EA 4708

La Madeleine, France
La Madeleine, France
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Toumi H.,EA 4708 | Larguech G.,Institute of Sports and Physical Education | Filaire E.,University Paris - Sud | Pinti A.,EA 4708 | Lespessailles E.,EA 4708
Journal of Anatomy | Year: 2012

We investigated whether there were regional differences in the quadriceps enthesis and the patella bone structure that could suggest unequal force transmission to the patella. Quadriceps tendon enthesis was removed by cutting the patellae transversally in the middle and the quadriceps tendon approximately 1cm from the bone. Tissues were post-fixed, decalcified, dehydrated through and embedded in paraffin wax. Serial longitudinal sections were cut, mounted on glass slides at 1-mm intervals and slides were stained. Trabecular architecture was analysed from digital images taken from the histological slides, and regional differences at the enthesis in the thickness of the uncalcified fibrocartilage and the cortical zone of calcified tissue (calcified cartilage and lamellar bone) were evaluated. At the quadriceps enthesis, the thickness of the cortical zone of calcified tissue was significantly greater in the central part of the enthesis than medially and laterally. The trabeculae were thicker in the central and lateral parts compared with the medial region. Similarly, the zone of uncalcified fibrocartilage was thicker laterally and centrally than medially. Bone structure and the thickness of uncalcified fibrocartilage presented a similarity between the centre and the lateral parts; however, the medial side was different. We suggest that the mechanical stress at the proximal quadriceps tendon enthesis is higher laterally and centrally compared with medially. This could induce a lateral patellar translation, which is potentially a risk factor for knee osteoarthritis. © 2012 The Authors. Journal of Anatomy © 2012 Anatomical Society.

Pinti A.,University of Valenciennes and Hainaut‑Cambresis | Coursier R.,Groupe Hospitalier Of Linstitut Catholique Of Lille | Watelain E.,University of Valenciennes and Hainaut‑Cambresis | Watelain E.,University of Toulon | Toumi H.,EA 4708
IEEE 12th International Conference on BioInformatics and BioEngineering, BIBE 2012 | Year: 2012

We present a fully automatic model based system for segmenting bone MR images of the knee. The segmentation method is based on a fast Active Appearance Models (AAM) based on canonical correlation analysis algorithm (CCA-AAM) where the dependency between texture residuals and model parameters are estimated in fast manner. The model is built from manually segmented examples from the knee images. The model has been applied to some challenging knee MR images. Experiments show that CCA-AAMs based segmentation, while requiring similar implementation effort, consistently outperform segmentation model based traditional AAM. Finally, we show results on knee image to illustrate the performance that are possible. © 2012 IEEE.

Derraz F.,University of Lille Nord de France | Derraz F.,Abou Bekr Belkaid University Tlemcen | Pinti A.,University of Lille Nord de France | Pinti A.,University of Valenciennes and Hainaut‑Cambresis | And 4 more authors.
Pattern Recognition and Image Analysis | Year: 2015

In this paper, we have proposed a new framework to use both PET and CT images simultaneously for tumor segmentation. Our method combines the strength of each imaging modality: the superior contrast of PET and the superior spatial resolution of CT. We formulate this problem as a Non-Local Active Contours (NL-AC) based-variational segmentation framework incorporating Belief Functions (BFs). The proposed method used all features issued from both modalities (CT and PET) as a descriptor to drive the NL-AC curve evolution. The new segmentation framework allows us to incorporate in the same framework heterogeneous knowledge in order to reduce the imprecision due to noise poor contrast, weak or missing boundaries of objects, inhomogeneities, etc. The proposed method was evaluated on relevant tumor segmentation problems. The results showed that our method can effectively make use of both PET and CT image information, yielding segmentation accuracy of 81.52% in Dice Similarity Coefficient (DSC) and the Average Symmetric Surface Distance (ASSD) of 1.2 ± 0.8 mm, which is 10% (resp., 16%) improvement compared to two state of art segmentation methods using the PET (resp., CT) images. © 2015, Pleiades Publishing, Ltd.

Tronel C.,University of Tours | Rochefort G.Y.,EA 4708 | Arlicot N.,University of Tours | Bodard S.,University of Tours | And 2 more authors.
Oxidative Medicine and Cellular Longevity | Year: 2013

Heme oxygenase-1 (HO-1) induction is associated with beneficial or deleterious effects depending on the experimental conditions adopted and the neurodegenerative rodent models used. The present study aimed first to evaluate the effects of cerebral HO-1 induction in an in vivo rat model of neuroinflammation by intrastriatal injection of quinolinic acid (QA) and secondly to explore the role played by reactive oxygen species (ROS) and free iron (Fe2+) derived from heme catabolism promoted by HO-1. Chronic I.P. treatment with the HO-1 inductor and substrate hemin was responsible for a significant dose-related increase of cerebral HO-1 production. Brain tissue loss, microglial activation, and neuronal death were significantly higher in rats receiving QA plus hemin (H-QA) versus QA and controls. Significant increase of ROS production in H-QA rat brain was inhibited by the specific HO-1 inhibitor ZnPP which supports the idea that ROS level augmentation in hemin-treated animals is a direct consequence of HO-1 induction. The cerebral tissue loss and ROS level in hemin-treated rats receiving the iron chelator deferoxamine were significantly decreased, demonstrating the involvement of Fe2+in brain ROS production. Therefore, the deleterious effects of HO-1 expression in this in vivo neuroinflammatory model were linked to a hyperproduction of ROS, itself promoted by free iron liberation. © 2013 Claire Tronel et al.

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