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Jung J.,Duksung Womens University
Toxicological Research | Year: 2014

Xenograft models of human cancer play an important role in the screening and evaluation of candidates for new anticancer agents. The models, which are derived from human tumor cell lines and are classified according to the transplant site, such as ectopic xenograft and orthotopic xenograft, are still utilized to evaluate therapeutic efficacy and toxicity. The metastasis model is modified for the evaluation and prediction of cancer progression. Recently, animal models are made from patient-derived tumor tissue. The patient-derived tumor xenograft models with physiological characters similar to those of patients have been established for personalized medicine. In the discovery of anticancer drugs, standard animal models save time and money and provide evidence to support clinical trials. The current strategy for using xenograft models as an informative tool is introduced. Source


Kim T.-H.,Duksung Womens University
Journal of Plant Biology | Year: 2014

Recent progress has been made in understanding the mechanism of ABA signal transduction based on identification of novel genetic components as well as decoding of signaling networks. This has resulted in a wide range of genetic targets for manipulation of crop genomes to obtain drought-tolerant traits. Early events in ABA signaling involve PYR/PYL/RCAR ABA receptors as well as two phosphatase/kinase enzyme pairs, PP2Cs and SnRK2s, with opposite functions. In the end, a number of transcription factors under the control of SnRK2s activate the ABA-dependent gene expression resulting in drought-resistant responses. Due to the evolutionary conservation of ABA signaling and plant drought stress responses in vascular plants, genes identified as major ABA signaling components in Arabidopsis can be used as targets for genetic manipulation of profitable crop species. Therefore, modulation of genes or application of small compounds that specifically function in ABA signal transduction might offer a unique pathway to addressing the global demand aims for the drought- or water deficiency-resistant crop lines without growth penalty. © 2014 Korean Society of Plant Biologists and Springer-Verlag Berlin Heidelberg. Source


Chung W.-H.,Duksung Womens University
Personal and Ubiquitous Computing | Year: 2012

Mobile surveillance service is regarded as one of the Internet applications to which much attention is recently given. However, the time and cost problem resulting from using heterogeneous platforms and proprietary protocols must be a burden to developing such systems and expanding their services. In this paper, we present a framework of mobile surveillance service for smartphone users. It includes the design and implementation of a video server and a mobile client called smartphone watch. A component-based architecture is employed for the server and client for easy extension and adaptation. We also employ the well-known standard web protocol HTTP to provide higher compatibility and portability than using a proprietary one. Three different video transmission modes are provided for efficient usage of limited bandwidth resource. We demonstrate our approach via real experiments on a commercial smartphone. © Springer-Verlag London Limited 2011. Source


Kang K.-T.,Duksung Womens University
Toxicological Research | Year: 2014

Endothelium-derived relaxing factors (EDRFs), including nitric oxide (NO), prostacyclin (PGI2), and endothelium-derived hyperpolarizing factor (EDHF), play pivotal roles in regulating vascular tone. Reduced EDRFs cause impaired endothelium-dependent vasorelaxation, or endothelial dysfunction. Impaired endothelium-dependent vasorelaxation in response to acetylcholine (ACh) is consistently observed in conduit vessels in human patients and experimental animal models of hypertension. Because small resistance arteries are known to produce more than one type of EDRF, the mechanism(s) mediating endothelium-dependent vasorelaxation in small resistance arteries may be different from that observed in conduit vessels under hypertensive conditions, where vasorelaxation is mainly dependent on NO. EDHF has been described as one of the principal mediators of endothelium-dependent vasorelaxation in small resistance arteries in normotensive animals. Furthermore, EDHF appears to become the predominant endothelium-dependent vasorelaxation pathway when the endothelial NO synthase (NOS3)/NO pathway is absent, as in NOS3-knockout mice, whereas some studies have shown that the EDHF pathway is dysfunctional in experimental models of hypertension. This article reviews our current knowledge regarding EDRFs in small arteries under normotensive and hypertensive conditions. Source


Choi E.J.,Duksung Womens University | Kim G.-H.,Duksung Womens University
Molecular Medicine Reports | Year: 2013

In this study, we investigated the antiproliferative activity of the isoflavones daidzein and genistein in three breast cancer cell lines with different patterns of estrogen receptor (ER) and c.erbB.2 protein expression (ERα-positive MCF-7 cells, c-erbB-2-positive SK-BR-3 cells and ERα/c-erbB-2-positive ZR-75-1). After treatment at various concentrations (1-200 μM for 72 h), the effect of daidzein and genistein on the proliferation of different cell types varied; these effects were found to be associated with ERα and c-erbB-2 expression-Daidzein and genistein exhibited biphasic effects (stimulatory or inhibitory) on proliferation and ERα expression in MCF-7 cells. Although 1 μM daidzein significantly stimulated cell growth, ERα expression was unaffected. However, genistein showed marked increases in proliferation and ERα expression after exposure to <10 μM genistein. Notably, the inhibition of cell proliferation by 200 μM genistein was greater compared to that by daidzein at the same concentration-Daidzein and genistein significantly inhibited proliferation of SK-BR-3 and ZR-75-1 cells in a dose-dependent manner. In addition, ERα and c-erbB-2 expression was reduced by daidzein and genistein in both SK-BR-3 and ZR-75-1 cells in a dose-dependent manner. However, the effect of genistein was greater compared to that of daidzein. In conclusion, the isoflavones daidzein and genistein showed anti-breast cancer activity, which was associated with expression of the ERα and c-erbB-2 receptors. Source

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