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Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 4.01M | Year: 2012

OLIMPIA is a training network initiative built on research and development of innovative organic optoelectronic devices interfaced and integrated with living systems. The living systems of choice are neural cells (glia and neuron) that will be interfaced and integrated in vitro and in vivo with different organic electronic and optoelectronic devices (such as OLED, OFET/OLET, OECT, OPD). The major objective of OLIMPIA is to establish an innovative training program aimed at enabling and supporting the development of a novel supradisciplinary field that combines the worlds of organic optoelectronics and of neuroscience. Novel tools based on organic optoelectronic devices will be engineered and developed to stimulate and to record neuron bioelectrical activity, such as neuron excitability and membrane polarization, as well as to modulate cell proliferation and neurite outgrowth. The OLIMPIA research will provide radically new understanding of neural cell-cell communication processes and will impact a wide variety of fields, from biomedical research to neuro-regenerative medicine. The OLIMPIA consortium is both interdisciplinary and intersectorial. It includes key European players with long standing and internationally recognized research tradition in the field of organic electronics and optoelectronics, organic synthesis as well as neural cell biology and neurophysiology and, as such, is uniquely qualified to implement this ambitious supradisciplinary training program. Moreover, the consortium combines 10 partners belonging to 6 European countries from academia, public research centers and industrial labs thereby offering an exciting and broad training landscape to the new generation of researchers.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.78M | Year: 2013

Organic Bioelectonics is a new discipline which holds promise to shape, direct, and change future medical treatments in a revolutionary manner over the next decades. At the moment Europe has a unique leading position in this area, being almost all the world-leading groups in this field located in Europe and constituting the core of this international training network. However, realizing the promise of Organic bioelectronics requires research and training not only crossing disciplines, such as electrical engineering, biology, chemistry, physics, and materials science, but also crossing our European countries. The EU will add value on the global scene only if it acts jointly. OrgBIO is at the core of European technological innovation and will become an indispensable part of the educational canon. It will establish a world-class training platform spreading around the highly interdisciplinary / intersectorial European-led area of organic bioelectronics. Education along with science and entrepreneurial mindsets and attitudes is the core of the OrgBIO training programme, which aims at excellence and innovation, at all level. Excellence in science is guaranteed by the world-leading groups which founded this research area. Innovation in education is guaranteed by the involvement of researchers on education, business experts. Using different sensors, actuators, electronic and interconnect technologies the network will develop multifunctional systems based on organic devices and materials with high sensitivity that are also flexible, conformable and present over large areas for various biomedical / biological applications in the life science. Multi-analyte and disposable analytical systems manufactured by large-area printing methods will provide services to the individuals and healthcare community. Targeted implemented interactions with a wide network of venture capitals and business actors will immediately transfer the research outcome to the European Industry.


Patent
Jean Monnet University, Ecole Nationale Superieure des Mines de Saint - Etienne CMP and Etablissement Francais Du Sang | Date: 2013-03-14

A device for the storage of a corneal specimen has means for the reception and entrapment of a corneal specimen, connected to the means for the creation of a pressure gradient with overpressure on the endothelial side and to the preservation medium circulation means in the layouts that present the means for the reception and entrapment of the cornea specimen. The means for the reception and entrapment of the corneal specimen entrap the sclera ciliary zone surrounding the cornea in an airtight manner to delimit a separate endothelial chamber and epithelial chamber in which the preservation medium can circulate with an overpressure in the endothelial chamber; The intermediate component and the endothelial lid comprise inlet and outlet orifices for the preservation medium which are connected to the means for the circulation of the preservation medium and the creation of a pressure gradient between the endothelial chamber and the epithelial chamber with overpressure in the endothelial chamber.


Battaia O.,Ecole Nationale Superieure des Mines de Saint - Etienne CMP | Dolgui A.,Ecole Nationale Superieure des Mines de Saint - Etienne CMP
International Journal of Production Economics | Year: 2013

Line balancing belongs to a class of intensively studied combinatorial optimization problems known to be NP-hard in general. For several decades, the core problem originally introduced for manual assembly has been extended to suit robotic, machining and disassembly contexts. However, despite various industrial environments and line configurations, often quite similar or even identical mathematical models have been developed. The objective of this survey is to analyze recent research on balancing flow lines within many different industrial contexts in order to classify and compare the means for input data modelling, constraints and objective functions used. This survey covers about 300 studies on line balancing problems. Particular attention is paid to recent publications that have appeared in 2007-2012 to focus on new advances in the state-of-the-art. © 2012 Elsevier B.V.


Malliaras G.G.,Ecole Nationale Superieure des Mines de Saint - Etienne CMP
Biochimica et Biophysica Acta - General Subjects | Year: 2013

Background: This issue of "Biochimica et Biophysica Acta - General Subjects" is dedicated to organic bioelectronics, an interdisciplinary field that has been growing at a fast pace. Bioelectronics creates tremendous promise, excitement, and hype. The application of organic electronic materials in bioelectronics offers many opportunities and is fuelled by some unique features of these materials, such as the ability to transport ions. Scope of review: This is a perspective on the history and current status of the field. Major conclusions: Organic bioelectronics currently encompasses many different applications, including neural interfaces, tissue engineering, drug delivery, and biosensors. The interdisciplinary nature of the field necessitates collaborations across traditional scientific boundaries. General significance: Organic bioelectronics is a young and exciting interdisciplinary field. This article is part of a Special Issue entitled Organic Bioelectronics - Novel Applications in Biomedicine. © 2012 Elsevier B.V.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.1.4 | Award Amount: 5.10M | Year: 2012

The security of modern ICT (Information and Communication Technologies) systems relies fundamentally on the integrity of hardware components. This is the case for user identification and authentication as in smartcards, e-Id, e-Passports, e-health devices or for the integrity checking of computers and mobile systems as in trusted computing and TPMs. But it is also the case for telecommunication infrastructure as e.g. for servers or routers to support cloud computing.\nUnfortunately, attacks on hardware devices keep on improving. Physical attacks, giving access to internal information, side channel attacks, using passive observations of execution time, power consumption or electro-magnetic radiations, or fault injection attacks using power glitches, light, laser and electro-magnetic perturbations are proven ways of retrieving secrets. Today security circuits are protected to a certain level against these attacks, but an absolute protection (Tamper resistance) is unrealistic and the need of extra barriers arises.\nNew security challenges arise: counterfeiting of hardware components is dramatically increasing (some studies indicate from 5 to 20 % of counterfeited components on the market) and the threat of Trojans or hidden functions in Integrated Circuits is moving from theoretical to real.\nThe HINT project addresses these new challenges by proposing the development of novel integrity technologies to guarantee that a system is a genuine, non-modified one including the hardware components. Innovative hardware authentication and integrity checking technologies, based on PUF (Physically Unclonable Functions) and on Physical measurements (Side Channel Analysis) will be developed to offer an extra security barrier based on paradigms complementary to cryptography. The approach is related to the Trusted Computing one, but the major difference is the addition of hardware authentication and hardware integrity checking features to the software integrity checking chain.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-IF-EF-ST | Phase: MSCA-IF-2015-EF | Award Amount: 173.08K | Year: 2016

In the European Union alone, the annual number of bone fractures is projected to reach 4.5 million in 2025. Despite the advances in implant technology, grafts prepared using bone extracted from the patient to fill the bone defect are the only material reported so far to retain any significant efficacy in sustaining new bone formation. However, the aging worldwide population and increased life expectancy call for a different answer to the growing need for effective implants for bone fracture healing. The 3D-BONE project will develop an in vitro 3D model to investigate electrical stimulation of stem cells based on biocompatible electroactive 3D scaffolds produced by the ice-templating technique. Electrical stimulation has been shown to positively affect stem cells differentiation into both bone- and vessels-forming cells. One of the key novelty of the 3D-BONE project is the use of human neural crest-derived stem cells (NCSCs). The study of this system in vitro will contribute to increasing the knowledge on a cell population that has the remarkable characteristic of preserving their potentialities to differentiate towards multiple lineages also in the adult. They can thus be isolated from the patient in need of the bone graft, with no need of external donors. Cells response to the applied electrical stimulus will be investigated using an organic electrochemical transistor (OECT) that will be integrated in the developed device and will allow for label-free monitoring of cells through an electronic readout. Altogether, the results of these studies will prove beneficial to increase the knowledge on electrically stimulated stem cells differentiation, providing new key tools for the development of implants to be successfully used in critical size defects healing.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2013-IRSES | Award Amount: 121.80K | Year: 2013

The goal of the PolyMed project is to develop a lasting collaboration between top class research teams in Europe and the US/Canada that fosters progress in the broad area of organic bioelectronics through progress in materials science. This will be realized via a cross-European, trans-continental network. Such a network is required as materials science is a discipline that has emerged first from a convergence of chemistry and physics, but has also recently embraced biological sciences, gaining cues from biological processes for design of novel materials. The PolyMed network will be a key driver for materials science through rapid identification and development of novel applications for existing and new materials, and will advance technological processes by building in enhanced capabilities in devices made from these materials; for example for sensing biological events or indeed acting as surrogates in case of biological dysfunction, i.e. in prosthetics. The combined expertise in PolyMed is essential to achieve a transformative impact.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-IEF | Phase: FP7-PEOPLE-2012-IEF | Award Amount: 269.74K | Year: 2013

ProtEprobe takes advantage of the recent cutting edge developments in protein conformation control at the Malliaras group and high sensitive protein sensing using high sensitivity factor triangular silver nanoplates by the fellow. Misfolding of a protein occurs when it becomes trapped in a local potential energy minimum where the conformation differs from the native-state structure. External electric fields have been demonstrated to distinctly alter protein secondary structures. Proteins associated with protein misfolding diseases, incuding neurodegenerative diseases such as Alzheimers, undergo conformational changes such as the transformation of largely random coiled or -helix structures to the highly ordered -structures found in protein fibrils. Amyloid fibrils formed from peptide Amyloid beta (A), are a major component of amyloid plaques in the brains of Alzheimers patients. The ProtEprobe technique will use electrical potential gradients to stimulate and control the conformation transitions of proteins including the cell adhesion protein Fibronectin and A on 3D electrospun conductive polymer tissue scaffolds. The high sensitive spectral response of the nanoplate monitors will be used to analyse protein conformational transitions and observe the progression of A fibril formation. Investigations will be carried out to ascertain the impact of the presence of an electric field and the capacity to tune the strength in order to enable improved understanding and selection of protein conformations on tissue scaffolds, towards enhancing cell surface interactions, healing of misfolding and facilitating the restoration of the structure and function of diseased tissues. In a paradigm step towards imparting a new dimension to tissue regeneration, ProtEprobe will develop 3D bioactive scaffolds with electrically programmable protein conformation and in situ real-time protein nanomonitors paving the way for the treatment and prevention of many neurodegenerative diseases.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-IEF | Phase: FP7-PEOPLE-2013-IEF | Award Amount: 194.05K | Year: 2015

There is a pressing need to move away from animal testing and animal models for the toxicological profiling of chemical substances and new drug formulations. For this reason the generation and validation of alternative test methods of in vitro tissue models is required. The IN TIME project proposes to bring together recent advances in the fields of organ-on-chips (micro-fluidics incorporating in vitro cell growth) with a highly performant electronic monitoring system to provide in-line monitoring of target parameters. The IN TIME platform will use state of the art micro-fluidic technology which will allow for realistic stresses and flows that mimic those to which tissue is subjected to in vivo. It will also harness recent advances in the field of organic bioelectronics which have seen the development of cutting edge devices capable of interfacing with biological systems for rapid and highly sensitive monitoring of tissue in vitro. A key advantage of the proposed platform is that it will use low cost approaches and materials, compatible with current cell culture laboratories for easy integration and use. Through the collaborations of specialists in biology and bioelectronics, the applications micro-fluidics and OECTs for in-line biomedical applications will be exploited. The success of the IN-TIME project will result in a novel organ-on-chip platform that will assist significantly in realizing the 3Rs goal of replacement, refinement and reduction of animal testing, thus contributing to the competitiveness of European research teams, and the training of European researchers in this area of strategic importance.

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