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Dublin, Ireland

Dublin City University is a university situated between Glasnevin, Santry, Ballymun and Whitehall on the Northside of Dublin in Ireland. Created as the National Institute for Higher Education, Dublin in 1975, it enrolled its first students in 1980 and was elevated to university status in 1989 by statute. Wikipedia.

Harvey A.L.,Dublin City University | Harvey A.L.,University of Strathclyde | Edrada-Ebel R.,University of Strathclyde | Quinn R.J.,Griffith University
Nature Reviews Drug Discovery | Year: 2015

Natural products have been a rich source of compounds for drug discovery. However, their use has diminished in the past two decades, in part because of technical barriers to screening natural products in high-throughput assays against molecular targets. Here, we review strategies for natural product screening that harness the recent technical advances that have reduced these barriers. We also assess the use of genomic and metabolomic approaches to augment traditional methods of studying natural products, and highlight recent examples of natural products in antimicrobial drug discovery and as inhibitors of protein-protein interactions. The growing appreciation of functional assays and phenotypic screens may further contribute to a revival of interest in natural products for drug discovery. © 2015 Macmillan Publishers Limited. All rights reserved. Source

Jordan A.,Dublin City University | Gathergood N.,Tallinn University of Technology
Chemical Society Reviews | Year: 2015

The importance of biodegradation data as part of the design of safer chemicals is presented using ionic liquids (ILs) as a model study. Structural features that promote/impede IL biodegradation, IL design strategies, methods of biodegradation analysis, properties of IL/surfactant derivatives and computational methods of predicting biodegradation are discussed. The importance of metabolite studies as part of biodegradation assays is highlighted. The relevance of applying the lessons learned developing biodegradable ILs to other chemical classes is proposed. A comprehensive appendix of IL biodegradation data published since 2010 (∼300 ILs) has been compiled. © The Royal Society of Chemistry. Source

Henry D.,Dublin City University
Journal of Mathematical Fluid Mechanics | Year: 2012

For capillary-gravity water waves with vorticity, in the absence of stagnation points, we prove that if the vorticity function has a Hölder continuous derivative then the free surface will be smooth. Furthermore, once we assume that the vorticity function is real analytic it will follow that the wave surface profile is also analytic. In particular this scenario includes the case of irrotational fluid flow where the vorticity is zero. © 2011 Springer Basel AG. Source

The use of unsupervised self-testing as part of a national screening program for HIV infection in resource-poor environments with high HIV prevalence may have a number of attractive aspects, such as increasing access to services for hard to reach and isolated populations. However, the presence of such technologies is at a relatively early stage in terms of use and impact in the field. In this paper, a principle-based approach, that recognizes the fundamentally utilitarian nature of public health combined with a focus on autonomy, is used as a lens to explore some of the ethical issues raised by HIV self-testing. The conclusion reached in this review is that at this point in time, on the basis of the principles of utility and respect for autonomy, it is not ethically appropriate to incorporate unsupervised HIV self-testing as part of a public health screening program in resource-poor environments. © 2014 Springer Science+Business Media New York. Source

This article deals with the transnational healthcare practices of Central and Eastern European migrants in Europe, taking the case of Romanian migrants in Ireland. It explores the implications of migrants' transnational healthcare practices for the transformation of citizenship in Europe, more particularly in terms of access to free public healthcare. The article places these practices in the larger perspective of global care chains, seen as including transnational flows of healthcare seekers and healthcare workers that link distant healthcare systems in an emerging European healthcare assemblage.The study adopted a holistic perspective, taking into account both formal and informal practices, as well as the use of healthcare services in both the host and the origin countries of migrants. These were explored during multi-sited fieldwork in Romania and Ireland, conducted between 2012 and 2013, and combining a variety of sources and methods (semi-structured interviews, informal conversations, documentary analysis, etc.).The article explores the links between migrants' transnational healthcare practices and two other important processes: 1) inequalities in access to healthcare services in migrants' countries of origin and of destination; and 2) the contribution of healthcare privatisation to these inequalities. It shows that Romanian migrants' transnational healthcare practices function as strategies of social mobility for migrants, while also reflecting the increasing privatisation of healthcare services in Ireland and Romania. The article argues that these processes are far from specific to Ireland, Romania, and the migration flows uniting them. Rather, they draw our attention to the rise of an unevenly developed European healthcare assemblage and citizenship regime in which patients' movements across borders are closely interlinked with diminishing and increasingly unequal access to public healthcare services. © 2014 Elsevier Ltd. Source

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