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Pittsburgh, PA, United States

Duquesne University of the Holy Spirit is a private Catholic university in Pittsburgh, Pennsylvania, United States. Founded by members of the Congregation of the Holy Spirit, Duquesne first opened its doors as the Pittsburgh Catholic College of the Holy Ghost in October 1878 with an enrollment of 40 students and a faculty of six. In 1911, the college became the first Catholic university in Pennsylvania. It is the only Spiritan institution of higher education in the world.Duquesne has since expanded to over 10,000 graduate and undergraduate students within a self-contained 49-acre hilltop campus in Pittsburgh's Bluff neighborhood. The school maintains an associate campus in Rome and encompasses ten schools of study. The university hosts international students from more than 80 countries although most students — about 80% — are from Pennsylvania or the surrounding region. Duquesne is considered a research university with high research activity institution by the Carnegie Foundation for the Advancement of Teaching. There are more than 79,000 living alumni of the university including two cardinals and the current bishop of Pittsburgh.The Duquesne Dukes compete in NCAA Division I. Duquesne men's basketball appeared twice in national championship games in the 1950s and won the NIT championship in 1955. Wikipedia.


The present invention provides tricyclic compounds having cytostatic and cytotoxic activity in a single molecule having receptor tyrosine kinase(s), dihydrofolate reductase, thymidylate synthase and/or dihydroorotate dehydrogenase inhibitory activity, which are useful as anti-angiogenic and anti-tumor agents. Also provided are methods of utilizing these inhibitors to treat tumor cells and other proliferative diseases and disorders.


Patent
Wayne State University and Duquesne University | Date: 2015-01-08

A method for treating cancer tumors, particularly ovarian cancer tumors, is described, where fused cyclic pyrimidine having a cancer treating ability is selectively delivered to an FR expressing cancerous tumor.


The present invention provides tricyclic compounds, pharmaceutically acceptable salts, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds for treating tumor cells and inhibiting mitosis of cancerous cells.


Patent
Duquesne University and Wayne State University | Date: 2015-08-07

This invention provides substituted pyrimidine compounds having the formula: wherein X is absent, CH


Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity are provided in the present invention. The compositions of the present invention possess dual activity in a single agent of potent vascular endothelial growth factor receptor inhibitory activity as well as antitubulin activity. Water soluble salts of these compositions are also described. Methods of treating a patient having cancer, macular degeneration, and arthritis with the compositions and salts thereof of the present invention are disclosed.

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