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Kütahya, Turkey

Emir E.,Eskiehir Osmangazi University | Beyhan S.,Dumlupnar University
Acta Geodynamica et Geomaterialia | Year: 2016

When it's essential to conduct intact rock strength tests on saturated samples to be representative of rock mass, clay bearing rocks such as marl which might present water sensitive behavior should be carefully inspected. In the following water table study, rock samples of Tunçbilek region that tend to fracture were alternatively conditioned in a climate cabin. According to the underground mine weather information taken from Tunçbilek region, triaxial compression tests were performed on oven dried marl samples and conditioned in 60 % Relative Humidity (RH), 80 % RH and 90 % RH at 17.6 °C. Calculated values of Mohr-Coulomb and Hoek-Brown failure criteria parameters depending on triaxial test results showed inverse change which does not let evaluate rock material strength. To achieve this goal, numerical modeling analyses were used. This allowed evaluating of intact rock triaxial strength by the effect of intact rock properties on the behavior of rock mass. Finally; it was found that moisture decreased the strength of marl rock material, and conditioning by moisture diffusion is an appropriate procedure for evaluating water sensitive rocks such as marl. © 2016, Academy of Sciences of the Czech Republic. All rights reserved. Source

Aksoy A.N.,Nenehatun Hospital | Gozukara I.,Nenehatun Hospital | Kucur S.K.,Dumlupnar University
Journal of Obstetrics and Gynaecology Research | Year: 2014

Aim: The aim of this casecontrol study was to compare the efficacy of ethinyl estradiol/drospirenone and Fructus agni casti in women with severe primary dysmenorrhea measuring uterine artery blood flow via Doppler ultrasonography. Methods: A total of 60 women with severe primary dysmenorrhea and 30 healthy women (control) were included in this study. Thirty patients were treated with ethinyl estradiol 0.03 mg/drospirenone (group 1) and another 30 were treated with Fructus agni casti (group 2) during three menstrual cycles. Before and at the end of third month of therapy visual analog scale (VAS) scores, pulsatility index (PI), resistance index (RI) of uterine artery were recorded before and after receiving therapy on the first day of the menstrual cycle. Results: Mean PI and RI values in patients with severe primary dysmenorrhea were significantly higher than in the control groups on the first day of the menstrual cycle (P < 0.0001). Mean PI and RI values were significantly lower after the treatment in both groups compared to before values (P < 0.001 for both). After using the drugs for three menstrual cycles, VAS scores were significantly dropped in both groups compared to before treatment values (P < 0.0001 for both); however, there were no significant differences in terms of Doppler findings between group 1 and 2. Conclusion: The effectiveness of Fructus agni casti was similar to that of ethinyl estradiol/drospirenone in patients with primary dysmenorrhea. © 2013 Japan Society of Obstetrics and Gynecology. Source

Acaravci A.,Mustafa Kemal University | Erdogan S.,Mustafa Kemal University | Akalin G.,Dumlupnar University
International Journal of Energy Economics and Policy | Year: 2015

This study aims to explore both the long-run and causal relationships between electricity consumption per capita, real gross domestic product (GDP) per capita, trade openness and foreign direct investment inflows per capita in Turkey during the time period 1974-2013. The study employs the autoregressive distributed lag model and the augmented Granger causality model. The bounds F-test for cointegration test yields evidence of a longrun relationship between variables. The overall results from the three error-correction based Granger causality models show that there is an evidence of unidirectional short-run, long-run and strong causalities running from the electricity consumption per capita to real GDP per capita. But, there is no causal evidence from the real GDP per capita to electricity consumption per capita. This result also support that, “growth hypothesis” is confirmed in Turkey. As a policy implication, the energy growth policies regarding electricity consumption should be adapted in such a way that the development of this sector stimulates economic growth. © 2015, Econjournals. All rights reserved. Source

Ekinci D.,Ondokuz Mayis University | Avdar H.,Dumlupnar University | Durdagi S.,University of Calgary | Talaz O.,University of Art | And 2 more authors.
European Journal of Medicinal Chemistry | Year: 2012

Several 5,10-dihydroindeno[1,2-b]indole derivatives incorporating methoxy, hydroxyl, and halogen (F, Cl, and Br) moieties on the indene fragment of the molecule were prepared and tested against five carbonic anhydrase (CA, EC isoforms. The inhibitory potencies of these compounds against the human (h) isoforms hCA I, II, IV, VI and bovine (b) isoform bCA III were assessed. Most of them exhibited low micromolar inhibition of these enzymes. K I values of these compounds against hCA I and hCA II were in the range of 2.14-16.32 μM, and 0.34-2.52 μM, respectively. Isozyme hCA IV was inhibited with K I-s in the range of 0.435-5.726 μM, while hCA VI with K I-s of 1.92-12.84 μM bCA III was inhibited with K I-s in the range of 2.13-17.83 μM. The structurally related compounds, 1,2-dimethoxybenzene, catechol and indole were also tested in order to understand the structure activity relationship. In silico docking studies of some derivatives within the active site of hCA I and II were also carried out in order to rationalize the inhibitory properties of these compounds and understand their inhibition mechanism. © 2012 Elsevier Masson SAS. All rights reserved. Source

Ozkul C.,Dumlupnar University
Environmental Monitoring and Assessment | Year: 2016

Tunçbilek, one of the major thermal power plants (TTPP) in Turkey running on coal, has capacity to generate 365 MW (per year) electricity. Fifty top soil samples were collected from a depth about 0–20 cm in the close vicinity of the TTPP from random points and at different distances. The samples were analyzed using ICP-MS for heavy metals. Heavy metal contents in soils around TTPP varied from 4.4 to 317.5 mg/kg for As, 0.03 to 0.26 mg/kg for Cd, 20.3 to 1028 mg/kg for Cr, 4.8 to 76.8 mg/kg for Cu, 0.09 to 9.3 mg/kg for Hg, 16.6 to 2385 mg/kg for Ni, 4.8 to 58.6 mg/kg for Pb, and 14.5 to 249.5 mg/kg for Zn. Geoaccumulation index (Igeo) and enrichment factor (EF) have been calculated in order to evaluate heavy metal pollution in the soils. According to the Igeo calculations, the surface soils around TTPP are contaminated by As, Hg, and Ni from uncontaminated to extremely contaminated. Igeo values for Cr show practically uncontaminated to be heavily contaminated. The contamination of soil samples changes from practically uncontaminated to moderately contaminated degree for Pb and Zn. The soil samples were uncontaminated for Cd and Cu metals. The enrichment factors of As, Cr, Hg, and Ni in most of the sampling locations indicate significant to extremely high enrichment. The EF for Pb is also high and indicates moderate to very high enrichment of chromium in the soils. The average EF values for Cd, Cu, and Zn are showing moderate enrichment. © 2016, Springer International Publishing Switzerland. Source

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