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Lamont R.W.,University of The Sunshine Coast | Conroy G.C.,University of The Sunshine Coast | Reddell P.,EcoBiotics Ltd | Ogbourne S.M.,University of The Sunshine Coast
BMC Plant Biology | Year: 2016

Background: Fontainea picrosperma, a subcanopy tree endemic to the rainforests of northeastern Australia, is of medicinal significance following the discovery of the novel anti-cancer natural product, EBC-46. Laboratory synthesis of EBC-46 is unlikely to be commercially feasible and consequently production of the molecule is via isolation from F. picrosperma grown in plantations. Successful domestication and plantation production requires an intimate knowledge of a taxon's life-history attributes and genetic architecture, not only to ensure the maximum capture of genetic diversity from wild source populations, but also to minimise the risk of a detrimental loss in genetic diversity via founder effects during subsequent breeding programs designed to enhance commercially significant agronomic traits. Results: Here we report the use of eleven microsatellite loci (PIC = 0.429; P ID = 1.72 × 10-6) to investigate the partitioning of genetic diversity within and among seven natural populations of F. picrosperma. Genetic variation among individuals and within populations was found to be relatively low (A = 2.831; H E = 0.407), although there was marked differentiation among populations (PhiPT = 0.248). Bayesian, UPGMA and principal coordinates analyses detected three main genotypic clusters (K = 3), which were present at all seven populations. Despite low levels of historical gene flow (N m = 1.382), inbreeding was negligible (F = -0.003); presumably due to the taxon's dioecious breeding system. Conclusion: The data suggests that F. picrosperma was previously more continuously distributed, but that rainforest contraction and expansion in response to glacial-interglacial cycles, together with significant anthropogenic effects have resulted in significant fragmentation. This research provides important tools to support plantation establishment, selection and genetic improvement of this medicinally significant Australian rainforest species. © 2016 Lamont et al. Source


Patent
Ecobiotics Ltd | Date: 2013-05-17

The present invention relates to spiroketal compounds that are useful in methods of treating or preventing protozoal infections, parasitic infections, bacterial infections, cell proliferative disorders and anti inflammatory disorders. The spiroketal compounds are also useful as immunosuppressive agents, and also in methods of controlling pests.


Patent
Ecobiotics Ltd | Date: 2011-08-11

The present invention relates to spiroketal compounds that are useful in methods of treating or preventing protozoal infections, parasitic infections, bacterial infections, cell proliferative disorders and anti inflammatory disorders. The spiroketal compounds are also useful as immunosuppressive agents, and also in methods of controlling pests.


Maslovskaya L.A.,QIMR Berghofer Medical Research Institute | Savchenko A.I.,University of Queensland | Krenske E.H.,University of Queensland | Gordon V.A.,EcoBiotics Ltd | And 4 more authors.
Chemical Communications | Year: 2014

Investigation of Croton insularis afforded the first in class seco-casbane diterpene, EBC-329. A highly oxidised casbane, EBC-324, was also isolated. The structural motif within EBC-324, which consists of an epoxidised hemi-acetal endoperoxide, is new to the casbane family. This journal is © the Partner Organisations 2014. Source


Maslovskaya L.A.,University of Queensland | Savchenko A.I.,Queensland Institute of Medical Research | Gordon V.A.,EcoBiotics Ltd | Reddell P.W.,EcoBiotics Ltd | And 3 more authors.
Organic Letters | Year: 2011

The proposed cleistanthol biosynthetic intermediate en route to spruceanol, and other related family members, was isolated for the first time from Croton insularis, confirming the Jacobs-Reynolds hypothesis. Anticancer evaluation of the new isolates and their aerial oxidation products is also reported.(Figure Presented) © 2011 American Chemical Society. Source

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