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Lincoln, IL, United States

Eastern Illinois University is a state university located in Charleston, Illinois, United States. Established in 1895 as the Eastern Illinois State Normal School, a teacher's college offering a two-year degree, Eastern Illinois University gradually expanded into a comprehensive university with a broad curriculum, including Baccalaureate and Master's degrees in education, business, arts, science, and humanities. Wikipedia.

Chesner C.A.,Eastern Illinois University
Quaternary International | Year: 2012

The Toba Caldera in Indonesia is one of the most remarkable volcanic features formed during Quaternary geologic time. Its rich history of research for over a century has yielded important information on the physical volcanology of silicic calderas and super-eruptions, geochemical evolution of silicic magma bodies, and geophysical imaging of active sub-volcanic systems. During the past 1.3 my, the Toba area has erupted intermediate composition lavas, followed by intermediate pyroclastics, three quartz-bearing silicic tuffs, and most recently, intermediate to silicic lavas. This pattern represents the incremental assembly and periodic eruption of a crustal magma body of batholithic proportions. The apparent migration of activity to the west, may have implications for the next? Toba super-eruption. © 2011 Elsevier Ltd and INQUA.

The present study examined the incremental validity of Wechsler Adult Intelligence Scale- 4th Edition (WAIS-IV; Wechsler, 2008a) factor index scores in predicting academic achievement on the Wechsler Individual Achievement Test-2nd Edition (WIAT-II; Psychological Corporation, 2002a) and on the Wechsler Individual Achievement Test-3rd Edition (WIAT-III; Wechsler, 2009a) beyond that predicted by the WAIS-IV Full Scale IQ (FSIQ). As with previous intelligence test incremental validity studies, the WAIS-IV FSIQ accounted for statistically significant and generally large portions of WIAT-II and WIAT-III subtest and composite score variance. WAIS-IV factor index scores combined to provide statistically significant increments in variance accounted for in most WIAT-II and WIAT-III subtest and composite scores over and above the FSIQ score; however, the effect sizes ranged from trivial to medium as observed in investigations with other intelligence tests (i.e., Glutting, Watkins, Konold, & McDermott, 2006; Youngstrom, Kogos, & Glutting, 1999). Individually, the WAIS-IV factor index scores provided trivial to small unique contributions to predicting WIAT-II and WIAT-III scores. This finding indicated that the FSIQ should retain primacy and greatest interpretive weight in WAIS-IV interpretation, as previously indicated by WAIS-IV subtest variance partitions form hierarchical exploratory factor analyses (Canivez & Watkins, 2010a, 2012b) © 2013 American Psychological Association.

Agency: NSF | Branch: Standard Grant | Program: | Phase: Chemical Measurement & Imaging | Award Amount: 267.97K | Year: 2015

With this award, the Chemical Measurement and Imaging Program of the Division of Chemistry is funding Professor Hongshan He of Eastern Illinois University to develop new chemical compounds for bio-imaging and sensing. These compounds can be used to label tissues or other target structures, and after being activated by a light source, emit light, enablingimaging. Professor Hes approach is to develop compounds that (i) do not need to be activated by ultraviolet light as such high energy radiation can damage biological tissues, and (ii) emit light at characteristic wavelengths that are not present in background emissions associated with biological systems. The project aims to provide opportunities for undergraduates to participate in research and gain hands-on research experience. The participation of high school students and science teachers in summer workshops is designed to stimulate student interest in pursuing studies in STEM fields.

Fluorescent materials are used for a variety of biomedical diagnostic applications, such as immunoassays. The significant overlap of biological substrate autofluorescence and fluorescence from commercially available probes dramatically compromises detection sensitivity. This project is aimed to address fundamental questions and such technical issues by developing rationally designed near-infrared emitting lanthanide materials through synthesis, computation, and photophysical studies. The project is focusing on BODIPY-based chromophores and aims to address a long-standing corollary concern of poor near-infrared emission of lanthanide materials in aqueous solutions. To meet the challenge, the lanthanide complexes are to be transformed to metallopolymers through carbon-carbon coupling reactions to suppress quenching and enable efficient near-infrared emission to be retained. The metallopolymers being targeted are designed to emit in the near-infrared region of the spectrum (900-1600 nm) under longer excitation wavelengths,thereby reducing autofluorescence and photobleaching.

Agency: NSF | Branch: Continuing grant | Program: | Phase: SOLID STATE & MATERIALS CHEMIS | Award Amount: 225.00K | Year: 2015

Non-technical Abstract
With the support of the Solid State and Materials Chemistry program in the Division of Materials Research, this project explores how molecular shape impacts the internal organization of crystalline solids. Because material properties intimately relate to the composition of the building-blocks and their alignment, a greater understanding of the factors that influence component interactions holds much importance to the development of advanced materials that exhibit a wide-variety of functional properties. The project is anchored by a research team at Eastern Illinois University and will prove useful for probing the structural boundaries of the recognition process by investigating the complementary shapes of molecular neighbors. The educational and service component of the activity focuses on training students (undergraduate and Masters level) as scientists for careers in STEM fields, developing teaching modules for the introductory organic laboratory, and providing X-ray instrument services to the greater academic community of small colleges and universities that support rigorous undergraduate research programs.

Technical Abstract
Many functions of solid materials require exquisite control over the molecular architectures of their building blocks. The construction of structurally controlled supramolecular assemblies (e.g., bulk solids) is still at a primitive level despite great progress in the chemical synthesis of discrete molecules over the past few decades. This project explores the structural boundaries of molecular shape to the molecular recognition process by using the quasiracemate approach for constructing bimolecular compounds. Chiral building blocks formulated from known organic precursors will be synthesized via diarylamide and Pemoline templates. Since it is well known that a high propensity exists for organic molecules to arrange in centrosymmetric relationships, this activity explores the supramolecular behavior of these molecules to form quasicentrosymmetrically related aggregates. Video-supported thermomicroscopy and calorimetric techniques will be used to investigate the ability of pairs of materials to assemble. X-ray diffraction techniques will help determine the detailed structures of the materials obtained and assist with determining the topological contributions to these molecular assemblies.

Agency: NSF | Branch: Standard Grant | Program: | Phase: Chemistry of Life Processes | Award Amount: 396.36K | Year: 2016

With this award, the Chemistry of Life Processes in the Chemistry Division is funding Dr. Mary E. Konkle (Department of Chemistry, Eastern Illinois University), Dr. Michael A. Menze (Department of Biological Sciences, Eastern Illinois University), and Dr. Nilay Chakraborty (Department of Engineering, University of Michigan-Dearborn) to investigate the novel chemical properties of the recently described human protein mitoNEET and their impact on life processes. Energy can be produced through different pathways in cells. How the traffic of fuel through these pathways is directed is still unclear. Evidence suggests that mitoNEET, a novel iron-sulfur containing human protein, regulates the flow of fuel through different pathways in a tissue specific manner. This role directly links chemistry of iron-sulfur proteins to the life process of energy generation. Our integrated approach combines techniques from biochemistry, molecular biology, and bioengineering to address the role of mitoNEET in cells. Students are acquiring training in protein expression, genetic engineering, and cellular imaging provided by the three participating laboratories. Furthermore, the Investigators are extending outreach opportunities to high school students and teachers. This collaboration gives students access to cutting edge molecular research while simultaneously encourages development of diverse talent in the science and engineering pipeline.

MitoNEET was discovered as the first member of the [2Fe-2S]-containing family of CISD proteins in 2004, but the biochemical and physiological function(s) of these proteins are still ill-defined. Knockdown models of mitoNEET have shown that this protein impacts the generation of ATP by oxidative phosphorylation (OXPHOS) in a tissue specific manner. The central hypothesis of this project is that the oxidation state and association of mitoNEET with dehydrogenase enzymes constitutes a tissue specific link between cellular energy metabolism and iron redox chemistry. In three different cell types, the cellular distribution of oxidized and reduced mitoNEET is characterized with the use of Raman interferometry. In addition, the impact of mitoNEET binding on allosteric control of glutamate dehydrogenase 1 and the cellular functions of cytoplasmic glyceraldehyde-3-phosphate dehydrogenase are characterized through a range of cellular experiments. The project goals are to elucidate the mechanisms by which mitoNEET modulates cellular energy production through regulation of iron homeostasis and control of carbon flux through dehydrogenase enzymes in various tissue types.

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