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Ayoub D.,Dr Erfan and Bagedo General Hospital | Lopetuso L.R.,Catholic University of the Sacred Heart | Chamseddine F.,American University of Beirut | Dajani A.,ADS Center | And 8 more authors.
European Review for Medical and Pharmacological Sciences | Year: 2016

Objective: Gastroenteritis represents with respiratory tract infection the most common infectious disease syndrome of humans in developing countries. Gut microbiota regional variation and dysbiosis play a crucial role in triggering and worsening this devastating GI disease. Materials and Methods: With this manuscript, we want to explore and emphasize the critical aspect of acute gastroenteritis in Middle-East Countries and its correlation with the clinical aspect of gut microbiota modification and intestinal homeostasis. Results: Approximately 1 of 50 children born each year in developed nations is hospitalized for acute gastroenteritis sometime during childhood. The highest rate of illness occurs in children between 3 and 24 months of age. The common causes of diarrhea are infections with viruses and bacteria, diarrhea due to a systemic infection other than gastrointestinal, diarrhea associated with antibiotic administration, and feeding related diarrhea. The single most common diarrheal disorder observed in the Emergency Department and general practice is viral gastroenteritis. In particular, Rotavirus is the cause of more than 2 million hospitalizations and over half a million deaths from acute GE in infants and young children. This burden produces also direct and indirect economic costs. The use of probiotics to counterbalance commensal dysbiosis is emerging as a standard medical practice in these countries. Conclusions: In this scenario, one of the most interesting aspects is that probiotics and gut microbiota modulation could deeply improve the prevention and treatment of this devastating GI pathology. At the same time, vaccination might represent a cost-effective strategy to reduce the health and economic burden of some pathogens, such as rotavirus.

Mane R.S.,DY Patil Medical College and Hospital | Patil B.C.,DY Patil Medical College and Hospital | Mohite A.A.,DY Patil Medical College and Hospital
Clinical Rhinology | Year: 2012

Mucormycosis refers to a severe infection with fungi of order Mucorales, seen in diabetic and immunocompromised patients. Rhino-orbito-cerebral mucormycosis is known to exist in two forms, the well-known acute form and the less well-recognized chronic form. The most common presenting features of the chronic form are ophthalmologic, including ptosis, proptosis, visual loss and ophthalmoplegia. Here, we report a case of chronic rhinocerebral mucormycosis (RCM) presented with nonhealing oroantral fistula in a diabetic patient without any orbital symptoms. We are reporting this case for its unusual presentation.

Mehta K.,Dy Patil Medical College And Hospital | Sahasrabudhe T.R.,Dy Patil Medical College And Hospital
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

The aim of the study was to study the differences in various parameters of lung function as assessed by spirometry in subjects who do regular aerobic exercises versus those not doing regular aerobic exercises in healthy young adults(mean age 26-28 years). Duration of Study was of 1 month. Sample Size was (n) =50 in each group. The groups were defined as follows: Group A (Study Group): Doing regular aerobic exercise for at least 20 minutes a day, for at least five days a week, for at least one year. Group B (Control Group): Not doing regular exercise as described above. A spirometry was performed. Mean FEV1/FVC in the study group was 85.39 as compared to 83.8 in the control group. Lung functions as assessed by spirometry are not significantly better in the persons doing regular aerobic exercises as compared to the persons not doing regular exercises. The good effects of regular exercises on respiratory function may be apparent after a longer duration of exercises and also may become more apparent in relatively older population when the functions of body systems start derailing. Doing a similar study in older population (age above 40 years) may help us to assess this hypothesis.

Singh P.K.R.,Dy Patil Medical College And Hospital | Sahasrabudhe T.,Dy Patil Medical College And Hospital | Dharmadhikari V.,Dy Patil Medical College And Hospital
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Asthma being one of the most common respiratory disorder among children should be controlled in early childhood to prevent its long term complication. A number of misconceptions and wrong practices lead to poor compliance with the treatment thus causing uncontrolled disease and increasing the morbidity and mortality among the pediatric population. The present study was aimed to assess the knowledge of asthma and various misconception in parents of asthma patients. It was a questionnaire based study and each subject was interviewed personally. No leading question was given to the subjects. Of all subjects 37% of parents believed that the disease is not controllable, 51% of them believed that their children will not be able to take part in sports, almost half of then believes that tablets are a better then inhalers for treatment. 2% of the parent believed that the disease is contagious, 60% of them do not know about the chronic nature of disease. Most of the parents are not aware about the correct technique of taking DPI/PMDI. It was concluded that a number of misconceptions and wrong practices regarding use of inhalers are prevalent and thus various educational programs on the management of asthma needs to be organized.

Badhwar V.R.,DY Patil Medical College and Hospital | Ganapathy S.,Gurunanak Hospital | Prabhudesai P.P.,Lilavati Hospital and Research Center | Tulara N.K.,Dr Lh Hiranandani Hospital | And 2 more authors.
Journal of Association of Physicians of India | Year: 2016

In community and family practice, infections are a common OPD presentation. In the management of common bacterial infections seen in community especially RTI, UTI, SSTI; cefuroxime a second generation cephalosporin with a broad spectrum of activity can be used for empirical treatment. To know current place of cefuroxime in the management of infections, physicians, surgeons, microbiologist, chest physician, gynecologist and pediatrician came together to discuss and debate their experience with cefuroxime and its place in today's world. Cefuroxime is a drug which balances efficacy with safety. Several international bodies and guidelines including the US FDA and The British Thoracic Society, the World Society of Emergency Surgery (WSES) have recommended cefuroxime for the management of community acquired pneumonia and skin and soft tissue infection respectively. Cefuroxime has been recommended in the 2015 list of the US FDA list of drugs which can be used safely during pregnancy. Cefuroxime can become a useful empiric choice antibiotic for the Indian physicians treating urinary tract infections, respiratory tract infections and skin and soft tissue infections in their outpatient departments. © 2016, Journal of Association of Physicians of India. All rights reserved.

Borle M.,DY Patil Medical College and Hospital | Pande V.,DY Patil Medical College and Hospital | Agarkhedkar S.R.,DY Patil Medical College and Hospital | Singh A.,DY Patil Medical College and Hospital
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

We conducted a cross sectional observational study in a tertiary care hospital. We studied the breast feeding pattern and knowledge of mother about breastfeeding.160 mothers were included in the study. This study was designed to determine breastfeeding practices, knowledge and associated socio-demographic factors of mothers attending immunization OPD, in those mothers who delivered in that tertiary care hospital. It was found that early initiation of breastfeeding, avoidance of prelacteal feeds, exclusive breastfeeding were more prevalent in educated mothers. To determine breastfeeding practices and knowledge of mothers, attending immunization OPD in paediatrics, in those mothers who delivered in that tertiary care hospital. To determine impact of education, parity, type of family on breastfeeding practices.

Mhase A.,Dy Patil Medical College And Hospital | Sahasrabudhe T.,Dy Patil Medical College And Hospital | Meshram S.,Dy Patil Medical College And Hospital
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Inhalational medicines are the mainstay of treatment of OAD. It is however a common observation of the clinicians that many patients are hesitant to use these devices or tend to stop them. As poor adherence to a inhalational medication regimen and inhalation technique are closely related to inadequate disease control, poor health outcomes, increasing utilization of health services and economic loss due to ineffective treatment. It is important to find out the reasons for such non-adherence. Therefore we thought to evaluate these factors in our patients so as to improve adherence to inhalational devices through proper counseling. After getting informed consent from patients, 102 patients were enrolled in the study. Predefined Questionnaire in patients own language were given to the patient and that was filled by marking true or false. This questionnaire included questions assessing adherence and non-adherence to inhalational therapy was then checked. Data of all such patients was analyzed at the end. Out of 102 patients 61 patients(59.80 %) were adhere to inhalational therapy and 41 patients (40.20 %) were non adherence to Inhalational therapy. And common reasons for adherence and non adherence were identified.

PubMed | Dy Patil Medical College And Hospital
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016

Drug Induced Lupus Erythematous (DILE) is a rare adverse reaction to a large variety of drugs including Isoniazid (INH), with features resembling idiopathic Systemic Lupus Erythematosus (SLE). Diagnosis require identification of a temporal relationship between drug administered and symptom. It is an idiosyncratic reaction, with no pre-existing lupus. Our case highlights a rare presentation of isoniazid induced lupus with profound pancytopenia and mucosal ulcers, thus posing a diagnostic challenge. The patient was on multidrug treatment for pulmonary and knee joint tuberculosis. DILE was diagnosed on basis of strongly positive Anti Nuclear Antibodies (ANA), anti ds DNA and antihistone antibodies with clinical response to cessation of INH.

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