Time filter

Source Type

Pittsburgh, PA, United States

Duquesne University of the Holy Spirit is a private Catholic university in Pittsburgh, Pennsylvania, United States. Founded by members of the Congregation of the Holy Spirit, Duquesne first opened its doors as the Pittsburgh Catholic College of the Holy Ghost in October 1878 with an enrollment of 40 students and a faculty of six. In 1911, the college became the first Catholic university in Pennsylvania. It is the only Spiritan institution of higher education in the world.Duquesne has since expanded to over 10,000 graduate and undergraduate students within a self-contained 49-acre hilltop campus in Pittsburgh's Bluff neighborhood. The school maintains an associate campus in Rome and encompasses ten schools of study. The university hosts international students from more than 80 countries although most students — about 80% — are from Pennsylvania or the surrounding region. Duquesne is considered a research university with high research activity institution by the Carnegie Foundation for the Advancement of Teaching. There are more than 79,000 living alumni of the university including two cardinals and the current bishop of Pittsburgh.The Duquesne Dukes compete in NCAA Division I. Duquesne men's basketball appeared twice in national championship games in the 1950s and won the NIT championship in 1955. Wikipedia.

Bosco G.L.,Duquesne University
TrAC - Trends in Analytical Chemistry | Year: 2010

This is a report on the Pittcon 2009 Waters Symposium, which featured five speakers on the history and fast-growing applications of near-infrared spectroscopy (NIRS). Often called the "Father of NIRS", Karl Norris described the development and the initial refinement of the first NIR instruments for use in whole-sample grain measurements. Peter Flinn provided an explanation of the science behind this technology and explained the need for and use of chemometrics in interpreting NIRS data. Franklin "Woody" Barton explained how the first official, standardized methods were developed and described the development of compact, dedicated NIR spectrometers for rapid, non-destructive, at-line and in-line analysis of material. Phil Williams detailed the introduction of NIRS to the world of commerce and the spread of NIR worldwide. Finally, Robert Lodder explained some out-of-the-box modern applications of NIRS in the fields of aging, artificial intelligence and astrobiology. Source

Ruggieri E.,Duquesne University
International Journal of Climatology | Year: 2013

Given distinct climatic periods in the various facets of the Earth's climate system, many attempts have been made to determine the exact timing of 'change points' or regime boundaries. However, identification of change points is not always a simple task. A time series containing N data points has approximately Nk distinct placements of k change points, rendering brute force enumeration futile as the length of the time series increases. Moreover, how certain are we that any one placement of change points is superior to the rest? This paper introduces a Bayesian Change Point algorithm which provides uncertainty estimates both in the number and location of change points through an efficient probabilistic solution to the multiple change point problem. To illustrate its versatility, the Bayesian Change Point algorithm is used to analyse both the NOAA/NCDC annual global surface temperature anomalies time series and the much longer δ18O record of the Plio-Pleistocene. © 2012 Royal Meteorological Society. Source

Lapinsky D.J.,Duquesne University
Bioorganic and Medicinal Chemistry | Year: 2012

Photoaffinity labeling has a longstanding history as a powerful biochemical technique. However, photoaffinity labeling has significantly evolved over the past decade principally due to its coupling with bioorthogonal/click chemistry reactions. This review aims to highlight tandem photoaffinity labeling-bioorthogonal conjugation as a chemical approach in medicinal chemistry and chemical biology. In particular, recent examples of using this strategy for affinity-based protein profiling (AfBPP), drug target identification, binding ensemble profiling, studying endogenous biological molecules, and imaging applications will be presented. Additionally, recent advances in the development of 'all-in-one' compact moieties possessing a photoreactive group and clickable handle will be discussed. © 2012 Elsevier Ltd. All rights reserved. Source

Pintauer T.,Duquesne University
European Journal of Inorganic Chemistry | Year: 2010

Transition-metal-catalyzed atom-transfer radical addition (ATRA) and cyclization (ATRC) are considered fundamental reactions in organic chemistry for the formation of C-C bonds using free-radical means. Until recently, both processes were plagued by the large amounts of catalysts needed to achieve high selectivity towards the desired target compound (as high as 30 mol-%). The principal problem was the accumulation of the transition metal complex in the higher oxidation state as a result of unavoidable radical-radical termination reactions. In this article, recent advanced in the area of catalyst regeneration in transition-metal-mediated ATRA and ATRC reactions in the presence of free-radical diazo initiators or magnesium, as reducing agents are reviewed. The role of the reducing agent in both systems is to continuously regenerate the activator (transition metal complex in the lower oxidation state) from the deactivator (transition metal complex in the higher oxidation state). As a result, ATRA and ATRC reactions can be conducted using very small concentrations of metal catalysts, making this methodology a "greener" alternative to currently available synthetic processes for such organic transformations. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA. Source

Elinson R.P.,Duquesne University
Current Topics in Developmental Biology | Year: 2013

The evolutionary removal of the tadpole from the frog life history is a very successful strategy, particularly in the tropics. These direct developers form limbs and a frog-like head early in embryogenesis, and they have reduced or lost tadpole-specific structures, like gills, a long, coiled intestine, and tadpole teeth and jaws. Despite the apparently continuous development to the frog morphology, the direct developer, Eleutherodactylus coqui, undergoes a cryptic metamorphosis requiring thyroid hormone. As in Xenopus laevis, there is a stimulation by corticotrophin-releasing factor (CRF) and an upregulation of thyroid hormone receptor β (thrb). In addition to changes in skin and muscle, thyroid hormone stimulates yolk utilization for froglet growth from a novel tissue, the nutritional endoderm. The activities of CRF and corticosterone (CORT) in metamorphosis may provide the basis for the multiple evolutionary origins of direct development in anuran amphibians. Potential roles for maternally supplied thyroid hormone and its receptor and for deiodinases in regulating tissue sensitivity to thyroid hormone should be the subjects of future investigations. © 2013 Elsevier Inc.. Source

Discover hidden collaborations