Relation between structure and function, of the cerebral artery "carotid" in laboratory rat submitted to atherogenic diet [Relation entre structure et fonction de lartère cérébrale «carotide» chez le rat Wistar soumis à un régime athérogène]
Ainouz L.,Ecole nationale superieur veterinaire |
Ainouz L.,Mohammed V University |
Baz A.,Mohammed V University |
Ammar Aouchiche M.A.,Mohammed V University |
And 5 more authors.
Annales de Cardiologie et d'Angeiologie | Year: 2015
Objective of the study: The aim of our investigation was the study of the pathophysiology of the carotid artery in cases of nutritional stress in male atheroresistant Wistar rats. Materials and methods: Were administered daily by gavage to experimental rats a high fat diet consisting of peanut oil, cholesterol (3%) and sodium cholate (1%). Throughout this experiment, we conducted monitoring of some biochemical parameters and the morpho-histopathology of the carotid cerebral artery. The results obtained are compared to those of control rats in the same experimental conditions. Results: We found that this fat diet resulted in experimental rats disruption of biochemical tests and tissular and cellular alterations in carotid wall. Indeed, the biochemical examination shows a significant increase of the parameters studied. Morphological examination revealed thickening of the carotid wall and histopathological examination of this artery, highlights the installation of a vascular remodeling from thickening of the intima-media to the installation of a probable atherosclerosis accompanied by a possible hyalinization and a net fibrosis. Conclusion: At the end of this study, although notes that our fat diet could cause a metabolic disorder that can cause multiple tissue and cell damage observed in cerebral artery "carotid" of atheroresistant rats. © 2015 Elsevier Masson SAS.