Jena, Germany
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Patent
Dyomics GmbH and Pierce Biotechnology Inc. | Date: 2012-08-10

Compounds useful as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.


Patent
Dyomics GmbH and Pierce Biotechnology Inc. | Date: 2013-08-20

Compounds used as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.


Patent
Pierce Biotechnology Inc. and Dyomics GmbH | Date: 2016-10-19

Compounds of formula (Ia) or (Ib) used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.


Patent
Dyomics GmbH and Pierce Biotechnology Inc. | Date: 2011-12-20

Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.


Patent
Pierce Biotechnology Inc. and Dyomics GmbH | Date: 2015-12-11

Compounds useful as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.


Patent
Pierce Biotechnology Inc. and Dyomics GmbH | Date: 2014-10-29

A phosphine derivative of DyLight dyes modified with ethylene glycol or (poly)ethylene glycol groups. In one embodiment, the compounds are useful in chemoselective ligation reactions.


Patent
Pierce Biotechnology Inc. and Dyomics GmbH | Date: 2016-06-08

Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.


Patent
Dyomics GmbH and Pierce Biotechnology Inc. | Date: 2011-12-20

Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.


Patent
Dyomics GmbH and Pierce Biotechnology Inc. | Date: 2011-12-20

Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.


The invention concerns compounds based on benzoxazoles wherein selected substituents are each a reactive group A bound via a linker L and adapted to covalently bond a compound of the invention to a to-be-marked molecule K, wherein A is an amine, hydroxy or phosphoramidite function, a carboxylic acid, an alkyl or active ester derived therefrom; a carboxylic acid hydrazide; or a carboxylic acid amide where K is a covalently bound component selected from the group haptenes, proteins (antibodies), low molecular weight drug compounds, peptides, nucleotides, nucleosides, DNA oligomers, polymers, and t is from 1 to 10, and L is a linker selected from a group featuring (CH_(2))_(s), [(CH_(2))_(m)O]_(p)(CH_(2))_(m), NR10-(CH_(2))_(s), O(CH_(2))_(s), S(CH_(2))_(s), NR10-C(O)(CH_(2))_(s), NR10-C(O)O(CH_(2))_(s), NR10-C(O)NR11-(CH_(2))_(s) or SO_(2)NR10-(CH_(2))_(s), wherein R10 and R11 are each independently hydrogen, alkyl and alkoxy-alkyl ([(CH_(2))_(m)O]_(p)CH_(3)), -sulfoalkyl ((CH_(2))_(r)SO_(3)), m represents the numbers of 2-5, p, r and s each independently represent the number of 1-10.

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