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PubMed | Academian En Meshalkin Novosibirsk State Research Institute Of Circulation Pathology
Type: Journal Article | Journal: Kardiologiia | Year: 2013

We assessed objective parameters of cerebral oxygen supply in 469 patients with multifocal atherosclerosis, hemodynamically significant lesions in brachiocephalic arteries in dependence on degree of severity of vascular cerebral insufficiency according to A.V. Pokrovsky classification of chronic disturbances of cerebral circulation. Comparison of clinical classification with parameters of cerebral oximetry and level of cerebral tolerance to hypoxia allowed to characterize pathophysiological mechanisms of cerebral oxygen metabolism, what was important for determination of risk of surgical treatment and postoperative prognosis.


PubMed | Academian En Meshalkin Novosibirsk State Research Institute Of Circulation Pathology
Type: Journal Article | Journal: Kardiologiia | Year: 2013

We present in this paper experience of the use of implantable devices for long-term monitoring of cardiac rhythm after one stage operation of coronary artery bypass grafting (CABG) and radiofrequency ablation of atrial fibrillation (AF) source and results of a prospective randomized study, in which we included patients (n=95) with persistent AF and ischemic heart disease. These patients were randomized into 3 groups: with radiofrequency isolation of ostia of pulmonary veins (group 1, n=31), radiofrequency modified mini-maze procedure (group 2, n=30); CABG without AF elimination (control group 3, n=34). Implantable devices Reveal XT were used in 53 patients (21, 25, and 7 in groups 1, 2, and 3, respectively). According to data obtained with these devices AF was absent in 86.7, 95.6, 53%, and in 80, 86.2, 44.1% of patients in groups 1, 2, 3 after 1 and 2 years after operation, respectively). In 24% of patients Reveal devices also registered asymptomati-c arrhythmias. The use of implantable devices for monitoring of rhythm allowed to detect such arrhythmia and to provide timely correction of therapy.


PubMed | Academian En Meshalkin Novosibirsk State Research Institute Of Circulation Pathology
Type: Journal Article | Journal: Kardiologiia | Year: 2013

We studied occurrence of allele variants *1, *2, *3, and *17 of CYP2C19 gene and polymorphic variants of ABCB1 gene in clopidogrel treated patients from West Siberian and Far Eastern regions and determined contribution of these polymorphisms to laboratory efficacy of clopidogrel. In dependence on magnitude of change of platelet aggregation we distinguished groups of patients with different sensitivity to clopidogrel. We found association between polymorphic variant CYP2C19*2 with changes of platelet aggregation after administration of clopidogrel. An additional group of patients with augmented platelet aggregation after administration of clopidogrel was detected. There was no correlation between the latter effect and any of studied polymorphisms.

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