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University of Technology of Compiègne, France

Leclerc J.,EA1254 Microbiologie Risques Infectieux | Rosenfeld E.,University of La Rochelle | Trainini M.,EA1254 Microbiologie Risques Infectieux | Martin B.,EA1254 Microbiologie Risques Infectieux | And 7 more authors.
PLoS ONE | Year: 2015

Porphyromonas gingivalis is an etiologic agent of periodontal disease in humans. The disease is associated with the formation of a mixed oral biofilm which is exposed to oxygen and environmental stress, such as oxidative stress. To investigate possible roles for cytochrome bd oxidase in the growth and persistence of this anaerobic bacterium inside the oral biofilm, mutant strains deficient in cytochrome bd oxidase activity were characterized. This study demonstrated that the cytochrome bd oxidase of Porphyromonas gingivalis, encoded by cydAB, was able to catalyse O2 consumption and was involved in peroxide and superoxide resistance, and dioxygen tolerance. © 2015 Leclerc et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Source

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