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Buffalo, NY, United States

D'Youville College is a private, coeducational independent college, with a Roman Catholic tradition located in the historic Prospect Hill neighborhood on the West Side of Buffalo, New York within the Diocese of Buffalo. The college is a few blocks from the international Peace Bridge and has students from around the world Wikipedia.

Andreeff R.,DYouville College
Journal of Physician Assistant Education | Year: 2014

Purpose: This study examined the association between academic performance in undergraduate science courses — chemistry I, pathophysiology, and biochemistry — and student scores on the PANCE. Covariates gender, age, and admission GPA were included in the analysis to identify factors predicting student passage of the PANCE. Methodology: A retrospective cohort study of student records of first-attempt chemistry I, pathophysiology, and biochemistry course grades and first-attempt PANCE scores for PA graduates from D’Youville College (n = 155) from 2006–2010 were included, along with age, gender, and admission GPA. Results: Pathophysiology (P <.001) and biochemistry (P =.01) had significant positive regression coefficients, predicting higher PANCE scores of 62.13 points and 33.82 points, respectively, for every one unit increase in pathophysiology and biochemistry course grade (ie, B to A) after controlling for age, gender, and admission GPA. Admission GPA had a significant (P =.02) positive regression coefficient, suggesting that for every unit increase in admission GPA, PANCE score will increase 50.48 points when controlling for age and gender. Conclusion: Higher first-attempt PANCE scores were predicted by higher admission GPA and first-attempt grades achieved in pathophysiology and biochemistry. Identifying predicting factors of PANCE passage may help to identify a student’s ability to pass the PANCE early in the curriculum, as well as improve program quality and graduate success. © 2014, Physician Assistant Education Association. All rights reserved.

Mollica M.,Medical University of South Carolina | Mollica M.,DYouville College | Nemeth L.,Medical University of South Carolina
Cancer Nursing | Year: 2015

Background: Breast cancer is the most common cancer among African American (AA) women, with a survival rate of 79%, lower than for other ethnic and racial groups in the United States. Minorities experience disparities in timeliness of care, delivery of culturally sensitive care, and outcomes. Transition from active treatment to survivorship presents an opportunity for exploration. Purpose/Objectives: This qualitative, grounded theory study examined the experiences and coping of AA women as they transition from being a breast cancer patient to being a breast cancer survivor.Methods: This study included 15 community-based AA women aged 35 to 75 years in Charleston, South Carolina, and Buffalo, New York, who had completed treatment for primary breast cancer between 6 and 18 months prior. A semistructured interview explored experiences as they finished treatment, support from family, role of spirituality, physical and emotional concerns, needs of the survivor, as well as suggestions for possible interventions for other survivors. Two investigators reviewed transcripts and coding to confirm and refine the findings.Results: Four main themes were identified: perseverance through struggles supported by reliance on faith, persistent physical issues, anticipatory guidance needed after treatment, and emotional needs as important as physical.Conclusions: The transition from cancer patient to survivor is a pervasive time filled with stress, loss of safety net, and significant coping measures. Participants expressed the need to have support from another AA breast cancer survivor as they complete treatment.Implications for Practice: Nurses and providers can assess and address stressors in transition. Nurses should design patient-centered interventions using peers as direct support to promote effective coping strategies.

Shemenski J.,DYouville College
Medical Hypotheses | Year: 2016

Lyme disease, caused by the spirochete Borrelia burgdorferi (Bb), is the most common vector-borne illness in the United States. It is a complex disease which may affect the skin, joints, heart, eyes, and central nervous system. Prompt diagnosis and treatment is curative in most instances. However, a significant percentage of patients experience ongoing symptoms after treatment. Currently, there is much controversy regarding the diagnosis, pathophysiology, and treatment of Lyme disease. Pathogen persistence despite treatment lies at the heart of this debate.Many believe that the ongoing symptoms are due to factors such as autoimmunity or permanent damage that is incurred during the active infection. However, there is an emerging school of thought that states that ongoing symptoms are due to a persistent infection that is able to survive both the immune response and antibiotic therapy. Numerous studies have shown that Bb can indeed persist within the host despite treatment and several mechanisms have been proposed to explain Bb's persistence capabilities. These include: polymorphism, antigenic variance, biofilm formation, persister cells, and immunomodulation.There is evidence that Bb is able to alter cytokine profiles within the host which may allow the organism to survive the immune response. This immunomodulation follows a pattern of T-helper 1 (TH1) suppression in favor of T-helper 2 (TH2) processes. In contrast, it has been shown that the optimal immune response to Bb infection involves an early, robust TH1 response and a later conversion to TH2 dominance once the infection is controlled or cleared. It has been proposed that a reconstitution of proper immune-competency in the infected host may improve clinical outcomes in Lyme disease.Cimetidine (CIM) is an over-the-counter histamine-2 (H2) antagonist that is primarily used to lower acid secretions in the stomach. T-regulatory (Treg) cells also possess the H2 receptor, which has spurred interest in CIM as a potential immunomodulator. CIM therapy has been shown to increase levels of the TH1 associated cytokines IL-12, TNF-α, and IFN-γ while decreasing levels of the TH2 associated cytokine IL-10. The author proposes a novel theory that CIM therapy during early Bb infection may promote a more appropriate immune response and increase the utility of antibiotic therapy during early stage Lyme disease, thus improving clinical outcomes of the disease. © 2016 Elsevier Ltd.

This analysis involves an investigation of the corporate control of food in relation to low income and culturally dominated schoolchildren in cities. This includes an exploration of the problem as expressed globally and historically in relation to transnational policy networks. Since corporate growth always necessitates controlling the direction of what people talk about on the ground, I additionally critique the emerging popularity of the policy-linked language of 'food deserts' and 'food security.' I reveal these terms as postcolonial constructs, forged out of the tradition that those with power control both material and mental production. Given the economic struggles now felt by the middle classes, I contend such language seeks to contain this growing anxiety. Lastly, I review some widespread failed efforts to address the problem of lack of access to healthy and affordable food among marginalized urban communities. All of these attempts are shaped as part of broader and evolving policy networks and in this research include progressive resistance collectives, policies as commodities, and big box failures. I focus here on city initiatives in particular given the ongoing urban implosion taking place in much of the world as people continue to lose their access to land. Although I consider conditions in the USA, these arguments can be applied in various ways to other contexts. © 2013 Taylor & Francis.

Alfonso L.,DYouville College | Ai G.,South Dakota State University | Spitale R.C.,University of California at Irvine | Bhat G.J.,South Dakota State University
British Journal of Cancer | Year: 2014

Salicylates from plant sources have been used for centuries by different cultures to treat a variety of ailments such as inflammation, fever and pain. A chemical derivative of salicylic acid, aspirin, was synthesised and mass produced by the end of the 19th century and is one of the most widely used drugs in the world. Its cardioprotective properties are well established; however, recent evidence shows that it can also act as a chemopreventive agent. Its antithrombotic and anti-inflammatory actions occur through the inhibition of cyclooxygenases. The precise mechanisms leading to its anticancer effects are not clearly established, although multiple mechanisms affecting enzyme activity, transcription factors, cellular signalling and mitochondrial functions have been proposed. This review presents a brief account of the major COX-dependent and independent pathways described in connection with aspirin's anticancer effects. Aspirin's unique ability to acetylate biomolecules besides COX has not been thoroughly investigated nor have all the targets of its primary metabolite, salicylic acid been identified. Recent reports on the ability of aspirin to acetylate multiple cellular proteins warrant a comprehensive study to investigate the role of this posttranslational modification in its anticancer effects. In this review, we also raise the intriguing possibility that aspirin may interact and acetylate cellular molecules such as RNA, and metabolites such as CoA, leading to a change in their function. Research in this area will provide a greater understanding of the mechanisms of action of this drug. © 2014 Cancer Research UK.

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