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Kandekar P.V.,Ibn Sina National College for Medical Studies | Tamgadge A.,DY Patil Dental College and Hospital | Meshram S.,JKK Nataraja Dental College and Hospital
Der Pharma Chemica | Year: 2014

Dipeptidyl Peptidase IV (DPP IV) is an enzyme which splits N-terminal X-proline from peptides. The objective of this study was to present a reliable test to quantitatively estimate the serum Dipeptidyl Peptidase IV enzyme in oral cancer patients and to ascertain if Dipeptidyl Peptidase IV can be used as a tumor marker in the early diagnosis of cancer. The study was performed on 31 patients with different stages of oral squamous cell carcinoma as a study group and 10 control healthy group. The mean DPP IV activity in study group was significantly lower than control group. Among the study group, well differentiated squamous cell carcinoma had the highest mean serum DPP IV activity than moderately and poorly differentiated squamous cell carcinoma. We hence conclude that DPP IV activity in serum can be used as a biochemical marker in the diagnosis of oral squamous cell carcinoma.

Puthran R.M.,DY Patil Dental College and Hospital | Nair G.,Mahatma Gandhi Dental College and Hospital
BMJ Case Reports | Year: 2011

Chondro-ectodermal dysplasia is a rare autosomal recessive disorder which affects the ectodermal, mesodermal and endodermal derivatives. There are numerous conditions reported under this title which include Ellis van Creveld syndrome. The oral fi ndings include multiple gingivolabial frena, dental abnormality, malocclusion and hypodontia. The diagnosis of Ellis van Creveld syndrome is based on the presence of oral mucosal changes like notching of the lower alveolus, fusion of the upper lip and gingival mucosa; dental changes like oligodontia, conical shape of anterior teeth and occasional presence of neonatal teeth. The authors report a rare case of Ellis van Creveld syndrome occurring among two siblings with oral mucosal, dental and skeletal abnormalities. Copyright 2011 BMJ Publishing Group. All rights reserved.

Prasad M.,Narayana Dental College and Hospital | Hussain M.Z.,Narayana Dental College and Hospital | Shetty S.K.,KVG Dental College | Ashok Kumar T.,Narayana Dental College | And 3 more authors.
Journal of Natural Science, Biology and Medicine | Year: 2013

Objective: To measure the arch width and Median mandibular flexure (MMF) values at relative rest and maximum jaw opening in young adults with Dolichofacial, Mesofacial, and Brachyfacial types and tested whether the variation in the facial pattern is related to the MMF values in South Indian population. Materials and Methods: This Prospective clinical study consisted of sample of 60 young adults. The subjects were grouped into 3 groups: Group 1: Brachyfacial, Group 2: Mesofacial and types, Group 3: Dolichofacial. Impressions were taken for all the 60 subjects and the casts were scanned and digitized. The intermolar width was measured for Dolichofacial, Mesofacial, and Brachyfacial subjects at relative rest (R) and maximum opening (O). Results: The statistical analysis of the observations included Descriptive and Inferential statistics. The statistical analysis was executed by means of Sigma graph pad prism software, USA Version-4. Kruskal wallis (ANOVA) followed by Dunns post hoc test was performed. Mann Whitney U-test was performed to assess the difference in MMF values between Males and Females of the three groups. The Mean (SD) Mandibular flexure in individuals with Brachyfacial type was 1.12 (0.09), Mesofacial type was 0.69 (0.21), and Dolichofacial type was 0.39 (0.08). Conclusions: The Mean intermolar width was maximum in Brachyfacial type and minimum in Dolichofacial type. MMF was maximum at the maximum mouth opening position and was maximum in individuals with Brachyfacial type.

Savant S.,Ymt Dental College And Hospital | Shetty D.,BVP Dental College and Hospital | Phansopkar S.,DY Patil Dental College and Hospital | Jamkhande A.,University of Pune
Journal of the College of Physicians and Surgeons Pakistan | Year: 2014

Electronic cigarettes (EC), a proxy to conventional cigarettes, gained popularity on the basis of its own advocacy, marketing and large scale publicity. Sometimes marketed as an adjunct to quitting or a substitute for cigarettes, its popularity rose. However, its sale in the global markets was subjected to prejudice. Reasons cited by the regulatory bodies for its ouster were the toxic contents it contained. Some countries preferred to ban them while some have legalised them. However, the manufacturers have claimed that it does have the potential to help smokers quit or at least replace the conventional cigarettes which cause millions of death globally. Research is hence needed to prove the efficacy and utility of this device for welfare of people who are looking for better options than puffing cigarettes.

Panvalkar P.S.,DY Patil Dental College and Hospital | Deshpande R.R.,DY Patil Dental College and Hospital | Kulkarni A.A.,DY Patil Dental College and Hospital | Gadkari T.V.,Sai Advantium
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

As we enter the era of genomic medicine, sialochemistry will play an increasingly important role in the early detection, the monitoring and progression of the systemic and oral diseases and serve as a tearless diagnostic tool. For saliva to play a role as a diagnostic aid it is necessary to examine the consequences of preanalytical physiologic variations with respect to age .Thus the aim of this study was to detect the physiologic levels of different electrolytes, total proteins and amino acids with the use of newer biochemical methods like atomic absorption spectroscopy and Light chromatography coupled with mass spectroscopy. Calcium, magnesium and silica levels showed a linear increase in concentration from primary to mixed to permanent dentition age groups. Salivary potassium concentration showed a significant increase in the mixed dentition age group. The amino acids isolated from the salivary samples did not show any specific trend depending on age. Establishment of amino acid sequences and not only individual amino acids is necessary to establish the genetic component of saliva along with our quest to establish saliva as a diagnostic fluid. With new and highly sensitive techniques, however, the lower level of analytes in saliva is no longer a limitation. Almost anything one can measure in blood, one can measure in saliva.

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