel form of broadcast omnidirectional video content production and delivery that offers end-users a coherent audiovisual experience across head mounted displays, second screens and the traditional TV set, instead of having their attention divided across them. This novel kind of content will seamlessly integrate with and further augment traditional TV and second display consumer habits. ImmersiaTV will assemble an end-to-end toolset covering the entire audiovisual value chain: immersive production tools, support for omnidirectional cameras, including ultra-high definition and high dynamic range images, and adaptive content coding and delivery, and demonstrate it through 3 pilot demonstrations addressing both on-demand and live content delivery.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: LCE-02-2015 | Award Amount: 5.04M | Year: 2016

The aim of CHEOPS is to develop very low-cost but highly performing photovoltaic (PV) devices based on the emerging perovskite (PK) technology. At lab scale (<0.5cm2), PK energy conversion was rapidly advanced to efficiencies >20%. But only few attempts at upscaling have been made, yielding significantly reduced efficiencies <9% on aperture area. In addition, the very question about material stability and reliable measurement procedures are still debated. CHEOPS will now scale up the lab results to single junction modules manufactured in a pre-production environment while maintaining high efficiencies (>14% stable for aperture area in modules >15x15cm2). This will demonstrate the potential of PK as a very low-cost technology (target <0.3/Wp) well suited for building-integrated PV. In parallel, CHEOPS will develop materials and processes to achieve very high efficiency (>29% on 2x2cm2 cells) at low cost (target <0.4/Wp) using a tandem configuration with a crystalline silicon heterojunction cell. CHEOPS will also perform a sustainability assessment from a life-cycle perspective to anticipate potential risks for the technology (including business, technological, environmental, social & political risks). CHEOPS will establish a quantified future development roadmap as well as protocols for stability testing and for reliable measurements. CHEOPS partners cover the whole value added chain: key PK researchers, groups with track records of scaling up high efficiency and tandem cell developments, specialised technology and service providers as well as SMEs and industry partners with already strong IP portfolios, ready to exploit the CHEOPS results. Transferring the results to other growing industry sectors such as lighting or organic large area electronics will additionally benefit European industry. In summary, CHEOPS will decisively advance the potentially game-changing PK technology towards the market and will thus help to face the energy challenge in Europe and beyond.


Grant
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: ICT-25-2015 | Award Amount: 1.12M | Year: 2015

The objective of this project is to elaborate a new roadmap for Nanoelectronics, focused on the requirements of European semiconductor and applications industry, and the advanced concepts developed by Research centers in order to achieve an early identification of promising novel technologies, and cover the R&D needs all along the innovation chain. The final result will be a roadmap for European micro- and nano-electronics, covering all TRL, with a clear identification of short, medium and long term objectives. The roadmap will be divided into main technology sectors and include also cross-functional enabling domains. A proper dissemination of results will take place through the close relationship of the project with the leading European organizations in the field of micro- and nano-electronics, and sanity checks are foreseen during the project with the users world.


Grant
Agency: Cordis | Branch: H2020 | Program: SGA-RIA | Phase: FETFLAGSHIP | Award Amount: 89.00M | Year: 2016

Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses ICT to integrate neuroscience data from around the world, to develop a unified multi-level understanding of the brain and diseases, and ultimately to emulate its computational capabilities. The goal is to catalyze a global collaborative effort. During the HBPs first Specific Grant Agreement (SGA1), the HBP Core Project will outline the basis for building and operating a tightly integrated Research Infrastructure, providing HBP researchers and the scientific Community with unique resources and capabilities. Partnering Projects will enable independent research groups to expand the capabilities of the HBP Platforms, in order to use them to address otherwise intractable problems in neuroscience, computing and medicine in the future. In addition, collaborations with other national, European and international initiatives will create synergies, maximizing returns on research investment. SGA1 covers the detailed steps that will be taken to move the HBP closer to achieving its ambitious Flagship Objectives.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SPIRE-02-2016 | Award Amount: 6.54M | Year: 2016

The goal of CoPro is to develop and to demonstrate methods and tools for process monitoring and optimal dynamic planning, scheduling and control of plants, industrial sites and clusters under dynamic market conditions. CoPro will provide decision support to operators and managers and develop closed-loop solutions to achieve an optimally energy and resource efficient production. In most plants of the process industries, the energy and resource efficiency of the production depends critically on discrete decisions on the use of equipment, shutdowns, product changeovers and cleaning or regeneration of equipment. CoPro will consider these discrete decisions in plant-wide dynamic optimization and develop integrated scheduling and control solutions. Advanced online data analytics will be developed for plant health and product quality monitoring. The detection of anomalies will trigger fast re-scheduling and re-optimization. CoPro will demonstrate advanced plant-wide and site-wide coordination and control in five typical use cases that cover a wide range of sectors of the process industries, and the whole value chain: - Petrochemical production site - Base chemicals and polymer production site - Recycling system in cellulose production - Consumer product formulation and packaging plant - Food processing plant In addition,CoPro will develop methods for the coordination of plants in industrial parks that belong to different companies, thus providing a basis for future industrial symbiosis. CoPro pays special attention to the role of operators and managers in plant-wide control solutions and to the deployment of advanced solutions in industrial sites with a heterogeneous IT environment. As the effort required for the development and maintenance of accurate plant models is the bottleneck for the development and long-term operation of advanced control and scheduling solutions, CoPro will develop methods for efficient modelling and for model quality monitoring and model adaption


Grant
Agency: Cordis | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2008-1.1.1 | Award Amount: 32.30M | Year: 2009

Particle physics stands at the threshold of a new era of discovery and insight. Results from the much awaited LHC are expected to shed light on the origin of mass, supersymmetry, new space dimensions and forces. In July 2006 the European Strategy Group for Particle Physics defined accelerator priorities for the next 15 years in order to consolidate the potential for discovery and conduct the required precision physics. These include an LHC upgrade, R&D on TeV linear colliders and studies on neutrino facilities. These ambitious goals require the mobilisation of all European resources to face scientific and technological challenges well beyond the current state-of-the-art and the capabilities of any single laboratory or country. EuCARD will contribute to the formation of a European Research Area in accelerator science, effectively creating a distributed accelerator laboratory across Europe. It will address the new priorities by upgrading European accelerator infrastructures while continuing to strengthen the collaboration between its participants and developing synergies with industrial partners. R&D will be conducted on high field superconducting magnets, superconducting RF cavities which are particularly relevant for FLASH, XFEL and SC proton linacs, two-beam acceleration, high efficiency collimation and new accelerator concepts. EuCARD will include networks to monitor the performance and risks of innovative solutions and to disseminate results. Trans-national access will be granted to users of beams and advanced test facilities. Strong joint research activities will support priority R&D themes. As an essential complement to national and CERN programmes, the EuCARD proposal will strengthen the European Research Area by ensuring that European accelerator infrastructures further improve their performance and remain at the forefront of global research, serving a community of well over 10,000 physicists from all over the world.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.99M | Year: 2016

The world economy is dependent on fossil resources: oil, gas and coal. The fossil resources are finite and their consumption causes catastrophic environmental changes. Therefore we need to move towards sustainable economy using renewable resources for energy and chemicals production. Via metabolic engineering approach, novel microbial cells can be created that can convert biomass and waste into fuels and chemicals. Metabolic engineering however distinguishes itself from other engineering disciplines by low predictability of the design and long turnover times for the cell factory construction and screening. Therefore there is a need for scientists, who can address these challenges. European Training Network on Predictable and Accelerated Metabolic Engineering Networks (PAcMEN) will be established at 5 renowned European universities and 2 SMEs with participation of 5 industrial and 1 academic partner organizations. In this program 16 PhD students (of which 15 funded by EU contribution) will learn to conduct state-of-the-art research on metabolic engineering of microbial cell factories and learn to commercialize innovations. This will be achieved via collaborative research projects under supervision of top scientists from academia and industry, network training, secondments with network partners, training on innovation and entrepreneurship, and individual career coaching. Altogether, PAcMEN training programme will provide young scientists with the ideal combination of scientific, technological, industrial and management skills to prepare them for their role as breakthrough pioneers in the establishment of tomorrows biorefineries. The PAcMEN project will have an overall positive impact by strengthening the research networks in the area of metabolic engineering, establishing long-term collaborations between the universities and industry, and by creating a framework for future interdisciplinary training programs.


Europe has invoked the SET-Plan to design and implement an energy technology policy for Europe to accelerate the development and deployment of cost-effective renewable energy systems, including photovoltaics. With lower cost of solar electricity, PV could significantly contribute to the achievements of the 20-20-20 objectives. The Joint Program on PV of the European Energy Research Alliance (EERA-PV) aims to increase the effectiveness and efficiency of PV R&D through alignment and joint programming of R&D of its member institutes, and to contribute to the R&D-needs of the Solar Europe Industry Initiative. In CHEETAH, all EERA-PV members will, through collaborative R&D activities, (1) focus on solving specific bottlenecks in the R&D Joint Program of EERA-PV, (2) strengthen the collaboration between PV R&D performers in Europe through sharing of knowledge, personnel and facilities, and (3) accelerate the implementation of developed technologies in the European PV industry. Specifically, CHEETAH R&D will support Pillar A (performance enhancement & energy cost reduction) of the SEII Implementation Plan, through materials optimization and performance enhancement. CHEETAHs objectives are threefold: 1) Developing new concepts and technologies for wafer-based crystalline silicon PV (modules with ultra-thin cells), thin-film PV (advanced light management) and organic PV (very low-cost barriers), resulting in (strongly) reduced cost of materials and increased module performance; 2) Fostering long-term European cooperation in the PV R&D sector, by organizing workshops, training of researchers, efficient use of infrastructures; 3) Accelerating the implementation of innovative technologies in the PV industry, by a strong involvement of EPIA and EIT-KIC InnoEnergy in the program It is the ambition of CHEETAH to develop technology and foster manufacturing capabilities so that Europe can regain and build up own manufacturing capacity in all parts of the value chain in due time.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: MG-3.6a-2015 | Award Amount: 9.61M | Year: 2016

ADAS&ME (Adaptive ADAS to support incapacitated drivers &Mitigate Effectively risks through tailor made HMI under automation) will develop adapted Advanced Driver Assistance Systems, that incorporate driver/rider state, situational/environmental context, and adaptive interaction to automatically transfer control between vehicle and driver/rider and thus ensure safer and more efficient road usage. To achieve this, a holistic approach will be taken which considers automated driving along with information on driver/rider state. The work is based around 7 provisionally identified Use Cases for cars, trucks, buses and motorcycles, aiming to cover a large proportion of driving on European roads. Experimental research will be carried out on algorithms for driver state monitoring as well as on HMI and automation transitions. It will develop robust detection/prediction algorithms for driver/rider state monitoring towards different driver states, such as fatigue, sleepiness, stress, inattention and impairing emotions, employing existing and novel sensing technologies, taking into account traffic and weather conditions via V2X and personalizing them to individual drivers physiology and driving behaviour. In addition, the core development includes multimodal and adaptive warning and intervention strategies based on current driver state and severity of scenarios. The final outcome is the successful fusion of the developed elements into an integrated driver/rider state monitoring system, able to both be utilized in and be supported by vehicle automation of Levels 1 to 4. The system will be validated with a wide pool of drivers/riders under simulated and real road conditions and under different driver/rider states; with the use of 2 cars (1 conventional, 1 electric), 1 truck, 2 PTWs and 1 bus demonstrators. This challenging task has been undertaken by a multidisciplinary Consortium of 30 Partners, including an OEM per vehicle type and 7 Tier 1 suppliers.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA | Phase: ICT-2013.4.2 | Award Amount: 2.60M | Year: 2014

The objective of the RETHINK big project is to bring together the key European hardware, networking, and system architects with the key producers and consumers of Big Data to identify the industry coordination points that will maximize European competitiveness in the processing and analysis of Big Data over the next 10 years. Specifically, RETHINK big will deliver a strategic roadmap for how technology advancements in hardware and networking can be exploited for the purpose of data analytics while also taking into consideration advancements in applications, algorithms and systems.\n\nIn this project, we will not carry out actual research on Hardware optimizations for Big Data, but rather survey the landscape of opportunities and propose a strategic roadmap from that landscape. The outcome of the project will be a series of detailed (mentioning specific technologies), realistic (considering our 10-year timeline), verifiable (including target metrics) and coordinated technology development recommendations that would be in the best interest of European Big Data companies to undertake in concert as a matter of competitive advantage.\n\nPractically speaking, the roadmap will be produced as a result of area specific and cross-functional working groups meetings and congresses. We will initially identify and evaluate the existing competencies across European Big Data application domains and technology providers in Europe and then identify the key European stakeholders, or the established and up-and-coming institutions that possess or are developing the technologies, processes or services that map to these competencies. From these stakeholder institutions, we will select technology and business experts that will chart the technological advancements, their respective challenges and the potential business opportunities that they present. These experts will not only share an interest in defining a credible roadmap, but also hold the decision-making power within their respective institutions (and collectively) to implement that roadmap.\n\nAt the highest level, this project will identify and evaluate the existing competencies across European Big Data Hardware and Networking technology sectors and application domains and prioritize the complementary interests and the shared opportunities that allow all key industrial stakeholder companies to unlock the highest return on their respective investments; it will result in a roadmap that would be irrational not to follow.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 3.23M | Year: 2010

The ITN DYNAMOL will establish a powerful new approach for the preparation of nanostructures based on dynamic covalent chemistry. This approach combines the advantages of covalent synthesis (robustness of bonds) with those of non-covalent synthesis (error correction, responsiveness) without any of the disadvantages. It therefore has the potential to provide unique solutions for several important challenges in the preparation of nanostructures that still need to be addressed. The ITN unites most European leading academic experts in the area of dynamic covalent chemistry with partners from the industrial sector. Expertise of all partners encompasses the areas of supramolecular chemistry and dynamic covalent chemistry, but individual research competences are quite diverse focussing on molecularly defined nanostructures, analysis of nanostructures, and novel applications. The complementarity and diversity thus realised is crucial for successful research and training in this area. Moreover, the two full partners from the private sector, both representing small and medium-sized enterprises, and the two associated partners, one a major chemical company, will have the critical role to bridge fundamental science with application and commercialisation of the results. The objectives of the network will be achieved by recruiting 11 early stage researchers and 1 experienced researcher. A mobility program will allow the researchers to spend time in the various laboratories of the network, thus facilitating sharing of resources and expertise. Local training at the host institutions will be supplemented by a training programme containing various elements such as biannual workshops and a summer school with the participation of experts from outside the network to realise efficient exchange of information and transfer of knowledge. The ITN thus combines world-class research with a unique education to strengthen Europes prominence in the timely field of nanoscience.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: ENV.2010.4.2.1-1 | Award Amount: 4.36M | Year: 2010

The development of interdisciplinary modelling tools and platforms to address the interactions between natural and socio-economic systems is an active research area in Europe. Nevertheless, notable gaps still exist in modelling capabilities, in particular, very little progress has been made to date in the direct coupling of models that resolve the spatial distribution of climate change with sectorally and regionally resolved economic models. Interactive couplings between climate and impact models are relatively underdeveloped. Likewise, the coupling of detailed economic models with impact and adaptation models is still at a relatively early stage. Finally, a coherent assessment of uncertainty is completely lacking in overall integrated assessments. The sustainability of agriculture and land-use policies and practices including water availability and the sustainability of climate policies that rely on high shares of bioenergy are critical applications that demand a spatially resolved representation of global environmental change including feedbacks between natural and socio-economic forces. ERMITAGE proposes to improve and extend existing modular frameworks for the coupling of intermediate complexity models of the natural and socio-economic systems to address the issues cited above. The resulting integrated assessment framework models will be applied to the analysis of post-2012 climate initiatives taking into account uncertainties and regional conflicts of interest in a coordinated way, propagating the analysis of uncertainty from climate simulation through to policy analysis, focusing particularly on the sustainability of agriculture, bioenergy and water resources.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.3.9 | Award Amount: 15.49M | Year: 2010

Best-Reliable Ambient Intelligent Nanosensor Systems e-BRAINS represent a giant leap for outstanding future applications in the area of ambient living with the ultimate need for integration of heterogeneous technologies, high-performance nanosensor devices, miniaturization, smart wireless communication and best-reliability.\ne-BRAINS with minimum volume and weight as well as reduced power consumption can be utilized in ambient living systems. Successful market entry of such innovative ambient intelligence products will be determined by the performance improvement achieved and the cost advantage in relation to the total system cost.\nThe basic requirement for robustness and reliability of the heterogeneous integration technologies and the nanosensor layers is in the focus of all e-BRAINS developments.\nThe designated nanosensor systems represent a very promising innovative approach with the potential to enable high-performance and precise functions in new products. The application of nanotechnology will allow large improvements in functionality and will open a wide range of applications for European companies.\nFuture e-BRAINS applications require significantly higher integration densities. Performance, multi-functionality and reliability of such complex heterogeneous systems will be limited mainly by the wiring between the subsystems. Suitable 3D integration technologies create a basis to overcome these drawbacks with the benefit of enabling minimal interconnection lengths. In addition to enabling high integration densities, 3D integration is a very promising cost-effective approach for the realization of heterogeneous systems.\nBesides the heterogeneous system integration the main criteria of e-BRAINS is the need for miniaturized energy storage/delivery systems, low power consumption, smart communication and methodology for reliability and robustness.\ne-BRAINS benefits from the established European 3D technology platform as major result of the IP e-CUBES.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP-SICA | Phase: HEALTH-2009-4.3.1-3 | Award Amount: 13.73M | Year: 2010

Worm infections are receiving increased attention due to: the wide geographic overlap in occurrence between worms and HIV, TB and malaria; the large proportion of individuals (minimal estimates around 25%) co-infected with worms and HIV/TB/ malaria; the potential risk of increasing disease burden; the very limited understanding of the impact by worm infections on HIV-, TB- and malaria-specific immune responses and on their clinical outcome; the lack of established intervention guidelines for treatment of worm infections; and the scarce information on the impact by worm infections on vaccination and vaccine-induced immune responses. In order to address these complex and challenging scientific issues, IDEA project will focus its efforts on four primary objectives: a) the worm-induced modulation of the functional and molecular profile of HIV-, TB- and malaria-specific immune responses, b) the impact by worm co-infections on measures of disease activity of PRDs, c) the immunologic markers of worm-, HIV-, TB- and malaria-specific immune responses associated with better control of pathogen replication and disease, and d) the modulation by worm co-infections of vaccine-induced immune responses. To achieve these objectives, IDEA project has developed a global and innovative strategy which includes: a) the alliance between African and European leading scientists in the field of worms, HIV, TB and malaria, b) the multidisciplinary expertise involving immunologists, parasitologists, epidemiologists, clinicians, and experts in vaccines, c) cutting edge immunology and the most innovative technologies to profile immune response, d) the access to large cohort studies bringing a number of centres working on worms and PRDs in Africa together, and e) the access to experimental HIV, TB and malaria vaccine candidates under clinical development in Africa.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SFS-07b-2015 | Award Amount: 9.01M | Year: 2016

This aim of IMAGE is to enhance the use of genetic collections and to upgrade animal gene bank management. IMAGE will better exploit DNA information and develop methodologies, biotechnologies, and bioinformatics for rationalising animal genetic resources. It will demonstrate the benefits brought by gene banks to the development of sustainable livestock systems by: enhancing the usefulness of genetic collections to allow the livestock sector to respond to environment and market changes; using latest DNA technology and reproductive physiology for collecting, storing and distributing biological resources; Minimising genetic accidents such as abnormalities or genetic variability tipping points; Developing synergies between ex-situ and in-situ conservation to maximise resources for the future. To this end, the project will involve stakeholders, SME, and academic partners to achieve the following objectives. At the scientific level, the project will: Assess the diversity available in genetic collections; Search for adaptive traits through landscape genetics in local populations; Contribute to elucidate local populations and major genes history; Identify detrimental variants that can contribute to inbreeding depression; Predict cryobank samples reproductive performance; Facilitate the use of collections for genome-assisted breeding. At the technological level, it will develop: Procedures for harmonising gene bank operations and rationalising collections; Conservation and reproductive biotechnologies; A central information system to connect available data on germplasm and genomic collections. At the applied level, it will develop methods and tools for stakeholders to: Restore genetic diversity in livestock populations; Create or reconstruct breeds fitting new environmental constraints and consumer demands; Facilitate cryobanking for local breeds; Define and track breed-based product brands; Implement access and benefit sharing regulations.


Grant
Agency: Cordis | Branch: H2020 | Program: FCH2-RIA | Phase: FCH-02-5-2016 | Award Amount: 3.15M | Year: 2017

The INSIGHT project aims at developing a Monitoring, Diagnostic and Lifetime Tool (MDLT) for Solid Oxide Fuel Cell (SOFC) stacks and the hardware necessary for its implementation into a real SOFC system. The effectiveness of the MDLT will be demonstrated through on-field tests on a real micro-Combined Heat and Power system (2.5 kW), thus moving these tools from Technology Readiness Level (TRL) 3 to beyond 5. INSIGHT leverages the experience of previous projects and consolidates their outcomes both at methodological and application levels. The consortium will specifically exploit monitoring approaches based on two advanced complementary techniques: Electrochemical Impedance Spectroscopy (EIS) and Total Harmonic Distortion (THD) in addition to conventional dynamic stack signals. Durability tests with faults added on purpose and accelerated tests will generate the data required to develop and validate the MDL algorithms. Based on the outcome of experimental analysis and mathematical approaches, fault mitigation logics will be developed to avoid stack failures and slow down their degradation. A specific low-cost hardware, consisting in a single board able to embed the MDLT will be developed and integrated into a commercial SOFC system, the EnGenTM 2500, which will be tested on-field. INSIGHT will then open the perspective to decrease the costs of service and SOFC stack replacement by 50%, which would correspond to a reduction of the Total Cost of Ownership by 10% / kWh. To reach these objectives, INSIGHT is a cross multidisciplinary consortium gathering 11 organisations from 6 member states (France, Italy, Denmark, Slovenia, Austria, Finland) and one associated country (Switzerland). The partnership covers all competences necessary: experimental testing (CEA, DTU, EPFL), algorithms developments (UNISA, IJS, AVL), hardware development (BIT), system integration and validation (VTT, SP, HTC), supported by AK for the project management and dissemination.


Patent
Ecole Polytechnique Federale de Lausanne and Sant'Anna School of Advanced Studies | Date: 2014-12-19

Integrated closed-loop real-time limb neuro-prosthetic system comprising an artificial limb, a microprocessor, sensors, a signal conditioner, a stimulator, at least one EMG electrode and at least one sensory feedback electrode, characterized by the fact that said sensory feedback electrode is an intraneural electrode which is adapted to be implanted in an intact and healthy portion of a nerve.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-IAPP | Phase: FP7-PEOPLE-2013-IAPP | Award Amount: 1.29M | Year: 2014

There exists an urgent need to advance methods for detection of bacteria in the body, primarily in the context of infectious disease research. Real-time in vivo analysis empowers the investigator with the ability to non-invasively assess bacterial activity over time, as well as host responses to infection and interventions. Optical Imaging (OI) modalities are based on the detection and quantification of bioluminescent or fluorescent light from the subject and represent powerful yet cost-efficient and convenient systems. By labelling of bacteria and/or host cells of interest, both bacterial and host responses can be assessed in rapid, high-throughput analyses, providing spatial, temporal and quantitative read-out, without the need for radioactivity. There is a large and increasing market need for efficient reagents for in vivo bacterial imaging. We aim to develop improved in vivo imaging and ex vivo analysis methods for the study of bacterial infectious diseases and host immune response to infections, to address the current need across the range of fields of infectious disease and vaccine research. A broad skill set is required in this rapidly advancing field, involving exposure to laboratory science, imaging technology, commercialisation of research and industrial processes. By bringing together an international network of leaders in the fields of molecular imaging, infectious disease, vaccine research and industry, we propose to address the current paucity of technology for imaging of bacteria in research animals. Novartis is a world leader in development of vaccines for infectious diseases, and will provide an industrial steer from the project outset. Through combining the various specialities of this IAPP, the proposed work programme will facilitate transfer of knowledge among project partners, promote the development and training of staff in both academia and industry, as well as providing the industry partner with new R&D tools.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY.2013.2.7.1 | Award Amount: 6.23M | Year: 2013

In the recent years due to tremendous development and integration of renewable energy resources in Europe, hydraulic turbines and pump-turbines are key technical components to contribute to renewable energy production and to compensate for the stochastic nature of the variable energy sources, preserving thus the electrical grid stability. As a result, the overarching objective of the project is the enhanced hydropower plant value by extending the flexibility of its operating range, while also improving its long-term availability. More specifically, the project aims to study the hydraulic, mechanical and electrical dynamics of several hydraulic machines configurations fresh and seawater turbines, reversible pump-turbines under an extended range of operations : from overload to deep part load. A two-pronged modelling approach will rely on numerical simulations as well as reduced-scale physical model tests. Upon suitable concurrence between simulations and reduced-scale physical models results, validation will take place on carefully selected physical hydropower plants properly equipped with monitoring systems. To address this ambitious research plan, a consortium has been assembled featuring three leading hydraulic turbines, storage pumps, reversible pump-turbine and electric equipment manufacturers, SME, as well as world-renowned academic institutions. Extensive tests both on both experimental rigs and real power plants will be performed in order to validate the obtained methodological and numerical results.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY.2012.3.2.2 | Award Amount: 17.57M | Year: 2012

ITAKA project is expected to support the development of aviation biofuels in an economically, socially, and environmentally sustainable manner, improving the readiness of existing technology and infrastructures. This will be achieved through the first of its kind collaborative project in the EU, that will develop a full value-chain in Europe to produce sustainable drop-in Hydroprocessed Esters and Fatty Acids at large scale enough (4,000 t) to allow testing its use in existing logistic systems and in normal flight operations in the EU. ITAKA will link supply and demand by establishing a relationship under specific conditions between feedstock grower, biofuel producer, distributor and final user (airlines). Sustainability, competitiveness and technology assessments will be carried out, studying economic, social and regulatory implications of large-scale use. The generated knowledge will aim to identify and address barriers to innovation and commercial deployment. In order to achieve this in the most efficient way ITAKA will target camelina oil as the best possible sustainable feedstock that can be produced timely at enough quantity within Europe. Used cooking oil (UCO) will also be considered as an alternative feedstock. The bio fuel sustainability will be assessed against the RSB EU RED Standard. Beyond this technological and research objectives, ITAKA is also willing to contribute to the achievement of a further EU objective: the need to coordinate efforts and complementarities among European Initiatives on sustainable aviation fuels, as highlighted during the Flight Path definition and identified in SWAFEA recommendations: Setting up a knowledge and test capability network within the EU to provide an EU based fuel evaluation capability. ITAKA has been built aiming to engage key stakeholders and to make a first significant step in the establishment of such a European network.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP-2008-4.0-1 | Award Amount: 12.25M | Year: 2010

Based on the clinical unmet needs and recent research in biomarkers on Rheumatoid Arthritis (RA) and Osteoarthritis (OA) the main objective of the project is to develop a nanotechnology based novel diagnostic tool for easy and early detection of biomarkers in inflammatory diseases especially RA and OA by using modified superparamagnetic nanoparticles (SPION) for (A) bioassay (ex-vivo application) and (B) MRI (in-vivo detection). A new technology based on multiple functionalized single nanoparticles specifically entering/attaching to cells, to enzymes in serous fluids or organelles in living cells will be used to detect, separate and identify low abundance biomarkers. Newly identified biomarkers will be used to decorate SPION with binding moieties which are specific to the biomarker(s) and can be used diagnostically such as in contrast agents (MRI). A sensitive micro-immunoassay will be developed for special use of these particles in biochemical tests for arthritis. This project is driven by the high clinical need to identify early arthritis and then segment RA and OA patients into progressors/responders or non-progressors/-responders to various treatment options. Inflammatory disorders like RA inducing the destruction of cartilage in 1% of the population which is accompanied by significant pain, morbidity and mortality leads to reduced capacity to work. OA, a degenerative arthritis is the leading cause of disability among the elderly population. As there is no cure for RA and finally the replacement of e.g. the knee in OA, early diagnostic tools for the detection of the disease progression and the ability to evaluate the efficacy of therapeutic interventions are necessary u.a. for drug development. Existing diagnostic methods often do not permit an early definite diagnosis, so new nanoparticle based diagnostic techniques targeting to the detection of molecular events (based on MRI) with higher sensitivity/specificity will be developed to satisfy the urgent need.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: NMP.2012.1.4-2 | Award Amount: 4.86M | Year: 2013

The Self-Assembled Virus-like Vectors for Stem Cell Phenotyping (SAVVY) project relies on hierarchical, multi-scale assembly of intrinsically dissimilar nanoparticles to develop novel types of multifunctional Raman probes for analysis and phenotyping of heterogeneous stem cell populations. Our project will address a large unmet need, as stem cells have great potential for a broad range of therapeutic and biotechnological applications. Characterization and sorting of heterogeneous stem cell populations has been intrinsically hampered by (1) lack of specific antibodies, (2) need for fluorescence markers, (3) low concentration of stem cells, (4) low efficiencies/high costs. Our technology will use a fundamentally different approach that (1) does not require antibodies, aptamers, or biomarkers, (2) is fluorescence-label free, and (3) is scalable at acceptable cost. The approach uses intrinsic differences in the composition of membranes of cells to distinguish cell populations. These differences will be detect by SERS and analysed through multicomponent analysis. We have combined the necessary expertise to tackle this challenge: Stellacci has developed rippled nanoparticles that specifically interact with and adhere to cell membranes (analogues to cell penetrating peptides). Lahann has developed bicompartmental Janus polymer particles that have already been surface-modified with rippled particles and integrate specifically in the cell membrane (analogues to viruses). Liz-Marzan has developed highly Raman-active nanoparticles and has demonstrated their selectivity and specificity in SERS experiments. These Raman probes will be loaded into the synthetic viruses to enable membrane fingerprinting. Stevens has developed a Bioinformatics platform for fingerprinting of stem cell populations using cluster analysis algorithms. The effort will be joined by two SMEs, ChipShop and OMT, that will be able to develop the necessary microfluidic and Raman detection hardware.


Grant
Agency: Cordis | Branch: FP7 | Program: CPCSA | Phase: ICT-2013.9.9 | Award Amount: 72.73M | Year: 2013

Understanding the human brain is one of the greatest challenges facing 21st century science. If we can rise to the challenge, we can gain profound insights into what makes us human, develop new treatments for brain diseases and build revolutionary new computing technologies. Today, for the first time, modern ICT has brought these goals within sight. The goal of the Human Brain Project, part of the FET Flagship Programme, is to translate this vision into reality, using ICT as a catalyst for a global collaborative effort to understand the human brain and its diseases and ultimately to emulate its computational capabilities. The Human Brain Project will last ten years and will consist of a ramp-up phase (from month 1 to month 36) and subsequent operational phases.\nThis Grant Agreement covers the ramp-up phase. During this phase the strategic goals of the project will be to design, develop and deploy the first versions of six ICT platforms dedicated to Neuroinformatics, Brain Simulation, High Performance Computing, Medical Informatics, Neuromorphic Computing and Neurorobotics, and create a user community of research groups from within and outside the HBP, set up a European Institute for Theoretical Neuroscience, complete a set of pilot projects providing a first demonstration of the scientific value of the platforms and the Institute, develop the scientific and technological capabilities required by future versions of the platforms, implement a policy of Responsible Innovation, and a programme of transdisciplinary education, and develop a framework for collaboration that links the partners under strong scientific leadership and professional project management, providing a coherent European approach and ensuring effective alignment of regional, national and European research and programmes. The project work plan is organized in the form of thirteen subprojects, each dedicated to a specific area of activity.\nA significant part of the budget will be used for competitive calls to complement the collective skills of the Consortium with additional expertise.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 3.66M | Year: 2012

The aim of this ITN is to promote research and training in the field of epigenetics associated with human disease. Expression of imprinted genes is mono-allelic and gamete of origin-dependent. This is due to different epigenetic modifications present on the maternal and paternal chromosomes. Failure in normal establishment, maintenance or erasure of these marks results in gene dosage dysregulation and Imprinting Disorders (IDs). This ITN brings together different expertise from both public and private sectors with the aim of investigating the physiology and pathology of Genomic Imprinting. We propose to define mechanisms, molecular factors and pathways regulating DNA-methylation and chromatin dynamics involved in gene expression control in human health and disease. This concerted approach has the potential to identify new and more effective diagnostic, preventive and therapeutic strategies for IDs, and more generally to elucidate roles and origin of epigenetic mutations in human pathologies, including common diseases. Early stage (ESRs) and experienced researchers (ERs) will have access to a range of cutting-edge methodologies to enable the application of integrated multidisciplinary strategies to analyse epigenetic phenomena. The excellent scientific and educational environment and the intense public-private sector collaboration will promote high-level training of the young researchers. The ESRs and ERs will acquire experience and expertise in a variety of disciplines, including molecular, cellular and developmental biology, genomics, bioinformatics, chromatin dynamics and epigenetics and phenotypic analysis, and state-of-the-art methodologies such as gene targeting, stem cell culture, epigenetic and chromatin technologies, and massively parallel sequencing. Hence, this ITN will generate a new cohort of scientists trained in contemporary post-genomic biology and able to apply advanced technological tools to investigate human disease in both academia and industry.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP-2009-2.2-1 | Award Amount: 15.77M | Year: 2010

The goal of IFOX is to explore, create and control novel electronic and magnetic functionalities, with focus on interfaces, in complex transition metal oxide heterostructures to develop the material platform for novel More than Moore (MtM) and beyond CMOS electronics, VLSI integratable with performance and functionality far beyond the state-of-the-art. To this end it will: -Establish a theoretical basis to identify the most promising materials/heterostructures and to understand the new functionalities relevant for electronic applications -Grow oxide films on commercial substrates with a quality comparable to state-of-the-art semiconductor growth -Establish their patterning and processing conditions within the boundary conditions of current fabrication technologies -Characterize their structural, electronic and magnetic properties to deliver concepts for novel charge and/or spin based devices in the areas of memories, logic and sensor applications. Investigations include ferroelectric and ferromagnetic oxides as well as artificial multiferroic heterostructures (deposited on large area silicon substrates) with as final deliverable concepts for multifunctional magneto-electronics devices controlled by electric and magnetic fields and ultimately by ultra short light pulses. The consortium of world leaders in the areas of theory, oxide deposition, lithography, device fabrication, and various characterization techniques will allow full control of all interface properties dominating the physical behaviour of oxide nano- and heterostructures. The goals of IFOX are driven by the needs of a large automotive company (FIAT) seeking to use oxides in electronic sensors for MtM and automotive applications. It is further supported by three SMEs with expertise and infrastructure for epitaxial oxide growth and upscaling on Si with the goal to transfer academic knowledge to industry.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SST.2008.3.1.1. | Award Amount: 3.97M | Year: 2010

The CATS project objective is the final development and experimentation of a new urban transport service based on a new generation vehicle. Its major innovation is the utilisation of a single type of vehicle for two different usages: individual use or collective transport. This new transport service is aimed at filling the gap between public mass transport and private individual vehicles. It is based on two operating principles: the self service concept where small and clean urban vehicles are offered on a short term rental basis, and the flexible shuttle service where a variable length of vehicles convoy, driven by a professional driver, operates at fixed hours along a line on a permanent basis or on a case by case basis. Both these principles are integrated in a single service (composed of vehicles and stations) called Cristal. The final aim of this new service is a more efficient mobility in cities through a more balanced use of small clean vehicles and mass transport. This inclusive new transport system is well adapted to the needs of people with reduced mobility, young passengers and tourists. Four Cristal vehicles and two stations will be made available by Lohr Industrie to the project for experiments. The CATS project will investigate through an in depth mobility needs analysis, on-site demonstration and showcases, the impact of the introduction of such a new system in three different European cities (Strasbourg FR, Ploeisti, RO, Formello, IT).The impact on environment and especially on CO2 emissions, as well as the acceptance and the evaluation of market take-up of the system will be studied. CATS will complement the design and manufacture of the Cristal vehicle via a detailed definition of its operating principles and by a design of its urban settings (stations, infrastructures,) in accordance with cities and citizens needs. A full evaluation plan is then foreseen as well as transferability assessment.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 4.38M | Year: 2010

The post-genomic era has been driven by the development of technologies that allow the function of cells and whole organisms to be explored at a molecular level. Metabolomics is concerned with the measurement of global sets of low-molecular-weight metabolites, which represent important indicators of physiological or pathological states of organisms. Such profiles provide a more comprehensive view of cellular control mechanisms in man and animals, and raise the possibility of identifying surrogate markers of disease. Metabolomic approaches use analytical different techniques to measure populations of low-molecular-weight metabolites in biological samples. To decipher large metabolic data sets advanced statistical and bioinformatic tools are commonly employed. Although metabolomics has only recently emerged, dynamic profiles generated in Metabolic Flux Analysis (MFA) are becoming increasingly important to analyse biological networks in a quantitative manner and as part of systems biology approaches. MFA allows us to probe hypotheses by incorporating a priori biological knowledge to provide practical descriptions of observed cell behaviours, and to characterise the outcome of network perturbations. Flux analysis is of particular value for the diagnosis, differentiation and elucidation of mechanisms in cancer. This was recognised as early as 1924 by the Nobel Prize winner Otto Warburg who attributed cancer to a change in cellular energy production. This theme has experienced a revival in recent years through research, which has established mitochondrial dysfunction as a major mechanism in cancer. This proposal seeks funding for a truly interdisciplinary European consortium to train researchers to exploit the gains of new technologies provided by metabolic flux analysis in the context of cancer with a mixed focus on new developments and applied end-points.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SEC-2011.5.1-1 | Award Amount: 4.74M | Year: 2012

Identity management using Biometrics is deployed in a growing number of applications ranging from identification platforms (e.g. biometric passports) to access control systems for border checks or banking transactions. Unfortunately, the reliability of these technologies remains difficult to compare. There are no european-wide standards for evaluating their accuracy, their robustness to attacks or their privacy preservation strength. BEAT will fill this gap by building an online and open platform to transparently evaluate biometric systems, designing protocols and tools for vulnerability analysis and developing standardization documents for Common Criteria evaluations. The planned impact is three-fold: the reliability of biometric systems becomes standardized and comparable, potentially leading to a meaningful increase in their performance; technology transfer from research to companies becomes easier with the use of an interoperable framework; authorities and decision-makers become more informed about the progress made in biometrics as results impact standards.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP.2012.1.4-1 | Award Amount: 13.40M | Year: 2013

In this proposed integrating project we will develop innovative in-line high throughput manufacturing technologies which are all based on atmospheric pressure (AP) vapour phase surface and on AP plasma processing technologies. Both approaches have significant potential for the precise synthesis of nano-structures with tailored properties, but their effective simultaneous combination is particularly promising. We propose to merge the unique potential of atmospheric pressure atomic layer deposition (AP-ALD), with nucleation and growth chemical vapour deposition (AP-CVD) with atmospheric pressure based plasma technologies e.g. for surface nano-structuring by growth control or chemical etching and, sub-nanoscale nucleation (seed) layers. The potential for cost advantages of such an approach, combined with the targeted innovation, make the technology capable of step changes in nano-manufacturing. Compatible with high volume and flexible multi-functionalisation, scale-up to pilot-lines will be a major objective. Pilot lines will establish equipment platforms which will be targeted for identified, and substantial potential applications, in three strategically significant industrial areas: (i) energy storage by high capacity batteries and hybridcapacitors with enhanced energy density, (ii) solar energy production and, (iii) energy efficient (lightweight) airplanes. A further aim is to develop process control concepts based on in-situ monitoring methods allowing direct correlation of synthesis parameters with nanomaterial structure and composition. Demonstration of the developed on-line monitoring tools in pilot lines is targeted. The integrating project targets a strategic contribution to establishing a European high value added nano-manufacturing industry. New, cost efficient production methods will improve quality of products in high market value segments in industries such as renewable energy production, energy storage, aeronautics, and space. DoW adaptations being made responding on requests from Phase-2 Evaluation Report In Phase-2 of the evaluation process, a number of points were noted by the evaluators where the project had insufficient information or could benefit from upgrading or justification. Our response and actions against each point raised has been summarized and send to the project officer, Dr. Rene Martins, in a separate document.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: INFRAIA-1-2014-2015 | Award Amount: 11.76M | Year: 2015

NFFA-EUROPE will implement the first open-access research infrastructure as a platform supporting comprehensive projects for multidisciplinary research at the nanoscale extending form synthesis to nanocharacterization to theory and numerical simulation. The integration and the extension of scope of existing specialized infrastructures within an excellence network of knowledge and know-how will enable a large number of researchers from diverse disciplines to carry out advanced proposals impacting science and innovation. The full suite of key infrastructures for nanoscience will become, through the NFFA-EUROPE project, accessible to a broader community extended to research actors operating at different levels of the value chain, including SMEs and applied research, that are currently missing the benefits of these enabling technologies. NFFA-EUROPE sets out to offer an integrated, distributed infrastructure to perform comprehensive nanoscience and nanotechnology projects from synthesis and nanolithography (with nanofoundry installations) to advanced characterization and theoretical modellization/numerical simulation (with experimental installations including analytical large scale facilities and a distributed theoretical installation including high-performance computing). Coordinated access will be given to complementary facilities co-located in nine well distributed main sites in Europe, ensuring the optimal match between user proposal and technical offer. The research activity of the Consortium will realize innovative solutions on key bottlenecks of nanoscience research, therefore upgrading the facility quality and uniqueness.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2013.8.1 | Award Amount: 9.94M | Year: 2013

Computer games represent a vast economic market, a key driver of technology, and an increasingly powerful medium for a broad range of applications. The latest wave of innovation for computer games is mobile and, more precisely, location-based. These outdoors mobile experiences are radically different from traditional computer games or their mobile equivalent. They focus the players attention on the real world around them as much as on the digital world of the game, aiming to create a powerful juxtaposition of the two.\nAlthough location-based gaming is an industry on the verge of explosive growth, the creation and deployment of such experiences, especially those involving multiple participants, is simply out of reach for the vast majority of creative industries and authors because of the blend of many cutting-edge technologies they require, their hard to master limitations, and the complex gaming concepts they employ.\nThe first objective of MAGELLAN is to deliver an unprecedented authoring environment based on visual authoring principles in order to enable non-programmers, as well as more advanced users, to cost-effectively author and publish multi-participant location-based experiences. The second objective is to deliver a scalable web platform featuring social networking means and supporting the publication, browsing and execution of a massive number of such experiences. Finally, MAGELLAN will produce a series of guides for authors of location-based experiences that will constitute a reference for interested people as well as a foundational document for future research in the field.\nTo achieve this, MAGELLAN will adopt a holistic approach integrating interdisciplinary research involving a complementary group of world-class experts from multiple scientific and technological domains. A user-centred approach will be adopted in order to place end-users, represented by the 5 SMEs partners and the open User Group members, at the heart of the project.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA | Phase: FoF-ICT-2013.7.2 | Award Amount: 1.38M | Year: 2013

The main aim of ManuSkills is to study the use of enhanced ICT-based technologies and training methodologies to facilitate an increase of young talent interest in manufacturing and to support their training of new manufacturing skills.\nThe project will experiment with a wide range of innovative delivery mechanisms such as serious games and teaching factory, supported by the use of social media augmented by gamification and leveraging the distribution channels preferred by young talent. In addition, the project will explore the pedagogical frameworks best suited to the personalization of individual learning needs taking into account the industrial demand. ManuSkills will address all three stages of the young talent pipeline (i.e. children, teenagers, young people), where in the early stages the focus will be to make manufacturing education more attractive to young talent, whilst in the later stages the focus will be to facilitate transformative deep learning of individuals, with reduced time-to-competence.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY.2012.8.1.1 | Award Amount: 3.82M | Year: 2012

The main objective of the project is the development of several reliable, safe, high efficiency and high capacity heat pumps working with the two most promising natural refrigerants: Hydrocarbons and CO2, together with a set of improved components and auxiliary devices adequate for the efficient and safe use of the two refrigerants. The project aims to reach a higher efficiency (10-20% SPF improvement) and lower Carbon footprint (20% lower TEWI) than the current state of the art HFCs/HFOs or Sorption heat pumps. The costs shall be very similar or slightly higher than the latter systems (10%). The project will also focus on the development of an efficient capacity modulation in order to enhance the integration capability with other renewable sources in the energy systems of Buildings and Industry. In this sense, if the project is successful, it will clearly bring a definitive step forward to overcome the barriers holding back the spread of natural refrigerants by proving that a new generation of heat pumps based on HCs and CO2 is perfectly feasible and commercially competitive. The first objective of the project is the identification of the cases in which the use of Natural refrigerants can lead to cost effective and high efficient solutions with a fast commercial exploitation. The following cases have already been identified for their potential interest: - Hydrocarbons (HCs): air or water to water heat pumps supplying hot water at (40-50C) for heating applications as well as to produce sanitary hot water at 60C. - CO2: heat pump of high capacity to produce sanitary hot water at 60C directly from city water (10-15C). Designs with higher temperatures in the range 70-90C should be also explored. The project involves 6 key industrial partners (component manufacturers and heat pump manufacturers) who will strongly cooperate with the RTD partners in order to achieve the targeted goals as well as to evaluate the necessary costs and measures to successfully bring the developed technology to the market.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: KBBE-2007-3-2-06 | Award Amount: 8.10M | Year: 2009

The NEMO project provides novel efficient enzymes and microbes for 2nd generation bioethanol production. It generates through metabolic engineering and mutagenesis & screening approaches robust yeast strains that have a broad substrate range and can (co-)ferment C6 and C5 sugars to ethanol with high productivity (rate and yield), and that are significantly more stress tolerant, i.e. inhibitor, ethanol and thermotolerant than the current S.cerevisiae strains used in ethanol production. The NEMO project also identifies and improves enzymes for hydrolysis of biomasses relevant for Europe. Novel enzymes are identified and improved through various approaches, based on screening, broad comparative genomics analyses, and protein engineering. These efforts will generate more thermostable enzymes for high temperature hydrolysis, more efficient enzymes for hydrolysis of the resistant structures in lignocellulose such as crystalline cellulose and lignin-hemicellulose complexes, enzymes with reduced affinity on lignin, and efficient thermo and mesophilic enzyme mixtures that are optimised and tailor-made for the relevant biomasses for Europe and European industry. These novel biocatalysts are tested in an iterative manner in process relevant conditions, including also pilot-scale operations, which ensure that the novel enzymes and microbes will be superior in real process conditions. Furthermore, optimal enzyme, microbe and process regime combinations are identified, providing basis for the development of the most economic and ecoefficient overall processes. The impact of the NEMO project on 2nd generation bioethanol production is significant because it provides most realistic but widely applicable technologies that could be exploited broadly by European industry. Its impact goes also much beyond bioethanol because NEMO provides technology improvements that are directly applicable and crucial for efficient and economic production of also other biofuels and bulk chemicals.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: EINFRA-1-2014 | Award Amount: 6.07M | Year: 2015

Recent years witness an upsurge in the quantities of digital research data, offering new insights and opportunities for improved understanding. Text and data mining is emerging as a powerful tool for harnessing the power of structured and unstructured content and data, by analysing them at multiple levels and in several dimensions to discover hidden and new knowledge. However, text mining solutions are not easy to discover and use, nor are they easily combinable by end users. OpenMinTeD aspires to enable the creation of an infrastructure that fosters and facilitates the use of text mining technologies in the scientific publications world, builds on existing text mining tools and platforms, and renders them discoverable and interoperablethrough appropriate registriesand a standards-based interoperability layer, respectively. It supports training of text mining users and developers alike and demonstrates the merits of the approach through several use cases identified by scholars and experts from different scientific areas, ranging from generic scholarly communication to literaturerelated tolife sciences, food and agriculture, and social sciences and humanities. Through its infrastructural activities, OpenMinTeDs vision is tomake operational a virtuous cycle in which a) primary content is accessed through standardised interfaces and access rules b) by well-documented and easily discoverable text mining services that process, analyse, and annotate text c) to identify patterns and extract new meaningful actionable knowledge, which will be used d) for structuring, indexing, and searching content and, in tandem, e) acting as new knowledge useful to draw new relations between content items and firing a new mining cycle. To achieve its goals, OpenMinTeD brings together different stakeholders, content providers and scientific communities, text mining and infrastructure builders, legal experts, data and computing centres, industrial players, and SMEs.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.07M | Year: 2015

The brain barriers function to protect the central nervous system (CNS) from neurotoxic compounds. By the same traits they unfortunately block delivery of drugs to the CNS thus hindering proper diagnosis and effective treatment of neurological disorders including Alzheimers disease and multiple sclerosis. The unusual complexity of the brain barriers has severely hampered progress in the market of CNS targeting therapeutics. BtRAIN bridges this gap by creating particular knowledge on vertebrate brain barrier signature genes and their specific roles in regulating brain barrier function in development, health, ageing and disease. Brain barrier signature genes will be identified by combining cross-species and cross-system brain barrier transcriptome analysis with dedicated bioinformatics. These data will be made available for brain barrier datamining in the userfriendly online platform BBBHub. Within BtRAIN, the side-by-side comparison of a unique and broad armamentarium of different vertebrate in vitro and in vivo brain barrier models will allow to develop and validate particular in vitro brain barrier models that are suited to reliably predict brain barrier function in vivo. Combined with an accompanying in depth analysis of the pathological alterations of the brain barriers during neurological disorders BtRAIN will create unique knowledge to overcome the unmet need for the development of diagnostic and therapeutic tools able to breach the brain barriers. In BtRAIN 12 academic, 6 non-academic partners and 1 European network will jointly train young researchers at unique interfaces of brain barrier research, bioinformatics, business development and science communication for an international research or entrepreneur career. To create this expert pool is the motivation for the involved partners as it will advance the Euopean capacity to bring innovative approaches to the untapped potential of the CNS therapeutic market.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FETOPEN-01-2016-2017 | Award Amount: 3.96M | Year: 2017

Controlling lightning is a long time dream of mankind. The goal of the present project is to investigate and develop a new type of lightning protection based on the use of upward lightning discharges initiated through a high repetition rate multi terawatt laser. The feasibility of the novel technique and the projects prospect of success are based on recent research providing new insights into the mechanism responsible for the guiding of electrical discharges by laser filaments, on cutting-edge high power laser technology and on the availability of the uniquely suitable Sntis lightning measurement station in Northeastern Switzerland. The LLR consortium is ideally positioned to succeed and to raise the competitiveness of Europe in lightning control as it relies on the integration of trans-disciplinary fields in laser development, nonlinear optics, plasma physics, remote sensing, and lightning: The project team is made up of leaders in the domains of high power nonlinear propagation of laser pulses in the atmosphere, laser control of electric discharges, lightning physics, high power laser development, and high-repetition-rate lasers. In addition, the largest European company in aeronautics brings its expertise in lightning direct effects and protection means on aircraft and infrastructures.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 4.20M | Year: 2013

RENESENG aims to prepare a new generation of highly-qualified researchers in Biorefinery and biobased chemicals Systems Engineering Sciences in Europe, expected to bear high impact in the design of newly establishing industrial complexes in biorefinering and more generally in eco-industries. The effort requires to bring together academic and industrial teams, with particularly interdisciplinary and high-quality expertise, embracing disciplines in agricultural sciences, chemistry and chemical eng., biology and biotechnology, computer science, process engineering, logistics and business economics, as well as social sciences with an emphasis on life cycle analysis skills. The principal scientific challenge of the network is to develop a program of inter-disciplinary research from expert groups with dedicated interests in biorenewables using a model-assisted systems approach as an integrating aspect, further capitalizing on its potential and role to address complex and large problems. The proposal brings state-of-the-art systems technologies mobilizing a critical mass in Europe that is already particularly active in this area but needs to coordinate the efforts and reduce fragmentation of knowledge. The aim is to develop and validate modelling, synthesis, integration and optimization technology addressing: 1)lignin-based and cellulosic processes2)water based paths to biomass production 3) waste treatment paths 4) combination of biorenewables processing with utilization of other renewable. In parallel RENESENG has developed a program of training activities including, development of communication, business, and social skills, visits and social events allowing to prepare a new profile of researchers able to transmit their knowledge in the next networking teams. RENESENG guaranties high quality careers perspective for all, through the active participation of 6 industrials, the creation of spin-offs and the sustainable implementation of a multicenter PhD training program.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SC5-06-2016-2017 | Award Amount: 5.88M | Year: 2016

EUCalc replies to topic a) Managing technology transition. The EUCalc project will deliver a much needed comprehensive framework for research, business, and decision making which enables an appraisal of synergies and trade-offs of feasible decarbonisation pathways on the national scale of Europe and its member countries \ Switzerland. The novel and pragmatic modelling approach is rooted between pure complex energy system and emissions models and integrated impact assessment tools, introduces an intermediate level of complexity and a multi-sector approach and is developed in a co-design process with scientific and societal actors. EUCalc explores decisions made in different sectors, like power generation, transport, industry, agriculture, energy usage and lifestyles in terms of climatological, societal, and economic consequences. For politicians at European and member state level, stakeholders and innovators EUCalc will therefore provide a Transition Pathways Explorer, which can be used as a much more concrete planning tool for the needed technological and societal challenges, associated inertia and lock-in effects. EUCalc will enable to address EU sustainability challenges in a pragmatic way without compromising on scientific rigour. It is meant to become a widely used democratic tool for policy and decision making. It will close - based on sound model components - a gap between actual climate-energy-system models and an increasing demands of decision makers for information at short notice. This will be supported by involving an extended number of decision-makers from policy and business as well as other stakeholders through expert consultations and the co-design of a Transition Pathways Explorer, a My Europe 2050 education tool and a Massive Open Online Course.


Chirality is a fundamental property of life, making chiral sensing and analysis crucial to numerous scientific subfields of biology, chemistry, and medicine, and to the pharmaceutical, chemical, cosmetic, and food industries, constituting a market of 10s of billion , and growing. Despite the tremendous importance of chiral sensing, its application remains very limited, as chiroptical signals are typically very weak, preventing important biological and medical applications. Recently, the project-coordinating FORTH team has introduced a new form of Chiral-Cavity-based Polarimetry (CCP) for chiral sensing, which has three groundbreaking advantages compared to commercial instruments: (a) The chiroptical signals are enhanced by the number of cavity passes (typically ~1000); (b) otherwise limiting birefringent backgrounds are suppressed; (c) rapid signal reversals give absolute polarimetry measurements, not requiring sample removal for a null-sample measurement. Together, these advantages allow improvement in chiral detection sensitivity by 3-6 orders of magnitude (depending on instrument complexity and price). ULTRACHIRAL aims to revolutionize existing applications of chiral sensing, but also to instigate important new domains which require sensitivities beyond current limits, including: (1) measuring protein structure in-situ, in solution, at surfaces, and within cells and membranes, thus realizing the holy-grail of proteomics; (2) coupling to high performance liquid chromatography (HPLC) for chiral identification of the components of complex mixtures, creating new standards for the pharmaceutical and chemical analysis industries; (3) chiral analysis of human bodily fluids as a diagnostic tool in medicine; (4) measurement of single-molecule chirality, by adapting CCP to microresonators, which have already demonstrated single-molecule detection; and (5) real-time chiral monitoring of terpene emissions from individual trees and forests, as a probe of forest ecology.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: SST.2012.3.1-4. | Award Amount: 15.65M | Year: 2012

European cities face four main mobility problems: congestion, land use , safety and environment. One of the main causes of such problems is the car-ownership rate. The centres of large cities address this issue combining efficient mass transits with car restriction policies but peripheral areas and smaller cities remain dominated by private cars. CityMobil has demonstrated how automating road vehicles can lead to different transport concepts, from partly automated car-share schemes through CyberCars and PRT, to BRT which can make urban mobility more sustainable. However CityMobil has also highlighted three main barriers to the deployment of automated road vehicles: the implementation framework, the legal framework and the unknown wider economic effect. The CityMobil2 goal is to address these barriers and finally to remove them. To smooth the implementation process CityMobil2 will remove the uncertainties which presently hamper procurement and implementation of automated systems. On one hand CityMobil2 features 12 cities which will revise their mobility plans and adopt wherever they will prove effective automated transport systems. Then CityMobil2 will select the best 5 cases (among the 12 cities) to organise demonstrators. The project will procure two sets of automated vehicles and deliver them to the five most motivated cities for a 6 to 8 months demonstration in each city. To change the legal framework CityMobil2 will establish a workgroup with scientists, system builders, cities, and the national certification authorities. The workgroup will to deliver a proposal for a European Directive to set a common legal framework to certify automated transport systems. Finally an industrial study will assess the industrial potential of automated systems on European economy and any eventual negative effect and make a balance of them.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2010.2.3.2-2 | Award Amount: 8.47M | Year: 2011

Early stage Drug Discovery efforts over the last 5 years have resulted in the identification of a number of promising lead compounds in the fight against TB. These leads need to be further progressed and optimised into candidates for pre-clinical development through the Drug Development progression cascade. Three compound families are of particular interest: 1) InhA Inhibitors, 2) New potent whole cell anti-tubercular compounds with unknown mode of action and 3) new Beta-lactam/Beta-lactamase combinations for TB. A preclinical package is already in place for some of them, but further work is necessary for others in order to justify the progression of a single anti-tubercular family to the more resource intensive stages of preclinical and clinical development. The project will encompass the parallel progression of the three compound families through: A) Lead Optimization Chemistry efforts and MoA studies (Genetic and Proteomic) for whole cell inhibitors, B) In vitro and in vivo evaluation of a new orally bioavailable Beta-lactam alone or in combination with a Beta-lactamase inhibitor to evaluate the sterilising potential of the new drug/s and C) the optimization of an InhA inhibitor for later preclinical development. These efforts will yield candidate molecules for new information rich in vitro assays of antimycobacterial activity (artificial granuloma, activity against slow/non growing cells and activity against clinical isolates) as well as for in vivo safety and efficacy evaluation in different animal models of infection (acute and/or chronic). At this stage a single compound family will be prioritized. Further studies will be performed assessing the potential for shortening treatment in stand alone therapy as well as in combination regimens both in vitro and in vivo. Finally a Clinical Development plan will be put in place for the selected candidate molecule.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: LCE-07-2016-2017 | Award Amount: 6.62M | Year: 2016

The DISC project addresses the need to reduce the consumption of fossil fuels by developing key technologies for the next generation of high-performance photovoltaic (PV) solar cells and modules, allowing ultra-low solar electricity costs with minimum environmental impact. DISC focuses on the only way to fully exploit the potential of silicon to its maximum: through the use of carrier selective junctions, i.e., contacts which allow charge carriers to be extracted without recombination. Such contacts allow for simple device architecture as considered in DISC - non-patterned double-side contacted cells which can be fabricated within a lean process flow, either by upgrading existing or within future production lines. In DISC, a unique consortium of experienced industrial actors will collaborate with a set of institutes with demonstrated record devices and worldwide exceptional experience in the R&D field of carrier selective contacts. DISC will target efficiencies >25.5% on large area cell and >22% at module level while demonstrating pilot manufacturing readiness at competitive costs. Together with a reduction of non-abundant material consumption (Ag, In), with an enhancement of the energy yield, with modern module design ensuring outstanding durability, DISC will provide the key elements for achieving in Europe very low Levelized Costs of Electricity between 0.04 0.07$/kWh (depending on the irradiation), with mid-term potential for further reduction, making solar one of the cheapest electricity source. The high efficient PV modules developed in DISC are predestined for rooftop installations, i.e., neutral with respect to land use aspects. A life cycle approach applied in DISC prevents the shifting of environmental or social burdens between impact categories. DISC has a chance to contribute towards mitigating the impacts of climate change, improving energy access and towards bringing Europe back at the forefront of solar cell science, technology and manufacturing.


Grant
Agency: Cordis | Branch: FP7 | Program: NOE | Phase: ICT-2011.1.6 | Award Amount: 5.99M | Year: 2011

The goal of EINS is coordinating and integrating European research aimed at achieving a deeper multidisciplinary understanding of the development of the Internet as a societal and technological artefact, whose evolution is increasingly interwined with that of human societies. Its main objective is to allow an open and productive dialogue between all the disciplines which study Internet systems under any technological or humanistic perspective, and which in turn are being transformed by the continuous advances in Internet functionalities and applications. EINS will bring together research institutions focusing on network engineering, computation, complexity, security, trust, mathematics, physics, sociology, game theory, economics, political sciences, humanities, law, energy, transport, artistic expression, and any other relevant social and life sciences.\nThis multidisciplinary bridging of the different disciplines may also be seen as the starting point for a new Internet Science, the theoretical and empirical foundation for an holistic understanding of the complex techno-social interactions related to the Internet. It is supposed to inform the future technological, social, political choices concerning Internet technologies, infrastructures and policies made by the various public and private stakeholders, for example as for the far-ended possible consequences of architectural choices on social, economic, environmental or political aspects, and ultimately on quality of life at large.\nThe individual contributing disciplines will themselves benefit from a more holistic understanding of the Internet principles and in particular of the network effect. The unprecedented connectivity offered by the Internet plays a role often underappreciated in most of them; whereas the Internet provides both an operational development platform and a concrete empirical and experimental model. These multi- and inter-disciplinary investigations will improve the design of elements of Future Internet, enhance the understanding of its evolving and emerging implications at societal level, and possibly identify universal principles for understanding the Internet-based world that will be fed back to the participating disciplines. EINS will:\nCoordinate the investigation, from a multi-disciplinary perspective, of specific topics at the intersection between humanistic and technological sciences, such as privacy & identity, reputation, virtual communities, security & resilience, network neutrality\nLay the foundations for an Internet Science, based i.a. on Network Science and Web Science, aiming at understanding the impact of the network effect on human societies & organisations, as for technological, economic, social & environmental aspects\nProvide concrete incentives for academic institutions and individual researchers to conduct studies across multiple disciplines, in the form of online journals, conferences, workshops, PhD courses, schools, contests, and open calls


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-SA | Phase: NMP.2011.4.0-5 | Award Amount: 470.09K | Year: 2012

The Piezo institute AISBL (PI) emerged from NoE MIND (Multifinctional & Integrated Piezoelectric Devices). PI is well a functioning non profit organisation with ongoing activities dedicated to support the integration of the fragmented European expertise and deliver innovative educational tools through postgraduate degrees combining materials, technology and device knowledge. It needs, however, to continue strengthening its visibility through increasing dissemination and building out all the existing activities within education, research and training. The new knowledge under development within PI supports the environmental, safety and health policies of EU and is designed to facilitate next generation of material technologies for autonomous monitoring systems incl. Energy Harvesters. To achieve further defragmentation, PI will increase the shared research support activities incl. the preparation of proposals, active participation in programming activities for future calls, further developing of European postgraduate degrees, offering of expertise and support of innovation within the field to European industry and in particular to SMEs. To increase its visibility and support dissemination to public and professionals, PI will organise conferences, workshops, tutorials and industrial courses. PI plans to widen the offer of industrial training, based on accredited courses within technology and modelling. Thanks to complementary expertise of its members, and history of extensive collaboration, PI has developed substantial expertise within lead-free piezoelectric materials, their processing and technology, the knowledge of which combined with the design expertise, PI will exploit to support industrial implementation of, serving the environmentally friendly innovation. The scientists with PIs international degree will have a thorough and sound grounding to support Europes environmentally friendly processing, modelling and development of next generation technologies.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: ENV.2008.1.3.3.1. | Award Amount: 8.77M | Year: 2009

SafeLand will develop generic quantitative risk assessment and management tools and strategies for landslides at local, regional, European and societal scales and establish the baseline for the risk associated with landslides in Europe, to improve our ability to forecast landslide hazard and detect hazard and risk zones. The scientific work packages in SafeLand are organised in five Areas: Area 1 focuses on improving the knowledge on triggering mechanisms, processes and thresholds, including climate-related and anthropogenic triggers, and on run-out models in landslide hazard assessment; Area 2 does an harmonisation of quantitative risk assessment methodologies for different spatial scales, looking into uncertainties, vulnerability, landslide susceptibility, landslide frequency, and identifying hotspots in Europe with higher landslide hazard and risk; Area 3 focuses on future climate change scenarios and changes in demography and infrastructure, resulting in the evolution of hazard and risk in Europe at selected hotspots; Area 4 addresses the technical and practical issues related to monitoring and early warning for landslides, and identifies the best technologies available both in the context of hazard assessment and in the context of design of early warning systems; Area 5 provides a toolbox of risk mitigation strategies and guidelines for choosing the most appropriate risk management strategy. Maintaining the database of case studies, dissemination of the project results, and project management and coordination are defined in work packages 6, 7 and 8.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: LCE-07-2016-2017 | Award Amount: 5.67M | Year: 2016

The NextBase project, involving 8 research institutions and 6 companies, deals with the development of innovative high-performance c-Si solar cells and modules based on the interdigitated back-contacted silicon heterojunction (IBC-SHJ) solar cell concept targeting cells with efficiency above 26.0% and corresponding solar modules with efficiency above 22.0%. In particular, a number of new design and process innovations throughout the wafer, cell and module fabrication that go beyond the state-of-the-art will be introduced into the device to achieve the targeted efficiency values. At the same time, the NextBase project pursues the development of a new industrial manufacturing tool and low-cost processes for the IBC-SHJ solar cells enabling a competitive IBC-SHJ solar module cost of < 0.35 /Wp.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: AAT.2010.1.1-1.;AAT.2010.1.3-2. | Award Amount: 2.23M | Year: 2010

The X-NOISE EV Coordination Action, through its network structure and comprehensive workplan involving experts groups, scientific workshops, international cooperation seminars and a common information system, addresses the noise challenges faced by Aviation. To this end, it will more specifically: - Evaluate EU-funded projects results and assess their contribution to the state-of-the-art. - Formulate, through development of common strategies and complementarity with national activities, priorities and key topics for future projects aimed at noise reduction at source, low noise operations, and improved understanding and modelling of the impact of aircraft noise in the community, including environmental interdependencies. - Ensure dissemination and exploitation of research findings, including technical information aimed at Regulatory Bodies and Policymaking Agencies. - Contribute to an improved integration of the European Aviation Noise Research Community through a network of National Focal Points covering all countries with such technical interest - Identify potential reinforcement of future projects partnership through extended international networking and dedicated processes to foster new collaborations and promote novel ideas. The project scope is fully consistent with the FP7 Transport workprogramme (Aeronautics), significantly contributing to the objectives of reducing Aircraft Noise by 10 dB per operation as set by the ACARE 2020 Vision,.while addressing key factors associated with Airport Noise issues. Over 4 years, the project will involve 29 partners from 21 countries (FR, UK, ES, NL, BE, DE, SE, IT, PL, HE, HU, CZ, LT, IE, PT, RO, CH, RU, UKR, EG, BR), combining the complementary skills and expertise of industry partners, SMEs, universities and research establishments to cover the whole field of interest.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 4.04M | Year: 2010

Cement is the primary binding phase of concrete. It is millennia old and ubiquitous worldwide. As a building material, it is unrivalled in terms of tonnage used, price per tonne, and CO2 production per tonne. Yet its very success means that cement production account for about 5% of global man-made CO2 emissions. The cement industry urgently requires more sustainable cement based products with equal or better performance to current materials over the life time of buildings and infra-structure (~100 years). Most of the CO2 associated with cement manufacture comes mainly from the breakdown of limestone into calcium oxide and carbon dioxide. Therefore improvements must come from better materials with different chemistries. If the construction industry is to embrace new materials, then it must trust them. Water transport underpins almost all degradation. Degradation must be understood to ensure durability, which is the major obstacle to the introduction of new, more sustainable cementitious materials. Hence the industry is calling urgently for the researchers with the ability to predict water transport in concretes. Without this, there can be no confidence in the introduction and use of new materials; the status quo based on years of experience but relatively little scientific understanding will prevail for decades to come. Through the TRANSCEND Initial Training Network we will provide the trained personnel who can. (i) Enable the construction industry to predict water transport in cements and concretes and hence design appropriate tests to predict concrete degradation. (ii) Provide a basis for user confidence which enables the cement industry to introduce new more sustainable cements. The network will closely integrate the academic and private sectors. The later will directly employ 4 of the 15 fellows. The formal training programme will provide the basis for a European doctoral school in Cement and Concrete Science and technology.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY.2012.10.2.1 | Award Amount: 3.83M | Year: 2012

Aim of the project Photogenerated Hydrogen by Organic Catalytic Systems (PHOCS) is the realization of a new-concept,photoelectrochemical system for hydrogen production, based on the hybrid organic/inorganic and organic/liquid interfaces. PHOCS takes the move from the recent demonstration of reduction/oxidation reactions taking place, under visible light and at zero bias, at the interface of an organic semiconductor and an aqueous electrolyte, obtained by the coordinators group. PHOCS intends to combine the visible-light absorption properties of organics, together with the enhanced charge transport capabilities of inorganic semiconductors, in order to build a hybrid photoelectrode for hydrogen generation. New organic donor and acceptor materials (conjugated polymers and fullerenes derivatives) will be synthesized, properly tuning HOMO-LUMO levels position and energy gap extent for semi-water splitting purposes. In order to build properly-working photo-electrochemical cells, issues such as stability, wettability, catalytic functionality, electron transfer processes at the polymer/electrolyte interface will also be faced during the synthesis step. Multifunctional, high surface area, inorganic electrodes will be moreover developed, in order to increase surface area, provide ohmic contact to the organic active layer, 3D control of the donor-acceptor junction and advanced light management. Spectro-electrochemical characterization of organic/inorganic and organic/electrolytic solution interfaces will be continuously performed, in order to deep characterize charge transfer phenomena and improve the device performances. Final aim of PHOCS project is the realization of a scaled-up, 10x10 cm2, 1% solar-to-hydrogen energy conversion efficient device, as a tangible first step towards the new organic water splitting technology.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2010.2.4.1-6 | Award Amount: 3.90M | Year: 2011

Pancreatic ductal adenocarcinoma (PDAC) causes 34000 deaths in the EU every year. Conventional cancer treatments have close to no impact on this disease. As a result, almost all patients diagnosed with PDAC develop metastases and eventually die. Given this poor outlook, the search for new therapeutics is mandatory. These will have to target relevant cancer pathways and be designed based on the available knowledge on the genetic alterations that characterize this malignancy. We propose to build a team composed of clinicians, translational cancer researchers, chemists, and two pharmaceutical enterprises, to synthesize and implement new drugs for PDAC. The focus of the participants in this project will be on pathways and cellular functions broadly involved in PDAC metastasis and immune escape. These drugs are meant to work through diverse and novel modes of action and will be validated using genetically engineered PDAC mouse models that we have established at the Center for Integrated Oncology in Bonn. By creating and exploring diverse classes of compounds capable of arresting tumor growth and of interfering with its metastatic spread, this project will deliver a high number of new molecules with potential as anticancer therapeutics. In particular, our consortium will produce new indoleamine 2,3-dioxygenase-2 (IDO2) inhibitors, galectin-3 inhibitors, edelfosine analogues, inhibitors of the Hippo signaling pathway, alpha-mannosidase inhibitors, SIRT6 inhibitors, and therapeutics acting by synthetic lethality. For compounds with strong proof-of-concept activity, our consortium will perform the Investigational New Drug (IND)-Enabling Studies, with the goal of delivering a new drug ready to be tested clinically by the end of the project. The PANACREAS project is meant to help find better treatments for PDAC, boost research on this form of cancer in the EU, and open new avenues for scientific and technological innovation.


Grant
Agency: Cordis | Branch: H2020 | Program: COFUND-EJP | Phase: EURATOM | Award Amount: 856.96M | Year: 2014

A Roadmap to the realization of fusion energy was adopted by the EFDA system at the end of 2012. The roadmap aims at achieving all the necessary know-how to start the construction of a demonstration power plant (DEMO) by 2030, in order to reach the goal of fusion electricity in the grid by 2050. The roadmap has been articulated in eight different Missions. The present proposal has the goal of implementing the activities described in the Roadmap during Horizon 2020 through a joint programme of the members of the EUROfusion Consortium. ITER is the key facility in the roadmap. Thus, ITER success remains the most important overarching objective of the programme and, in the present proposal the vast majority of resources in Horizon 2020 are devoted to ensure that ITER is built within scope, time and budget; its operation is properly prepared; and a new generation of scientists and engineers is properly educated (at undergraduate and PhD level) and trained (at postdoctoral level) for its exploitation. DEMO is the only step between ITER and a commercial fusion power plant. To achieve the goal of fusion electricity demonstration by 2050, DEMO construction has to begin in the early 2030s at the latest, to allow the start of operation in the early 2040s. DEMO cannot be defined and designed by research laboratories alone, but requires the full involvement of industry in all technological and systems aspects of the design. Specific provisions for the involvement of industry in the Consortium activities are envisaged.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: ENERGY.2009.9.2.1 | Award Amount: 2.46M | Year: 2010

The three year coordinating action THINK will improve the knowledge support to policy making by the European Commission in the context of the Strategic Energy Technology Plan. THINK is organized around a multidisciplinary group of 24 experts covering five dimensions of energy policy: science and technology, market and network economics, regulation, law, and policy implementation. The Think Tank will respond to the European Commissions evolving needs on a semester basis and produce 12 dossiers and a book. Each semester, two projects will go through the quality process of the Think Tank, including an expert hearing to test the robustness of the work, a discussion meeting inside the Think Tank, and a public consultation to test the public acceptance of different policy options by involving the broader community. Each Think Tank dossier will therefore include four chapters: 1) the Think Tank assessment of the energy policy options with clear recommendations for policy makers from the drafting team under guidance of the Project Leader, 2) a report including the comments from two Think Tank Advisors, 3) the expert hearing summary, and 4) the public consultation conclusions. The coordinating action THINK will reduce the costs related to the implementation of the ambitious EU energy policy targets by assessing the impacts of policy options using an innovative organisational and analytical frame. With a core group of about 15 nationalities, this coordinating action will also help counter the fragmentation of research in Europe and bridge the gap between Member States and the European Commission by creating a common knowledge base for decision making in energy policy.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENV.2012.6.5-1 | Award Amount: 6.97M | Year: 2012

WeSenseIt will develop a citizen-based observatory of water, which will allow citizens and communities to become active stakeholders in information capturing, evaluation and communication. We propose: (i) data collection: (a) a first hard layer consisting of low-cost, static and portable devices that sense and transfer water information when automatically monitored or when initiated by citizens from their mobile devices; (b) a second soft layer consisting of techniques to harness citizens Collective Intelligence, i.e. the information, experience and knowledge embodied within individuals and communities, both in terms of enabling direct messages to the authorities (with mobile-phone pictures, messages, etc.) and in terms of crowd-sourcing (e.g. by mining social networks like Twitter and Facebook, as well as bulletin boards, RSS feeds, etc.). (ii) the development of descriptive and predictive models and decision-making tools integrating sensor and citizen-based data; the data suppliers (physical sensors or people) are seen as nodes of an integrated heterogeneous data collection network which undergoes progressive multi-objective optimization and tuning. (iii) two-way feedback and exchange of environmental knowledge/experience between citizens and authorities for decision-making and governance within an e-collaboration framework ,enabling improved transparency, knowledge management, accountability and responsiveness, as well as facilitating participation in water management. We will test, experiment and demonstrate the citizen observatory of water in three different case studies in water management with civil protection agencies in UK, NL and Italy. The topic is the entire hydrologic cycle with a major focus on variables responsible for floods and drought occurrences. The project results have the potential to fundamentally change the traditional concept of environmental monitoring and forecasting, as well as models of governance.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.2.2.1-5 | Award Amount: 8.03M | Year: 2013

Amputation of a limb may result from trauma or surgical intervention. The amputation traumatically alters the body image, but often leaves sensations that refer to the missing body part. In 50-80% amputees, neuropathic pain develops, also called phantom limb pain (PLP). Both peripheral and central nervous system factors have been implicated as determinants of PLP. Also, PLP may be triggered by physical (changes in the weather) and psychological factors (emotional stress). Recent evidence suggests that PLP may be intricately related to neuroplastic changes in the cortex, and that these changes may modulated by providing sensory input to the stump or amputation zone. However, the understanding of why PLP occurs is still poor, the basic research results have not been tested on a large scale in the clinic, and there are no fully effective, long-term treatments readily available on the market. We aim to challenge the status-quo of PLP therapy by offering technological solutions that will invasively or non-invasively induce natural, meaningful sensations to the amputee to restore the neuroplastic changes in the cortex and thereby control and alleviate PLP. We will assess the effect of cortical neuroplastic, psychological and cognitive components of pain and integrate the knowledge into clinical guidelines. The proposed work directly targets the HEALTH.2013.2.2.1-5 topic. The consortium will build solutions based on existing technologies emerging from previous EU funded research which are presently only available in experimental settings. We believe that implementation of proposed work will be the cornerstone needed to exploit, validate and translate the basic research results into clinical applications and provide long-term, patient-specific solutions to a large group of patients suffering from PLP. The work will assist to improve the quality of life for amputees suffering from phantom limb pain and is of high socio-economic relevance to the EU.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.45M | Year: 2013

In vivo Magnetic Resonance Spectroscopy and Spectroscopic Imaging (MRS(I)) are unique, indispensable techniques for non-invasive metabolic imaging. Important areas where MRS(I) can make a difference are oncology and neurology, where metabolic changes due to, e.g., tumour formation, can be detected earlier and more sensitively than with morphological imaging modalities alone. Despite its huge proven potential, MRS(I) is not yet a routine clinical tool operated solely by clinicians. This requires reliable automation of complex procedures, strengthening standardisation and quality control. This in turn requires significant research progress and training of a new generation of scientists. Specifically, TRANSACT aims at: - Training 13 young scientists as future leaders in the field of MRS(I), capable of contributing with essential new developments such as spectral quality assurance criteria and standards, and optimal exploitation of complementarities between multi-modal magnetic resonance imaging modalities. - Pursuing research advances in theoretical and practical aspects of MRS, in particular experimental design by quantum mechanical simulation, data acquisition, data processing, data fusion and biomedical applications in oncology and neurology. - Establishing Europe as leader in the field within three sectors: academia, industry, clinic. TRANSACT links 10 academic and 4 industrial partners with complementary expertise in basic science, clinical research and information technology. Through a detailed training programme consisting of individual research projects, well-targeted secondments, scientific network-wide workshops, transferable skills courses, and individualized progress follow-up, TRANSACT will ensure a successful outcome in terms of career perspectives for the recruited researchers, continued collaboration between the partners and a more structured doctoral training in this field.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: ENERGY.2011.2.1-2;NMP.2011.1.2-1 | Award Amount: 12.88M | Year: 2012

In recent years, the effort in thin-film silicon (TFSi) was made at solving industrialization issues. In 2010, several companies demonstrated 10% stable modules (> 1 m). The major bricks for efficient production are now in place. Next challenges are linked to the fact that TFSi multi-junction devices, allowing for higher efficiency, are complex devices, in which the substrate geometry and each layer have an impact on the full device. This explains why the first industrializations focused on single technology roads (e.g., Jlich-AMAT or EPFL-Oerlikon approaches). This project focuses at bringing the next-generation technology to the market, using newly developed state-of-the art knowledge to solve the complex puzzle of achieving at the same time strong light in-coupling (high current) and good electrical properties (open-circuit voltage and fill factor). In a unique collaborative effort of the leading EU industries and research institutions in the field, the consortium will go beyond the current technology status by Introducing novel materials, including multi-phase nanomaterials (such as doped nc-SiOx, high crystallinity nc-Si materials), stable top cell materials, nanoimprinted substrates and novel or adapted transparent conductive oxides; Designing and implementing ideal device structures, taking into account the full interaction of layers in multi-junction devices; Controlling the growth of active layers on textured materials; Working at processes that could allow a further extension of the technology such as very high rate nc-Si deposition or multi-step superstrate etching; Transferring processes, including static and dynamic plasma deposition, from the laboratory to pilot scale, with first trials in production lines. The targets of the project is to achieve solar cells with 14% stable efficiency, leading to the demonstration of reliable production size prototypes module at 12% level. Potential cost below 0.5/Wp should be demonstrated.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY.2010.10.2-1 | Award Amount: 3.59M | Year: 2010

The proposed project comes with a visionary approach, aiming at development of highly efficient molecular-wire charge transfer platform to be used in a novel generation thin film dye-sensitized solar cells fabricated via organic chemistry routes. The proposed technology combines the assembled dye monolayers, linked with organic molecular wires to semiconducting thin film deposited on optically transparent substrates. Current organic photovoltaic (OPV) cell designs made a significant step towards low cost solar cells technology, however in order to be competitive with Si and CIGs technologies, OPVs have to demonstrate long term stability and power conversion efficiencies above 10% The highest reported power conversion efficiency for OPV device based on bulk heterojunction device with PCBM and low band gap conjugated polymers is today 6.4% but this system seems reaching its limit. Offsets in the energetics of these systems lead to large internal energy losses. The dye-sensitized solar cells (DSC) reach the efficiency above 11% but the problems with the stability of the electrolyte are the current bottleneck. The MOLESOL comes with a novel concept of hybrid device combining the advantages of both concepts (i.e. dye coupled with organic molecular wire to a conductive electrode). This concept will lead to stable cells with enhanced conversion efficiency based on: Reduction of critical length for the charge collection generated in the dye monolayer by the inorganic bottom electrode, using short molecular wires compatible with exciton diffusion length. Replacing current inorganic ITO/FTO (n-type) layer by novel transparent wide band p-type semiconductor with a possibility of engineering the surface workfunction and leading to perfect matching between HOMO of the dye layer and the valence band of semiconductors, allowing larger Voc.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY.2009.2.1.1 | Award Amount: 8.85M | Year: 2010

In this project we will increase the efficiency of thin-film silicon solar cells on flexible substrates by solving the issues linked to material quality, interface properties and light management, thus enabling lower production costs per Watt-peak. The general technological objectives of the project are the development of better materials and enhanced interfaces for thin film silicon solar cells, and to transfer the developed processes to an industrial production line. The most important project goals are: 1) Reduction of optical reflection and parasitic absorption losses: Design and industrial implementation of textured back contacts in flexible thin film silicon solar cells. 2) Reduction of recombination losses: Development and implementation of improved silicon absorber material. 3) Reduction of electric losses: Graded TCO layers which minimize the work function barrier between the p-layer and the TCO layer without loss of conductivity and transmission of the TCO. In addition, the top layer of the TCO stack should provide a good protection against moisture ingression. In order to achieve these objectives more in-depth knowledge is needed for several relevant key areas for thin film silicon solar cells. The main scientific objectives are: 1) Identification of the ideal texture for the back contact. This structure should maximize the light trapping in thin film silicon solar cells without deterioration of open-circuit voltage and fill factor. 2) Paradigm shift for the growth of microcrystalline silicon. In this project we want to show that it is possible to use microcrystalline silicon with high crystalline fractions leading to better current collection without voltage losses, and without crack formation when grown on nano-textured substrates. 3) Deeper understanding of moisture degradation mechanisms of common TCOs like ITO and AZO.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.1.2-1 | Award Amount: 7.83M | Year: 2014

Background: Hyperinsulinaemic hypoglycaemia (HH) is a potentially lethal disease caused by over functioning beta cells derived from the pancreatic islets of Langerhans. Lethal HH and brain damage is a problem especially in infants with congenital HH. Current therapeutic approaches are associated with severe side effects/morbidity (diabetes, exocrine pancreas insufficiency etc.) considered acceptable in relation to the lethal outcome of HH although massively reducing quality of life and also life expectancy. Aims and objectives: In order to significantly improve therapy of this awful disorder, we propose to develop a simultaneous imaging/therapy platform allowing diagnostic imaging as well as image guided surgical, photodynamic or radiopeptide therapy to selectively resect/destroy diseased beta cells. This platform will enable delivery of patient-individual tailored therapy, increasing cure rate while significantly reducing or even avoiding side effects. The platform will integrate information from pre-clinical imaging for optimal therapy planning with intra-operative imaging for image guided surgery. By implementation of extended field optical coherence tomography, information on a histopathological level will allow increased precision of therapy. Highly innovative photodynamic therapy will enable selective (endoscopic) destruction of diseased beta cells without resection of pancreatic tissue. Outcome: Our highly-innovative integrated imaging/therapy (theranostic) platform will allow diagnosis and monitoring of disease, support and guide therapeutic intervention, predict outcome of intervention and individual prognosis. This technology will massively improve therapy, especially in infants, by improving cure rates while significantly reducing morbidity for improved quality of life and increased life expectancy. We will contribute to the goals of the International Rare Diseases Research Consortium (IRDiRC): 200 new therapies.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: SEC-2011.4.2-2 | Award Amount: 17.31M | Year: 2012

Recent dramatic events such as the earthquakes in Haiti and LAquila or the flooding in Pakistan have shown that local civil authorities and emergency services have difficulties with adequately managing crises. The result is that these crises lead to major disruption of the whole local society. The goal of ICARUS is to decrease the total cost (both in human lives and in ) of a major crisis. In order to realise this goal, the ICARUS project proposes to equip first responders with a comprehensive and integrated set of unmanned search and rescue tools, to increase the situational awareness of human crisis managers and to assist search and rescue teams for dealing with the difficult and dangerous, but life-saving task of finding human survivors. As every crisis is different, it is impossible to provide one solution which fits all needs. Therefore, the ICARUS project will concentrate on developing components or building blocks that can be directly used by the crisis managers when arriving on the field. The ICARUS tools consist of assistive unmanned air, ground and sea vehicles, equipped with human detection sensors. The ICARUS unmanned vehicles are intended as the first explorers of the area, as well as in-situ supporters to act as safeguards to human personnel. The unmanned vehicles collaborate as a coordinated team, communicating via ad hoc cognitive radio networking. To ensure optimal human-robot collaboration, these ICARUS tools are seamlessly integrated into the C4I equipment of the human crisis managers and a set of training and support tools is provided to the human crisis to learn to use the ICARUS system. Furthermore, the project aims to provide an integrated proof-of-concept solution, to be evaluated by a board of expert end-users that can verify that operational needs are addressed.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENV.2013.6.4-4 | Award Amount: 3.98M | Year: 2013

Critical Infrastructures (CIs) provide essential goods and services for modern society; they are highly integrated and have growing mutual dependencies. Recent natural events have shown that cascading failures of CIs have the potential for multi-infrastructure collapse and widespread societal and economic consequences. Moving toward a safer and more resilient society requires improved and standardized tools for hazard and risk assessment of low probability-high consequence (LP-HC) events, and their systematic application to whole classes of CIs, targeting integrated risk mitigation strategies. Among the most important assessment tools are the stress tests, designed to test the vulnerability and resilience of individual CIs and infrastructure systems. Following the results of the stress tests recently performed by the EC for the European Nuclear Power Plants, it is urgent to carry out appropriate stress tests for all other classes of CIs. To this end, STREST will establish a common and consistent taxonomy of CIs; develop a rigorous, consistent modelling approach to hazard, vulnerability, risk and resilience assessment of LP-HC events; design a stress test framework and specific applications to address the vulnerability, resilience and interdependencies of CIs. STREST will focus on earthquakes, tsunamis, geotechnical effects and floods, and on three principal CI classes: (a) individual, single-site, high risk infrastructures, (b) distributed and/or geographically extended infrastructures with potentially high economic and environmental impact, and (c) distributed, multiple-site infrastructures with low individual impact but large collective impact or dependencies. STREST will work with key European CIs, to test and apply the developed stress test methodologies to specific CIs, chosen to typify general classes of CIs, with the final goal of enabling the implementation of European policies for the systematic implementation of stress tests.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-CSA-Infra-PP | Phase: INFRA-2010-2.2.7 | Award Amount: 6.99M | Year: 2010

Euro-BioImaging brings together imaging technologies stretching from basic biological imaging with advanced light microscopy, in vivo molecular imaging of single cells to animal models up to the clinical and epidemiological level of medical imaging of humans and populations. Euro-BioImaging, in close consultation with its stakeholders, will address the imaging requirements of both biological and medical imaging research communities by creating a coordinated and harmonized plan for infrastructure deployment in Europe. Euro-BioImaging infrastructures will be planned to provide access to state-of-the-art equipment as well as to provide training and continue the development of imaging technologies to be able to offer them as new services. The vision of Euro-BioImaging is to provide a clear path of access to imaging technologies for every biomedical scientist in Europe. The Euro-BioImaging infrastructure will be focused on imaging technologies grouped around different scales of biological organization, from the single molecule to the whole human organism. Euro-BioImaging will therefore develop a plan to construct and operate a set of complementary and strongly interlinked infrastructure facilities appropriately distributed across the European member states. To achieve this, Euro-BioImaging will define the legal and governance framework with its currently 22 member states and develop a finance plan in close cooperation with national funding bodies as well as with the European Commission. The key objective of the Euro-BioImaging preparatory phase project is to integrate these plans into an overarching business plan that provides a realistic basis for construction and operation of the Euro-BioImaging infrastructure. Through the combination of these technological and strategic objectives, Euro-BioImaging will be able to address the key elements of successful infrastructures: supporting research, training and innovation in biomedical imaging across Europe.


Grant
Agency: Cordis | Branch: H2020 | Program: IA | Phase: FoF-04-2014 | Award Amount: 5.25M | Year: 2015

Known as either Industrial Revolution 4.0 or as Industrial Renaissance, the need for new manufacturing approaches is widely accepted in the EU. SatisFactory aims to contribute to the transformation of traditional industrial environments using cutting-edge technologies in ways that are both productive and appealing to youth. The fundamental component of the proposed system will be the assessment and storage of the explicit and tacit knowledge created on the shop floor by aggregating a set of heterogeneous smart devices and sensors (Linksmart/FIT, Smart Sensors/ISMB) and extracting context-aware information based on their measurements (Semantics Engine/EPFL). The distribution of this knowledge will be based on 3 important system tools. Firstly, a training platform will allow the fast and intuitive education of employees (R3Donline/Regola). Secondly, a collaboration platform (CoSpaces/FIT) will stimulate and promote team interactions. Finally, ubiquitous user interfaces (BRIDGE/FIT) will support all employees seamlessly in real time and on the move. SatisFactory will also utilise the aggregated knowledge in order to leverage the control and re-adaptation of facilities (mainDSS/ABE) and streamline the workload (Human Behavior Analysis/CERTH). In order to enhance working experience and thus increase the workplace attractiveness, augmented reality and gamification (CollabReview/FIT) approaches will be utilized. Additionally modern wearable devices (ISMB; Glasses/GlassUp) will allow the interaction of workers with the system without disrupting their workflow. All 12 foreseen products of SatisFactory will be deployed and evaluated in two industrial sites representing automotive industry (COMAU) and battery construction (SUNLIGHT). Validation will assess the impact and reveal the capabilities of SatisFactory towards the promotion of novel and viable business models for increased innovation potential, flexibility and productivity,while enhancing workplace attractiveness


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 3.04M | Year: 2012

Systems Chemistry (the chemistry of complex mixtures of interacting molecules) is a rapidly developing new fronteir in the chemical sciences. Where chemistry has for centuries been a firmly reductionistic science, Systems Chemistry breaks with this tradition by focussing on complexity and emergent behaviour. This network brings together nearly all major academic players active in Europe on experimental approaches to Systems Chemistry in general and molecular networks in particular. Our consortium is of exceptional quality and is a balanced mix of highly experienced scientists with mutiple publications in Science and/or Nature and talented young scientists of whom four have recently been awarded prestigious ERC starting grants. We have two full partners from industry that provide essential analytical support and the perspective on commercialisation of complex chemical systems. Aim of our high-level consortium is to provide a comprehensive high-quality training program on Systems Chemistry, in the context of a cutting-edge and wide-ranging research program, focusing on two important phenomena: adaptation and replication in molecular networks. These subjects will be developed towards application in enantioselective organoautocatalysis, molecular Boolean logic protocols, self-synthesising materials that exhibit electronic conductivity and adaptive biological functionality, sensing of bio-analytes, assessing molecular similarity and materials for anti-counterfeiting. Our comprehensive training and research program will deliver a new generation of young researchers eager to push the frontiers of the rapidly emerging field of Systems Chemistry, expanding Europes lead in this exciting new area.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-SICA | Phase: NMP.2012.2.2-6 | Award Amount: 5.12M | Year: 2012

Limpid aims at generating new knowledge on photocatalytic materials and processes in order to develop novel depollution treatments with enhanced efficiency and applicability. The main goal of LIMPID is to develop materials and technologies based on the synergic combination of different types of nanoparticles (NPs) into a polymer host to generate innovative nanocomposites which can be actively applied to the catalytic degradation of pollutants and bacteria, both in air or in aqueous solution. Single component nanocomposites including TiO2 NPs are already known for their photocatalytic activities. LIMPID will aim at going one big step further and include, into one nanocomposite material, oxide NPs and metal NPs in order to increase the photocatalytic efficiency and allow the use of solar energy to activate the process. One of the main challenge of LIMPID is to design host polymers, such as hybrid organic inorganic and fluorinated polymers, since photocatalysts can destroy the organic materials. The incorporation of NPs in polymers will allow to make available the peculiar nano-object properties and to merge the distinct components into a new original class of catalysts. At the same time nanocomposite formulation will also prevent NPs to leach into water and air phase, thus strongly limiting the potential threat associated to dispersion of NPs into the environment. Therefore nanocomposites developed in LIMPID will be used as coating materials and products for the catalytic degradation of pollutants and bacteria in water and air, i.e. deposited onto re-usable micro-particles, or in pollutant degradation reactors, and even onto large surfaces, as a coating or paint. In addition such new class of nanocomposites will be also exploited for the fabrication of porous membranes for water treatment. In order to fulfill its objectives, the LIMPID consortium has been designed to combine leading industrial partners with research groups from Europe, ASEAN Countries and Canada.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: AAT.2008.1.4.1. | Award Amount: 30.00M | Year: 2009

Reducing noise from aircraft operations perceived by airport neighbouring communities is a major challenge facing the aircraft manufacturing industry, social society and the air transport business. By adopting a whole aircraft approach based on the latest developments in active / adaptive technologies, flow control techniques and advances in computational aero-acoustics applied to the major causes of noise at source, OPENAIR aims to deliver a step change in noise reduction, beyond the SILENCE(R) achievements. The workplan clearly supports realistic exploitation of promising design concepts driven by noise reduction and will result in the development and validation up to TRL 5 of 2nd Generation technology solutions. OPENAIRs multidisciplinary approach and composition is suited to the projected integrated, lightweight solutions. The process includes a down-selection in mid project. The selected technologies will be subjected to scaled rig tests, and the resulting data will support assessment of the noise reduction solutions on powerplant and airframe configurations across the current and future European range of products. The project exploitation plan will include detailed proposals for further demonstration in the Clean Sky JTI. The verification of the technologies applicability will be assured by addressing identified integration and environmental tradeoffs (performance, weight, emissions). In this way OPENAIR will develop solutions that can play a significant role, in continuity with the previous Generation 1 effort, enabling future products to meet the ACARE noise goals and improving current fleet noise levels through retrofitting. This capability is key to providing the flexibility needed to simultaneously accommodate market requirements in all segments, global traffic growth and environmental constraints, while addressing the global environmental research agenda of the EU.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SPA.2011.3.2-02 | Award Amount: 11.78M | Year: 2011

The QB50 Project will demonstrate the possibility of launching a network of 50 CubeSats built by CubeSat teams from all over the world to perform first-class science and in-orbit demonstration in the largely unexplored middle and lower thermosphere. Space agencies are not pursuing a multi-spacecraft network for in-situ measurements in the middle and lower thermosphere because the cost of a network of 50 satellites built to industrial standards would be very high and not justifiable in view of the limited orbital lifetime. No atmospheric network mission for in-situ measurements has been carried out in the past or is planned for the future. A network of satellites for in-situ measurements in the middle and lower thermosphere can only be realised by using very low-cost satellites, and CubeSats are the only realistic option. The Project will demonstrate the sustained availability of a low-cost launch opportunities, for launching small payloads into low-Earth orbit; these could be microsatellites or networks of CubeSats or nanosats or many individual small satellites for scientific, technological, microgravity or biology research. The Project will include the development of a deployment system for the deployment into orbit of a large number of single, double or triple CubeSats. Once the system is developed for QB50 it can be easily adapted to other missions. QB50 will also provide a launch opportunity for key technology demonstration on IOD CubeSats such as formation flying and aerobrakes. All 50 CubeSats will be launched together into a circular orbit at approximately 380 km altitude. Due to atmospheric drag, the orbits of the CubeSats will decay and progressively lower and lower layers of the thermosphere will be explored without the need for on-board propulsion, perhaps down to 200 km. QB50 will be among the first CubeSat networks in orbit.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: NMP.2011.4.0-3 | Award Amount: 5.57M | Year: 2012

This project will develop a fabric to harvest and store electrical energy within its fibrous matrix, to fulfill a need for an easily deformable, storable and transportable power supply. This will be achieved through the development of PV fibres and energy storage fibres integrated with control electronics into a textile. This unique approach, moving on from the current state of the art using rigid cell or film based PV materials and batteries, will allow development of large-area deformable products, including agricultural shading, automotive soft-tops, building facades, rollable shades, curtains and roofing, aerospace fabrics, and outdoor goods. The key challenges are: Formulation of PV and energy storage materials to be applied as flexible thin coatings on monofilament fibres. SME materials suppliers Cyanine (PV dyes) and PPC (polymer coatings) will work with universities, EPFL (PV) and Brunel (storage) who are leaders in these fields. Development and application of fibre spinning and coating methods to make the two multi-layer fibre types, followed by generation of a textile combining the two. Fibre and fabric manufacturers Sefar, CeNTI (SME) and VDS weaving (SME) will work with textile and coating experts, Centexbel and TWI. Integration of the two fibres, requiring end preparation to reveal conductors, interconnect and micro-circuitry, followed by attachment to a load device. Materials joining and smart textile experts, TWI, Cetemmsa and Ohmatex (SME) will work on this. Demonstration activities which will involve a small-scale autonomous airship by Lindstrand (SME), and agricultural textiles by BTF, both strong innovators in their fields. The 6 innovative SMEs, 2 LEs and the RTOs with extensive links in solar power, microsystems and textiles industries, are well placed to quickly exploit the project developments and provide extensive exposure of the ideas into a wide variety of markets requiring a continuous, fully autonomous and truly flexible pow


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FoF-05-2014 | Award Amount: 5.10M | Year: 2015

The undergoing transformation in our current socio-economic models, led by the advent of emerging technologies, has changed the relation of customers to products and services. Customers play no longer a passive role in the product and service development process as they express their product and service experiences and opinions through several channels such as discussion forums, blogs, chat, idea voting, and more. In addition, sensor systems in combination with products incorporated in the Internet of Things (IoT), are becoming increasingly common. The potential endless amounts of available information offer a rich ground for value creation in the product-service innovation chain. In this context FALCON envisions to provide a framework to enable the realization of new products and value-adding services, resulting from user-experiences and product and related services usage; undertaken with the principles of sustainability and social responsibility. FALCON will create impact through the following objectives: First the project will address product-service information collection through collaborative intelligence and Product Embedded Information Devices. Second, it will enable new mechanisms for product-service knowledge representation, exploitation, openness and diffusion. Third, it will strengthen collaboration and new product-service development through new feedback and feed forward mechanisms in the product life-cycle. Fourth, FALCON will explore manufacturing intelligence to support innovative product-services design and finally FALCON will improve product-service lifecycle assessment approaches through the real-time collection of product-service usage information and related experiences. The project is driven by a consortium of highly recognized researchers (BIBA, EPFL, TU Delft ), experienced solution providers (UBITECH, Holonix, Softeco, i-Deal) and industrial companies (Arcelik, Philipps, Dena Cashmere, DATAPIXEL, Vinci Consulting).


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP.2011.4.0-2 | Award Amount: 14.75M | Year: 2012

The NeTTUN 54M project will enable groundbreaking change in the construction, management and maintenance of tunnels in pursuit of the goals of NMP.2011.4.0-2 via 9 focussed WPs addressing key scientific and technical challenges: (i) a multi-sensor ground prediction system for TBMs to enable effective look-ahead during boring; (ii) a robotic maintenance system that enables automation of inspection and exchange of drag bits and disc cutters; (iii) the design of cutter tools with increased lifetime; (iv) a system for modelling of global risks on tunnel projects in order to quantify and manage uncertainties; (v) systems for modelling and controlling the impact of tunnelling on surrounding structures; (vi) a Decision Support system for tunnel maintenance management. The improvements enabled by this work programme will enhance every aspect of the lifecycle of tunnelling: from design, to construction, and maintenance of Europes extensive tunnel legacy. Each of the 21 partners in the NeTTUN Consortium Industrial, Research and Development and SME has been invited to participate because of unique scientific expertise and tunnelling sector experience. Ecole Centrale de Lyon, a French top-level engineering school involved in international research, will be the NeTTUN project coordinator. NFM, the French Tunnel Boring Machine manufacturer, will manage the scientific and technical aspects of the project. Both these organisations will work as a team. NeTTUN project results will impact the tunnelling industry by enlarging business perspectives, with productivity increase; delivering underground operations with zero impact on surroundings; answering societal needs by improving safety; and strengthening competitiveness of European industry. The Consortium will demonstrate project results on the site of Metro Line C construction under Romes ancient monuments, as well as with OHL on the Guadalquivir, and Razel on the Frjus Tunnels. Dissemination, Exploitation and Gender Equality Committees will ensure the Consortiums activities and successful project results are promoted to the target audiences of the general public, the tunnelling industry and education and academic sectors.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2007-1.4-4 | Award Amount: 14.73M | Year: 2009

For many disabling or fatal diseases, there is pre-clinical or clinical evidence of the potential therapeutic efficacy of gene therapy and, yet, the limitations of current gene transfer technologies have prevented success or even caused serious adverse events leading to termination of trials. PERSIST will explore the use of highly innovative gene-modifying and delivery technologies and capitalize on recent discoveries in gene expression control to develop radical solutions to the problem of precisely controlling the fate and expression of exogenous genetic information in gene therapy with applications in these and other deadly diseases. Our proposal combines 20 of Europes outstanding experts from 8 countries in the field of genetic engineering for persisting gene expression. Partners have pioneered the use of Zinc Finger Nucleases, engineered recombinases and transposases for gene targeting, synthetic promoters, epigenetic switches and micro-RNA for regulating gene expression, developed state-of-the-art gene delivery platforms based on lentiviral, AAV and gutless adenoviral vectors, conducted front-line clinical trials, and productively collaborated in previous FP projects. PERSIST includes 16 work packages of which 6 focus on vector innovations (part A: emerging technologies), 6 on applications & evaluation (part B), 1 on process development and the remaining 2 on training/dissemination and project management including IPR issues. Targeting deadly diseases, such as inherited immunodeficiencies, storage disorders and haemophilias, PERSIST is in line with the Strategic Research Agenda (SRA) of the Innovative Medicines Initiative (IMI) and will result in: faster discovery and development of better medicines; more attractive professional environment for scientists; better European expertise and know-how to attract biomedical R&D investment in Europe; and a stronger competitive advantage for SMEs, spin-offs and start-ups to enhance Europes economy.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.3.1 | Award Amount: 17.80M | Year: 2013

To extend beyond existing limits in nanodevice fabrication, new and unconventional lithographic technologies are necessary to reach Single Nanometer Manufacturing (SNM) for novel Beyond CMOS devices. Two approaches are considered: scanning probe lithography (SPL) and focused electron beam induced processing (FEBIP). Our project tackles this challenge by employing SPL and FEBIP with novel small molecule resist materials. The goal is to work from slow direct-write methods to high speed step-and-repeat manufacturing by Nano Imprint Lithography (NIL), developing methods for precise generation, placement, metrology and integration of functional features at 3 - 5 nm by direct write and sub-10nm into a NIL-template. The project will first produce a SPL-tool prototype and will then develop and demonstrate an integrated process flow to establish proof-of-concept Beyond CMOS devices employing developments in industrial manufacturing processes (NIL, plasma etching) and new materials (Graphene, MoS2). By the end of the project: (a) SNM technology will be used to demonstrate novel room temperature single electron and quantum effect devices; (b) a SNM technology platform will be demonstrated, showing an integrated process flow, based on SPL prototype tools, electron beam induced processing, and finally pattern transfer at industrial partner sites. An interdisciplinary team (7 Industry and 8 Research/University partners) from experienced scientists will be established to cover specific fields of expertise: chemical synthesis, scanning probe lithography, FEBIP-Litho, sub-3nm design and device fabrication, single nanometer etching, and Step-and-Repeat NIL- and novel alignment system design. The project coordinator is a University with great experience in nanostructuring and European project management where the executive board includes European industry leaders such as IBM, IMEC, EVG, and Oxford Instruments.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: GC-ICT-2011.6.8 | Award Amount: 5.75M | Year: 2012

Smart Power ICs are extensively used in automotive embedded systems due to their unique capabilities to merge low power and high voltage devices on the same chip, at competitive cost. In such devices, induced electrical coupling noise due to switching of the power stages, when integrating such high voltage (HV) devices with low voltage (LV) functions, is a big issue. During switching, parasitic voltages and currents, consisting of electrons and holes, lead to a local shift of the substrate potential that can reach hundreds of millivolts. This electrical coupling noise can severely disturb low voltage circuits. Such parasitic signals are known to represent the major cause of failure and costly circuit redesign in power integrated circuits. Furthermore, parasitic carrier injections are considerably increased under high temperature operation such as those encountered in automotive applications where this problem is even more severe since these dedicated ICs need to be highly reliable and stable with time. Most solutions are layout dependent and are thus difficult to optimize using available electrical simulator software. The lack for a model strategy that would enable to simulate accurately the injection of minority carriers in the substrate as part of the HV model, as well as its propagation in the substrate, is one of the main reasons for this critical situation. This lack for a design methodology prohibits an efficient design strategy and fails at giving clear predictions of perturbations in high voltage integrated circuits. This picture motivates this project proposal where all these aspects are addressed to create a link between circuit design, modeling and implementation in innovative computer aided design tools. This concerns smart power ICs dedicated to automotive applications requiring co-integration of high voltage power stages with low voltage analog/digital blocks on the same chip, still being reliable\nwhen operating at high temperature.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: KBBE.2013.3.6-02 | Award Amount: 9.41M | Year: 2013

Cellular signaling systems are crucially important for a broad range of critical health and disease areas and high value industrial applications. Signaling systems are the target for more than half of the medicines marketed by the pharmaceutical industry, and form the main R&D area for the nutrition, flavour and fragrance industries. SynSignal is a multidisciplinary high-tech consortium working in synthetic biologys area of greatest untapped potential, delivering a synthetic biology toolbox and finished products custom designed for major present and future industrial applications of cellular signaling. Based on the leading expertise and innovative drive of the partners, SynSignal will address this urgent and imposing bottleneck, by providing new and sophisticated synthetic biology tools and technologies to overcome the challenges currently facing signaling-based product development. Putting in place the technological innovations, toolboxes, and application-focused materials created during SynSignal will have a dramatic impact on the accessibility of drug discovery technologies, particularly for cancer and diabetes, and for enabling technologies to create the next generation of flavours, fragrances, and nutritional ingredients. Our innovations will provide immediate benefits to the health and well-being of Europes citizens and to the competitiveness of key European industries alike, and catalyze their transition towards sustainable production principles. In addition, all partners in SynSignal themselves will draw great benefit from the activities proposed. Private sector partners will considerably enhance their discovery and technology platforms, thereby increasing their efficiency, output and valuation. Academic partners in SynSignal will decisively advance fundamental life science research in their laboratories and in the larger scientific community by creating enabling tools to tackle biological questions of unprecedented complexity in cellular signaling.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.9.9 | Award Amount: 11.78M | Year: 2013

The overarching goal of our project is to develop systems based on direct and deterministic interactions between individual quantum entities, which by involving large-scale entanglement can outperform classical systems in a series of relevant applications.\nWe plan to achieve that by improving technologies from atomic, molecular and optical physics as well as from solid-state physics, and by developing new ones, including combinations across those different domains. We will explore a wide range of experimental platforms as enabling technologies: from cold collisions or Rydberg blockade in neutral atoms to electrostatic or spin interactions in charged systems like trapped ions and quantum dots; from photon-phonon interactions in nano-mechanics to photon-photon interactions in cavity quantum electrodynamics and to spin-photon interactions in diamond color centers.\nWe will work on two deeply interconnected lines to build experimentally working implementations of quantum simulators and of quantum interfaces. This will enable us to conceive and realize applications exploiting those devices for simulating important problems in other fields of physics, as well as for carrying out protocols outperforming classical communication and measurement systems.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2008-1.1.1 | Award Amount: 12.34M | Year: 2009

The Integrated Infrastructure Initiative for Neutron Scattering and Muon Spectroscopy (NMI3) aims at the pan-European coordination of neutron scattering and muon spectroscopy, maintaining these research infrastructures as an integral part of the European Research Area. NMI3 comprehensively includes all major facilities in the field, opening the way for a more concerted, and thus more efficient, use of the existing infrastructure. Co-ordination and networking within NMI3 will lead to a more strategic approach to future developments and thus reinforce European competitiveness in this area. NMI3 is a consortium of 22 partners from 13 countries, including 10 research infrastructures. The objective of integration will be achieved by using several tools: * Transnational ACCESS will be provided by 10 partners offering more than 4000 days of beam time. This will give European users access to all of the relevant European research infrastructures and hence the possibility to use the best adapted infrastructure for their research. * Joint Research Activities focusing on six specific R&D areas will develop techniques and methods for next generation instrumentation. They involve basically all those European facilities and academic institutions with major parts of the relevant know-how. * Dissemination and training actions will help to enhance and to structure future generations of users. * Networking and common management will help strategic decision-making from a truly European perspective.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.2.2.1-3 | Award Amount: 5.84M | Year: 2014

Conduct Disorder (CD) is the key paediatric disorder characterized by severe aggression. It is heterogeneous, and our understanding of the neurobiology to subtype aggression is limited. MATRICS is a multidisciplinary consortium of academic partners and SMEs that focuses on the subtyping of aggression both within CD and of the broader cross-disorder trait of aggression. MATRICS will test the hypothesis that reactive and instrumental aggression result from aberrant autonomic reactivity coupled to the differential impairment of three basic neural functions: 1) regulation of control mechanisms of aggression, 2) emotional value rating of others, and 3) empathy and moral decision making. MATRICS will employ the same psychological tasks assessing 1), 2) and 3) in animal aggression models and human CD samples concurrent with the assessment of neural, neurochemical, (epi)-genetic and autonomic nervous system markers. These data will be integrated with matching expression profiling from neurons derived from CD IPSCs. MATRICS also examines how environmental risks, whether or not they interact with genetic factors, are translated in epigenetic and neural changes. MATRICS will data-mine existing large integrated imaging-genetics cohorts (NeuroIMAGE; IMAGEN) and prospective cohorts (TRAILS; ALSPAC) with follow-up into adulthood and the (epi)genetic profiling of the PERS CD cohort, and collect a large new CD cohort and controls for collection of MRI, (epi)-genetic, biochemical and environmental measures. Bayesian machine learning tools will integrate multi-source and multi-level data, and generate predictive algorithms of persistent aggression into adulthood. MATRICS will identify new potentially druggable targets, develop novel animal models and conduct pilot medication and neuro/biofeedback studies in high-risk and CD patients. MATRICS builds on existing fruitful EU collaborations which maximises feasibility and successful output.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.93M | Year: 2014

TEMPO addresses the needs of European companies and society for embedded control technology, through training on cutting edge research in the rapidly emerging inter-disciplinary field of embedded predictive control and optimization. The key objectives are: - to expand the scientific and technical knowledge platform for Embedded Predictive Control and Optimization in Europe; - to exploit this platform to train a new generation of world class researchers and professionals that are highly attractive for employment by the European industry; - to establish structures for long-term cooperation and strengthen the relations among the leading universities and industry in Europe in this field, to continuously develop the research training platform that European industry relies on. To achieve the objectives listed above, the main tasks of TEMPO are: - to attract and train 14 Early Stage Researchers in embedded MPC and optimization via a joint academic/industrial program of cutting edge training-by-research, high quality supervision, complementary and transferable skills training, inter-network secondments, and workshops; - to create a closely connected group of leading European scientists that are highly sought after by European industry, and ready to push forward embedded MPC and optimization into new innovative products, industries and services; - to build a solid foundation for long-term European excellence in this field by disseminating the research and training outcomes and best practice of TEMPO into the doctoral schools of the partners, and by fostering long-term partnerships and collaboration mechanisms that will outlast the ITN; - to disseminate the know-how of the participants to each other and to external groups via networking activities, inter-sectoral exposure, secondments, workshops, demonstrations, sharing of learning material, public engagement and outreach activities, and open source public domain software outcomes.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 2.81M | Year: 2014

The aim of this Initial Training Network is to train a new generation of interdisciplinary researchers in sparse representations and compressed sensing, contributing to Europes leading role in scientific innovation. By bringing together leading academic and industry groups with expertise in sparse representations, compressed sensing, machine learning and optimization, and with an interest in applications such as hyperspectral imaging, audio signal processing and video analytics, this project will create an interdisciplinary, trans-national and inter-sectorial training network to enhance mobility and training of researchers in this area.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.70M | Year: 2013

Semiconductor industry rapidly approaches the performance limits of silicon-based CMOS technology. This proposal aims to pave the way to electronic circuits based on two-dimensional transition metal dichalcogenides (TMDs), newly emerging semiconducting analogues of graphene. TMDs can be rapidly exfoliated in the liquid phase into single layers starting from powders and provide solutions of 2D materials that can be coated over large areas. The recently achieved transistors based on single-layer MoS2 indicate a mobility comparable or even higher than silicon thin films or graphene nanoribbons, but with much lower leakage currents. In a joint effort of wet and gas phase chemistry and deposition techniques, nanoanalytics, electronic and optical spectroscopy, electronic device fabrication and characterisation, and theoretical modeling we aim to control the production and deposition of TMD nanolayers and nanoribbons, understand and control the interplay between morphology, defects and electrical properties, understand electrical transport through semiconducting nanolayers, and fabricate nanodevices. By combining the ease of processing commonly associated with organic electronics with superior electrical properties, we will demonstrate a new type of low-power, low-cost field effect transistor based on a single TMD layer and/or nanoribbon. The proposed outcomes of immediate interest for the three full partners from industry are (i) process flows and practices that enable fabrication of nanoscale transistor arrays for application in flexible electronics via spraying and/or ink-jet printing, (ii) software packages for modeling the electronic behavior of TMD nanolayers, and (iii) a prototype reactor for their large-scale growth and deposition. The training and dissemination activities will be complemented by an associated partner who will produce educational videos together with the young researchers of the consortium.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP.2013.1.3-3 | Award Amount: 8.92M | Year: 2014

Rapidly developing markets such as green construction, energy harvesting and storage, advanced materials for aerospace, electronics, medical implants and environmental remediation are potential key application targets for nanomaterials. There, nanotechnology has the potential to make qualitative improvements or indeed even to enable the technology. Impacts range from increased efficiency of energy harvesting or storage batteries, to radical improvements in mechanical properties for construction materials. In addition, concerns of these markets such as scarcity of materials, cost, security of supply, and negative environmental impact of older products could also be addressed by new nano-enabled materials (e.g. lighter aircraft use less fuel). FutureNanoNeeds will develop a novel framework to enable naming, classification, hazard and environmental impact assessment of the next generation nanomaterials prior to their widespread industrial use. It will uniquely achieve this by integrating concepts and approaches from several well established contiguous domains, such as phylontology and crystallography to develop a robust, versatile and adaptable naming approach, coupled with a full assessment of all known biological protective responses as the basis for a decision tree for screening potential impacts of nanomaterials at all stages of their lifecycle. Together, these tools will form the basis of a value chain regulatory process which allows a each nanomaterial to be assessed for different applications on the basis of available data and the specific exposure and life cycle concerns for that application. Exemplar materials from emerging nano-industry sectors, such as energy, construction and agriculture will be evaluated via this process as demonstrators. The FutureNanoNeeds consortium is uniquely placed to achieve this, on the basis of expertise, positioning, open mindedness and a belief that new approaches are required.


Grant
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: Health | Award Amount: 2.25M | Year: 2015

The European Consortium for Communicating Stem Cell Research (EuroStemCell) unites 33 partner institutions, that collectively represent >400 stem cell research groupings across Europe. Our common goal is to provide trusted high quality information on stem cells accessible to citizens and stakeholders across Europe, through support and further development of the multi-lingual European Stem Cell Information Portal www.eurostemcell.org. To achieve our aims, EuroStemCell will adopt the highly structured system for coordinated information management established by the FP7 Coordination and Support Action (CSA) also called EuroStemCell. From this, we will implement an ambitious programme of online and direct stakeholder engagement with stem cell research and regenerative medicine, aimed at European citizens at all educational levels. This will include provision of resources tailored specifically for decision-making on stem cell-related questions and an extensive programme of dissemination and capacity building in science communications and public engagement. The proposed work centres on an information hub team, which will link to all project partners and to stakeholders in the stem cell and regenerative medicine arenas and wider society, working with these groupings to implement the project. All outputs will be delivered in 6 European languages, to ensure broad accessibility, and will be rigorously evaluated against measurable objectives throughout the project duration. The proposed consortium comprises leading stem cell labs across Europe, including new member states, together with experts in ethical and societal concerns and evaluating clinical outcomes. It thus provides unparalleled European expertise across the fields of stem cell biology and regenerative medicine and is uniquely placed to maintain and further develop www.eurostemcell.org as a world-leading stem cell information resource, thus meeting the challenge outlined in Topic HOA-6-2014.


Urbani M.,Autonomous University of Madrid | Urbani M.,IMDEA Madrid Institute for Advanced Studies | Gratzel M.,Ecole Polytechnique Federale de Lausanne | Nazeeruddin M.K.,Ecole Polytechnique Federale de Lausanne | And 2 more authors.
Chemical Reviews | Year: 2014

Among the several approaches for harnessing solar energy and converting it into electricity, dye-sensitized solar cells (DSSC) represent one of the most promising methods for future large-scale power production from renewable energy sources. In these cells, the sensitizer is one of the key components harvesting solar radiation and converting it into electric current. The electrochemical, photophysical, and ground and excited state properties of the sensitizer play an important role for charge transfer dynamics at the semiconductor interface. Moreover, for long-term stability and practical applications, electrolytes based on the iodine/triiodine couple also suffer from two other disadvantages: the corrosive effect toward the metal electrodes, and the partial absorption of the visible light by triiodine anions. These issues hence constitute one of the reasons that have encouraged the development of alternative iodine-free redox couples in liquid electrolytes for DSSCs.


Falkowski A.,University Paris - Sud | Riva F.,Ecole Polytechnique Federale de Lausanne
Journal of High Energy Physics | Year: 2015

Abstract: We discuss electroweak precision constraints on dimension-6 operators in the effective theory beyond the standard model. We identify the combinations of these operators that are constrained by the pole observables (the W and Z masses and on-shell decays) and by the W boson pair production. To this end, we define a set of effective couplings of W and Z bosons to fermions and to itself, which capture the effects of new physics corrections. This formalism clarifies which operators are constrained by which observable, independently of the adopted basis of operators. We obtain numerical constraints on the coefficients of dimension-6 operator in a form that can be easily adapted to any particular basis of operators, or any particular model with new heavy particles. © 2015, The Author(s).


Hanahan D.,Ecole Polytechnique Federale de Lausanne | Hanahan D.,University of California at San Francisco | Weinberg R.A.,Whitehead Institute For Biomedical Research
Cell | Year: 2011

The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. Underlying these hallmarks are genome instability, which generates the genetic diversity that expedites their acquisition, and inflammation, which fosters multiple hallmark functions. Conceptual progress in the last decade has added two emerging hallmarks of potential generality to this list - reprogramming of energy metabolism and evading immune destruction. In addition to cancer cells, tumors exhibit another dimension of complexity: they contain a repertoire of recruited, ostensibly normal cells that contribute to the acquisition of hallmark traits by creating the "tumor microenvironment." Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer. © 2011 Elsevier Inc.


Bonini N.,King's College London | Garg J.,Massachusetts Institute of Technology | Marzari N.,Ecole Polytechnique Federale de Lausanne
Nano Letters | Year: 2012

We use first-principles methods based on density functional perturbation theory to characterize the lifetimes of the acoustic phonon modes and their consequences on the thermal transport properties of graphene. We show that using a standard perturbative approach, the transverse and longitudinal acoustic phonons in free-standing graphene display finite lifetimes in the long-wavelength limit, making them ill-defined as elementary excitations in samples of dimensions larger than ∼1 μm. This behavior is entirely due to the presence of the quadratic dispersions for the out-of-plane phonon (ZA) flexural modes that appear in free-standing low-dimensional systems. Mechanical strain lifts this anomaly, and all phonons remain well-defined at any wavelength. Thermal transport is dominated by ZA modes, and the thermal conductivity is predicted to diverge with system size for any amount of strain. These findings highlight strain and sample size as key parameters in characterizing or engineering heat transport in graphene. © 2012 American Chemical Society.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 5.72M | Year: 2012

Over the past year a new research field has emerged: cavity Optomechanics which brings the quantum regime of mechanical oscillators in reach and may allow to explore new fundamental measurements concepts, may lead to novel transducers and test quantum mechanics on a macroscopic scale. In this research field, which utilizes mechanical oscillators coupled to laser fields, Europe has played a pioneering role. The distinguishing feature of this ITN training network is that the partners are active in this research field (cavity Optomechanics), which facilitates and indeed leverages the collaborative effort and will make this ITN highly effective. Cavity optomechanics is moreover a field which is highly faceted in terms of the required and offered training skills that spans quantum optics, nanofabrication, finite element simulation and cryogenic expertise and techniques as well as quantum theory. To effectively train new students it is therefore pivotal to train students in all relevant skills and techniques and theory. The realization that a single group is much less efficient than a consortium is the major driving force behind the ITN network. It will provide a streamlined, high quality-training program that offers a remarkably diverse set of skills. This training program will be of immediate benefit to the partners that will thereby obtain a superior training of their PhD students, which therefore provides a build-in mechanism that will ensure the effective realization of the proposed ITN training program and it success. The existence of such a training program, which will be opened to international groups, will contribute to the visibility of the EU cavity optomechanics community in an international setting.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2011-IRSES | Award Amount: 374.30K | Year: 2012

THz band remains the last region of electromagnetic spectrum which does not have wide application in modern technology due to lack of solid state source of THz radiation: compact, reliable and scalable. Fundamental objection preventing creation of such source is small rate of spontaneous emission of the THz photons: according to the Fermi Golden rule this rate is about tens of inverse milliseconds, while lifetime of the charge carrier in the solid typically lies in picoseconds range due to the efficient interaction with phonons. The rate of spontaneous emission of THz photons can be increased by application Purcell effect, but even in this case cryogenic temperature is required for the operation of solid state THz devices. Further increase of emission rate can be achieved via bosonic stimulation, when THz radiative transition occurs into the quantum state, in which condensate of bosons is formed. Such situation can be realized for transition between upper and lower polariton state in semiconductor microcavity in polariton lasing regime, in the case when parity excitonic parts of upper and lower polariton states is made different. In this case emission of THz radiation characterized by substantial quantum efficiency can be achieved even at room temperature. Further, pronounced non-linear properties of polaritonic systems lead to various non-linear effects in coupled system of polaritons and THz photons, what open the way for development of novel class of solid state devices, like compact THz short pulse generators, THz switch, and THz detectors.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.9.13 | Award Amount: 16.30M | Year: 2011

DEEP proposes to develop a novel, Exascale-enabling supercomputing platform along with the optimisation of a set of grand-challenge codes simulating applications highly relevant for Europes science, industry and society. The DEEP System will realise a Cluster Booster Architecture that can cope with the limitations purported by Amdahls Law. It will serve as proof-of-concept for a next-generation 100 Petaflop/s PRACE production system, striving for independent provision of HPC technology, in particular general purpose Exascale performance supercomputers in Europe. The DEEP concept is based on the duality of an advanced multi-core Cluster system with InfiniBand interconnect complemented by a Booster of Intel many-core MIC processors connected through a Terabit EXTOLL network. A novel open source system software stack along with Cluster Booster adapted programming models, libraries, and performance tools will achieve high productivity and will enable unprecedented scalability on millions of cores. The DEEP hardware and software technology is developed in Europe while the new many-core processor is an essential component of international cooperation. The DEEP concept has the potential to improve the power efficiency of HPC systems by an order of magnitude. Its innovative cooling concept will allow approaching power usage effectiveness values very close to 1. Representative HPC codes from Health and Biology, Climatology, Seismic Imaging, Industrial Design, Space Weather, and Superconductivity will be optimised on DEEP and the extrapolation to millions of cores will be demonstrated. The pan-European DEEP consortium has proven competence to meet the projects massive technological and scientific challenges. DEEP aims at disseminating knowledge amongst major European industrial stakeholders and the entire PRACE consortium through its technical advisory group STRATOS and will contribute to the vision of the PROSPECT association for a European HPC technology platform.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.3.8 | Award Amount: 2.50M | Year: 2010

Cancer causes an increased expression of Heat Shock Protein HSP70 in the peripheral blood, at the surface of, and in cancer cells as a result of different sources of stress, including anti-cancer treatments. It was recently demonstrated that tumorigenicity, metastatic potential and resistance to chemotherapy correlated with an increased of expressed HSP70 in cancer cells. On the contrary, HSP70 depletion using combinatorial small peptides called peptide aptamers sensitizes cancer cells to die and could help in cancer therapy.\nThe core goal of this project is to combine the latest advances of nano-optics, optical manipulation and microfluidics with the ultimate understanding of HSP70 to develop a novel integrated and ultra sensitive sensing platform for early cancer detection. An early detection would benefit to traditional but also new cancer therapies based on peptide aptamers which could be delivered sooner and at lower doses. The planned sensing device, based on surface plasmon resonances supported by micro and nano-structures, will operate in a microfluidic circuit to minimize the volumes of analytes and increase reproducibility. Enhanced and confined plasmonic fields will be engineered at the nanoscale to implement two main sensing schemes: (i) ultra sensitive tracking of HSP70 proteins circulating in the peripheral blood based on resonance shift induced by specific protein/receptor binding, (ii) individual cell optical trapping (exploiting latest generation of plasmonics tweezers) combined with scattering imaging and Surface Enhanced Raman Scattering to monitor the concentration of HSP70 proteins at the membrane surface and achieve systematic cancer cell screening. These transduction mechanisms and plasmonic tweezers will be integrated into a compact platform to operate in a biological laboratory environment. Such a portable device should be seen as a precursor of a future device enabling point of care diagnostics in a medical environment and leading to individualized therapy.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA | Phase: ICT-2011.9.5 | Award Amount: 1.63M | Year: 2011

The human brain can be seen as an immensely powerful, energy efficient, self-learning, self-repairing computer. If we could understand and mimic the way the brain works, we could revolutionize information technology, medicine and society. But to do so we have to bring together everything we know and everything we can learn about the inner workings of the brains molecules, cells and circuits. The goal of the Human Brain Project (HBP) is to do this by integrating our knowledge in massive databases and in computer models of the brain. This will require breakthroughs in mathematics and software engineering and an international supercomputing facility more powerful than any before. This is all possible. Experimental and clinical data is accumulating exponentially. Computers powerful enough to meet the projects initial requirements are already here. An international team led by Europes best neuroscientists, doctors, physicists, mathematicians, computer engineers and ethicists have assembled to begin the mission. As technology progresses and the project discovers new principles of brain design it will build ever more realistic models to probe ever deeper principles. The benefits for society will be huge, even before the HBP achieves its final goals. Models of the brain will revolutionize information technology, allowing us to design computers, robots, sensors, prosthetics and other devices far more powerful, more intelligent and more energy efficient than today. They will help us understand the root causes of brain diseases, and to diagnose them early, when they can still be treated. They will reduce reliance on animal testing and make it easier to develop new cures for brain disease. They will help us understand how the brain ages, and how to slow these changes and nurture a healthy brain for our children. In summary, the HBP is poised to produce dramatic advances in technology, a new understanding of the way the brain works and a new ability to cure its diseases.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA | Phase: ICT-2009.3.1 | Award Amount: 1.36M | Year: 2010

This support action, EURO-DOTS, is aimed primarily at improving the offering and the quality of training proposed to European PhD students. It helps fulfilling the requirements for ECTS credits imposed to PhD students by major European universities for obtaining the Doctoral (PhD) degree in Engineering.\n\nA coherent set of advanced courses in micro/nano-electronics, explicitly accredited by major European universities in the framework of their Doctoral Program, will be made easily accessible to European PhD students, offering the opportunity to collect ECTS credits throughout Europe.\n\nThe global objective of EURO-DOTS is to create a delocalized (virtual) platform to serve the Doctoral Schools in Europe in micro/nano-electronics.\n\nThe courses will respect specific organization criteria (short, intensive one-week course modules with optional exam) that will make them very flexible, accessible and attractive as well for high-level continuous education of engineers from industry.\n\nScholarships will be made available to selected PhD students for boosting the start-up of the project, while other sources of scholarships and/or industrial support will be explored for the long-term continuation of the project.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.8.0 | Award Amount: 2.53M | Year: 2010

Algorithms in signal and image processing have reached an impressive level of sophistication and computing power still increases at an exponential rate. However, high-tech applications have an ever-increasing demand for even more efficient algorithms, even more powerful computers and new concepts for advancing applications.\nStarting from a recently discovered gap in the theory of uncertainty principles, this project aims at developing a framework for constructing problem adapted, ultra-efficient algorithms concerning (de-)coding and analyzing/synthesizing signals/images. We expect, that this will allow us to tackle complex applications in life sciences and ultra precise audio signal processing which presently cannot be solved appropriately with existing algorithms on existing computers.\nThe key for developing these algorithms is a representation of signals and images by function systems, which satisfy the following requirements:\n1.\tOptimal localization,\n2.\tEfficient discretization.\nThe theoretical foundation of this approach is based on the definition of suitable localization measures in generalized phase spaces and the construction of minimizing waveforms. These waveforms are then the basic building blocks in discretization schemes.\nWe expect that this approach allows us to shift the limits of the efficiency vs. precision paradigm considerably. The efficiency of an abstract algorithm has to be evaluated in connection with the computer hardware (parallelization, data exchange, storage) used. Accordingly, our proof of principle includes implementations of baseline algorithms as well as of advanced GPU implementations.\nAs final proof of principle we apply these methods for two challenging applications in audio signal design and life sciences (proteomics). The evaluation will be done by our industrial consortium partners together with our advisory board consisting of one SME, one world market leader and two internationally highly recognized scientific experts.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2013-IRSES | Award Amount: 898.80K | Year: 2014

GREAT will focus on the geotechnical and geological response to the global challenge of climate change. It aims to promote sharing of mitigation and adaptation strategies on a world-wide scale by involving 5 major European institutions and 6 ICPC institutions from three BRICS countries (China, India, and Brazil). The goal is to facilitate access of Europe to research and innovation carried out in emerging economies and, at the same time, to promote Europe as a pole of attraction for research and innovation on a global scale. GREAT will address four major research areas: i) climate resilient geo-infrastructure; ii) carbon-efficient geo-infrastructure; iii) carbon capture and energy extraction using conventional geo-infrastructure; and iv) geological carbon storage and deep geothermal extraction. GREAT will stimulate long-term collaboration between European and BRICS institutions via the secondment of ~50 PhD/Post-doc researchers and ~50 senior members of staff. The seconded PhD/Post-doc researchers will develop mini-projects jointly supervised by senior staff at home and host institution to ensure an effective scientific exchange. These mini-projects are integrated into the overall PhD/Post-doc activities and are anticipated to lead to a substantial number of joint publications. On the other hand, secondment of senior staff members will allow preparing joint proposals to be submitted during the 4-year period of the project. The project will fully exploit the opportunities for collaborative research jointly funded by European and ICPC councils to foster long-term cooperation between European and ICPC institutions. The project will also put in place mechanisms for sustainable networking (i.e. beyond the duration of the project) based on six-monthly virtual workshops, a Facebook portal to facilitate day-to-day interaction in particular between ESRs, and a dedicated Youtube channel for making lectures delivered by senior staff available across the continents.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2013.5.3 | Award Amount: 2.58M | Year: 2014

For visually impaired people it is difficult to digitally get graphical contents increasingly conveyed through sight. The sense of touch can potentially bridge the gap, as it is crucial - in absence of vision - for understanding abstract concepts and acquiring information about the surroundings. Examples are learning at school and developing mental maps in orientation and mobility daily tasks.\nHowever, available touch screens have limited or no tactile feedback at all. The potential and the market of tactile displays is largely unexploited, although there is a clear demand from users: these devices need to become more versatile, cheaper, portable and socially acceptable.\nThe objective the project is to make graphical contents accessible through touch by building and field-testing a Personal Assistive Device for BLIND and visually impaired people (BLINDPAD).\nBLINDPAD will put veridical touch-based information into the hands of users, exploiting and enhancing their residual sensory abilities.\nThe BLINDPAD will exploit the most effective between two new technologies of different risk level: MEMS nanocomposite membranes actuated by magnetic micro-coils and dry ionic electroactive actuators (bucky gels) operated at low voltages. The technologies will be developed, compared in terms of actuation force, resolution, safety, power consumption and reliability.\nBy adopting a user-centered approach within an accessible and usable ecosystem, we will assess, with serious games, how the BLINDPAD can help visually impaired people in two paramount use cases: touch-based learning of symbolic content at school age; orientation and mobility skills indoor and outdoor.\nBLINDPAD will be a personal, portable and cheap solution to improve knowledge and independence, thus increasing chances of employment, of social inclusion and, ultimately, of a better quality of life.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP.2013.1.4-2 | Award Amount: 12.85M | Year: 2013

The thermal properties of nanostructured materials are of fundamental importance to modern technology, but at present reproducible metrological definitions, tools and methods do not exist. This is because the mechanisms of heat transport at the nanoscale are entirely different to those at the macro scale. The project will place nanothermal metrology on a solid basis by an integrated physics-based experimental and modelling effort to: Define a common terminology for nanothermal measurement Realise standard materials and devices for measurement and calibration of nanothermal measurements Develop new instruments and methods for traceable nanothermal measurement Develop calibrated and validated thermal models covering the range from atomic to macro-scale Apply these tools to selected representative industrial problems Assess the tools for suitability for adoption as potential standards of measurement including their traceability and reproducibility The objectives will be achieved by a team comprising physicists, materials scientists, modellers, instrumentalists, microscopists, industrial partners (including SMEs and OEMs) and National Measurement Institutes. The outputs of QUANTIHEAT will be embodied in highly characterised reference samples, calibration systems, measurement tools, numerical modelling tools, reference measurements and documented procedures. The availability of calibrated numerical modelling tools will facilitate the rapid digital thermal design of new nanosystems without the need for extensive prototyping. Their validation against experiment over all length scales will provide a solid basis for the deployment of new nanostructured materials, devices and structures having optimised performance without the need for excessively conservative design. Standardization is a key driver of industrial and scientific progress: QUANTIHEAT is expected to constitute a de-facto standard for a key area of physical measurement at the nanoscale worldwide.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP.2010.2.3-1 | Award Amount: 14.80M | Year: 2012

The development of functional materials for tissue regeneration is today mostly based on perceived and limited design criteria often using a single point approach with lengthy animal trials. The outcome after in-vitro and in-vivo evaluation is often disappointing resulting in a tedious iteration process. The main objective of this project is to achieve radical innovations in state-of-the-art biomaterials and to design highly performing bioinspired materials learning from natural processes. By this outcome driven project comprising first class academic and industrial participants the project will create scientific and technical excellence and through links with these SMEs will strengthen the technological capacity and their ability to operate competitively on an international market. BIODESIGN will (i) perform a careful retrospective-analysis of previous outcomes from clinical studies performed with humans through animal modelling in a reverse engineering approach applied to an in-vitro to the molecular design level, (ii) develop new strategies for a more rational design of ECM mimetic materials serving both as gels and load carrying scaffolds, (iii) link novel designs to adequate and more predictive in-vitro methods allowing significant reduction in development time and use of animals and (iv) evaluate these concepts for musculoskeletal and cardiac regeneration. By the development of safe, ethically and regulatory acceptable, and clinically applicable materials this project will promote harmonization while at the same time creating awareness in society of the benefits of these innovations as one of the key points is to improve health and quality of life of the patients. BIODESIGN will stimulate technological innovation, utilization of research results, transfer of knowledge and technologies and creation of technology based business in Europe. It will also support the development of world-class human resources, making Europe a more attractive to top researchers.


Grant
Agency: Cordis | Branch: FP7 | Program: JTI-CP-FCH | Phase: SP1-JTI-FCH.2009.3.3 | Award Amount: 5.65M | Year: 2011

Long-term stable operation of Solid Oxide Fuel Cells (SOFC) is a basic requirement for introducing this technology to the stationary power market. Degradation phenomena limiting the lifetime can be divided into continuous (baseline) and incidental (transient) effects. This project is concerned with understanding the details of the major SOFC continuous degradation effects and developing models that will predict single degradation phenomena and their combined effect on SOFC cells and single repeating units. The outcome of the project will be an in-depth understanding of the degradation phenomena as a function of the basic physico-chemical processes involved, including their dependency on operational parameters. Up to now research has rarely succeeded in linking the basic changes in materials properties to the decrease in electro-chemical performance at the level of multi-layer systems and SOFC cells, and even up to single repeating units.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY.2012.10.2.1 | Award Amount: 3.55M | Year: 2013

Dye-sensitized solar cell (DSSC) is the leading technology of third-generation solution-processed solar cells with reported efficiencies in excess of 10%. However despite the huge efforts in the last two decades saturation effects are observed in their performance. Efforts so far have been concentrated towards engineering and fine-tuning of the dyes, the electrolytes and the interface of the dye to the electron acceptor, employing titania as the electron acceptor. DSSCs rely, then, on dyes for efficient light harvesting which in turn entails high fabrication costs associated to the Ru-based dyes as well as the use of 10 um thick devices. In addition, optimized titania requires high-temperature processing raising concerns for its potential for low-cost, flexible-platform fabrication. In this project we propose a disruptive approach; to replace titania with a novel electron accepting nanoporous semiconductor with a bandgap suitable for optimized solar harnessing and a very high absorption coefficient to allow total light absorption within 2 um across its absorption spectrum. In addition the deposition of the nanostructured platform will employ processing below 200oC, compatible with plastic, flexible substrates and cost-effective roll-to-roll manufacturing. We will focus on non-toxic high-abundance nanomaterials in order to enable successful deployment of DSSCs with targeted efficiencies in excess of 15% and 10% for SS-DSSCs, thanks to efficient solar harnessing offered by the novel nanocrystal electron acceptor. To tackle this multidisciplinary challenge we have assembled a group of experts in the respective fields: development of nanocrystal solar cells, DSSC technology and physics, atomic layer and surface characterisation and a technology leader (industrial partner) in the manufacturing and development of third generation, thin film, photovoltaic cells and modules (DSSCs).


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: INFRADEV-1-2014 | Award Amount: 3.99M | Year: 2015

The award of the 2013 Nobel Prize for Physics acknowledged the leading role of Europe in particle physics, which has a global community of over 10,000 scientists. To reinforce its pole position throughout the 21st century, Europe must be ready to propose an ambitious post-LHC accelerator project by 2018/19. This is one of the main recommendations of the updated European Strategy for Particle Physics, adopted by the CERN Council in May 2013. The EuroCirCol conceptual design study is a direct response to this recommendation, initiating a study for a 100 TeV energy-frontier circular collider through a collaboration of institutes and universities worldwide. A new research infrastructure of such scale depends on the feasibility of key technologies pushed beyond current state of the art. Innovative designs for accelerator magnets to achieve high-quality fields up to 16 T and for a cryogenic beam vacuum system to cope with unprecedented synchrotron light power are required. The effects of colliding two 50 TeV beams must be mastered to meet the physics research requirements. Advanced energy efficiency, reliability and cost effectiveness are key factors to build and operate such an accelerator within realistic time scale and cost. This proposal is part of the Future Circular Collider study under European leadership, federating resources worldwide to assess the merits of different post-LHC accelerator scenarios. It forms the core of a globally coordinated strategy of converging activities, involving participants from the ERA and beyond. Organisations joining this study from Japan and the USA are expected to take part in a global implementation project and a suitable governance model will be drawn-up accordingly. The main outcome of EuroCirCol will be laying the foundation of subsequent infrastructure development actions that will strengthen the ERA as a focal point of global research cooperation and as a leader in frontier knowledge and technologies over the next decades.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: INFRASUPP-03-2016 | Award Amount: 3.00M | Year: 2017

The objective of the AENEAS project is to develop a concept and design for a distributed, federated European Science Data Centre (ESDC) to support the astronomical community in achieving the scientific goals of the Square Kilometre Array (SKA). The scientific potential of the SKA radio telescope is unprecedented and represents one of the highest priorities for the international scientific community. By the same token, the large scale, rate, and complexity of data the SKA will generate, present challenges in data management, computing, and networking that are similarly world-leading. SKA Regional Centres (SRC) like the ESDC will be a vital resource to enable the community to take advantage of the scientific potential of the SKA. Within the tiered SKA operational model, the SRCs will provide essential functionality which is not currently provisioned within the directly operated SKA facilities. AENEAS brings together all the European member states currently part of the SKA project as well as potential future EU SKA national partners, the SKA Organisation itself, and a larger group of international partners including the two host countries Australia and South Africa.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY.2009.7.3.1 | Award Amount: 4.64M | Year: 2010

The project aims at developing a unique device for electricity networks: A superconducting fault current limiter (SFCL) based on coated conductor YBCO tape (cc-tape) or 2nd Generation HTS tape. The general trend in Europe to a higher meshing of distribution networks and the rapid growing integration of renewable energy sources leads to an increase of the fault current level by every new installation. As substations ratings are coming to their limits network operators have to either decline additional installations to their grids or to upgrade if not rebuild complete substations. The SFCL provides a solution to deal with the increasing incidence and level of fault currents and will contribute to improving the performance, stability and efficiency of electricity grids. It can be applied as a new tool for grid operation and will enhance the flexibility for further grid planning. SFCL are considered to be the most attractive superconducting devices as they offer unparalleled features compared to conventional techniques such as automatic ultrafast and effective current limitation, no external trigger (fail safe), rapid self recovery and negligible impedance during operation. In contrast to conventional solutions resistive type SFCL are also suitable for higher voltage levels. So far developed SFCL prototypes based on BSCCO material are exhibiting significant AC-losses at higher currents which oppose their commercial introduction. Today, the availability of cc-tape in longer lengths at reasonable cost makes a commercial breakthrough of FCL possible with unique features such as compactness, short recovery-time, low AC-losses. Leading industrial and academic institutions from Europe have teamed up to design, build, and test the first full 3-phase cc-tape FCL worldwide. The device will be long term tested or even permanently installed in the medium voltage grid. The strong demand for this device is emphasized by the large number of electric utilities participating as partner


Grant
Agency: Cordis | Branch: FP7 | Program: CSA | Phase: ICT-2011.3.1 | Award Amount: 357.31K | Year: 2013

This proposal is submitted to support and ensure continuation of the EURO-DOTS initiative, that was launched as a Support Action in response to the FP7-Call 5 and that has successfully realized all the objectives resulting in the installation of a virtual platform to serve the Doctoral Schools in Europe in micro/nano-electronics. When the present 2-year EURO-DOTS project ends on 30 April 2012, it will not only have a fully operational platform and system in place, but it will also have realized the build-up of a course portfolio of nearly 50 PhD course titles, offered and organized by universities all over Europe. The major objective of EURO-DOTS was to improve the offering and quality of training provided to European PhD students in the micro/nano-electronics area based on the comprehensive analysis of university offering and industrial needs. One week intensive courses help them fulfilling the requirements for ECTS credits imposed by European universities for obtaining the PhD degree in Engineering. Essential in this endeavor are the scholarships that PhD students can apply for. This boosts the mobility of students but most importantly, it allows them to attend the right course at the right place, where the expertise on the treated subject is guaranteed.The major objective of this EURO-DOTS-2 follow-up project with a 2 year duration, is to ensure the continuation and continuity of the present successful action. This implies maintaining and improving operation of the platform, managing course portfolio and planning, stimulating development and submission of new courses in response to the needs of industry and researchers, managing and attributing of scholarships for PhD students and promotion of platform service and course offering. The present partnership, installed committees and organization will be basically retained. This continuity can be realized with a limited but indispensable budget of which half will be used for the scholarships.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2013.9.1 | Award Amount: 2.00M | Year: 2013

The project is aimed at developing a new ICT paradigm, which considers multiple heterogeneous devices that cooperate in multiple signal processing tasks. This is radically different from current ICT paradigms, in which stand-alone devices merely focus on individual tasks or multiple devices perform one joint task, e.g., in a wireless sensor network (WSN). Examples of the heterogeneous devices considered are tablets, smartphones, handheld cameras, active headsets and hearing aids. Each device is equipped with one or several sensors, e.g., microphones and cameras, as well as with computing and wireless communication facilities, and has its own signal processing task, e.g., a local signal enhancement task. The aim is to achieve superior performance in these tasks through cooperation amongst the devices, which then effectively act as nodes in a WSN type set-up, where each node contributes to the other nodes tasks.The main objective is to develop distributed, cooperative and adaptive signal processing algorithms for the acquisition, coding, processing, and in-network fusion of multimedia signals, in particular for the enhancement of audio and video signals. The algorithms are operated in a heterogeneous, ad-hoc and dynamic network, where each node has its own signal processing task as well as its own specific mode of operation. Furthermore, the algorithms should be scalable and require minimal communication bandwidth and power. As the network nodes may be selfish or opportunistic, general operating principles will be designed that provide incentives for cooperation. A general bottom-up design strategy will be adopted, rather than the usual top-down approach used in WSNs.The project will yield new theoretical frameworks for distributed detection, classification, estimation, coding, topology inference and cooperation strategies. In addition, two use cases are proposed in the context of audio and video enhancement, which will eventually serve as a proof of concept.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: GC.SST.2012.3-1. | Award Amount: 4.16M | Year: 2012

The objective of Modulushca is to achieve the first genuine contribution to the development of interconnected logistics at the European level, in close coordination with North American partners and the international Physical Internet Initiative. The goal of the project is to enable operating with developed iso-modular logistics units of sizes adequate for real modal and co-modal flows of fast-moving consumer goods (FMCG), providing a basis for an interconnected logistics system for 2030. Modulushca integrates five interrelated working fields: (1) developing a vision addressing the user needs for interconnected logistics in the FMCG domain, (2) the development of a set of exchangeable (ISO) modular logistics units providing a building block of smaller units, (3) establishing digital interconnectivity of the units, (4) development of an interconnected logistics operations platform leading to a significant reduction in costs and CO2 emissions that will be (5) demonstrated in two implementation pilots for interconnected solutions. Modulushca will establish a robust and replicable methodology to develop and evaluate solutions for interconnected logistics looking at other elements of the supply chain. Two implementation pilots will be executed integrating key Modulushca developments in significantly different supply chains: (1) a closed pilot evaluating the benefits on a inter-site supply chain addressing handling and transportation of iso-modular logistics units within one company, and (2) an open network pilot will evaluate the impact of iso-modular logistics units in cross docking and transshipment processes. Modulushca efforts will lead to the development of a road map towards a fully interconnected logistics system in 2030. The road map will address the changes and necessary steps to change the logistics system gradually, exploiting progresses in digital, physical and operational interconnectivity, building on current players, assets and infrastructures.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.3.1 | Award Amount: 6.11M | Year: 2010

STEEPER addresses the development of Beyond CMOS energy-efficient steep subthreshold slope transistors based on quantum mechanical band-to-band tunnelling (tunnel FETs), with the aim of reducing the operation voltage of nanoelectronic circuits to sub-0.5V, and their power consumption by one order of magnitude.\nSTEEPER focuses on two technology tracks, united by same device principle, shared performance boosters, and compatibility with silicon CMOS. These are (i) Ultra-Thin-Body Silicon-On-Insulator technology for planar, tri-gate and nanowire tunnel FETs featuring ultra-low standby power and smartly exploiting additive boosters: high-k dielectrics, SiGe source, strain, and improved electrostatic design, and (ii) a III-V nanowire platform on silicon, as unique material to control staggered or broken bandgap boosters and devise a high performance (high-Ion, steep slope) implementation of tunnel FETs. Platform (i) will enable a hybrid platform combining high performance (HP) CMOS and low standby power (LSTP), low voltage tunnel FETs, supporting energy efficient hybrid CMOS/Tunnel-FET digital and analog/RF circuit design. In line with ITRS, STEEPER will evaluate in platform (ii) the physical and practical limits of boosting the performance of tunnel FETs with III-V nanowires on silicon, and resulting advantages for HP digital circuits.\nThe development of the two technology platforms are interactive and collaborative in terms of performance boosters, and will benefit from simulation and modelling support by the academic partners, and from investigation of the potentially critical variability and sensitivity of tunnel FETs. Industrial benchmarking is proposed at device and circuit levels by the key involved industries, and the figures of merit of hybrid CMOS/tunnel FET digital and analog circuit design will be investigated.\nThe project targets energy efficient nanoelectronic technology for high volume markets covering digital, analog/RF and mixed mode applications.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FETPROACT-01-2016 | Award Amount: 7.98M | Year: 2017

A novel concept for a photo-electro-catalytic (PEC) cell able to directly convert water and CO2 into fuels and chemicals (CO2 reduction) and oxygen (water oxidation) using exclusively solar energy will be designed, built, validated, and optimized. The cell will be constructed from cheap multifunction photo-electrodes able to transform sun irradiation into an electrochemical potential difference (expected efficiency > 12%); ultra-thin layers and nanoparticles of metal or metal oxide catalysts for both half-cell reactions (expected efficiency > 90%); and stateof- the-art membrane technology for gas/liquid/products separation to match a theoretical target solar to fuels efficiency above 10%. All parts will be assembled to maximize performance in pH > 7 solution and moderate temperatures (50-80 C) as to take advantage of the high stability and favorable kinetics of constituent materials in these conditions. Achieving this goal we will improve the state-of-the-art of all components for the sake of cell integration: 1) Surface sciences: metal and metal oxide catalysts (crystals or nanostructures grown on metals or silicon) will be characterized for water oxidation and CO2 reduction through atomically resolved experiments (scanning probe microscopy) and spatially-averaged surface techniques including surface analysis before, after and in operando electrochemical reactions. Activity and performance will be correlated to composition, thickness, structure and support as to determine the optimum parameters for device integration. 2) Photoelectrodes: This unique surface knowledge will be transferred to the processing of catalytic nanostructures deposited on semiconductors through different methods to match the surface chemistry results through viable up-scaling processes. Multiple thermodynamic and kinetic techniques will be used to characterize and optimize the performance of the interfaces with spectroscopy and photo-electrochemistry tools to identify best matching between light absorbers and chemical catalysts along optimum working conditions (pH, temperature, pressure). 3) Modeling: Materials, catalysts and processes will be modeled with computational methods as a pivotal tool to understand and to bring photo-catalytic-electrodes to their theoretical limits in terms of performance. The selected optimum materials and environmental conditions as defined from these parallel studies will be integrated into a PEC cell prototype. This design will include ion exchange membranes and gas diffusion electrodes for product separation. Performance will be validated in real working conditions under sun irradiation to assess the technological and industrial relevance of our A-LEAF cell.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: PHC-14-2015 | Award Amount: 7.10M | Year: 2016

Short Bowel Syndrome (SBS) is a condition that occurs when part or the entire small intestine is missing or has been removed during surgery. This condition renders the bowel incapable of fulfilling its nutritional function (intestinal failure). There is no cure for SBS. Parenteral (intravenous) nutrition (PN) and bowel transplantation are currently the preferred options for nutrition in children and adults who have lost their bowel. PN offers a low survival rate, compromised quality of life, and the economic cost for each patient is estimated to be 55,000 euro/year. Small intestinal transplant is also an option with one-year and 4-year survival rates of 90% and 60% respectively. However, because of the shortage of organs, high mortality, the severe side effects of immunosuppression and low quality of life, this is still a sub-optimal solution. The objective of this programme is to deliver a functional bowel reconstruction to patients with SBS through an autologous tissue engineering strategy, overcoming the shortage of organs, and avoiding the need for immunosuppression. It will be achieved by identifying the best autologous cell source; providing the ideal scaffold; engineering functional intestine for transplantation and engaging with patients, scientists and public. The work is designed to lead directly to a clinical trial for the application of the optimal protocol for tissue-engineered intestine. The consortium is uniquely positioned to complete this ambitious effort as we have an internationally pre-eminent, multi-disciplinary team, which possesses a combination of expertise from basic molecular biology, engineering, and surgery, combining knowledge from universities, hospitals and industry. Importantly we are one of the few groups in the world with experience, infrastructure, and track record to translate regenerative medicine solutions to patients, including true clinical translation of tissue engineered organs.


Grant
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: H2020-TWINN-2015 | Award Amount: 1.01M | Year: 2016

CHEM2NATURE addresses current limitations of UMINHO in the Chemistry field regarding its scientific know-how and partnerships with world-leading institutions. UMINHO seeks to improve the multifunctionality of natural-origin polymers, often with limited bioactivity and stimuli-responsiveness, and increase the performance of cell-based therapies. Introducing such properties by precision chemical modifications would allow the development of added-value products with instructive and adaptive properties for cellular response control, drug delivery and diagnosis. The main goal of CHEM2NATURE is to combat UMINHOs limited knowledge, expertise and experience on advanced chemical routes for biopolymer, biomaterials and living surface modification. To this aim, an international training and scientific network will be established to accelerate the generation of technologies amenable to be used in the production of innovative healthcare devices. The capability of UMINHO to train highly-qualified researchers and staff would greatly increase, giving rise to a new generation of specialized professionals with scientific/translational competence. The consortium will comprise UMINHO, UAVR and 3 international competitive institutions in Chemistry: 2 European and 1 Asian. The latter will improve UMINHOs know-how in the translational/clinical fields and raise opportunities to establish new contacts with high-performing and Emerging Asian countries. CHEM2NATURE proposes the joint organisation of events and short-term exchange of senior researchers and staff, aiming at training actions and execution of scientific work in the scope of ongoing scientific projects. Outputs include the increase of number and quality of scientific publications, intellectual property and regional-to-national economic development. CHEM2NATURE will endorse the establishment of a long-lasting consortium beyond the project timeframe for the preparation of new scientific projects and research lines in UMINHO.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA | Phase: ICT-2013.1.3 | Award Amount: 782.98K | Year: 2013

FutureEnterprise aims at opening new avenues for Internet-based Enterprise innovation by supporting and coordinating the research activities in Future Internet from the perspective and for the benefit of enterprises on the basis of an open mentality to bridge the past (FP7) with the future (Horizon 2020). Combining a community-driven approach with Web 2.0 collaboration tools, FutureEnterprise will fully align the scope of its activities to the priorities of DG CONNECT Unit E3: Net Innovation.\nIn FutureEnterprise, bridging research with entrepreneurship plays a pivotal role, which is driven by the consolidation of research results produced by the FP7 projects of the domain and their provision as digital innovation elements / entrepreneurship seeds. With regard to the roadmapping activities, FutureEnterprise will deliver crowdsourcing-driven, iterative and live versions of a research roadmap on new forms of Internet-based Enterprise innovation. Taking into account the transition to new EU-funded programmes, FutureEnterprise will also provide concrete recommendations toward Horizon 2020 for policy makers and the EC, treating Digital Enterprise, Web Entrepreneurship, Future Internet PPP and CAPS under a common perspective.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA | Phase: ICT-2011.9.5 | Award Amount: 1.63M | Year: 2011

The coordination action CA-RoboCom will design and describe the FET Flagship initiative Robot Companions for Citizens (RCC) including its: S&T framework, governance, financial and legal structure, RTD organization, funding scheme, competitiveness strategy and risk analysis. FET-Fi RCC will realize a multi-disciplinary science and engineering program supporting a radically new approach towards machines and how we deploy them in our society. RCC is an ecology of soft and sentient machines that will help and assist humans in the broadest possible sense to support and sustain our welfare. RCC will have soft bodies based on the novel integration of solid articulated structures with flexible properties and display soft behavior based on new levels of perceptual, cognitive and emotive capabilities. RCC will be cognizant and aware of their physical and social world and respond accordingly. RCC will attain these properties because of their grounding in the most advanced sentient machines we know: animals. Conversely, RCC will validate our understanding of the general design principles underlying biological bodies and brains, establishing a positive feedback between science and engineering. The driving metaphor of RCC is that of the robot dancing partner who will be able to autonomously dance together with a human at a high-level of performance a range of styles. Driven by the vision and ambition of RCC, CA-RoboCom will by means of an appropriate outreach strategy, involve all pertinent stakeholders: science and technology, society, finance, politics and industry. Other than the commitment of its Consortium, CA-RoboCom will involve a wide range of external experts in its working groups, its advisory board, and in its European and International Cooperation board. The CA-RoboCom consortium believes that given the potential transformative and disruptive effects of RCC in our society their development and deployment has to be based on a the broadest possible support platform.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.5.4 | Award Amount: 4.59M | Year: 2012

Healthy independent living is a major challenge for the ageing European population. Promotion of stimulating physical activity and prevention of falls are two key factors. Smart ICT offers unique proactive opportunities to support older people in their own homes. The FARSEEING project aims to provide groundbreaking results for health promotion, fall prevention and technical development. Falls in older persons are common, often leading to institutionalisation and loss of independence. FARSEEING aims to promote better prediction, prevention and support of older persons, by long-term analysis of behavioural and physiological data collected using Smartphones, wearable and environmental sensors: leading to self-adaptive responses. FARSEEING aims to build the worlds largest fall repository. This will include samples of both high functioning community-dwelling elders and high-risk groups of fallers. The architecture of the database will facilitate collection, analysis and processing of data related to falls, daily activity and physiological factors. The inclusion of a longstanding cohort study ensures a representative population sample, which is urgently needed to translate technological advance into real world service provision. Telemedicine service models using open technological platforms, independent of sensor systems, will be developed for detection of falls and exchange of information between the older person, family, caregivers and health-care personnel. Novel exercise regimens will be developed that increase adaptability and stimulate motor learning, and cognitive and emotional well being. The exercise model will focus on capacity to manage a complex challenging environment. User acceptability is central to FARSEEING. Psychological and gerontological expertise is a core activity, including ethical, privacy and e-inclusion dimensions. Data protection will be paramount to build and validate realistic business models and service provision.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2009-1.2-3 | Award Amount: 16.85M | Year: 2010

The SUBLIMA project aims at truly simultaneous, fully integrated, solid-state PET/MR technology for concurrent functional and anatomical imaging with unsurpassed image quality. It will combine the extremely sensitive functional imaging possibilities provided by PET with the excellent soft-tissue contrast and complementary functional imaging capabilities of MR. For the first time, time-of-flight (ToF) and depth-of-interaction (DoI) correction will be introduced together into a PET/MR system. SUBLIMA will also be the first to exploit the unique advantages of truly simultaneous PET/MR acquisition by enabling fully 4D MR-derived motion correction. Furthermore, artefacts seen in PET-CT will be eliminated by developing MR-based, motion-compensated PET attenuation correction. The SUBLIMA platform will thus realize a breakthrough in image quality and enable novel applications in oncology, cardio-vascular medicine, and neuro-degenerative diseases. SUBLIMA will not only introduce new methods and technologies in each important component of the imaging chain, but it will also analyse the system performance as a function of all relevant design parameters, in order to push the image quality to the physical limits by optimally merging these innovations into 7T preclinical and 3T whole-body human demonstrator systems. This integrated approach also warrants adaptation of the project results for optimum performance in stand-alone PET and SPECT applications. The consortium, lead by Philips, consists of universities, research institutes, industrial partners, and SMEs, spread over 7 different countries including the USA. While each partner has shown exceptional quality in its own field, the consortium brings together the wide and complementary range of expertise necessary to push the performance of ToF-PET/MR to the physical limits.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: KBBE-2009-3-4-01 | Award Amount: 1.34M | Year: 2010

The objective of the Global-Bio-Pact project is the development and harmonisation of global sustainability certification systems for biomass production, conversion systems and trade in order to prevent negative socio-economic impacts. A functioning and sustainable certification scheme requires reliable data and profound research in order to evaluate impacts of biomass production. Currently, the sustainability debate is faced by the lack of data on socio-economic impacts. Furthermore, mainly impacts of biofuels are investigated and impacts of bioproducts are neglected. Thus, a harmonised certification scheme for biofuels and bioproducts is required. In order to harmonise sustainability certification globally, the Global-Bio-Pact proposal includes partners from Europe, Latin America, Africa, Asia and USA. Emphasis of the Global-Bio-Pact proposal will be placed on a detailed assessment of the socio-economic impacts of raw material production and a variety of biomass conversion chains. The impact of biomass production on global and local food security and the links between environmental and socio-economic impacts will be analysed. The Global-Bio-Pact project will investigate the interrelationship of global sustainability certification systems with international trade of biomass and bioproducts. Furthermore, Global-Bio-Pact will assess public perception of biomass production for industrial uses. This will be completed by the development and test audit of a set of socio-economic sustainability criteria and indicators for inclusion into a future effective certification scheme. Thereby, opportunities and limitations of social issues in biomass/bioproducts certification schemes will be investigated. Finally, the project will elaborate recommendations on how to best integrate socio-economic sustainability criteria in European legislation and policies on biomass and bioproducts. Results of the Global-Bio-Pact project will contribute to the EU energy policy and to the MDG.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY.2012.10.2.1 | Award Amount: 3.97M | Year: 2013

GLOBASOL will develop new concepts, materials and devices for advanced light harvesting and light management for a panchromatic collection of the solar energy and an unprecedented power conversion efficiency. This will be accomplished by integrating in a single device three light-to-electricity converters, exploiting different regions of the solar spectrum based on sensitized mesoscopic solar cells (SMSC), photonic crystals, thermoelectric (TE) cells. The key elements of the project are: 1) new absorbers for SMSC, with a very high conversion efficiency in the UV-vis region; 2) novel photonic materials for the collection/split of the IR spectrum; 3) advanced nanostructured materials for TE conversion of the IR part of the spectrum; 4) radically new architectures for the integrated devices, to increase the total efficiency. The innovative materials will include organometallics, organic dyes and quantum dots as sensitizers, quasi-solid electrolytes, nanostructures and nanowires alloys as well as quantum dots for TE. The devices will be engineered either in tandem arrangements or with optical splitting of the incident radiation, and concentration of the IR fraction to the TE. The targeted power conversion efficiencies are above 15% and 10% for SMSC in high and medium energy spectral regions, respectively, and 6% for TE, to reach a global efficiency above 30%, well beyond the present limits, along with cost-effectiveness and environmental safety. Five Universities and one Research Institution guarantee a scientific and technological multidisciplinary research, based on top level theoretical and experimental approaches. The high degree of knowledge in solid-state physics and chemistry, nanoscience and nanotechnology and engineering of the researchers assures that the new concepts and the objectives proposed will be successfully developed/pursued. A high-tech SME will provide proof-of-concept prototypes to validate the innovative GLOBASOL devices.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: FoF-ICT-2011.7.2 | Award Amount: 11.64M | Year: 2012

Organic Electroluminescence (OLED) is the most promising technology to deliver flexible, thin, light weight, power efficient and environment-friendly light sources. Currently glass based OLED devices are slowly entering the market place, opening new possibilities for lighting solutions. By adding flexibility and robustness at a lower price point, flexible OLEDs will change the lighting industry and revolution the way we all experience lighting.\n\nThe introduction of flexible OLED lighting is hampered by a lack of reliable series production technologies, flexible OLEDs exist in the lab but not yet in the fab. Roll-to-roll (R2R) manufacturing of these devices is seen by many as the future cost-efficient manufacturing technology for flexible OLEDs. However, complete roll to roll manufacturing of flexible OLED is still years away and will not be able to bring flexible OLEDs to the market place within 10 years.\n\nThe overall objective of the Flex-o-Fab project is the demonstration of a reliable manufacturing process for OLED lighting foils enabling market introduction within 3 years after the end of the project.\n\nFlex-o-Fab will take existing technologies in use for the manufacturing of glass based bottom emissive small molecule OLEDs and use these as a basis to develop a pilot series manufacturing process for flexible OLEDs. By doing so, the project will be allowed to focus on the roadblocks and bridge the gap between sheet-to-sheet (S2S) produced glass OLEDs and the future envisioned complete R2R lighting foils.\n\nFlex-o-Fab will strengthen and expand the leading position of the European lighting industry by making the shift from lab to fab and make flexible OLED devices an industrial reality. Furthermore, the new sustainable disruptive technologies will create long-term European manufacturing jobs due to their high degree of technical novelty and specialization. Finally, the intellectual property generated will protect these advances from Asian and US competition.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2009-1.4-3 | Award Amount: 16.34M | Year: 2010

We propose to develop new strategies to mobilize skeletal muscle tissue-associated stem cells as a tool for efficient tissue repair. This will be combined with exploring novel approaches that limit tissue damage, and will focus on agents that modify muscle and muscle vasculature progenitor cells. These molecules include nitric oxide associated with non-steroidal anti-inflammatory drugs, HMGB1, Cripto, NAC, and present and improved deacetylase inhibitors. Three clinical trials will be run in tandem with efforts to dissect the underlying mechanisms of action. Importantly, we have already initiated a monocentric clinical trial that focuses on the efficacy of NO-donors plus NSAIDs in muscle pathologies. Our efforts will be complemented by novel biodelivery systems for effective targeting. Our efforts will be complemented by novel biodelivery systems for effective targeting. The most promising drugs, used alone or in combination, will be first validated in small and large animal models. Our project brings together leading investigators to examine how vascular and muscle progenitors participate in postnatal growth and muscle tissue repair. A key issue that this project addresses is the tissue environment in which endogenous stem cells are activated. We propose that muscle degeneration and fibrosis provokes altered vascularization and immune responses, which eventually affect negatively stem cell functions. Molecules that can be used to therapeutically target these key cells, and their communication with neighboring vascular, inflammatory and fibrotic cell types, will lead to more effective approaches to muscle regenerative medicine and to novel cures for degenerative diseases, including atherosclerosis, vascular damage in diabetes and in peripheral ischemic vascular disease.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2013.3.1 | Award Amount: 6.22M | Year: 2013

E2SWITCH focuses on Tunnel FET (TFETs) as most promising energy efficient device candidates able to reduce the voltage supply of integrated circuits (ICs) below 0.25V and make them significantly more energy efficient by exploiting strained SiGe/Ge and III-V platforms, with CMOS technological compatibility. A full optimization and DC/AC benchmarking for complementary n- and p-type TFETs, integrated on the same fabrication platform, is proposed. Compact models are developed and implemented in Verilog A, for portability, to support the design of low power ICs with CMOS architectural compatibility for: (i) digital and (ii) analog/RF. The device scalability, operational reliability and the operation from room to high temperature, as required by ITRS metrics, are priorities of our investigations. In order to push even more the III-V and SiGe/Ge TFET performance we propose to study, optimize and experimentally validate new device concepts such as a Density-Of-State (DOS) switch exploiting the effect of dimensionality. The DOS switch will deliver deep subthermal switching (subthreshold swing less than 10mV/decade, for at least four decades of current).An advanced TCAD simulation platform is developed for the selected material systems, able to capture quantum effects and to accurately predict the influence of dimensionality. TCAD will also support the optimization of TFETs on the two proposed material platforms, with emphasis on the role of strain and on the alignment between the tunneling path and the electric field.A full set of characterization techniques including DC, AC, low frequency noise, RF measurements (S-parameters) and large range of temperature is foreseen to support the device optimization, parameter extraction and the calibration of the compact models.We will deliver very first full digital and analog circuit demonstrators and will benchmark their operational performance, reliability and robustness compared to equivalent CMOS technology nodes.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.8.1 | Award Amount: 13.18M | Year: 2012

The Go-Lab project will open up remote science laboratories, their data archives, and virtual models (online labs) for large-scale use in education. Go-Lab enables science inquiry-based learning that promotes acquisition of deep conceptual domain knowledge and inquiry skills and directs students to careers in science.\nFor students (10 to 18-years old), Go-lab offers the opportunity to perform personalized scientific experiments with online labs in pedagogically structured and scaffolded learning spaces that are extended with social communication facilities.\nFor teachers, Go-Lab offers pedagogical plug, share, and play through a Web-based interface and a community framework to disseminate best practices and find mutual support. A modular approach and inquiry classroom scenarios promote a seamless incorporation of online labs into the classroom.\nFor lab-owners, Go-Lab provides open interfacing solutions to easily plug in their online labs, construct their virtual didactic counterparts, and share them in the Go-Lab federation of online labs. Go-Lab will thus promote their scientific activities.\nThe project starts with a set of online labs from worldwide renowned research organisations (e.g., CERN, ESA) and then from selected universities and, based on initial in-depth pilots, will gradually improve and expand its series of online labs and associated inquiry learning opportunities with the increasing contribution of teacher and lab-owner communities. More advanced and later versions will be evaluated and validated in large scale pilots.\nThe Go-Lab project throughout Europe will expand the resources for teaching science in schools and provide more challenging, authentic and higher-order learning experiences for students. Its sustainability will come from the opportunity for the larger science education community to add new online labs. An open and Web-based community will capitalize on the collective intelligence of students, teachers, and scientists.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: ICT-26-2014 | Award Amount: 3.39M | Year: 2015

The diagnosis and management of acute Sepsis is a critical area where fast and accurate results can translate into life changing health outcomes for individuals. The overall aim of RAIS is to develop a new point-of-care label-free microarray platform and validate it for quantifying levels of specific Sepsis biomarkers. The approach uses a novel interferometric technique ultimately capable of providing very large arrays of tests. Specific objectives and activities include: (i) an optical microarray reader based on a disruptive proprietary design combining interferometric lens-free microscopy and proximity CCD or CMOS image sensing; (ii) a microarray plate, in a proper microfluidic cartridge, consisting of a transparent slide with a novel nano-structured surface geometry to increase the detection sensitivity and covered by specific receptors to capture bio-markers; (iii) their integration in a portable and battery powered label free microarray platform potentially capable of measuring more than 1 million bio-targets simultaneously. The developed technology will be capable to detect micro-ribonucleic acids (microRNAs), interleukins and other specific proteins associated to Sepsis using a few microliters of blood or serum samples, in a concentration of a few pg/ml, within 30 minutes (sample to result) and at a cost per patient of less than 50. In this way, patients will be put on the right treatment more rapidly, potentially reducing the Sepsis mortality rate of more than 70%, with estimated cost savings of more than 10 billion per year as a consequence of shorter hospital stays, reduced use of unnecessary drugs and lower associated insurance bills. The technical approach, targeted device, application and the addressed market sector are perfectly in line with the call H2020-ICT-2014-1 - Photonics KET - Biophotonics for screening of diseases: Mobile, low-cost point-of-care screening devices for reliable, fast and non- or minimally-invasive detection of diseases.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.86M | Year: 2016

Infectious diseases are a major burden to public health and the global economy, not in the least due to antimicrobial resistance. Rapid point of care (POC) in vitro diagnostics (IVD) are key tools in the effective clinical management of patients with infectious diseases. Yet there is still a large unmet clinical need for more rapid POC IVDs generating more clinically relevant, actionable information. Effectively addressing this need requires a change in the current approach in training researchers on IVDs, generating a new breed of IVD researchers capable of closing the gap between the clinical and technological perspective. ND4ID takes up this challenge by offering 15 ESRs a world-class first of its kind training programme where they will be exposed to the full breadth of disciplines spanning clinical, technological and market-oriented viewpoints, from both the academic and non-academic sector. Through a set of synergistic research projects on novel POC assays, targeting the most important and urgent clinical needs at world leading academic or private sector research groups, the ESRs are offered a holistic training program, preparing them to be lead players in the future IVD field. This training through research is augmented by a unique comprehensive network-wide training programme covering clinical, technical and translational knowledge and skills of relevance to IVD research, development and exploitation. As such, ND4ID will deliver ESRs that will be in high demand serving as an example for other academic and non-academic actors active in training IVD researchers and further strengthening Europes position in the internally competitive arena of IVD technology.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: EINFRA-5-2015 | Award Amount: 4.07M | Year: 2015

Materials are crucial to scientific and technological advances and industrial competitiveness, and to tackle key societal challenges - from energy and environment to health care, information and communications, manufacturing, safety and transportation. The current accuracy and predictive power of materials simulations allow a paradigm shift for computational design and discovery, in which massive computing efforts can be launched to identify novel materials with improved properties and performance; behaviour of ever-increasing complexity can be addressed; sharing of data and work-flows accelerates synergies and empowers the science of big-data; and services can be provided in the form of data, codes, expertise, turnkey solutions, and a liquid market of computational resources. Europe has the human resources, track record and infrastructure to be worldwide leader in this field, and we want to create a CoE in materials modelling, simulations, and design to endow our researchers and innovators with powerful new instruments to address the key scientific, industrial and societal challenges that require novel materials. This CoE will be a user-focused, thematic effort supporting the needs and the vision of all our core communities: domain scientists, software scientists and vendors, end-users in industry and in academic research, and high-performance computing centres. The proposal is structured along two core actions: (1) Community codes, their capabilities and reliability; provenance, preservation and sharing of data and work-flows; the ecosystem that integrates capabilities; and hardware support and transition to exascale architectures. (2) Integrating, training, and providing services to our core communities, while developing and implementing a model for sustainability, with the core benefit of propelling materials simulations in the practice of scientific research and industrial innovation.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY.2013.2.1.1 | Award Amount: 10.26M | Year: 2013

The European photovoltaics PV market still represents the predominant share of worldwide installations and electricity generated from PV is becoming increasingly competitive, with an average levelized cost of energy (LCOE) estimated to be between 0.100.16 /kWh in 2011 . This constant reduction of LCOE means that the European industry can only regain its competitiveness with (i) a concomitant reduction of production and investment costs (current net price level ~0.81.0 /Wp today) in Europe in order to face the strong price competition of emerging countries (China and Taiwan), (ii) investment in novel advanced industrial processes allowing for high efficiencies and low-cost device production (iii) the development of high-end tools and processes which are more difficult to master and duplicate, securing a technology leadership. These conditions are necessary to ensure sustainable PV technology production in Europe and the construction of a robust European PV industry able to beat international competition. However, ultra-high-efficiency PV devices require manufacturing processes that are increasingly complex, which results in an increase in the related investment and fabrication costs. Given that the market still requires a reduction of the technology price, we are left with a paradox, and we must find ways to produce high-efficiency devices with competitive industrial processes. The concept proposed by the HERCULES project is to develop innovative n-type monocrystalline c-Si device structures based on back-contact solar cells with alternative junction formation, as well as related structures including hybrid concepts (homo-heterojunction). These concepts are the most promising technologies to reach ultra-high efficiencies with industrially relevant processes. The HERCULES strategy is to transfer the developed processes to the industrial scale by considering all major cost drivers of the entire manufacturing process chain of modules.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: FoF-ICT-2011.7.4 | Award Amount: 6.68M | Year: 2012

RLW Navigator aims to develop an innovative Process Navigator to configure, integrate, test and validate applications of Remote Laser Welding (RLW) in automotive assembly addressing todays critical needs for frequently changing operating conditions and product-mix provisions. Thus, RLW Navigator will crucially serve as an enabler for future energy efficient smart factories. RLW is emerging as a promising joining technology for sheet metal assembly due to benefits on several fronts including reduced processing time, (50-75%) and decreased factory floor footprint (50%), reduced environmental impact through energy use reduction (60%), and providing a flexible process base for future model introduction or product change. Currently, RLW systems are limited in their applicability due to an acute lack of systematic ICT-based simulation methodologies to navigate their efficient application in automotive manufacturing processes. The project aims to address this by developing a Process Navigator simulation system that will deal with three key challenges thereby allowing manufacturers to utilize the advantages of the RLW system.\nFirstly, the most critical obstacle that currently prevents the successful implementation of RLW is the need for tight dimensional control of part-to-part gap during joining operations, essential to ensure the quality of the stitch.\nSecondly, the existing assembly system architecture must be reconfigured to provide the opportunity to evaluate the RLW system in terms of its feasibility to perform all required assembly tasks. This will provide crucial information about the most advantageous workstation/cell reconfiguration, which will serve as the basis for optimal robot path planning to reduce joining process time and workstation level efficiency assessment.\nFinally the project will develop systematic evaluation and learning methods to assess and improve the overall performance, cost-effectiveness and eco-efficiency of the RLW system.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2007-1.4-6 | Award Amount: 16.56M | Year: 2009

This proposal aims to develop and implement efficacy of clinical trials with adult, tissue stem cells for degenerative diseases of epithelia and skeletal muscle. Extraordinary progress in the understanding of several key features of stem cells has been rapidly translated into novel cell therapy protocols that have yielded positive results in pre-clinical models of genetic and acquired diseases and in the first clinical trials. Much remains to be done on the basic biology of stem cells to provide new tools for cell therapy trials. Also transplantation related issues, such as engraftment, angiogenesis, tissue remodeling and immune response remain to be addressed. In general, cell therapy necessitates a continuous cross-talk among biologists and clinicians as well as crossing boundaries among different tissues/diseases. Despite many structural and functional differences, epithelia and skeletal muscle share some key features such as spatially ordered cell architecture, centered on a supporting basal lamina to which stem cells are anchored. Indeed mutations in structural proteins linking the cell membrane to the basal lamina are responsible for similarly devastating diseases such as muscular dystrophies and epidermolysis bullosa. A multi-tissue approach allows jointly addressing and solving not only scientific and clinical problems but also regulatory and ethical issues related to these novel procedures. Finally, sharing high valued dedicated platforms such as large animal facilities and GMP cell culture facilities increases performance and reduces costs. Based on these considerations, a network of internationally recognized experts in muscle and epithelial cell biology, immunology, angiogenesis, and molecular pharmacology with two stem cell-based Companies has been assembled, creating a synergistic approach that will increase the chance of success for ongoing and future clinical trials with stem cells, that are integral part of this proposal.


The decision-making in chemotherapy nowadays depends on standard methods that are liquid chromatography (LC-MS/MS) followed by mass spectrometry or capillary electrophoresis; both are labour- and cost-intensive and can be performed only in dedicated hospitals and laboratories. This lead to a minimal therapeutic drug monitoring in patients and hence that 30-60% of drugs are administered without clinical benefits. We propose to develop a point-of-care device for quantification of chemotherapeutic drugs in small body fluid samples by highly selective nanoparticle extraction and liquid crystal detection incorporated in microfluidic lab-on-chip device (optofluidics based) allowing the real-time drug monitoring. This will improve the therapeutic outcome and reduced health care costs.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY.2010.8.1-1 | Award Amount: 5.06M | Year: 2010

Low-temperature process waste heat is primarily valorized to provide heat to other applications and, more rarely, to provide cooling or to produce electricity, which is often perceived to be less attractive. However, generating electricity does represent a rational alternative, since it may circumvent drawbacks linked to demand seasonality and location. The LOVE project aims at developing innovative technological solutions to generate electricity from low-temperature (< 120C) waste heat sources identified within various industrial processes, in general, and specifically in the cement industry which is among the more energy-intensive applications worldwide. Innovative thermodynamic cycles will be investigated while existing ones will be optimized. Advanced solutions for heat exchangers operating in hostile environments will be developed along with a particularly efficient turbine solution. A systemic approach will be implemented using a computer-aided tool providing for overall system optimization. Two small and mobile demonstration units will be built and tested in a partner laboratory and again installed and tested at two partner industrial sites. Further applications of the proposed technological solutions to other energy-hungry industrial sectors and to the waste heat recovery on CHP plants will also be evaluated. This project will result in important advances in applied cycle thermodynamics, as well as in industrial system modeling and optimization, thus allowing for significant technological developments which will be applied to the cement production sector. The constitution of the consortium partners ensures an excellent cross-fertilization towards the realization of the project objectives. The consortium combines the strengths of leading actors in the industrial sector of interest, of equipment manufacturers active in the segment, and of academic organizations with active research on-going in the field, along with two major European energy providers.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-SA | Phase: INCO.2011-8.1 | Award Amount: 519.79K | Year: 2012

European MS & AC have a long tradition to collaborate with India, this has led both to a large potential for fruitful collaborations at EU level, and a fragmentation of actions at countries level. In order to push up a more ambitious integrated actions, and to be able to adopt the best practices in leveraging the science, technology, innovation (STI) relationship, and to cope with the intense worldwide competition for international alliances, EU must overcome this fragmentation. Hence we propose to provide the EC with a feasibility study of the opening of an INDIA SI HOUSE aimed at boosting the STI collaboration in a sustainable manner. The specific aims are to explore INDIA SI HOUSE projects partners, and beyond when possible: 1/ the political commitment; 2/ the legal frameworks; 3/ the scientific priorities. The results will be synthesized in a Forward Look that will provide recommendations. During this study, benchmarking, mapping, and SWOT analyses of existing bilateral and multilateral schemes of collaboration including PPP, to delineate the most common schemes of cooperation with India. This project is built upon the Indo-French CEFIPRA funding structure, which does exist for more than 20 years. For the strategic management of this project, an External Advisory Board (EAB) will be set up since the Month 1. Its composition will vary in function of the topic addressed. Besides the presence of Indian decision makers and partners, interested non-partner EU MS & AC will be invited to EAB. The INDIA SI HOUSE project will disseminate permanently its results thanks to its website and tool box, in an openly way, giving cooperatively access to other EU-India funded projects. The impacts of this project will spread up along three dimensions: 1/ boost in the coordination of EU MS & AC; 2/ increased visibility and improved quality of EU actions; 3/ enhanced coordination of science diplomacy.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP-2009-4.0-3 | Award Amount: 16.52M | Year: 2010

NAMDIATREAM will develop a cutting edge nanotechnology-based toolkit for multi-modal detection of biomarkers of most common cancer types and cancer metastases, permitting identification of cells indicative of early disease onset in a high-specificity and throughput format in clinical, laboratory and point-of-care devices. The project is built on the innovative concepts of super-sensitive and highly specific lab-on-a-bead, lab-on-a-chip and lab-on-a-wire nano-devices utilizing photoluminescent, plasmonic, magnetic and non-linear optical properties of nanomaterials. This offers groundbreaking advantages over present technologies in terms of stability, sensitivity, time of analysis, probe multiplexing, assay miniaturisation and reproducibility. The ETP in Nanomedicine documents point out that nanotechnology has yet to deliver practical solutions for the patients and clinicians in their struggle against common, socially and economically important diseases such as cancer. Over 3.2M new cases and 1.7M cancer-related deaths are registered in Europe every year, largely because diagnostic methods have an insufficient level of sensitivity, limiting their potential for early disease identification. We will deliver Photoluminescent nanoparticle-based reagents and diagnostic chips for high throughput early diagnosis of cancer and treatment efficiency assessment Nanocrystals enabling plasmon-optical and nonlinear optical monitoring of molecular receptors within body fluids or on the surface of cancer cell Multi-Parameter screening of cancer biomarkers in diagnostic material implementing segmented magnetic nanowires Validation of nano-tools for early diagnosis and highly improved specificity in cancer research. OECD-compliant nanomaterials with improved stability, signal strength and biocompatibility Direct lead users of the results will be the diagnostic and medical imaging device companies involved in the consortium, clinical and academic partners


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: FoF.NMP.2011-5 | Award Amount: 7.99M | Year: 2011

This project aims at developing an innovative Quality Control System that will drastically change the current concept of End Of Line quality control, going beyond currently established methodologies such as Six-sigma and SPC. It will prevent the generation of defects within the process at single stage and the propagation of defects between processes at multi-stage system level. This Quality Control System will be proactive, offering three different solution strategies to avoid End of Line defects: (i) elimination of the predicted defect through adjustment of process characteristics by proactively intervening on the inputs to the process (process parameters, etc.), (ii) on-line reworking of the product in order to eliminate the defect, (iii) on-line workpiece repair through defect elimination at consecutive process stages. Technological developments will be based on the design and development of new hardware technologies, techniques and software solutions that in turn are based on real-time multi-data gathering by the integration of new sensor and inspection equipment, development of intelligent actuators and the of new monitoring and prognosis knowledge-based models. To develop a universal system able to be integrated into different production processes, its feasibility will be demonstrated in machining and assembly processes at both macro and micro product scales. The integration of the in-process Quality Control system into the production chain will minimize the amount of defective part production, reaching process capability values of more than 2.0 in mass production, and equivalent reduction of defect amount in small-lots and customized product manufacturing. Application domains will include emerging strategic European sectors such as the production of electrical engines for sustainable mobility, large-part manufacturing for the wind power sector and the production of customized micro-intravascular catheters as high value medical products for the aging society.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.8.8 | Award Amount: 12.10M | Year: 2011

The BrainScaleS project aims at understanding function and interaction of multiple spatial and temporal scales in brain information processing. The fundamentally new approach of BrainScaelS lies in the in-vivo biological experimentation and computational analysis. Spatial scales range from individual neurons over larger neuron populations to entire functional brain areas. Temporal scales range from milliseconds relevant for event based plasticity mechanisms to hours or days relevant for learning and development. In the project generic theoretical principles will be extracted to enable an artificial synthesis of cortical-like cognitive skills. Both, numerical simulations on petaflop supercomputers and a fundamentally different non-von Neumann hardware architecture will be employed for this purpose.Neurobiological data from the early perceptual visual and somatosensory systems will be combined with data from specifically targeted higher cortical areas. Functional databases as well as novel project-specific experimental tools and protocols will be developed and used.New theoretical concepts and methods will be developed for understanding the computational role of the complex multi-scale dynamics of neural systems in-vivo. Innovative in-vivo experiments will be carried out to guide this analytical understanding.Multiscale architectures will be synthesized into a non-von Neumann computing device realised in custom designed electronic hardware. The proposed Hybrid Multiscale Computing Facility (HMF) combines microscopic neuromorphic physical model circuits with numerically calculated mesoscopic and macroscopic functional units and a virtual environment providing sensory, decision-making and motor interfaces. The project also plans to employ petaflop supercomputing to obtain new insights into the specific properties of the different hardware architectures.A set of demonstration experiments will link multiscale analysis of biological systems with functionally and architecturally equivalent synthetic systems and offer the possibility for quantitative statements on the validity of theories bridging multiple scales. The demonstration experiments will also explore non-von Neumann computing outside the realm of brain-science.BrainScaelS will establish close links with the EU Brain-i-Nets and the Blue Brain project at the EPFL Lausanne. The consortium consists of a core group of 15 partners with 18 individual groups.Together with other projects and groups the BrainScaelS consortium plans to make important contributions to the preparation of a future FET flagship project. This project will address the understanding and exploitation of information processing in the human brain as one of the major intellectual challenges of humanity with vast potential applications.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.9.2 | Award Amount: 1.66M | Year: 2013

If you visited a rock concert recently, or any other event that attracts crowds, you cannot ignore the many people taking videos of the scenario in that specific event at the same time, using their mobile phone cameras. Our vision involves using the power of the crowd of multiple mobile phone users to create a higher quality and 3 dimensional video experience that can be shared by social networks interested in this event. We would like to offer a two- fold infrastructure: technological and social so that the individual documented experience from the mobile users view point will lead into a 3D video experience that can be distributed into social networks and individual domains. Our aim is to have an aggregated 3D video feed that can be a live and interactive 3D scene application where you can travel across the 3D video, see people and stuff that is going on and manipulate the pictures according to multiple applications purposes. Beyond the individual experience, the people that contributed in sourcing and generating this 3D scene and who are interested in it will constitute an ad hoc virtual community.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2010.2.3.2-1 | Award Amount: 16.70M | Year: 2011

The More Medicines for Tuberculosis (MM4TB) consortium evolved from the highly successful FP6 project, New Medicines for TB (NM4TB), that delivered a candidate drug for clinical development two years ahead of schedule. Building on these firm foundations and exploiting its proprietary pharmacophores, MM4TB will continue to develop new drugs for TB treatment. An integrated approach will be implemented by a multidisciplinary team that combines some of Europes leading academic TB researchers with two major pharmaceutical companies and four SMEs, all strongly committed to the discovery of anti-infective agents. MM4TB will use a tripartite screening strategy to discover new hits in libraries of natural products and synthetic compounds, while concentrating on both classical and innovative targets that have been pharmacologically validated. Whole cell screens will be conducted against Mycobacterium tuberculosis using in vitro and ex vivo models for active growth, latency and intracellular infection. Hits that are positive in two or more of these models will then be used for target identification using functional genomics technologies including whole genome sequencing and genetic complementation of resistant mutants, yeast three hybrid, click chemistry and proteomics. Targets thus selected will enter assay development, structure determination, fragment-based and rational drug design programs; functionally related targets will be found using metabolic pathway reconstruction. Innovative techniques, based on microfluidics and array platforms, will be used for hit ranking, determining rates of cidality and confirming mechanism of action. Medicinal chemistry will convert leads to molecules with drug-like properties for evaluation of efficacy in different animal models and late preclinical testing.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.4.3 | Award Amount: 4.66M | Year: 2011

Data and knowledge management technologies are of strategic importance for industrial innovation, provided they are integrated in the company processes, in the organisational structure, and can be flexibly adapted to company evolution. In particular the Product Development Process (PDP) of manufacturing companies, requires the efficient management of huge amounts of data from different sources and their integration in the subprocesses that compose the product chain. The efficient use of information lifecycle, by the large adoption of virtual testing and by the inter-functional management of related data in the product management would become a strategic advantage for the innovation race. Present ICT solutions separately address parts of product development, but an integrated approach that includes data and services required for the whole Product Development Process does not yet exist.iProd will improve the efficiency and quality of the Product Development Process developing a flexible, service oriented, customer driven software framework that will be the backbone of computer systems associated with current and new development processes. To achieve these goals, iProd will rely on knowledge management (KM), knowledge based engineering (KBE) and process integration and automation technologies.iProd will assume the challenge of complexity, semantic diversity and richness of content establishing semantically rich, open and transparent methodologies that will enable knowledge workers from aerospace, automotive and home appliances industries to manage product and process complexity, managing higher value information like functional specifications, requirements, decision rationale and engineering and business knowledge in general. This knowledge base along with a reasoning engine will support information sharing, collaboration across companies, common understanding of PDP among different industries and will promote efficient decision taking.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.2.1 | Award Amount: 9.45M | Year: 2012

Enabling robots to competently perform everyday manipulation activities such as household chores exceeds, in terms of task,activity, behavior and context complexity, anything that we have so far investigated in motion planning, cognitive robotics, autonomous robot control and artificial intelligence at large. For achieving robust, adaptive, effective and natural performance of everyday manipulation tasks, it is not feasible to expect that programmers can equip the robots with plan libraries that cover such open-ended task spectrum competently.RoboHow.Cog targets at enabling autonomous robots to perform expanding sets of human-scale everyday manipulation tasks - both in human working and living environments. To this end, RoboHow.Cog will investigate a knowledge-enabled and plan-based approach to robot programming and control where knowledge for accomplishing everyday manipulation tasks is semi-automatically acquired from instructions in the World Wide Web, from human instruction and demonstration (videos), and from haptic demonstration.The knowledge-enabled control will be made possible through extensions of constraint- and optimization-based movement specification and execution methods that allow for the force adaptive control of movements to achieve the desired effects and avoid the unwanted ones. In addition, novel perception mechanisms satisfying the knowledge preconditions of plans and monitoring the effects of actions will make the RoboHow.Cog approach feasible.The software components that will come out of RoboHow.Cog will be integrated into complete generic robot control systems such as ROS, and, in particular, into Aldebarans humanoid platform Romeo. RoboHow.Cog will strive to make the code of many of its components - and even of large parts of the Milestone demonstrations -- publicly available under free/open source software licenses.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.9.1 | Award Amount: 2.09M | Year: 2012

We aim at designing, prototyping, and validating a new generation of ICT hardware and software technologies inspired from plant roots, called PLANTOIDS, endowed with distributed sensing, actuation, and intelligence for tasks of environmental exploration and monitoring. PLANTOIDS take inspiration from, and aim at reproducing, the amazing penetration, exploration, and adaptation capabilities of plant roots. Plants have evolved very robust growth behaviours to respond to changes in their environment and a network of highly sensorized branching roots to efficiently explore the soil volume, mining minerals and up-taking water. PLANTOID has two major goals: 1) to abstract and synthesize with robotic artefacts the principles that enable plant roots to effectively and efficiently explore and adapt to underground environments; 2) to formulate scientifically testable hypotheses and models of some unknown aspects of plant roots, such as the role of local communication among root apices during adaptive growth and the combination of rich sensory information to produce collective decisions. The PLANTOID artefact will be composed of a network of sensorized and actuated roots, displaying rich sensing and coordination capabilities as well as energy-efficient actuation and high sustainability, typical of the Plant Kingdom. Each PLANTOID root will consist of an apex that comprises sensors, actuators, control units, and by an elongation zone that mechanically connects the apex and the trunk of the robot. The new technologies expected to result from PLANTOID concern energy-efficient actuation systems, chemical and physical micro-sensors, sensor fusion techniques, kinematics models, and distributed, adaptive control in networked structures with local information and communication capabilities. The foundational research program of PLANTOID will be carried out by a consortium of engineers, plant biologists, and computer scientists with demonstrated experience in interdisciplinary work.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.72M | Year: 2013

The CI-NERGY Marie Curie Initial Training Network (ITN) aims to train young scientists to develop urban decision making and operational optimisation software tools to minimise non-renewable energy use in cities. The training will be carried out by a close collaboration of six of the best academic research centres and four leading industrial companies from the energy and software technology sector (Siemens, WienEnergie, EDF/EIFER, and IES). The research fellows will apply their results in two case study cities (Geneva and Vienna), which were chosen for their very ambitious sustainability goals. The CI-NERGY network will be a highly multi-disciplinary coordinated PhD programme on urban energy sustainability, covering the key challenges in cities related to a low carbon future. There is a gap in high level integrated training in the urban energy research field, which is due to the wide range of fragmented disciplines from building physics and energy supply technologies with electrical and thermal engineering up to software engineering and information technology. The CI-NERGY network wide training provided by excellent academic and industry partners from all areas of smart cities will close this gap. The impact of the network training activities will be highly noticeable for energy supply utilities, IT companies, policy makers, urban planners, researchers on sustainable urban energy systems and finally the inhabitants of cities themselves. All sectors mentioned will provide excellent career opportunities for the research fellows, who will gain excellent knowledge of the sectorial requirements by a structured secondment plan.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.48M | Year: 2013

One dimensional nanostructures (1DNS) produced from various elemental (Si and Ge) and compound (III-V and II-VI) semiconductors are receiving increasing worldwide attention due to their unique properties and potential for a wide range of applications. They are the building blocks for single photon emitters, third generation solar cells and the monolithic integration of optoelectronic devices. 1DNS can be used to fabricate the smallest light emitting devices and lasers. Despite recent progress, many fundamental and applied challenges still prevent transfer of 1DNS from laboratories to large scale industrial use. The proposed NanoEmbrace assembles eight leading industry partners and ten internationally renowned institutions in materials science, engineering, chemistry, condensed matter physics and nanoscale device fabrication. The original vision of NanoEmbrace is to gain superior control and understanding of 1DNS and to transfer 1DNS from laboratory to industry. It is probably the first organised attempt to put together all the competences and capabilities, experimental and theoretical, necessary for the comprehension of the mechanisms that govern the growth of 1DNS that cannot all be described by existing models. We also aim to provide the highest quality multidisciplinary and cross-sectoral training to early career researchers (ESRs) in nanoscience to create the next generation of research and industry leaders. The ESRs joining NanoEmbrace will have a unique opportunity to enjoy close personal contact with internationally renowned experts and to put together an unprecedented, complex but unified overall understanding of the growth of 1DNS and to develop the process required to produce practical commercial devices. To deliver the highest quality of training to young talented researchers, NanoEmbrace has identified the key research themes: controlled synthesis, theoretical modelling, characterisation of 1DNS and the integration of 1DNS into device fabrication.


Grant
Agency: Cordis | Branch: FP7 | Program: BSG-SME | Phase: SME-2011-1 | Award Amount: 1.52M | Year: 2011

Advances in micro-, nano-, and biotechnology put increasing demands on nanoscale microscopy and characterization. Atomic force microscopy (AFM) is one of the highest resolution microscopy methods used in this area. In this project, we will develop a new type of AFM sensor, which will significantly increase the performance of AFM and make it suitable for a much broader range of applications, especially in the life sciences. While traditional AFMs using optical detection of the cantilever sensor, yield very high resolution images, their imaging speed is low, they are difficult to automate and integration with other analysis techniques is limited due to the required optical components. This project aims at removing these limitations for a large area of attractive AFM-applications such as fast analysis in materials science and biological applications. The innovative concept is based on all electric bio cantilevers, ALBICAN. These cantilevers will use novel granular tunneling resistors (NTR), which are fabricated with a mask-less direct writing technique: focused electron beam induced deposited (FEBID). The AFM cantilever will be equipped with an NTR deflection sensor that directly measures the cantilever signal electrically, which removes the need for optical cantilever detection. Recent improvements in AFM cantilever technology have increased the imaging speed of AFM by up to two orders of magnitude by miniaturizing AFM cantilevers (SCL-Sensor.Tech., AMG-T). The unique approach in this proposal, which builds on new materials and fabrication processes (Nanoss), will allow the manufacturing of unprecedented small cantilever sensors with vastly superior performance in imaging speed and usability. These cantilevers will be compatible with a wide variety of existing AFMs and applications in materials and life science. Thereby providing a unique technological edge for the involved SMEs, and opening new avenues for the commercialization of their products and technologies.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP-2007-3.1-1 | Award Amount: 7.44M | Year: 2009

The proposal is addressing the need of European manufacturing companies of a new model that go beyond lean manufacturing to ensure the transformation of the enterprise into lean environment. This is to response to the customers and market demands of value creation incorporating sustainability, culture and customisation. A significant change in enterprise performance can come from the adoption of lean thinking throughout the entire product life cycle. The aim is to develop a new model based on lean thinking that will consider entire product life cycle, providing a knowledge based environment to support value creation to the customers in term of innovation and customisation, quality as well as sustainable and affordable products. This will be called Lean Product and Process Development (LeanPPD) paradigm. The required knowledge for value creation in LeanPPD model will be developed based on the European standard and open architecture to ensure data and knowledge integrity and to provide a lean environment across the product life cycle and the supply chain. The project proposes to develop novel set-based lean design tools that ensure the concurrent consideration and development of lean product design as well as it associated lean manufacturing system. The user driven approach will be ensured by the six business cases (BC) provided by the end-users from different sectors in the consortium. These BCs will serve to derive requirements upon the tools, methodology and models being developed , to test the solutions developed and will serve as industrial demonstrators of the proposed concept.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.8.0 | Award Amount: 2.60M | Year: 2011

STAMINA will leverage statistical physics inspired methods to deliver a novel foundational framework for managing complexity in information network mega-structures and for efficientlly solving large-scale network optimization problems that are intractable by classical methods.Recent success stories like the effective decoding of LDPC codes in information theory support the great promise of the approach.A cross-disciplinary work plan is proposed, at the interface of statistical physics, networking and computer science.A network optimization problem with given objective over a space of possible configurations is mapped to a statistical physics problem instance with probability distribution over possible configurations.Solving the optimization problem is equivalent to finding minimum energy configurations where probability distribution concentrates.Statistical mechanics theories from spin glass and disordered systems will establish fundamental connections among atomic micro-interactions, emergent network behaviour and phase transitions.Belief propagation message passing methods will be harnessed, that disassemble the hard centralized combinatorial problem to iterative lightweight local messaging, thus achieving autonomic network control at no cost for solution dissemination, and promoting green computing through ultra-low processing load.Flexibility and simplicity enable real-time adaptation at different time scales of variations through online construction of solutions.Three challenging case studies (energy-prudent control at device and network level, resource management regimes for optimal transport capacity and latency, and inference of hidden network states) serve as proof-of-concept for enabling novel, currently suppressed functionalities.A solid validation plan is laid, with large-scale simulation and test-bed experimentation. Notable achievements of members of our team make us optimistic about the potential of the methods and motivate our research agenda.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2011.1.1-1 | Award Amount: 5.90M | Year: 2011

The MEHTRICS proposal aims to challenge the current limits of HT cell-based screening by combining HT-RNAi with an emerging new technology for normalizing cultured cell behaviors, namely the growth of cells on adhesive micropatterns. Initial applications of this technology have already demonstrated its potential for enhancing the quality of existing high content analyses by radically reducing the cell populations phenotypic variability, resulting in much lower cell sampling requirements. This approach also promises to open up major new assay development space by broadening the range of analysis strategies that drive the novel cell-based assay designs, whose evolution has otherwise stagnated in recent years. The consortium will carry out several parallel and complementary lines of development to diversify the applicability of the MEHTRICS platform for both academic and industrial uses, ultimately validating the new capabilities through proof of principle screens. Our key objectives are 1) to optimize micropattern geometries and compositions to accommodate extended timelines typical of siRNA assays, 2) to integrate the promising Transfected Cell Array (TCA) technique to decrease cost and increase throughput, 3) to develop novel cell models of key diseases based on micropatterned adult stem cells and polarized epithelia/endothelial architectures and 4) to validate each of these implementations in key industry-relevant siRNA screening applications. Since experimental designs required to run RNAi screens are among the most demanding of all HT/HC studies and encompass virtually all technical challenges also encountered in compound screens, we expect the proposed scope of activities to deliver the maximal potential for impactful innovation, widespread adoption and clear relevance for all major applications of HT/HC cell screening. The resulting new tools and methodologies will be incorporated into the commercial offerings of the consortiums two key SMEs, CYTOO and CENIX.


Grant
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: NMBP-24-2016 | Award Amount: 3.95M | Year: 2016

The aim of the EMMC-CSA is to establish current and forward looking complementary activities necessary to bring the field of materials modelling closer to the demands of manufacturers (both small and large enterprises) in Europe. The ultimate goal is that materials modelling and simulation will become an integral part of product life cycle management in European industry, thereby making a strong contribution to enhance innovation and competitiveness on a global level. Based on intensive efforts in the past two years within the European Materials Modelling Council (EMMC) which included numerous consultation and networking actions with representatives of all stakeholders including Modellers, Software Owners, Translators and Manufacturers in Europe, the EMMC identified and proposed a set of underpinning and enabling actions to increase the industrial exploitation of materials modelling in Europe EMMC-CSA will pursue the following overarching objectives in order to establish and strengthen the underpinning foundations of materials modelling in Europe and bridge the gap between academic innovation and industrial application: 1. Enhance the interaction and collaboration between all stakeholders engaged in different types of materials modelling, including modellers, software owners, translators and manufacturers. 2. Facilitate integrated materials modelling in Europe building on strong and coherent foundations. 3. Coordinate and support actors and mechanisms that enable rapid transfer of materials modelling from academic innovation to the end users and potential beneficiaries in industry. 4. Achieve greater awareness and uptake of materials modelling in industry, in particular SMEs. 5. Elaborate Roadmaps that (i) identify major obstacles to widening the use of materials modelling in European industry and (ii) elaborate strategies to overcome them. This EMMC-CSA stems directly out of the actions of the EMMC and will continue and build upon its existing activities.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.88M | Year: 2016

The unprecedented properties of optical fibres make them ideal to be implemented as artificial nervous systems, enabling any tool or structure to become a sensitive and smart object. Conventional optical fibres are small, low-cost and can be seamlessly integrated in materials, in engineering structures and in the environment. By exploiting the most advanced light-matter interactions, these tiny luminous wires can realize distributed sensing, which means that each point along an optical fibre can separately and selectively sense quantities such as temperature, strain, acoustic waves and pressure, in perfect similarity to a real organic nerve. These remarkable features have attracted the interest of different end-users covering application domains as diverse as pipeline protection, oil and gas well exploitation, electricity transport, perimeter, fire alarm, etc., leading to a sustained market growth in the last years. However, the full potential of state-of-the-art distributed fibre sensing is exploited in a fairly narrow range of applications only. This is mainly due to the lack of trained scientific personnel capable of creating the link between the sensors and possible applications. The ambition of FINESSE is therefore to educate and to train researchers in the development of a set of disruptive new optical artificial nervous systems with improved sensitivity, precision and new sensing abilities, and to boost the industrial uptake of these sensors by training these researchers to valorise their work. The ultimate vision empowering the project is the widespread implementation of fibre-optic nervous systems dedicated to: (i) contributing to a safer society by returning early warnings for danger and (ii) ensuring sustainable development through the efficient exploitation of natural resources. The full set of specialists, who can turn this ambitious concept into a reality, is present in Europe and have teamed up to propose FINESSE training network.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 4.00M | Year: 2017

Nanowires (NWs) exhibit unique properties that make them potential building blocks for a variety of next generation NanoElectronics devices. Recent advances have shown that NWs with predefined properties can be grown, offering a new paradigm enabling functional device prototypes including: biosensors, solar cells, transistors, quantum light sources and lasers. The critical mass of scientific knowledge gained now needs to be translated into NW technologies for industry. FP7-MC NanoEmbrace (ITN) and FUNPROB (IRSES), made substantial contributions to NW research, producing excellent scientific and technological results (>100 journal papers published) and delivered outstanding training in nanoscience and transferable skills to ESRs. Despite demonstrable scientific and technological advantages of NWs, NW-based technology concepts have not yet been translated into market-ready products, because industry and academia have not worked hand-in-hand to commercialize the research findings. Thus, it is essential that NW research is now directed towards customer-oriented scientific R&D; whilst applying innovative industrial design techniques to ensure rapid translation of the basic technologies into commercial devices. This ambitious challenge requires close collaboration between academia and the nascent NW industry, combining the efforts of scientists and engineers to address market needs. Building upon our previous achievements, a team of leading scientific experts from top institutions in Europe, strengthened by experts in innovative design and industrial partners with an excellent track record of converting cutting edge scientific ideas into market products has formed the INDEED network to address this challenge. To enhance employability, INDEED will train young ESRs to become experts with a unique skill set that includes interdisciplinary scientific techniques, industrial experience through R&D secondments and innovative design skills.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: NFRP-06-2014 | Award Amount: 4.71M | Year: 2015

The multidisciplinary project will address key technical issues that must be tackled to support the implementation of planned geological disposal projects for higher-level radioactive wastes across the EU. Our current understanding of the impact of microbial metabolism on the safety of geological repositories remains tenuous, even though microorganisms may have controlling influences on wasteform evolution in situ, multibarrier integrity and ultimately radionuclide migration from the repository. This proposal targets a number of high urgency and high importance topics identified in the most recent IGD-TP Strategic Research Agenda, focusing specifically on the influence of microbial processes on waste forms and their behavior, and the technical feasibility and long-term performance of repository components. The project will bring together, for the first time, 15 European groups working on the impact of microbial processes on safety cases for geological repositories across the EU, focusing on key questions posed by waste management organisations. The emphasis will be on quantifying specific measureable impacts of microbial activity on safety cases under repository-relevant conditions, thus altering the current view of microbes in repositories and leading to significant refinements of safety case models currently being implemented to evaluate the long-term evolution of radwaste repositories. The integration of society and policy oriented studies in the project will also extend the impact of the project outside the scientific and technical domain, while a study of expert conceptualization, public perception and risk communication concerning microbial influences in geological disposal, will improve awareness of microbial issues on a broader level. The programme will help the EU claim international leadership in the understanding of the impact of microbial processes on geodisposal, and indeed other technological areas pertinent to the exploitation of the subsurface.


Hannestad S.,University of Aarhus | Hansen R.S.,University of Aarhus | Tram T.,Ecole Polytechnique Federale de Lausanne
Physical Review Letters | Year: 2014

Short baseline neutrino oscillation experiments have shown hints of the existence of additional sterile neutrinos in the eV mass range. However, such neutrinos seem incompatible with cosmology because they have too large of an impact on cosmic structure formation. Here we show that new interactions in the sterile neutrino sector can prevent their production in the early Universe and reconcile short baseline oscillation experiments with cosmology. © 2014 American Physical Society.


Hanahan D.,Ecole Polytechnique Federale de Lausanne | Coussens L.,Oregon Health And Science University
Cancer Cell | Year: 2012

Mutationally corrupted cancer (stem) cells are the driving force of tumor development and progression. Yet, these transformed cells cannot do it alone. Assemblages of ostensibly normal tissue and bone marrow-derived (stromal) cells are recruited to constitute tumorigenic microenvironments. Most of the hallmarks of cancer are enabled and sustained to varying degrees through contributions from repertoires of stromal cell types and distinctive subcell types. Their contributory functions to hallmark capabilities are increasingly well understood, as are the reciprocal communications with neoplastic cancer cells that mediate their recruitment, activation, programming, and persistence. This enhanced understanding presents interesting new targets for anticancer therapy. © 2012 Elsevier Inc.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: ICT-30-2015 | Award Amount: 9.43M | Year: 2016

The Internet of Things (IoT) brings opportunities for creating new services and products, reducing costs for societies, increasing the service level for the citizens in a number of areas, and changing how services are sold and consumed. Despite these opportunities, current information system architectures create obstacles that must be addressed for leveraging the full potential of IoT. One of the most critical obstacles are the vertical silos that shape todays IoT because they constitute a serious impediment to the creation of cross-domain, cross-platform and cross-organisational applications and services. Those silos also hamper developers from producing new added value across multiple platforms due to the lack of interoperability and openness. bIoTope provides the necessary Standardized Open APIs for enabling horizontal interoperability between silos. Such horizontal interoperability makes it possible to develop Systems of Systems where cross-domain information from platforms, devices and other information sources can be accessed when and as needed. bIoTope-enabled Systems can seamlessly exploit all available information, which makes them smart in the sense that they can take or propose the most appropriate actions depending on the current Users or Objects Context/Situation, and even learn from experience. bIoTope capabilities lay the foundation for open innovation ecosystems where companies can innovate both by the creation of new software components for IoT ecosystems, as well as create new Platforms for Connected Smart Objects with minimal investment. Large-scale pilots implemented in smart cities will provide both social, technical and business proofs-of-concept for such IoT ecosystems. This is feasible because the bIoTope consortium combines unique IoT experience, commercial solution providers and end-users, thus ensuring the high quality and efficiency of the results and implementations.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: SPA.2010.2.2-01 | Award Amount: 2.72M | Year: 2011

A range of new applications will be enabled by ultra-precise optical clocks, some of which by using them in space, near or far distant from Earth. They cover the fields of fundamental physics (tests of General Relativity), time and frequency metrology (comparison of distant terrestrial clocks, operation of a master clock in space), geophysics (mapping of the gravitational potential of the Earth), and potential applications in astronomy (local oscillators for radio ranging and interferometry in space). We propose to (1) develop two engineering confidence ultra-precise transportable lattice optical clock demonstrators with relative frequency instability < 110-15/root(tau)1/2, inaccuracy < 510-17, one of which as a breadboard. They will be based on trapped neutral Ytterbium and Strontium atoms. Goal performance is about 1 and 2 orders better than todays best transportable clocks, in inaccuracy and instability, respectively. The two systems will be validated in a laboratory environment (TRL 4) and performance will be established by comparison with laboratory optical clocks and primary frequency standards. (2) We will develop the necessary laser systems (adapted in terms of power, linewidth, frequency stability, long-term reliability, and accuracy), atomic packages with control of systematic (magnetic fields, black-body radiation, atom number), where novel solutions with reduced space, power and mass requirements will be implemented. Some of the laser systems will be developed towards particularly high compactness and robustness. Also, crucial laser components will be tested at TRL 5 level (validation in relevant environment). The work will build on the expertise of the proposers with laboratory optical clocks, and the successful development of breadboard and transportable cold Sr and Yb atomic sources and ultrastable lasers during the ELIPS-3 ESA development project Space Optical Clocks (SOC).


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.2.1 | Award Amount: 4.19M | Year: 2010

The development of flexible mobile manipulation systems is a promising area for the robotics industry as it allows to combine the success of manipulation robots with the flexibility of mobile robots. In the past, there has been a tremendous success in the areas of robotic manipulators and mobile robots. Many industrial processes highly depend on the reliability and robustness of robotic manipulators. On the other hand, research on mobile robots has led to systems that demonstrated the capability of safe and accurate navigation. The goal of this project is to integrate these two areas in the context of a real-world application scenario to build the basis for a new generation of autonomous mobile manipulation robots that can flexibly be instructed to perform complex manipulation and transportation tasks. The project will develop a novel robot programming environment that allows even non-expert users to specify complex manipulation tasks in real-world environments. In addition to a task specification language, the environment includes concepts for probabilistic inference and for learning manipulation skills from demonstration and from experience. The project will build upon and extend recent results in robot programming, navigation, manipulation, perception, learning by instruction, and statistical relational learning to develop advanced technology for mobile manipulation robots that can flexibly be instructed even by non-expert users to perform challenging manipulation tasks in real-world environments.The project results will be evaluated in a real-world setting involving mobile manipulation platforms built from state-of-the-art components and controlled by a fully integrated software system containing all developed components. The integrated system will, starting from a task specification, be capable of acquiring necessary low-level manipulation skills, imitating mobile manipulation behaviors demonstrated by a human it interacts with and, most importantly, will be able to generalize over such demonstrated behaviors to autonomously solve other tasks.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: AAT.2010.6.3-3. | Award Amount: 4.50M | Year: 2011

Considering the prevailing congestion problems with ground-based transportation and the anticipated growth of traffic in the coming decades, a major challenge is to find solutions that combine the best of ground-based and air-based transportation. The optimal solution would consist in creating a personal air transport system (PATS) that can overcome the problems associated with all of our current methods of transportation. We propose an integrated approach to enable the first viable PATS based on Personal Aerial Vehicles (PAVs) envisioned for travelling between homes and working places, and for flying at low altitude in urban environments. Such PAVs should be fully or partially autonomous without requiring ground-based air traffic control. Furthermore, they should operate outside controlled airspace while current air traffic remains unchanged, and should later easily be integrated into the next generation of controlled airspace. The myCopter project aims to pave the way for PAVs to be used by the general public within the context of such a transport system. Our consortium consists of experts on socio-technological evaluation to assess the impact of the envisioned PATS on society, and of partners that can make the technology advancements necessary for a viable PATS. To this end, test models of handling dynamics for potential PAVs will be designed and implemented on unmanned aerial vehicles, motion simulators, and a manned helicopter. In addition, an investigation into the human capability of flying a PAV will be conducted, resulting in a user-centred design of a suitable human-machine interface (HMI). Furthermore, the project will introduce new automation technologies for obstacle avoidance, path planning and formation flying, which also have excellent potential for other aerospace applications. This project is a unique integration of social investigations and technological advancements that are necessary to move public transportation into the third dimension.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.7.2 | Award Amount: 4.33M | Year: 2010

MUNDUS is an assistive framework for recovering direct interaction capability of severely motor impaired people based on arm reaching and hand function. Most of the solutions provided by Assistive Technology for supporting independent life of severely impaired people completely substitute the natural interaction with the world, reducing their acceptance. Human dignity and self-esteem are more preserved when restoring missing functions with devices safeguarding self perception and first hand interaction while guaranteeing independent living.\nMUNDUS uses any residual control of the end-user, thus it is suitable for long term utilization in daily activities. Sensors, actuators and control solutions adapt to the level of severity or progression of the disease allowing the disabled person to interact voluntarily with naturality and at maximum information rate.\nMUNDUS targets are the neurodegenerative and genetic neuromuscular diseases and high level Spinal Cord Injury.\nMUNDUS is an adaptable and modular facilitator, which follows its user along the progression of the disease, sparing training time and allowing fast adjustment to new situations. MUNDUS controller integrates multimodal information collected by electromyography, bioimpedance, head/eye tracking and eventually brain computer interface commands. MUNDUS actuators modularly combine a lightweight and non-cumbersome exoskeleton, compensating for arm weight, a biomimetic wearable neuroprosthesis for arm motion and small and lightweight mechanisms to assist the grasp of collaborative functional objects identified by radio frequency identification. The lightness and non cumbersomeness will be crucial to applicability in the home/work environment.\nSpecific scenarios in the home and work environment will be used to assess, subjectively and quantitatively, the usability of the system by real end-users in the living laboratory facility.


Grant
Agency: Cordis | Branch: H2020 | Program: IA | Phase: GALILEO-2-2014 | Award Amount: 1.53M | Year: 2015

The first objective is to build a mature prototype of a novel tandem terrestrial-aerial mapping system based on a terrestrial vehicle (TV) and on an unmanned aircraft (UA), both equipped with remote sensing payloads. The UA will follow the TV at a constant flying height above ground while geodata are acquired simultaneously from the TV and the UA. The final product is high resolution, oriented, calibrated and integrated images of a corridor and its environment. The second objective is to demonstrate services; i.e., the technical/commercial feasibility of the concept. The third objective is to develop the market: at the end of the project, contracts or negotiations shall be in place so the prototype can be used in operational conditions. MapKITE targets corridor mapping. It is a terrestrial-aerial surveying system that combines the advantages of the terrestrial and airborne (manned or unmanned) ones. It responds to corridor mapping market needs only fulfilled by much more expensive separate terrestrial and aerial missions. An enabling component is the navigation payload based on EGNOS and the E5 AltBOC Galileo signal, superior to existing/planned GPS signals and of particular interest for robustness/integrity. An octocopter of UAVision will be modified and equipped with the avoidance collision system of CATUAV. Due to the low weight of the UA (less than 5 kg), to its low flying altitude (range between 30 m and maximum allowed height) and to its inbuilt line of sight [TV to UA] keeping feature, mapKITE does not suffer from the regulations affecting UAS civilian use. Its design is dominated by safety and abidance to current and foreseeable rules for small UA. Unrestricted testing will be conducted in a segregated airspace area that has been recently awarded by the Spanish aviation authorities. MapKITE is highly innovative: new surveying paradigms, new mathematical models, new ways of fusing sensors and a new map product. It is protected by the Spanish patent 2012312


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: ICT-23-2014 | Award Amount: 6.93M | Year: 2015

The subject of this proposal is a robot assistant that is trained to understand maintenance tasks so that it can either pro-actively or as a result of prompting, offer assistance to maintenance technicians performing routine and preventative maintenance. Conceptually the robots task is to provide a second pair of hands to the maintenance engineer, such that once the robot has been trained it can predict when and how it can usefully provide help. The robots behavioural repertoire is learnt in a training phase that includes the monitoring of maintenance technician activity, the construction of a knowledge base that describes the context of a task, and a theory of action that enables dynamic behaviour generation. The result is a set of competencies coupled with an ability to recognise the state of a task and an understanding of how these competencies can be usefully deployed given the state. The scope of work includes the construction of a robot assistant, the systems that facilitate the training, the actual training on a number of representative tasks, perceptual systems that facilitate activity recognition, and validation of the systems ability to usefully contribute to tasks in collaboration with a maintenance engineer. Assessment of the system will test its ability to recognise when it doesnt know something as well as its ability to generalise its knowledge to previously unseen tasks.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP-2008-4.0-1 | Award Amount: 7.39M | Year: 2009

We propose a multidisciplinary program, focusing on the development of novel approaches for directing the differentiation, proliferation and tissue-tropism of specific hematopoietic lineages, using micro- and nano-fabricated cell chips. We will use advanced nanofabricated surfaces functionalized with specific biomolecules, and microfluidics cell chips to specify and expend regulatory immune cells for treating diverse inflammatory and autoimmune disorders in an organ- and antigen-specific manner. The proposed cell-chip will create ex-vivo microenvironments mimicking in-vivo cell-cell interactions and molecular signals involved in differentiation and proliferation of hematopoietic cells. Cell chip development and optimization will be supported by high throughput microscopy to select for optimal conditions. Educated cells will be employed for in vivo experiments in mice and the methodology will be further adapted for human cell populations, and applied for clinical diagnosis and therapy as well as the developments of clinically-relevant devices. Regulatory T-cells are extremely promising cells for treatment of inflammatory and auto-immune disease, as well as for tolerance induction in organ transplantation. To be effective they must be produced conveniently, at large numbers with an optimally tuned phenotype. The methodology is suggested to overcome current obstacles in obtaining therapeutically significant numbers of T cells. We propose to apply the suggested methodology for treating different inflammatory or autoimmune diseases including type-1 diabetes using targeted immunotherapeutic approaches. Developing new methods for producing large numbers of finely-tuned and tissue-targeted regulatory cells will make this approach clinically viable. This novel methodology can be extended to directing differentiation of other specific T-cell and hematopoietic lineages, with possible applications for targeting other autoimmune diseases and treating tumors or graft rejection.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.9.10 | Award Amount: 7.65M | Year: 2013

The aim of ASSISI_bf is to develop (1) a fundamental new class of distributed ICT systems, which are bio-hybrid collective adaptive systems (CASs) that consist of two sub-systems: One is a self-organising society of animals; the other one is a society of technical devices. These CASs will solve problems by distributed spatial computation; this heterogeneous system (animals, robots, nodes) will perform collective decision-making and maintain internal homeostasis. (2) We plan to develop a fundamental new method to design CASs by exploiting evolutionary computation on mathematical models that are used to drive the engineered part of the CAS. This way the collective of animals and robots will adapt to environmental changes and will maximize its efficiency and stability. (3) We will develop several novel benchmarks, using the level of acceptance of robots by the animal society as a hard-to-reach criterion. (4) Finally, we will derive a general model for heterogeneous CASs, which will be used to develop new algorithms for other heterogeneous robotic CASs. We address all 3 principles that should be researched for CASs, which are: design, operation and evolution. The project tackles several severe engineering challenges. It has a high potential of impact and foundational character on several communities. On the one hand it has the potential to establish a new field of science, which focuses on self-adapting engineered systems able to integrate themselves into an existing natural society. On the other hand, the proposed long-term impact reaches from establishing important new methods in agriculture, environmental sustainability policies, live stock management, environmental monitoring, bio-hybrid engineering and pharmaceutical industry, as our proposed technology allows fully automated (but non-invasive, non-harmful) experimentation with social animals. By deducting models and algorithms our project can also influence and promote general research of distributed ICT systems.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SPA.2013.2.1-01 | Award Amount: 2.55M | Year: 2013

The iMars project will focus on developing tools and value-added datasets to massively increase the exploitation of space-based data from NASA and ESA mission imaging and 3D data beyond the PI teams. iMars proposes to add value by creating more complete and fused 3D models of the surface from combined stereo and laser altimetry and use these 3D models to create a set of co-registered imaging data through time, permitting a much more comprehensive interpretation of the Martian surface to be made. Emphasis will be placed on co-registration of multiple datasets from different space agencies and orbiting platforms around Mars and their synergistic use to discover what surface changes have occurred since NASAs Viking Orbiter spacecraft in the mid-1970s. iMars brings together the best expertise in Europe for the processing of Martian orbital data within a single environment for handling, visualising and interpreting these data. The ESA Mars Express High Resolution Camera (HRSC) will provide the base data, where possible. The iMars base data can then be used by the ESA ExoMars Trace Gas Orbiter 2016 and subsequent ESA missions to provide the necessary inputs for selection of a future landing site for the ESA ExoMars 2018 rover and for any Mars Sample Return missions in the 2020s. It will greatly extend the use of archived data by providing mapped and co-registered images. The resultant time-stamped imagery will be interfaced to automated data mining analysis software based on techniques developed for Earth surveillance. We will also build on the huge momentum, developed in the Zoouniverse system by building a MarsZoo project for mass public participation in the feature mapping of Mars. Co-operation with US colleagues will be through the Technical Advisory board at annual project meetings and with European scientists through the workshops as well as the exploitation of the 3D datasets in visualisation engines such as Google Mars. The iMars datasets and tools will allow the creation of new communities of geoscientists. iMars will also allow much greater public participation in data analysis so stimulating a much greater interest in space-based data.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: FoF-ICT-2011.7.4 | Award Amount: 12.56M | Year: 2011

What is clearly missing in the current ICT landscape for manufacturing is an integrated, holistic view on data across the full product lifecycle. Especially the design and engineering of products and manufacturing processes is decoupled from the actual process execution. As experiences of the past show, a tight integration of all tools used throughout a product lifetime is not feasible.\nLinkkME addresses these shortcomings by providing an integrated, holistic view on data, persons and processes across the product lifecycle as a vital resource for the outstanding competitive design of novel products and manufacturing processes. To achieve this goal the project will develop the Linked Engineering and mAnufacturing Platform (LEAP) as an integrated information system for manufacturing design. LEAP federates all product lifecycle information relevant to drive engineering and manufacturing processes, independent of its format, location, originator, and time of creation. Besides the unified access to the integrated information, LEAP will provide specific knowledge exploitation solutions like sentiment analysis and design decision support systems to analyse the integrated information.\nWithin LinkkME we aim for a user-centric lifecycle information management. LEAP will provide a context-driven access to federated information and knowledge and foster cross-discipline collaborations between users by novel approaches for collaborative engineering.\nFinally, LinkkME will provide tight feedback connections to existing engineering tools (e.g., CAx Systems) in order to push back formalised knowledge to enable the automated design of elementary product components.\nAll concepts and components developed within the LinkkME project will be evaluated using three application prototypes deployed at the application partners industry sites. Further, the project team will develop four show case demonstrators in the Living Labs associated to the consortium.\nIn terms of impact, partners estimate reductions of up to 50% in time spent for search and knowledge acquisition through the improved (collaborative) information access and reductions of over 20% in time to market through support and automation of product and manufacturing design provided by the engineering platform.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-SA | Phase: INCO.2011-7.4 | Award Amount: 2.35M | Year: 2011

EUJO-LIMMS aims to reinforce research collaboration between Europe and Japan to tackle new challenges in micro and nano technologies. The strategy consists in opening the activity of an international laboratory, the Laboratory for Integrated Micro Mechatronic Systems (LIMMS), located in Tokyo, to European partners. The LIMMS is a research unit between CNRS and the Institute of Industrial Sciences of the University of Tokyo (UT-IIS). More than 100 French researchers have stayed at LIMMS and have combined their scientific and technological expertise with their Japanese hosts. EUJO-LIMMS will open LIMMS structure and hosting capacities to researchers from three European partners. To guaranty a smooth evolution, the partners having already networking activities with both CNRS and UT agreed to join the program. These partners are EPFL in Switzerland, IMTEK in Germany and VTT in Finland. The scientific challenge of EUJO-LIMMS is to push the frontiers of micro and nano systems technology in capitalising the complementary expertise of UT and European partners. The hosted European researchers will develop joint projects for new applications in flexible electronics, optics, nanotechnology, molecular and cellular bio-engineering. At mid-project a call will be organised to expend the collaboration to European researchers from other Member States or Associated Countries. The proposals will be stimulated by an open workshop in Europe and the new partner will be selected by the EUJO-LIMMS consortium. The opening of the institutional arrangement of LIMMS/CNRS-UT to additional partners will be studied on the basis of the experience acquired by UT and CNRS, and on the discussions with the consortium. The EUJO-LIMMS targets significant enhancement of EU-Japans collaborations, as the scientific topic addresses micro- and nanotechnologies, a blooming area where many applications are foreseen. Japan is ahead in that field and is a country where the Technology is a Science.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.8.5 | Award Amount: 7.94M | Year: 2010

Future software-intensive systems, such as sensor networks, power grids, satellite and robot swarms, will generally exhibit a number of characteristic features:* Massive numbers of nodes, nodes with complex behavior, or complex interactions between nodes.* Operation in open and non-deterministic environments with variable network topology.* Need for adaptation, e.g., to changing environments and requirements.We call this future generation of software-intensive systems ensembles. The potentially huge impact - both positive and negative - of ensembles means that we need to understand ways to reliably and predictably model, design, and program them.Although there is a lot of research in this area, so far no theoretically well-founded technique for building ensembles exists. The goal of the ASCENS project is to develop such a method and to demonstrate its feasibility in three important application domains: robot swarms, cloud computing and e-mobility.


Grant
Agency: GTR | Branch: EPSRC | Program: | Phase: Research Grant | Award Amount: 605.74K | Year: 2015

The project Compressive Imaging in Radio Interferometry (CIRI) aims to bring new advances for interferometric imaging with next-generation radio telescopes, together with theoretical and algorithmic evolutions in generic compressive imaging. Radio Interferometry (RI) allows observations of the sky at otherwise inaccessible angular resolutions and sensitivities, providing unique information for astrophysics and cosmology. New telescopes are being designed, such as the Square Kilometer Array (SKA), whose science goals range from astrobiology and strong field gravity, to the probe of early epochs in the Universe when the first stars formed. These instruments will target orders of magnitudes of improvement in resolution and sensitivity. In this context, they will have to cope with extremely large data sets. Associated imaging techniques thus literally need to be re-invented over the next few years. The emerging theory of compressive sampling (CS) represents a significant evolution in sampling theory. It demonstrates that signals with sparse representations may be recovered from sub-Nyquist sampling through adequate iterative algorithms. CIRI will build on the theoretical and algorithmic versatility of CS and leverage new advanced sparsity and sampling concepts to define, from acquisition to reconstruction, next-generation CS techniques for ultra-high resolution wide-band RI imaging and calibration techniques. The new techniques, and the associated fast algorithms capable of handling extremely large data sets on multi-core computing architectures, will be validated on simulated and real data. Astronomical imaging is not only a target, but also an essential means to trigger novel generic developments in signal processing. CIRI indeed aims to provide significant advances for compressive imaging thereby reinforcing the CS revolution, which finds applications all over science and technology, in particular in biomedical imaging. CIRI is thus expected to impact science, economy, and society by developing new imaging technologies essential to support forthcoming challenges in astronomy, and by delivering a new class of compressive imaging algorithms that can in turn be transferred to many applications, starting with biomedical imaging.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FETPROACT-01-2016 | Award Amount: 10.00M | Year: 2017

The hybrid optomechanical technologies (HOT) consortium will lay the foundation for a new generation of devices, which connect, or indeed contain, several platforms at the nanoscale in a single hybrid system. As hybrid interfaces they will allow to harness the unique advantages of each subsystem within a nano-scale footprint, while as integrated hybrid devices they will enable entirely novel functionalities. A particular focus will be on nano-optomechanical devices that comprise electrical, microwave or optical systems with micro- and nano-mechanical systems. Research in the past decade, in particular by European groups, has shown the significant technological potential that such nano-optomechanical systems can offer, in particular by establishing a new way in which optical, radio-frequency and microwave signals can be interfaced. The present consortium includes leading academic groups and industrial partners to explore the potential of these hybrid-nano-optomechanical systems. It will explore hybrid opto- and electro-mechanical devices operating at the physical limit for conversion, synthesis, processing, sensing and measurement of EM fields, comprising radio, microwave frequencies to the terahertz domain. These spectral domains open realistic applications in the existing application domains of medical (e.g. MRI imaging), security (e.g. Radar and THz monitoring), positioning, timing and navigations (Oscillators) and for future quantum technology. The research aims at specific technological application, with realistic operating conditions and seeks to develop actual system demonstrators. In addition, it will explore how these hybrid transducers can be fabricated within standard CMOS processing, and thereby be made compatible with current manufacturing methods. The HOT devices will thereby impact todays technology and likewise address potential future need for the manipulation of quantum signals.


Grant
Agency: Cordis | Branch: H2020 | Program: IA | Phase: ICT-14-2016-2017 | Award Amount: 3.94M | Year: 2017

AEGIS, brings together the data, the network & the technologies to create a curated, semantically enhanced, interlinked & multilingual repository for public & personal safety-related big data. It delivers a data-driven innovation that expands over multiple business sectors & takes into consideration structured, unstructured & multilingual datasets, rejuvenates existing models and facilitates organisations in the Public Safety & Personal Security linked sectors to provide better & personalised services to their users. AEGIS will introduce new business models through the breed of an open ecosystem of innovation & data sharing principles. From the technology perspective, AEGIS targets to revolutionise semantic technologies in big data, big data analytics & visualisations as well as security & privacy frameworks by addressing current challenges & requirements of cross-domain & multilingual applications. The main benefits derived from AEGIS to data identification, collection, harmonisation, storage & utilisation towards value generation for these sectors will be: Unified representation of knowledge; Accelerated, more effective & value-packed cycles of intelligence extraction & of services & applications development; Introduction of novel business models for the data sharing economy & establishment of AEGIS as a prominent big data hub, utilising cryptocurrency algorithms to validate transactions & handle effectively IPRs, data quality & data privacy issues though a business brokerage framework. Based on an early market analysis, the Total Addressable Market of AEGIS is up to $31bn (27.1bn); AEGIS is able not only to capture a portion of the market size, but also to expand the pie through creating additional uncaptured value based on small data integration in typical big data repositories & algorithms. Based on the same analysis, the project will break even & will be viable from its launch (2020) & will have a ROI investment of EU-commission in the first years.


Grant
Agency: Cordis | Branch: H2020 | Program: IA | Phase: ICT-22-2016 | Award Amount: 6.34M | Year: 2017

Next-Lab intends to change the educational landscape of science and technology education in Europe on a very large scale. The project offers a unique and extensive collection of interactive online (virtual and remote) laboratories that, through a process of mixing and re-use, can be straightforwardly and efficiently combined with dedicated support tools (learning apps) and multimedia material to truly form open, cloud-based, shareable educational resources with an embedded pedagogical structure. Next-Lab offers extensive opportunities for localisation and personalisation together with analytics facilities monitoring students progress and achievements. Next-Lab is designed to rely on full co-creation with users in combination with rapid development and testing cycles. Next-Lab builds on the highly successful (FP7) Go-Lab project that already offers online labs, inquiry learning apps, and authoring facilities for inquiry learning. To amplify the existing impact to the next-level innovation stage, Next-Lab extends the Go-Lab system with tools for the learning of 21st century skills, facilities for self- and peer-assessment and portfolio development, as well as opportunities to include learning by modeling. Next-Lab will cover secondary and also primary education, to ensure an early positive attitude towards science and technology and the continuous availability of innovative learning material throughout students school career. To guarantee long-term impact, Next-Lab also addresses the teachers of the future by its presence in pre-service teacher training programs throughout Europe. To evaluate its impact, Next-Lab combines usage data analysis techniques for very large-scale pilots with in-depth, qualitative, case-based, assessments. Next-Lab prepares for a following sustainable stage of the product. As it builds upon and extends existing networks of teachers, professional associations, and policymakers, the impact of Next-Lab will be massive.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FETHPC-1-2014 | Award Amount: 5.80M | Year: 2015

MANGO targets to achieve extreme resource efficiency in future QoS-sensitive HPC through ambitious cross-boundary architecture exploration for performance/power/predictability (PPP) based on the definition of new-generation high-performance, power-efficient, heterogeneous architectures with native mechanisms for isolation and quality-of-service, and an innovative two-phase passive cooling system. Its disruptive approach will involve many interrelated mechanisms at various architectural levels, including heterogeneous computing cores, memory architectures, interconnects, run-time resource management, power monitoring and cooling, to the programming models. The system architecture will be inherently heterogeneous as an enabler for efficiency and application-based customization, where general-purpose compute nodes (GN) are intertwined with heterogeneous acceleration nodes (HN), linked by an across-boundary homogeneous interconnect. It will provide guarantees for predictability, bandwidth and latency for the whole HN node infrastructure, allowing dynamic adaptation to applications. MANGO will develop a toolset for PPP and explore holistic pro-active thermal and power management for energy optimization including chip, board and rack cooling levels, creating a hitherto inexistent link between HW and SW effects at all layers. Project will build an effective large-scale emulation platform. The architecture will be validated through noticeable examples of application with QoS and high-performance requirements. Ultimately, the combined interplay of the multi-level innovative solutions brought by MANGO will result in a new positioning in the PPP space, ensuring sustainable performance as high as 100 PFLOPS for the realistic levels of power consumption (<15MWatt) delivered to QoS-sensitive applications in large-scale capacity computing scenarios providing essential building blocks at the architectural level enabling the full realization of the ETP4HPC strategic research agenda.

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