Kulkarni P.S.,Serum Institute of India Ltd. |
Manjunath K.,Lambda Therapeutics Pvt. Ltd. |
Agarkhedkar S.,Dy Patil Medical College
Vaccine | Year: 2012
An alum adjuvanted whole virion inactivated vaccine against the A (H1N1) 2009 pandemic virus was developed in India. Two double-blind, randomized studies were conducted. Fifty adults (18-50 years) were enrolled in the Phase I study, whereas the Phase II/III study consisted of 330 adults (≥18 years) and children ≥3 years. Safety (both studies) and immunogenicity (Phase II/III study) by hemagglutination inhibition (HI) antibody titers, of 10. μg or 15. μg of hemagglutinin (HA) antigen were compared. In the Phase I study, mostly mild and transient injection site and systemic reactions were reported. Similar events were seen in the Phase II/III study. The overall seroprotection was 96% and 89% with 10 and 15. μg doses, respectively, while the seroconversion was 92% and 88%. The new Indian-made pandemic H1N1 vaccine is safe and immunogenic in adults and children above 3 years of age. © 2012 Elsevier Ltd.
Dhikav V.,Guru Gobind Singh Indraprastha University |
Karmarkar G.,DY Patil Medical College |
Gupta R.,Krishna Hospital |
Verma M.,Krishna Hospital |
And 3 more authors.
Journal of Sexual Medicine | Year: 2010
Introduction: Yoga is a popular form of complementary and alternative therapy. It is practiced both in developing and developed countries. Female sexual dysfunctions are common and do not always get adequate clinical attention. Pharmacotherapies for treating female sexual dysfunctions are available but suffer from drawbacks such as poor compliance, low efficacy, and side effects. Many patients and yoga protagonists claim that it is useful in improving sexual functions and treating sexual disorders. Aim.: To establish the effect yoga can have on female sexual functions. Methods.: We recruited 40 females (age range 22-55 years, average age 34.7 ± 8.49 years) who were enrolled in a yoga camp and were given a standardized questionnaire named Female Sexual Function Index (FSFI) before and after the 12 weeks session of yoga. Main Outcome Measures.: FSFI scores. Results.: It was found that after the completion of yoga sessions; the sexual functions scores were significantly improved (P < 0.0001). The improvement occurred in all six domains of FSFI (i.e., desire, arousal, lubrication, orgasm, satisfaction, and pain). The improvement was more in older women (age > 45 years) compared with younger women (age < 45 years). Conclusions.: Yoga appears to be an effective method of improving all domains of sexual functions in women as studied by FSFI. © 2009 International Society for Sexual Medicine.
Goel A.,Kem Hospital |
Goel A.,University College London |
Satoskar S.,Kem Hospital |
Mehta P.,Dy Patil Medical College
Journal of Craniovertebral Junction and Spine | Year: 2014
Aim: The authors report experience with 14 cases where two screws or ′′double insurance′′ screws were used for transfacetal fixation of each joint for stabilization of the lumbar spinal segment. The anatomical subtleties of the technique of insertion of screws are elaborated. Materials and Methods: During the period March 2011 to June 2014, 14 patients having lumbar spinal segmental instability related to lumbar canal stenosis were treated by insertion of two screws into each articular assembly by transfacetal technique. After a wide surgical exposure, the articular cartilage was denuded and bone chips were impacted into the joint cavity. For screw insertion in an appropriate angulation, the spinous process was sectioned at its base. The screws (2.8 mm in diameter and 18 mm in length) were inserted into the substance of the medial or inferior articular facet of the rostral vertebra via the lateral limit of the lamina approximately 6-8 mm away from the edge of the articular cavity. The screws were inserted 3 mm below the superior edge and 5 mm above the inferior edge of the medial (inferior) facets and directed laterally and traversed through the articular cavity into the lateral (superior) articular facet of the caudal vertebra toward and into the region of junction of base of transverse process and of the pedicle. During the period of follow-up all treated spinal levels showed firm bone fusion. There was no complication related to insertion of the screws. There was no incidence of screw misplacement, displacementor implant rejection. Conclusions: Screw insertion into the firm and largely cortical bones of facets of lumbar spine can provide robust fixation and firm stabilization of the spinal segment. The large size of the facets provides an opportunity to insert two screws at each spinal segment. The firm and cortical bone material and absence on any neural or vascular structure in the course of the screw traverse provides strength and safety to the process.
Kadavkolan A.S.,NUSI Wockhardt Hospital |
Wasnik S.S.,DY Patil Medical College
Current Orthopaedic Practice | Year: 2015
Fractures of the proximal end of the humerus are one of the more common fragility fractures seen in the elderly; in the younger and active population, they may represent a consequence of high-velocity trauma. The anatomical or the surgical neck may be involved with varying degrees of involvement of the humeral head. The treatment options depend on a variety of factors. This review examines the various fracture types, their treatment options, the associated complications, and the recent developments in the management of this challenging fracture. © 2015 Wolters Kluwer Health, Inc.
Singh P.,Dy Patil Medical College |
Verma S.K.,P.A. College
Indian Journal of Forensic Medicine and Toxicology | Year: 2015
Road traffic accidents (RTA) are among the leading cause of morbidity and mortality worldwide and will be the second most common cause of disability-adjusted life years in developing countries by the year 2020. A five year retrospective study of road traffic injury cases was conducted at the newly established Index Medical College Hospital and Research Center Indore M.P. A total of 596 medicolegal cases were studied, accidents 484(81.20%) accounted as the major cause of all incidences and road traffic accidents 362(60.7%) alone constituted the majority. Out of the 362 cases of RTA, 282(79.9%) were male and 80(22.1%) female victims with male to female ratio of 3.5:1. Highest number of victims, 120(33.2%), belonged to 21-30 years age group. Month of April recorded the maximum cases 48(13.2%), the most common time interval of accident remained 1601-2000 hours and included 139 (38.4%) of cases. Ninety (24.9%) cases had hospital stay of under 24 hours, 243(67.1%) were discharged after satisfactory management. Two-wheelers use was the most common mode of injury 217(59.9%) and also the most common means of victim being hit 123(34%). Head and neck region with 140 (38.7%) cases, was the most common part of the body involved in road traffic injury; 47% of the males and 23.8% of females in the study suffered fracture and 53% of all fractures involved the lower-limb. © 2015, Indian Journal of Forensic Medicine and Toxicology. All rights reserved.
Singh P.,Dy Patil Medical College |
Verma S.K.,P.A. College
Medico-Legal Update | Year: 2015
Profiling of the medicolegal cases is important to know the quality and quantity of caseload to be expected by the medicolegal workforce serving the area. A retrospective study was conducted at Index Medical College Hospital and Research Center Indore M.P. covering the first five years of its establishment as a teaching hospital in the rural area of central India. The study revealed that road traffic accidents (60.7%) constituted the majority of medicolegal cases out of the total 596 cases, followed by poisoning (14.3%) and assault (10.6%). Accidents were the major cause of injury; male preponderance was at 2.6: 1, most affected age group was 21-30 years (36.2%). The peak time of incidence was during 1601-2000 hours (36.4%) and the maximum cases were recorded in the month of April (11.1%). Out of the 596 cases 408 (68.5%) were discharged and 12 (2%) died due to their injuries. © 2015, World Informations Syndicate. All rights reserved.
Khane R.S.,Dy Patil Medical College
Journal of Clinical and Diagnostic Research | Year: 2012
Breast cancer is the commonest cancer in women worldwide. Today, there is no woman in the world who is at a truly low risk of developing the disease. In India, the growing epidemic of breast cancer presents a major challenge to the global public health, especially, given the failure to cope with the current situation. The burden of breast cancer will continue to increase, not only in terms of the absolute number of cases, but also in terms of its incidence. It has long been observed that 5 to 10% of the breast cancers are the result of an inherited familial predisposition. So, the precise knowledge of the underlying genetic processes is useful for the early detection and prevention of breast cancer. As mammography will be difficult to be implemented in India for various reasons and also because of its complex nature and high cost, genetic testing is not presently routinely available in India. So, efforts should be made to detect breast cancer at an early stage by educating the people about the risk factors and screening methods like Breast Self Examination, because late stage presentation is the main problem in India, which leads to a poorer prognosis. In this review, the risk factors for the development of breast cancer, the role of various genes in the pathogenesis of breast cancer, the possible options for high risk women and the socio-cultural issues regarding breast cancer have been outlined.
Chaudhary S.,Dy Patil Medical College
Medico-Legal Update | Year: 2012
This study was carried out to estimate the relationship between foot dimensions and stature using simple linear regression analysis based on a sample of male and female of Kolhapur district. Measurements of the foot length, foot breadth and stature were taken from 1200 subjects (600 male, 600 female). Obtained data was analysed and attempt was made to find out correlation between the foot dimensions and stature of an individual. A good correlation of height was observed with foot dimensions and it was statistically significant. The results of the present study would be useful for anthropologists and forensic medicine experts.
Pawar A.Y.,Dy Patil Medical College |
Biswas S.K.,Dy Patil Medical College
Asian Spine Journal | Year: 2016
Postoperative spinal wound infection increases the morbidity of the patient and the cost of healthcare. Despite the development of prophylactic antibiotics and advances in surgical technique and postoperative care, wound infection continues to compromise patient outcome after spinal surgery. Spinal instrumentation also has an important role in the development of postoperative infections. This review analyses the risk factors that influence the development of postoperative infection. Classification and diagnosis of postoperative spinal infection is also discussed to facilitate the choice of treatment on the basis of infection severity. Preventive measures to avoid surgical site (SS) infection in spine surgery and methods for reduction of all the changeable risk factors are discussed in brief. Management protocols to manage SS infections in spine surgery are also reviewed. © 2016 by Korean Society of Spine Surgery.
Kulkarni K.R.,Dy Patil Medical College |
Kadam A.I.,Dy Patil Medical College |
Namazi I.J.,Dy Patil Medical College
Indian Journal of Anaesthesia | Year: 2010
Stellate ganglion block (STGB) is commonly indicated in painful conditions like refl ex sympathetic dystrophy, malignancies of head and neck, Reynaud's disease and vascular insuffi ciency of the upper limbs. The sympathetic blockade helps to relieve pain and ischaemia. Diagnostic STGB is usually performed with local anaesthetics followed by therapeutic blockade with steroids, neurolytic agents or radiofrequency ablation of ganglion. There is increasing popularity and evidence for the use of adjuvants like opioid, clonidine and N Methyl d Aspartate (NMDA) receptor antagonist - ketamine - for the regional and neuroaxial blocks. The action of ketamine with sympatholytic block is through blockade of peripherally located NMDA receptors that are the target in the management of neuropathic pain, with the added benefit of counteracting the "wind-up" phenomena of chronic pain. We studied ketamine as an adjuvant to the local anaesthetic for STGB in 20 cases of peripheral vascular disease of upper limbs during the last 5 years at our institution. STGB was given for 2 days with 2 ml of 2% lignocaine + 8 ml of 0.25% bupivacaine, followed by block with the addition of 0.5 mg/kg of ketamine for three consecutive days. There was signifi cant pain relief of longer duration with signifi cant rise in hand temperature. We also observed complete healing of the gangrenous fi ngers in 17/19 patients.