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News Article | October 25, 2016
Site: news.mit.edu

Ten affiliates of the MIT Department of Physics are among those recently honored with prizes and fellowships by the the American Physical Society (APS). The awardees include six faculty, three alumni, and a former Pappalardo Fellow, representing all divisions within the department. A faculty member in the Department of Mechanical Engineering also joined the new APS fellows, making a total of four from MIT this year. As the leading membership organization for physicists from academia, industry, and the national laboratories, the APS prizes are highly regarded and showcase critical recognition by peers worldwide. “I’m delighted to see how many of our faculty, students and alumni have been honored by the APS this year,” said Peter Fisher, head of the department. William Detmold, assistant professor of physics, who was elected for his "pioneering work in calculating few-body hadronic systems from first principles using lattice quantum chromodynamics, including the spectrum of the light nuclei and hypernuclei, Bose-condensed multimeson systems, and the first inelastic nuclear reaction.” Affiliated with both the MIT Center for Theoretical Physics and Laboratory for Nuclear Science, Detmold is also a recipient of a U. S. Department of Energy Outstanding Junior Investigator award. Ahmed Ghoniem, the Ronald C. Crane (1972) Professor in the Department of Mechanical Engineering, for “contributions to computational fluid dynamics with vortex and particle methods, flame modeling for turbulent combustion, and explanation and control of combustion dynamics.” Ghoniem serves as director of MIT's Center for Energy and Propulsion Research and of the Reacting Gas Dynamics Laboratory. William Oliver, professor of the practice in physics and principal investigator in MIT's Engineering Quantum Systems Group, and a senior member of the Quantum Information and Integrated Nanosystems Group at MIT Lincoln Laboratory, for “pioneering contributions to the physics and associated engineering of robust, reproducible, superconducting quantum systems and high-performance cryogenic control electronics.” Oliver also serves on the U. S. Committee for Superconducting Electronics. Martin Zwierlein, professor of physics, in recognition of his “groundbreaking experiments with ultracold Fermi gases.” Zwierlein also received the I.I. Rabi Prize in Atomic, Molecular, and Optical Physics, for his “seminal studies of ultracold Fermi gases, including precision measurements of the equation of state, the observation of superfluidity, solitons, vortices, and polarons, the realization of a microscope for fermions in a lattice; and the production of chemically stable polar molecules.” Among other honors, he is a recipient of a 2010 Presidential Early Career Award and a 2010 David and Lucille Packard Fellowship. Henriette Elvang, associate professor of physics at the University of Michigan at Ann Arbor, and 2005-2008 MIT Pappalardo Fellow in Physics, received the Maria Goeppert Mayer Award for “discovering new types of black holes in higher dimensions, and giving us a deeper understanding of scattering amplitudes in quantum field theory.” Elvang’s previous honors include a 2010 NSF Career Award; a 2013 Cottrell Scholar Award from the Research Corporation for Science Advancement; the University of Michigan 2014 Individual Award for Outstanding Contributions to Undergraduate Education; and a 2015 Henry Russell Award. Yonatan Kahn PhD ’15 received the J.J. and Noriko Sakurai Dissertation Award in Theoretical Particle Physics for “proposing a novel method to detect dark photons, for developing halo-independent techniques of direct dark matter detection, and for finding a new viable supersymmetric extension of the standard model.” Kahn earned his PhD at MIT under the supervision of Professor Jesse Thaler, and received the department's 2014 Andrew M. Lockett III Memorial Fund Award. Kahn is currently a postdoc at Princeton University. Daniel Kleppner, the Lester Wolfe Professor of Physics Emeritus, was awarded the APS Medal for Exceptional Achievement in Research for his “seminal research setting the direction for modern atomic, molecular, and optical physics, including precision measurements with hydrogen masers, the physics of Rydberg atoms and their quantum chaotic behavior in high fields, cavity quantum electrodynamics, and the production of quantum degenerate atomic gases.” The atomic, molecular, and optics physics leader is the second winner of the recently-endowed annual award. In addition to his pioneering research, Kleppner has been a dedicated mentor and educator, whose many awards and honors include the 2006 National Medal of Science and the 2005 Wolf Prize. Sekazi Mtingwa ’71 was one of three co-winners of the Robert R. Wilson Prize for Achievement in the Physics of Particle Accelerators for his “detailed, theoretical description of intrabeam scattering, which has empowered major discoveries in a broad range of disciplines by a wide variety of accelerators, including hadron colliders, damping rings / linear colliders, and low emittance synchrotron light sources.” The first African-American scientist to receive a prize from the American Physical Society, Mtingwa was also 2001-2003 MLK, Jr., Visiting Professor at MIT. He is currently a principal partner with Triangle Science, Education and Economic Development in North Carolina. Nicholas Rivera ’16 was named co-winner of the LeRoy Apker Award for contributing to “important advances in the field of photonics and exceptional leadership of the Society of Physics Students.” As an undergraduate, Rivera worked under the supervision of Professor Marin Soljacic in the MIT Photonics and Modern Electromagnetics Group. In 2016, he received the department’s Order of the Lepton Award and was a co-winner of the Joel Matthew Orloff Award for Research and Service. Rivera is a member of Sigma Pi Sigma and Phi Beta Kappa, and is currently a PhD candidate in MIT’s Department of Physics. Tracy Slatyer, the Jerrold R. Zacharias Career Development Assistant Professor of Physics, received the Henry Primakoff Award for Early-Career Particle Physics for her “innovative theoretical calculations and data analyses of the multi-wavelength sky to probe the nature of dark matter.” A theoretical physicist who works on particle physics, cosmology, and astrophysics, Slatyer is also a co-winner of the 2014 Bruno Rossi Prize of the American Astronomical Society. Xiao-Gang Wen, the Cecil and Ida Green Professor of Physics, was named a co-winner of the Oliver E. Buckley Condensed Matter Physics Prize for his “theories of topological order and its consequences in a broad range of physical systems.” Given annually, the Buckley Prize recognizes outstanding theoretical or experimental contributions to condensed matter physics. Among other honors, Wen is an APS Fellow; Distinguished Moore Scholar at Caltech; Newton Chair at the Perimeter Institute for Theoretical Physics, and a Sloan Fellowship recipient.

News Article | November 9, 2015
Site: www.biosciencetechnology.com

In a dimly lit room, next to a supersonic jet engine test rig, three Stanford engineering graduate students sat around a whiskey bottle. All was quiet on this Friday evening in 2013 except for their lab’s visceral hum, a rumbling of fans, flames and gases rushing through jet-propulsion nozzles. These three rocket-combustion experts — Christopher Strand, Victor Miller and Mitchell Spearrin — were talking about the future. In a few months they would have doctoral degrees, and then what? As boys, all three grew up away from big city lights, with a clear view of the stars in the night sky. And they dreamed about rockets and exploring space. Now that the space shuttle was grounded and its successor scrapped for being over budget, what would they do instead? Work at an aerospace company? Consult on military projects? It was Strand who initiated a series of brainstorming sessions that challenged them to think beyond outer space. “Somewhere between ideas on fixing San Francisco’s parking problem and inventing a marijuana Breathalyzer, we decided to see if we could use our education and expertise in combustion science to analyze human breath for disease,” said Miller. After all, the human body is essentially a biochemical engine. It consumes fuel and exhales waste gases. Maybe the three of them could engineer a disease Breathalyzer? It would be a gadget straight out of Star Trek — a quick, noninvasive way to detect everything from diabetes to cancers. Many have tried and failed to create such a device. But these guys are rocket men. They assume risks without fear. They achieve the impossible without breaking a sweat. They take giant leaps for mankind. Sure, they didn’t know much about medicine, but they figured that with a little luck and a lot of hard work, they just might be able to do it. The first step was to find medical experts to help, so they contacted a group of pediatricians at Stanford’s medical school. Five years ago, professor of pediatrics Gregory Enns, M.D., was called into the neonatal intensive care unit at Lucile Packard Children’s Hospital Stanford to help a newborn in trouble. The child’s mother, Tiffany Nguyen, was a business software consultant and his father, Luan Pham, was a systems engineer. They were immigrants from South Vietnam, excited about starting a family in the United States. After 18 hours of labor, their baby boy was born. They called him Ethan, a biblical name that means “enduring strength” in Hebrew. But the morning after his birth, Ethan cried continually. By noon, his blood sugar and temperature dropped. His body became limp. The attending pediatrician couldn’t figure out what was wrong, so two days after Ethan’s birth, the infant was moved from a San Jose community hospital to Lucile Packard Children’s Hospital Stanford. That was when Enns, a biochemical geneticist who diagnoses and treats metabolic diseases, was contacted. When Enns first examined Ethan, the prognosis was grim. Ethan’s tiny heart was beating erratically and his blood sugar level was dangerously low. Enns didn’t think the child would survive the night. But he put this possibility out of his mind and did his best. Enns, with his reassuring smile, quirky cartoon ties and clear blue eyes, is also a professional optimist. First, the cardiac team was called in to help stabilize Ethan’s heart. Then Enns tried to figure out why Ethan’s blood sugar was so low. He suspected that Ethan had a genetic defect of the metabolic system. This could result in a buildup in the bloodstream of ammonia, a chemical that is normally detoxified by the liver. The blood test for this condition, called hyperammonemia, is slow and unreliable. Its analysis takes about an hour. By the time Ethan’s blood test came back, the level of toxic ammonia was almost 10 times higher than normal. Even if Ethan survived the next few days, he would always be at risk of another ammonia surge that could cause serious brain damage if not treated promptly. Ammonia is a chemical byproduct released when the human body turns one type of fuel — specifically, digested protein molecules — into energy. The body eliminates this toxic waste by converting it in the liver to nontoxic urea, then sending it through the kidneys so it can be eliminated in urine. If anything goes wrong in this chain of organs and biochemical processes, ammonia builds up. At this point there wasn’t time to do an in-depth genetic analysis to figure out what was wrong, so Enns expedited a biochemical blood test that revealed Ethan’s body was unable to digest long-chain fatty acids, a major component of breast milk and its precursor, colostrum. Because of this, Ethan’s body lacked enough energy to fuel his vital organs. So Enns fed Ethan intravenously with a solution of high-calorie sugar and medium-chain fats. Then he administered a drug to remove the excess ammonia circulating in his bloodstream. Against the odds, this strategy saved Ethan’s life. “Ethan was the sickest child in the intensive care unit I’ve ever seen turn around,” Enns said. Once Ethan was out of danger, Enns sat down with the parents to talk about the realities of caring for a child with a metabolic disorder. It requires constant vigilance. They have to protect Ethan’s metabolism from stress, especially viruses. And they have to be alert to signs of lethargy and confusion — indications of high ammonia levels. If they suspect an excess of ammonia, a life-or-death drill will be initiated. Rush to the hospital. Watch a phlebotomist poke the child with needles for the blood tests. Wait an hour for test results. If the result is high, hospital staff will administer ammonia-grabbing drugs and intravenous fluids, retest the blood and repeat as needed. Delayed treatment could lead to permanent brain damage or even death. Enns has a superhuman ability to connect with patients and families in these difficult situations. Most of the children he works with have extremely rare diseases, for which research is limited and treatment plans are based on comfort care, guesswork or some combination. He is able to talk with a 10-year-old with severe developmental disabilities at exactly the right level, then turn to offer advice to parents on health insurance issues, never lapsing into technical doctor-speak. When asked how he protects himself from the emotional stress associated with these conversations, Enns pointed to his prematurely silver hair and said, “I don’t.” This was the dilemma for Enns: He could save these newborns, but then what? Hope came out of the blue two years later, when he received a call from David Stevenson, M.D., senior associate dean for maternal and child health at Stanford. Stevenson told him he knew of three Stanford rocket engineers with a novel idea for analyzing human breath, and they were looking for a medical condition to try it on. Would Enns collaborate with them? Enns immediately thought about patients like Ethan, and he jumped at the chance to help. “Maybe these engineers could succeed where many others had failed,” said Enns. “I thought, after all, they’re rocket scientists.” The idea for the disease breath analyzer was born in Stanford’s High Temperature Gas Dynamics Laboratory. This lab, tucked into an unobtrusive, sandstone-and-tile building behind Stanford’s Main Quad, has served as the launch pad for almost 100 combustion engineers, all of whom earned their doctorates under the mentorship of mechanical engineering professor Ronald Hanson, Ph.D.. In 2013, two of Hanson’s students — Christopher Strand and Victor Miller — sat at adjacent desks overlooking a “Rockets of the World” poster. They were both finishing dissertations on supersonic combustion ramjets, called scramjets for short. Strand was working on better ways to measure engine gas mixtures using lasers. Miller was developing gas-flow visualization techniques using lasers and high-speed cameras. Scramjet technology, conceptualized in the 1950s, still presents researchers with extreme technical challenges. These engines use atmospheric oxygen to burn their fuel rather than having to carry liquid oxygen along for the ride. This allows scramjet-equipped craft to fly at speeds of more than five times the speed of sound. Theoretically, aircraft equipped with these engines could fly anywhere on Earth within 120 minutes. Scramjet space planes could carry greater payloads and operate more efficiently. Strand, now 30, tall and lean with British-schoolboy wavy brown hair, has always wanted to be an astronaut. He was raised on a small farm in rural Alberta, Canada, the son of a single mother who worked as a bookkeeper. Strand didn’t apply to college during high school. But when he accompanied his girlfriend (now wife) to her first day of classes at the University of Alberta, he realized he’d made a horrible mistake. “All of a sudden I knew that I belonged at a university,” Strand said. So that week, through a fortuitous connection, he met with the dean of engineering and talked his way into the school’s engineering-physics program. Miller, 28, with mischievous eyes and the energy level of someone who just downed a triple espresso, is a fix-anything guy with a penchant for testing boundaries. He’s also a drummer in a ’90s cover band called Cloning Dolly. He grew up in Watertown, Wisconsin, a small town an hour east of Madison. His father was an ex-Marine-turned-engineer and his mother was a travel agent. As a boy, he was obsessed with airplanes. He graduated from Cornell University, summa cum laude, in mechanical and aerospace engineering. Miller’s worldview had been influenced by a year in Stanford’s Accel Innovation Scholars program, which gives 12 Ph.D. students access to entrepreneurial leaders in Silicon Valley. This program encourages bright engineering scholars to explore ways to apply their knowledge to some of society’s biggest challenges. In other words, Miller had absorbed the culture of Stanford entrepreneurship. Strand also felt the allure of inventing a Silicon Valley “new new thing,” he said. “I think Vic and I empowered each other to pursue breath sensing. There is a certain confidence that comes with having a partner.” When the team first began looking into the breath analyzer idea, a search of scientific literature revealed that breath testing with the human nose has been used in medicine since ancient times. The rotten-apple smell of acetone is a sign of diabetes. The smell of putrid socks is associated with kidney problems. A fishy smell is indicative of liver disease. Though these nose-based diagnostic skills are still used by some clinicians today, many researchers have recognized the opportunity to develop a medical device that could transform this art into a science. The late Nobel laureate and Stanford chemistry professor Linus Pauling was one of the pioneers of modern breath testing. In the 1970s, he used a gas chromatograph to detect several hundred volatile organic compounds in breath, providing the first evidence that it is a more complex mixture of gases than anyone had imagined. Since then, more than 3,000 compounds have been detected. And though the signatures of ingested chemicals, like alcohol, may be easy to measure, it’s much more difficult to detect disease biomarkers, unique combinations of small molecules that may be present only in trace quantities in human breath. The engineers figured that the technology they used in rocket testing, laser absorption spectroscopy, would be sensitive enough to make measurements of trace compounds in the breath. For detecting gases in combustion flows, the technology works like this: A laser beam at a specific frequency is fired across a stream of burning gases, and a sensor on the other side of the beam measures the quantity of light that is transmitted through the gases. From this information, gas properties like temperature, velocity and the chemical composition of the exhaust gas mixture can be identified almost instantaneously. Just as engineers can use these data to tell if an engine is operating efficiently, they could tell if a human “engine” is operating in a healthy range. To analyze the gases in human breath, Miller and Strand realized they’d need a laser that emits light in the mid-infrared frequency range. They also needed someone experienced in this range, and luckily, there was just such an expert on the other side of the rocket lab: Mitchell Spearrin. Spearrin’s life trajectory was set when he watched a rocket from Cape Canaveral soar over his home near Bryceville, Florida, population 3,000. “I wanted to be an astronaut,” said Spearrin, 31, who is married with two daughters and looks like someone who might be cast as a square-jawed hero in a Hollywood blockbuster. Although the U.S. space program was nearby, this career goal seemed light years away from his small, rural town. As a kid, he focused on sports and became the captain of his high school football and baseball teams, a natural leader. He also was good at math and graduated as the straight-A valedictorian of his senior class. Encouraged by his parents, an elevator mechanic and a stay-at-home mom, Spearrin was determined to be the first in his family to attend college. He also hoped to play sports at the collegiate level, and it was through football that he found himself unexpectedly recruited by Harvard late in his senior year. In a matter of weeks he went from never having considered an Ivy League school to committing to Harvard’s football program and, in turn, an education he could not have fathomed. It eventually led him to Stanford’s mechanical engineering doctoral program. During his time at Harvard, Stanford and a stint at aerospace manufacturer Pratt & Whitney, Spearrin fell in love with rocketry. “These machines represent a certain pinnacle of engineering: rockets control a convolution of physical extremes with a precision driven by intolerance for human error,” he said. Spearrin, who at one point was voted by his Harvard football teammates as “most likely to start a business,” liked the idea of the breath analyzer, so he joined the effort. And at that point, they had a team in place. Strand knew about lasers. Miller knew about gas handling and photonics hardware. Spearrin knew about rapid analysis of gases using mid-infrared lasers. And Enns agreed to be their medical research mentor. They started off the project with two roundtable discussions that included Enns, Stevenson and several other pediatricians. (Stevenson had worked on breath analysis of bilirubin, a chemical that can signal jaundice in newborns, early in his career.) They discussed the most urgent clinical needs for newborns, and ammonia screening rose to the top. A second priority would be to detect acetone, a diabetes marker, in newborns. The graduate students then wrote a three-page proposal for their breath ammonia analyzer and submitted it for a pilot grant from Spectrum, a Stanford program that funds researchers with bold ideas for addressing important health-care problems. (Primary funding for these grants comes from the Spectrum Clinical and Translational Science Award from the National Institutes of Health.) They were awarded $49,000 to launch the project and teamed up with an industry mentor, Darlene Solomon, Ph.D., senior vice president and chief technology officer of Agilent Technologies. Then the countdown began. They had a year to get a prototype working. “I thought it was a simple, elegant solution — though at the time, it seemed as if was too simple to actually work, given the small quantities of ammonia they were trying to measure within the complexity of human breath” said Solomon. The project got off to a slow start. The funds were delayed, and all three engineers had rocket science “day jobs” to work around. They began with a schematic on how their device works. A person blows into a tube and breath gases are collected in a pressure-regulated cylinder that directs a controlled gas stream across a mid-infrared laser beam. When the beam hits ammonia, the molecules absorb specific wavelengths of light. A photodetector measures the amount of light that passes through the ammonia, then custom software calculates quantities of ammonia and plots it on an easy-to-read graph on a laptop computer. The device also measures carbon dioxide as a way of telling the software that one breath cycle is complete and another one is beginning. The first prototype used a clear quartz tube for the gas cylinder, which Miller purchased for $50 on eBay from an equipment salvager in Austin, Texas. The breathing tube was attached to one end of the cylinder. Flow meters, pumps and valves were attached to the other end, all scavenged from the rocket lab. These would direct the gas stream across the laser beam. Optical mirrors directed the laser beam onto the photodetector. Initially, the prototype was built on an 8- by 4-foot table with a Rube Goldberg array of gas-handling tubes, pumps and pressure gauges sprawled above and below. The team began to make its first measurements of breath ammonia, and during the first trial runs realized why no one had ever successfully developed an ammonia breath analyzer. “Ammonia is a nightmare to work with,” said Spearrin. Because the molecules are highly soluble in water and have an unstable electrical charge, they tend to stick to everything, including the inside of the human mouth and the walls of plastic tubing. So they switched to nonstick Teflon tubing. Temperature fluctuations distorted ammonia measurements, so an on-board heater and insulation had to be added to the device. Finally, after six months of tweaking, the team brought its second-generation prototype into a quarterly grant-review meeting. The prototype was packed inside a custom box, which was placed on a wheeled cart. Beneath were a data acquisition system and various measurement instruments, all of which would be miniaturized into a more compact format in a commercial product. A volunteer from the meeting blew into the tube, and a graph of the levels of ammonia and carbon dioxide in that given breath appeared on the computer screen. Enns’ first impression of the rapid, easy-to-use device was “jaw-dropping amazement.” With the help of Enns, the engineers received Institutional Review Board permission to test their ammonia breath analyzer on human subjects, specifically two 16-year-old boys admitted to the hospital for hyperammonemia. These teens were representative of their target patient population — they were cognitively and physically impaired from ammonia surges. One used a wheelchair. Both spoke slowly, in broken sentences. It brought home the importance of why the team was working on the breath analyzer project. Their plan was to have the teens blow into the device’s breathing tube after each of their blood draws over the two or three days it would take to normalize their ammonia levels. But they soon realized that it was difficult to explain to the teens how hard to blow. Finally, Strand figured out a strategy that worked. He gave the boy the tube and said, “Pretend that this is your elephant nose and make a sound like an elephant.” This insight prompted the team to redesign the software to provide visual feedback that showed patients when they were blowing hard enough. They also started designing a passive, under-nose breathing tube that could be used without active blowing, which will be necessary for some patients but requires more sensitive detection. Patient testing also refined their thinking on the technological advantage their device brings to the field. The major weakness of the ammonia blood test is that by the time the results are received by a treating physician, it is hour-old information that may not represent the true ammonia levels of a patient. The breath analyzer enables super-fast, repeatable testing so ammonia levels can be verified and treatment can begin immediately. “Babies breathe so fast that it’s hard to get an accurate ammonia reading using a device with a slow response time,” said Spearrin. “What our device is really good at is rapidly measuring intra-breath dynamics, showing how the chemical composition of a breath changes over time.” In just a year, the team had gone from a rough idea on paper to a working prototype, patient-tested. This is warp speed in the medical device world. They are also preparing articles for publication describing the underlying spectroscopy, the device and, ultimately, their clinical studies. Spearrin didn’t realize how hard this project was supposed to be until he called a respected expert on hyperammonemia for advice. Before Spearrin could ask his questions, the expert said, “You’ve chosen a horribly challenging project because ammonia is the most difficult molecule to measure and newborns are the most difficult patient population to work with.” Spearrin replied, “But we’ve already built a working prototype and we’ve tested it on two patients.” In the fall of 2015, the team is planning a second, larger patient trial that will involve younger children. There’s a good chance Ethan will be in that trial. Since they finished their first prototype, they’ve received grants from the NIH’s Small Business Technology Transfer program and the Wallace H. Coulter Foundation. The Stanford Office of Technology and Licensing has filed a provisional patent, and the team has formed a company, Lumina Labs. The company, funded by the NIH small business grant, has established a research consortium with Enns and Stanford. “What impressed me about this development team is that they really listened to all the advisers’ technical concerns, methodically addressing each one. And they did so while still getting a prototype into testing amazingly quickly,” said Solomon. Five years after his birth, Ethan Pham, with chubby cheeks and bear-cub ears, looks and acts like a typical kindergartener. His mother — a halo of dark hair framing her ivory face — plays with him as he sits in his hospital bed, happily singing with cartoon farm animals on TV. On the bed tray is a sheet of paper where he has practiced writing his name with crayons. Ethan is recovering from a surgical procedure to insert a tube through his chest into an artery of his heart. This permanent IV port will make it easier for the care team to quickly administer ammonia-grabbing drugs when needed. In the past, a nurse would have done this by inserting a syringe into an arm blood vessel, but with so many pokes over the years, it became hard to find an undamaged, free-flowing vein. He’s also under observation for high, unexplained fluctuations of ammonia. It takes a dedicated team to keep Ethan alive. His family, schoolteachers and medical practitioners are continually on the lookout for signs of high ammonia levels. Episodes can happen at any time. Each incident means a 30-minute drive to the critical care unit, where staff members stand ready to draw blood. Ethan’s medical team — his pediatrician, Rebecca Fazilat, M.D., at Sutter Health San Jose; Enns; and the hospital staff at Stanford Children’s Health — is on call 24/7. Many times the ammonia blood tests, which can be done only at the hospital, are wrong or ambiguous. If the test is positive, it typically takes a day or two in the hospital to normalize the ammonia levels, with repeated blood tests every few hours. Sometimes the family is halfway home when a nurse calls them back to redo a test. Ethan has spent about half of his kindergarten year in the hospital. Ethan’s teachers have been trained to accommodate his condition. His work areas must be extra clean and sick kids need to be kept away. His diet is carefully monitored — no birthday cake, since he can’t digest it. Ethan doesn’t have the muscle strength to climb on the playground equipment, so he often sits on the side, playing with his plastic farm animals or trying to kiss Catherine, a girl in his class he really likes. Nguyen and Pham, like most parents who have children with metabolic defects, are perpetually fatigued. When Ethan is in the hospital, Nguyen stays by his side and her husband joins her after work. They often eat dinner at the hospital cafeteria. Nguyen’s parents and sister live close by, and they help out when they can. For Nguyen, it’s a full-time job keeping Ethan from slipping into an ammonia-induced coma. What keeps them going is their faith (Nguyen is a Catholic and Pham is a Buddhist) and the hope that someone, maybe even the rocket men, will find a better way to test ammonia levels in children with metabolic diseases at the hospital and at home. This would allow Ethan, with his enduring strength, and his family to live a more normal life. It’s worth looking at the breath analyzer project and asking, what can fuel more of these big ideas in medicine? Spearrin recently summed up what motivated his team: “For us, it’s not that ammonia sensing is the perfect challenge. It’s that the breath analysis field is underdeveloped. We’re leaders in this particular gas-analysis technology, and there are clinical researchers here at Stanford really open to collaborating with us. It gives us a chance to make a significant contribution through cross-disciplinary efforts.” What worked was to empower an ambitious team of young engineers to look at an old medical problem with fresh eyes. They were given starter funds to try out their big ideas without fear of failure. There was institutional buy-in, making it acceptable for people outside of the medical system to observe, ask questions and change the way things have been done in the past. And they were given access to mentors who could inspire them, help remove bureaucratic roadblocks and keep them from making big mistakes. Strand added, “Being in a clinic and working with kids gave me a unique sense of purpose that I haven’t felt in my research before. I’ve had the good fortune of getting to be part of a lot of exciting and challenging research, but never where the need is so tangible, urgent and, most certainly, so personal. It makes a difference if this problem is solved today instead of tomorrow.” Of course, anyone familiar with medical device development would be quick to add that there’s a tremendous amount of work to be done before the ammonia breath analyzer is widely available. There need to be more prototypes. Clinical trials. Independent validations. But one thing we all can probably agree on is this: Medicine needs more rocket scientists.

News Article | February 23, 2017
Site: www.eurekalert.org

MIAMI--Last year's devastating category-5 hurricane--Matthew--may be one of many past examples of a tropical storm fueled by massive rings of warm water that exist in the upper reaches of the Caribbean Sea. In a study conducted in the region two years prior to when Matthew's trekked across the Caribbean Sea, the research team in the Upper Ocean Dynamics Laboratory at the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science deployed 55 aircraft ocean instruments from the National Oceanographic Atmospheric Administration's WP-3D aircraft. The purpose of the scientific mission was to measure ocean temperature, salinity, and currents to understand the structure of these warm-water eddies. The science team obtained vital information about the physical characteristics within one large warm-water eddy, which likely originated from the North Brazil Current, and analyzed its potential influence on sub-surface ocean conditions during the passage of tropical cyclones. When analyzing the data, they found a barrier layer, an upper ocean feature created by the Amazon-Orinoco freshwater river outflow, that makes mixing in the upper ocean waters less efficient during wind events. This feature, and the fact that warm ocean eddies are known to assist in the intensification of hurricanes due to deep warm thermal layers, lead the researchers to theorize that the barrier layer within a warm ocean eddy may result in an even more favorable upper ocean environment for hurricane intensification. "Our study is important because tropical cyclone intensity forecasts for several past hurricanes over the Caribbean Sea have under-predicted rapid intensification events over warm oceanic features," said Johna Rudzin, a PhD student at the UM Rosenstiel School and lead author of the study. Tropical storms receive energy from their surrounding ocean waters. As a storm moves across the water, it may interact with rings of warm water known as eddies. As the storm moves forward over these eddies, the warm ocean waters below help fuel the storm's intensity through enhanced and sustained heat and moisture fluxes. Similar warm ocean eddies exist in the Gulf of Mexico, a result of their separation from the warm-water Loop Current, are also of interest to the research team involved in this study. Last year, Hurricane Matthew rapidly intensified from a tropical storm to hurricane status as it moved over the Caribbean Sea in the location where a warm ocean eddy exists, and in close proximity to where these measurements were taken for this study two years prior. Matthew continued to intensify to a category-5 storm and into one of the strongest in Atlantic basin history, which made landfall and devastated portions of Haiti, Cuba, and the eastern United States. According to the researchers, to better understand if Matthew's intensification was aided by the warm-water eddies and the residing barrier layer in the Caribbean Sea's upper ocean, more ambient and in-storm upper ocean observations in this basin are needed to improve forecast models for the region. The study, titled "Upper Ocean Observations in Eastern Caribbean Sea Reveal Barrier Layer within a Warm Core Eddy," as published Feb. 10 in Journal of Geophysical Research: Oceans, DOI: 10.1002/2016JC012339. The study's authors include: Johna E. Rudzin, Lynn "Nick" Shay, Benjamin Jaimes, and Jodi K. Brewster of the UM Rosenstiel School. Support was provided by National Aeronautical Space Agency (NASA) through grant # NNX15AG43G. The University of Miami is one of the largest private research institutions in the southeastern United States. The University's mission is to provide quality education, attract and retain outstanding students, support the faculty and their research, and build an endowment for University initiatives. Founded in the 1940's, the Rosenstiel School of Marine & Atmospheric Science has grown into one of the world's premier marine and atmospheric research institutions. Offering dynamic interdisciplinary academics, the Rosenstiel School is dedicated to helping communities to better understand the planet, participating in the establishment of environmental policies, and aiding in the improvement of society and quality of life. For more information, visit: http://www. and Twitter:UMiamiRSMAS

News Article | November 16, 2016
Site: phys.org

Large amplitude rolling motion makes large container ships extremely unstable and vulnerable to crew and cargo accidents, machinery failure, structural damage and possibly capsizing. Large amplitude rolling due to parametric excitation occurs when the length of the wave is comparable to the ship length leading to especially pronounced variations in stability of the ship as it sails through rough seas. The ship is alternately pushed from side to side, and—in only a few  cycles, elevated waves with rolling angles of more than 35 degrees are formed—making it dangerous for the crew and the cargo. "The motion of a ship or offshore structure in waves has always been a fascinating problem for the naval architect," said Dr. Jeffrey Falzarano, professor in the new Department of Ocean Engineering at Texas A&M University. Falzarano, a naval architect by training has been studying the phenomenon of fishing vessels roll motion and capsizing since his days as a graduate student. "Large amplitude parametric rolling motion of container ships in head seas where the waves run directly against the course of a ship, however, is a relatively new problem," he said. "It has posed severe concerns of ship stability." Falzarano, along with former student Dr. Amitava Guha and graduate students Dr. Abhilash Somayajula and Yujie Liu, has developed the Marine Dynamics Laboratory (MDL) Suite, a series of software programs that predict the probability of large amplitude rolling motion. Reducing the likelihood of an accident caused by the rolling is considered a more effective approach than mitigating the consequences. Supported by the Office of Naval Research's's Environmental Ship Motion Forecasting program, the group is helping develop the next generation roll motion prediction tools  for naval architects. "Much of the stability criteria for ship design currently fails to account for the dynamic motions of the ship," said Somayajula. "The older criteria assume the waters are calm and so we need a new set of next generation stability rules based on the vessel's dynamic response in realistic waves ." According to the researchers, new and improved design and operation of container ships can effectively reduce the likelihood of large amplitude rolling motion occurring. Falzarano and Guha developed MDL HydroD, a frequency-domain tool that analyzes interactions of waves and structures. The software program is a three-dimensional panel code that calculates first and second order wave loads and motion response at zero and forward speed in deep and shallow water. Falzarano and Somayajula expanded on Guha's work to develop SIMDYN, a time-domain tool that uses the frequency-domain results of MDL HydroD. The software program analyzes accurate models of the vessel's motion in random waves. SIMDYN considers concepts such as nonlinear hydrostatics, nonlinear Froude Krylov forces and calculated roll damping to simulate the nonlinear and random vessel motions. Somayajula is currently applying this tool to analyze parametric roll of ships in irregular seas and solve the problem of optimization of ship design for safer, more stable and efficient vessels. Falzarano and Liu's research extends Guha's MDL HydroD program to consider multiple vessels. It is designed to accurately evaluate the hydrodynamic responses of multiple floaters considering first and second order wave loads between multiple vessels, side by side offloading and analysis of wave elevation between the vessels. "There is a tremendous amount of interaction between multiple ships of varying sizes because of the gap between them," said Falzarano. "This is not well predicted well in the models and we need to analyze experimental data to improve the prediction." Researchers say, this potential flow software program addresses the need for a reliable tool seeking practical and cost-effective solutions in applications of offshore technology. There is a growing interest in understanding how they will interact with each other and seeking for a reliable and economically efficient plan. To accurately predict rolling motion, Falzarano and his team analyzed the model test data taken from experiments conducted on R/V Melville, a general-purpose oceanographic research vessel operated by the University of California San Diego's Scripps Institution of Oceanography. The researchers are currently extending the MDL Suite of software programs to study steady wave resistance in a ship. The potential flow method is known for its efficiency and can used as an initial screening to identify promising candidates. These candidates can then be further analyzing using more sophisticated techniques such as computational fluid dynamics or model testing. This allows for the sequential use of these approaches in order to simultaneously optimize hull forms for motions and wave resistance. Their next step includes using the MDL Suite to study other important problems such as offshore floating wind turbines and nonlinear wave loading. Explore further: Maths could help search and rescue ships sail more safely in heavy seas

Bucher I.,Dynamics Laboratory
Journal of Sound and Vibration | Year: 2011

This paper presents a method to separate the complex vibration pattern of a rotating disk into simpler entities. The decomposition transforms data measured by an array of sensors into time domain signals representing the contribution of individual modes of vibration. Having performed the decomposition with respect to wavelength, speed and direction of travel, the obtained measurements can be projected onto a rotating body experiencing variable rotational speed relative to the sensors. Unlike previous works, the vibrations here are decomposed into time domain signals that provide better insight into stress levels and fatigue than frequency domain based decompositions. Furthermore, the proposed method works under non-stationary conditions, e.g. under rapid angular acceleration and during transient motions. By exploiting the spatial deployment of sensors, the proposed transformation can produce information about the deformations in the body-fixed or material coordinates which is essential for stress analysis. The main feature of the method is the ability to separate modes of vibration that normally overlap in the frequency domain, to enable better insight into the sources of vibration. The method is demonstrated by analytical, numerical and experimental examples. © 2010 Elsevier Ltd. All rights reserved.

Bucher I.,Dynamics Laboratory | Shomer O.,Dynamics Laboratory
Mechanical Systems and Signal Processing | Year: 2013

Asymmetry and anisotropy are important parameters in rotating devices that can cause instability; indicate a manufacturing defect or a developing fault. The present paper discusses an identification method capable of detecting minute levels of asymmetry by exploiting the unique dynamics of parametric excitation caused by asymmetry and rotation. The detection relies on rigid body dynamics without resorting to nonlinear vibration analysis, and the natural dynamics of elastically supported systems is exploited in order to increase the sensitivity to asymmetry. It is possible to isolate asymmetry from other rotation-induced phenomena like unbalance. An asymmetry detection machine which was built in the laboratory demonstrates the method alongside theoretical analysis. © 2013 Elsevier Ltd.

Bucher I.,Dynamics Laboratory | Halevi O.,Dynamics Laboratory
Mechanical Systems and Signal Processing | Year: 2014

Sensor calibration is a routine task which is often performed under the assumption of linearity and immediate response. The present paper addresses the task of calibrating a statically or zero-memory nonlinear sensor given delayed measurements that can give rise to a multi-valued relationship. A simple, optimal, non-parametric figure-of-merit is proposed to eliminate the delay or phase lag in sensing without the use of parametric models or Fourier transformation. The phase estimation at a selected frequency is not accurate when some nonlinear distortions are present. It is shown that a delayed measurement of a calibration device under periodic oscillations, creates a Lissajous-like curve which encloses an area directly proportional to the delay time. An efficient numerical optimization based on Green's integral, the time-shift of the reference sensor is varied until a non-delayed, single-valued calibration curve is obtained. Copyright © 2013 Published by Elsevier Ltd. All rights reserved.

Dolev A.,Dynamics Laboratory | Bucher I.,Dynamics Laboratory
Proceedings of the ASME Design Engineering Technical Conference | Year: 2015

The present work introduces a tunable parametric amplifier (PA) with a hardening, Duffing-type nonlinearity. By introducing a multi-frequency parametric excitation, one is able to achieve both: (i) High amplification of the weak, lowfrequency external excitation (ii) Projection of the low frequency on any natural frequency of the system, thus transforming the low frequency excitation to a frequency band where signal levels are considerably higher. Having developed multiple-scales based expressions for the response of such systems, it is demonstrated that (a) The analytical analysis agrees well with numerically obtained simulations. (b) Both the phase, magnitude and spatial projection of this force on any system's eigenvector can be retrieved by appropriate selection of parameters, with superior signal to noise levels. Closed form analytic expressions for the sensitivity and gain are derived and analyzed. Additionally, some practical applications envisaged for the proposed method will be outlined. © Copyright 2015 by ASME.

Loading Dynamics Laboratory collaborators
Loading Dynamics Laboratory collaborators