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Lidman G.Yu.,E N Meshalkin Institute Of Circulatory Diseases | Larionov P.M.,E N Meshalkin Institute Of Circulatory Diseases | Savchenko S.V.,Novosibirsk State Medical University | Lushnikova E.L.,Russian Academy of Medical Sciences | And 6 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2010

Morphological and spectral X-ray analysis of carious and noncarious extracted teeth showed the patterns of dentin ossification in caries of different degree. Parietal ectopic ossification of the canal and cavity lumens in stages III and IV dental caries is regarded as a specific structural marker of pathological regeneration. The X-ray spectral analysis showed that the progress of carious process is paralleled by loss of mineral components. Laser-induced fluorescent study of tissues in extracted teeth showed 4 spectral bands corresponding to mineral and protein components of the tooth. The progress of carious process was associated with reduction of the fluorescence intensities of the spectral bands characteristic of dental collagen and mineral components. © 2010 Springer Science+Business Media, Inc.

Ragino Yu.I.,Russian Academy of Medical Sciences | Chernjavski A.M.,E N Meshalkin Institute Of Circulatory Diseases | Polonskaya Ya.V.,Russian Academy of Medical Sciences | Volkov A.M.,E N Meshalkin Institute Of Circulatory Diseases | And 3 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2012

The concentrations of LPO products (including those present in LDL), oxidative modification of proteins, paraoxonase activity, concentrations of antioxidants, lipid values and biomarkers of endothelial dysfunction were studied in the blood and coronary artery intima/media of male patients with coronary atherosclerosis without acute coronary syndrome. Blood levels of LDL oxidized apolipoproteins and lipoprotein (a) were higher, while the content of NO metabolites, sVCAM endothelial adhesion molecules, and LDL oxidation resistance were lower in men with mainly unstable atherosclerotic plaques in the coronary arteries in comparison with men with mainly stable plaques in the coronary arteries. Of these blood biomarkers, only NO metabolites, oxidized proteins, and sVCAM correlated with the presence of unstable atherosclerotic plaques. A significant correlation between the levels of biomarkers in the vascular wall and blood was detected only for LPO parameters. © 2012 Springer Science+Business Media, Inc.

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