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Artigues-près-Bordeaux, France

Melser S.,EA4576 | Melser S.,University of Bordeaux 1 | Melser S.,CSIRO | Lavie J.,EA4576 | And 3 more authors.
Biochimica et Biophysica Acta - Molecular Cell Research | Year: 2015

Mitochondria are intracellular power plants that feed most eukaryotic cells with the ATP produced by the oxidative phosphorylation (OXPHOS). Mitochondrial energy production is controlled by many regulatory mechanisms. The control of mitochondrial mass through both mitochondrial biogenesis and degradation has been proposed to be one of the most important regulatory mechanisms. Recently, autophagic degradation of mitochondria has emerged as an important mechanism involved in the regulation of mitochondrial quantity and quality. In this review, we highlight the intricate connections between mitochondrial energy metabolism and mitochondrial autophagic degradation by showing the importance of mitochondrial bioenergetics in this process and illustrating the role of mitophagy in mitochondrial patho-physiology. Furthermore, we discuss how energy metabolism could coordinate the biogenesis and degradation of this organelle. This article is part of a Special Issue entitled: Mitophagy. © 2015 Elsevier B.V. Source


Melser S.,EA4576 | Melser S.,University of Bordeaux Segalen | Chatelain E.H.,French Institute of Health and Medical Research | Chatelain E.H.,University of Bordeaux Segalen | And 18 more authors.
Cell Metabolism | Year: 2013

Mitophagy has been recently described as a mechanism of elimination of damaged organelles. Although the regulation of the amount of mitochondria is a core issue concerning cellular energy homeostasis, the relationship between mitochondrial degradation and energetic activity has not yet been considered. Here, we report that the stimulation of mitochondrial oxidative phosphorylation enhances mitochondrial renewal by increasing its degradation rate. Upon high oxidative phosphorylation activity, we found that the small GTPase Rheb is recruited to the mitochondrial outer membrane. This mitochondrial localization of Rheb promotes mitophagy through a physical interaction with the mitochondrial autophagic receptor Nix and the autophagosomal protein LC3-II. Thus, Rheb-dependent mitophagy contributes to the maintenance of optimal mitochondrial energy production. Our data suggest that mitochondrial degradation contributes to a bulk renewal of the organelle in order to prevent mitochondrial aging and to maintain the efficiency of oxidative phosphorylation. © 2013 Elsevier Inc. Source

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