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Singh P.,Dy Patil Medical College | Verma S.K.,P.A. College
Indian Journal of Forensic Medicine and Toxicology | Year: 2015

Road traffic accidents (RTA) are among the leading cause of morbidity and mortality worldwide and will be the second most common cause of disability-adjusted life years in developing countries by the year 2020. A five year retrospective study of road traffic injury cases was conducted at the newly established Index Medical College Hospital and Research Center Indore M.P. A total of 596 medicolegal cases were studied, accidents 484(81.20%) accounted as the major cause of all incidences and road traffic accidents 362(60.7%) alone constituted the majority. Out of the 362 cases of RTA, 282(79.9%) were male and 80(22.1%) female victims with male to female ratio of 3.5:1. Highest number of victims, 120(33.2%), belonged to 21-30 years age group. Month of April recorded the maximum cases 48(13.2%), the most common time interval of accident remained 1601-2000 hours and included 139 (38.4%) of cases. Ninety (24.9%) cases had hospital stay of under 24 hours, 243(67.1%) were discharged after satisfactory management. Two-wheelers use was the most common mode of injury 217(59.9%) and also the most common means of victim being hit 123(34%). Head and neck region with 140 (38.7%) cases, was the most common part of the body involved in road traffic injury; 47% of the males and 23.8% of females in the study suffered fracture and 53% of all fractures involved the lower-limb. © 2015, Indian Journal of Forensic Medicine and Toxicology. All rights reserved.

Singh P.,Dy Patil Medical College | Verma S.K.,P.A. College
Medico-Legal Update | Year: 2015

Profiling of the medicolegal cases is important to know the quality and quantity of caseload to be expected by the medicolegal workforce serving the area. A retrospective study was conducted at Index Medical College Hospital and Research Center Indore M.P. covering the first five years of its establishment as a teaching hospital in the rural area of central India. The study revealed that road traffic accidents (60.7%) constituted the majority of medicolegal cases out of the total 596 cases, followed by poisoning (14.3%) and assault (10.6%). Accidents were the major cause of injury; male preponderance was at 2.6: 1, most affected age group was 21-30 years (36.2%). The peak time of incidence was during 1601-2000 hours (36.4%) and the maximum cases were recorded in the month of April (11.1%). Out of the 596 cases 408 (68.5%) were discharged and 12 (2%) died due to their injuries. © 2015, World Informations Syndicate. All rights reserved.

Khane R.S.,Dy Patil Medical College
Journal of Clinical and Diagnostic Research | Year: 2012

Breast cancer is the commonest cancer in women worldwide. Today, there is no woman in the world who is at a truly low risk of developing the disease. In India, the growing epidemic of breast cancer presents a major challenge to the global public health, especially, given the failure to cope with the current situation. The burden of breast cancer will continue to increase, not only in terms of the absolute number of cases, but also in terms of its incidence. It has long been observed that 5 to 10% of the breast cancers are the result of an inherited familial predisposition. So, the precise knowledge of the underlying genetic processes is useful for the early detection and prevention of breast cancer. As mammography will be difficult to be implemented in India for various reasons and also because of its complex nature and high cost, genetic testing is not presently routinely available in India. So, efforts should be made to detect breast cancer at an early stage by educating the people about the risk factors and screening methods like Breast Self Examination, because late stage presentation is the main problem in India, which leads to a poorer prognosis. In this review, the risk factors for the development of breast cancer, the role of various genes in the pathogenesis of breast cancer, the possible options for high risk women and the socio-cultural issues regarding breast cancer have been outlined.

Kulkarni P.S.,Serum Institute of India Ltd | Manjunath K.,Lambda Therapeutics Pvt. Ltd. | Agarkhedkar S.,Dy Patil Medical College
Vaccine | Year: 2012

An alum adjuvanted whole virion inactivated vaccine against the A (H1N1) 2009 pandemic virus was developed in India. Two double-blind, randomized studies were conducted. Fifty adults (18-50 years) were enrolled in the Phase I study, whereas the Phase II/III study consisted of 330 adults (≥18 years) and children ≥3 years. Safety (both studies) and immunogenicity (Phase II/III study) by hemagglutination inhibition (HI) antibody titers, of 10. μg or 15. μg of hemagglutinin (HA) antigen were compared. In the Phase I study, mostly mild and transient injection site and systemic reactions were reported. Similar events were seen in the Phase II/III study. The overall seroprotection was 96% and 89% with 10 and 15. μg doses, respectively, while the seroconversion was 92% and 88%. The new Indian-made pandemic H1N1 vaccine is safe and immunogenic in adults and children above 3 years of age. © 2012 Elsevier Ltd.

Chaudhary S.,Dy Patil Medical College
Medico-Legal Update | Year: 2012

This study was carried out to estimate the relationship between foot dimensions and stature using simple linear regression analysis based on a sample of male and female of Kolhapur district. Measurements of the foot length, foot breadth and stature were taken from 1200 subjects (600 male, 600 female). Obtained data was analysed and attempt was made to find out correlation between the foot dimensions and stature of an individual. A good correlation of height was observed with foot dimensions and it was statistically significant. The results of the present study would be useful for anthropologists and forensic medicine experts.

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