Eastern Connecticut State University is a public, coeducational liberal arts university and a member of the Council of Public Liberal Arts Colleges. Founded in 1889, it is the second-oldest campus in the Connecticut State University System and third-oldest public university in the state. Eastern is located on Windham Street in Willimantic, Connecticut, on 182 acres 30 minutes from Hartford, lying midway between New York City and Boston. Although the majority of courses are held on the main campus, select classes take place at Manchester Community College, Capital Community College, and a satellite center in Groton.Eastern Connecticut State University is a member of the Connecticut State Colleges and Universities, with governance provided by the Connecticut Board of Regents for Higher Education.The university is ranked #108 for regional universities in the north in the 2014 edition of the U.S. News and World Report List of Best Colleges. Eastern is also one of 225 institutions that the Princeton Review lists as "Best Regional College" in the northeast.The president of Eastern is Dr. Elsa Nuñez. Wikipedia.
Cunningham D.,Eastern Connecticut State University
Journal of Structural Geology | Year: 2013
This paper presents a review of the Quaternary-Recent deformation field and mountain building processes within the Gobi Corridor region of Central Asia, which includes the North Tibetan foreland, Beishan, Gobi Altai and easternmost Tien Shan. The region can be considered the 'soft core' of Central Asia which has been reactivated due to the continuing Indo-Eurasia collision to the south. Favourable preconditions for reactivation of Gobi Corridor basement include a mechanically weak Palaeozoic terrane collage sandwiched between rigid Precambrian basement blocks to the north and south, thermally weakened crust due to Jurassic-Miocene volcanism and widespread Palaeozoic-Mesozoic granitic magmatism with associated high radiogenic heat production, and crustal thinning due to widespread Cretaceous rift basin development. The network of Quaternary-Recent faults within the entire region defines a diffuse sinistral transpressional deformation field that has generated a transpressional basin and range physiographic province. Typically, thrust and oblique-slip thrust faults are WNW-striking and reactivate basement faults and fabrics, whereas left-lateral strike-slip faults are ENE-striking and cut across basement trends. The angular relationship between SHmax and pre-existing basement structural trends is the fundamental control on the kinematics of Late Cenozoic deformation. Along-strike and across-strike growth and coalescence of restraining bends, other transpressional ranges and thrust ridges is an important mountain building process. Thrust faults throughout the region are both NNE and SSW directed and thus there is no common structural vergence, nor orogenic foreland or hinterland. Root structures appear to be vertical faults, not low-angle decollements and flower structure fault geometries within individual ranges are common. Published earthquake and geodetic data are consistent with a diffusely deforming continental interior region with tectonic loading shared amongst a complex network of faults. Therefore, earthquake prediction is likely to be more complex than in plate boundary settings and extrapolation of derived Late Quaternary fault slip rates is not straightforward. Modern mountain building within the Gobi Corridor demonstrates that reactivation of ancient accretionary and collisional orogens within continental interiors can play an important role in continental evolution and the life cycle of orogenic belts. © 2012 Elsevier Ltd.
Schaller J.,Eastern Connecticut State University |
Valente J.M.S.,University of Porto
Computers and Operations Research | Year: 2012
This paper considers a problem in which there is a set of jobs to be sequenced on a single machine. Each job has a weight and the objective is to sequence the jobs to minimize total weighted squared tardiness. A branch-and-bound algorithm is developed for optimally solving the problem. Several dominance conditions are presented for possible inclusion in the branch-and-bound algorithm. The dominance conditions are included in the branch-and-bound algorithm, which is tested on randomly generated problems of various numbers of jobs, due date tightness and due date ranges. The results show that the dominance conditions dramatically improve the efficiency of the branch-and-bound algorithm. © 2011 Elsevier Ltd. All rights reserved.
Dancik G.M.,Eastern Connecticut State University |
Owens C.R.,Aurora University |
Iczkowski K.A.,Aurora University |
Theodorescu D.,Aurora University
Stem Cells | Year: 2014
There are two distinct forms of urothelial (bladder) cancer: muscle-invasive (MI) and nonmuscle invasive (NMI) disease. Since it is currently believed that bladder cancer arises by transformation of urothelial cells of the basal layer, bladder cancer stem cells (CSCs) have been isolated based on expression markers found in such cells. However, these CSCs have only been identified in MI tumors raising the intriguing hypothesis that NMI tumor progenitors do not arise from the basal compartment. To test this hypothesis, we carried out genome-wide expression profiling of laser capture microdissected basal and umbrella cells, the two most histologically distinct cell types in normal urothelium and developed a cell of origin (COO) gene signature that distinguishes these. The COO signature was a better predictor of stage and survival than other bladder, generic, or breast CSC signatures and bladder cell differentiation markers in multiple patient cohorts. To assess whether NMI and MI tumors arise from a distinct progenitor cell (DPC) or common progenitor cell, we developed a novel statistical framework that predicts COO score as a function of known genetic alterations (TP53, HRAS, KDM6A, and FGFR3) that drive either MI or NMI bladder cancer and compared this to the observed COO score of the tumor. Analysis of 874 patients in five cohorts established the DPC model as the best fit to the available data. This observation supports distinct progenitor cells in NMI and MI tumors and provides a paradigm shift in our understanding of bladder cancer biology that has significant diagnostic and therapeutic implications. © 2013 AlphaMed Press.
Anderson K.G.,West Virginia University |
Diller J.W.,Eastern Connecticut State University
Behavioural Pharmacology | Year: 2010
Biological differences may underlie individual differences in impulsive behavior, such as choice for a smaller, more immediate reinforcer over a larger, more delayed reinforcer. Repeated exposure to drugs of abuse may have different effects on such behavior. To evaluate the acute and repeated effects of nicotine on impulsive choice, two strains of rats that have been shown to differ in impulsive choice were tested in a delay-discounting paradigm. Eight Lewis and eight Fischer 344 rats were allowed to choose between one food pellet delivered immediately and three food pellets delivered after a delay. The delay systematically increased in blocks of trials within each session, and the delay value at which the choice for the two alternatives was equal (i.e. the indifference point) was interpolated. Effects of nicotine (0.1-1.0 mg/kg, subcutaneous) on percent choice and indifference points were determined during the acute-testing phase and during the redetermination of effects of each dose after at least 30 sessions of repeated 1.0 mg/kg nicotine exposure. The Lewis rats had shorter indifference points (i.e. made fewer larger-reinforcer choices) compared with the Fischer 344 rats. Acute nicotine administration increased the mean larger-reinforcer choices at the 0.3 mg/kg dose in the Lewis rats and at the 1.0 mg/kg dose in the Fischer 344 rats. After repeated exposure to nicotine, indifference points returned to near-baseline (predrug) levels for both the strains. Strain differences were observed in the rates of delay discounting, and nicotine may decrease the impulsive choice acutely, but this effect does not seem to be long lasting. Behavioural Pharmacology. © 2010 Wolters Kluwer Health Lippincott Williams & Wilkins.
Carter T.,Eastern Connecticut State University |
Humi M.,Worcester Polytechnic Institute
Celestial Mechanics and Dynamical Astronomy | Year: 2012
A new approach is presented for the problem of planar optimal impulsive rendezvous of a spacecraft in an inertial frame near a circular orbit in a Newtonian gravitational field. The total characteristic velocity to be minimized is replaced by a related characteristic-value function and this related optimization problem can be solved in closed form. The solution of this problem is shown to approach the solution of the original problem in the limit as the boundary conditions approach those of a circular orbit. Using a form of primer-vector theory the problem is formulated in a way that leads to relatively easy calculation of the optimal velocity increments. A certain vector that can easily be calculated from the boundary conditions determines the number of impulses required for solution of the optimization problem and also is useful in the computation of these velocity increments. Necessary and sufficient conditions for boundary conditions to require exactly three nonsingular non-degenerate impulses for solution of the related optimal rendezvous problem, and a means of calculating these velocity increments are presented. A simple example of a three-impulse rendezvous problem is solved and the resulting trajectory is depicted. Optimal non-degenerate nonsingular two-impulse rendezvous for the related problem is found to consist of four categories of solutions depending on the four ways the primer vector locus intersects the unit circle. Necessary and sufficient conditions for each category of solutions are presented. The region of the boundary values that admit each category of solutions of the related problem are found, and in each case a closed-form solution of the optimal velocity increments is presented. Similar results are presented for the simpler optimal rendezvous that require only one-impulse. For brevity degenerate and singular solutions are not discussed in detail, but should be presented in a following study. Although this approach is thought to provide simpler computations than existing methods, its main contribution may be in establishing a new approach to the more general problem. © 2012 Springer Science+Business Media B.V. 2012.
Dancik G.M.,Eastern Connecticut State University |
Theodorescu D.,Aurora University
PLoS ONE | Year: 2014
Few prognostic biomarkers are approved for clinical use primarily because their initial performance cannot be repeated in independent datasets. We posited that robust biomarkers could be obtained by identifying deregulated biological processes shared among tumor types having a common etiology. We performed a gene set enrichment analysis in 20 publicly available gene expression datasets comprising 1968 patients having one of the three most common tobacco-related cancers (lung, bladder, head and neck) and identified cell cycle related genes as the most consistently prognostic class of biomarkers in bladder (BL) and lung adenocarcinoma (LUAD). We also found the prognostic value of 13 of 14 published BL and LUAD signatures were dependent on cell cycle related genes, supporting the importance of cell cycle related biomarkers for prognosis. Interestingly, no prognostic gene classes were identified in squamous cell lung carcinoma or head and neck squamous cell carcinoma. Next, a specific 31 gene cell cycle proliferation (CCP) signature, previously derived in prostate tumors was evaluated and found predictive of outcome in BL and LUAD cohorts in univariate and multivariate analyses. Specifically, CCP score significantly enhanced the predictive ability of multivariate models based on standard clinical variables for progression in BL patients and survival in LUAD patients in multiple cohorts. We then generated random CCP signatures of various sizes and found sets of 10-15 genes had robust performance in these BL and LUAD cohorts, a finding that was confirmed in an independent cohort. Our work characterizes the importance of cell cycle related genes in prognostic signatures for BL and LUAD patients and identifies a specific signature likely to survive additional validation. © 2014 Dancik, Theodorescu.
Shinn-Thomas J.H.,University of Connecticut Health Center |
Mohler W.A.,Eastern Connecticut State University
International Review of Cell and Molecular Biology | Year: 2011
Many types of eukaryotic cells can fuse together as part of their normal developmental program or life cycle. This review describes a diverse set of examples of such cell types and focuses attention on several molecules that appear intimately involved in the process of plasma membrane merger that lies at the crux of every cell-fusion event. Some of these examples come from experimental systems where the discovery of molecules essential for cell fusion is sped by the approachability of the experimental organism itself. In other cases, especially in the many fusing human cell types, the molecular players in cell-cell membrane fusion are still to be discovered. © 2011 Elsevier Inc.
Schaller J.E.,Eastern Connecticut State University
Computers and Industrial Engineering | Year: 2014
This paper presents several procedures for scheduling identical parallel machines with family setups when the objective is to minimize total tardiness. These procedures are tested on several problem sets with varying numbers of families, jobs and machines, varying setup time distributions and various levels of due date tightness and variability. The results show that genetic algorithms are the most effective algorithms for the problem. © 2014 Elsevier Ltd. All rights reserved.
Veldman J.W.,University of Wisconsin - Madison |
Mattingly W.B.,University of Wisconsin - Madison |
Mattingly W.B.,Eastern Connecticut State University |
Brudvig L.A.,Michigan State University
Ecology | Year: 2013
Although savanna trees and forest trees are thought to represent distinct functional groups with different effects on ecosystem processes, few empirical studies have examined these effects. In particular, it remains unclear if savanna and forest trees differ in their ability to coexist with understory plants, which comprise the majority of plant diversity in most savannas. We used structural equation modeling (SEM) and data from 157 sites across three locations in the southeastern United States to understand the effects of broadleaf savanna trees, broadleaf forest trees, and pine trees on savanna understory plant communities. After accounting for underlying gradients in fire frequency and soil moisture, abundances (i.e., basal area and stem density) of forest trees and pines, but not savanna trees, were negatively correlated with the cover and density (i.e., local-scale species richness) of C4 graminoid species, a defining savanna understory functional group that is linked to ecosystem flammability. In analyses of the full understory community, abundances of trees from all functional groups were negatively correlated with species density and cover. For both the C4 and full communities, fire frequency promoted understory plants directly, and indirectly by limiting forest tree abundance. There was little indirect influence of fire on the understory mediated through savanna trees and pines, which are more fire tolerant than forest trees. We conclude that tree functional identity is an important factor that influences overstory tree relationships with savanna understory plant communities. In particular, distinct relationships between trees and C4 graminoids have implications for grass-tree coexistence and vegetation-fire feedbacks that maintain savanna environments and their associated understory plant diversity. © 2013 by the Ecological Society of America.
Schaller J.,Eastern Connecticut State University
International Journal of Production Research | Year: 2012
This paper presents several procedures for scheduling a permutation flow shop with family setups when the objective is to minimise total tardiness. These procedures are tested on several problem sets with varying numbers of families, jobs, and machines, three setup time distributions, and various levels of due date tightness and variability. The results show that variable greedy algorithms are effective when solving small problems, but a neighbourhood search procedure that includes searches with a neighbourhood defined by the sequence of batches of jobs belonging to the same setup family is more effective when solving large problems. Results are also presented, showing that significant reductions in total tardiness can be obtained if the time required to perform the family setups is reduced. © 2012 Copyright Taylor and Francis Group, LLC.