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Dubai, United Arab Emirates

The Dubai Pharmacy College is the first pharmacy institution in the United Arab Emirates, established in 1992 by Dubai philanthropist Haji Saeed Bin Ahmed Al Lootah. In 2005, it won the Dubai Quality Appreciation Programme award for education presented by Sheikh Mohammed bin Rashid Al Maktoum, Crown Prince of Dubai. Wikipedia.

Chaudhary S.A.,National Institute of Pharmaceutical Education and Research, Ahmedabad | Shahiwala A.F.,Dubai Pharmacy College
Expert Opinion on Drug Delivery | Year: 2010

Importance of the field: Over the years, patient convenience and patient compliance-orientated research in the field of drug delivery has resulted in bringing out potential innovative drug delivery options. Out of which, medicated chewing gum (MCG) offers a highly convenient patient-compliant way of dosing medications, not only for special population groups with swallowing difficulties such as children and the elderly, but also for the general population, including the young generation. Areas covered in this review: In this review, various formulation ingredients, different manufacturing processes, and assessment of in vivo and in vitro drug release from MCG are thoroughly discussed along with the therapeutic potential and limitations of MCG. What the reader will gain: Readers will gain knowledge about the rationale and prominent formulation and performance evaluation strategies behind chewing gum as a drug delivery system. Take home message: The availability of directly compressible co-processed gum material enables rapid, safe and low-cost development of MCG as a drug delivery option. By MCG formulation, revitalization of old products and reformulation of new patented products is possible, to differentiate them from upcoming generics competition in the market. © 2010 Informa UK Ltd.

Shahiwala A.,Dubai Pharmacy College
European Journal of Drug Metabolism and Pharmacokinetics | Year: 2013

Physicochemical properties, such as molecular weight, size, partition coefficient, acid dissociation constant and solubility have a great impact on pharmacokinetics of traditional small molecule drugs and substantially used in development of small drugs. However, predicting pharmacokinetic fate (absorption, distribution, metabolism and elimination) of protein therapeutics from their physicochemical parameters is extremely difficult due to the macromolecular nature of therapeutic proteins and peptides. Their structural complexity and immunogenicity are other contributing factors that determine their biological fate. Therefore, to develop generalized strategies concerning development of therapeutic proteins and peptides are highly challenging. However, reviewing the literature, authors found that physiochemical properties, such as molecular weight, charge and structural modification are having great impact on pharmacokinetics of protein therapeutics and an attempt is made to provide the major findings in this manuscript. This manuscript will serve to provide some bases for developing protein therapeutics with desired pharmacokinetic profile. © 2013 Springer-Verlag France.

Shehab N.G.,Cairo University | Abu-Gharbieh E.,Dubai Pharmacy College
Evidence-based Complementary and Alternative Medicine | Year: 2014

Reported researches dealing with either composition or bioactivity of Salsola imbricata are limited. This study was conducted aiming to investigate the phenolic composition of the plant and evaluate its efficacy as male contraceptive. Polyphenols, namely, phenolic acids and flavonoids, were qualitatively and quantitatively analysed by RP-HPLC in the hydrolysed methanol extract using two different wavelengths, 280 and 330 nm. The efficiency of different solvents in extracting the plant phenolics was assessed via spectrophotometric determination of the total phenolic and flavonoid contents. Acute toxicity study was carried out on the ethanolic extract to ascertain its safety prior to biological evaluation. The contraceptive effect was assessed, in male rats, by oral administration of the extract at two doses (250 and 500 mg/kg b. wt.), over a period of 65 days. HPLC analyses allowed the identification and quantification of a total of 13 and 8 components in the hydrolysed-methanol extract; the overall phenolic composition was dominated by quercitrin (12.692%) followed by coumaric acid (4.251%). Prolonged oral administration of the ethanolic extract caused slight reduction in the testis weight only. A significant decrease in the sperm count was observed (P<0.01) in the two treated groups while significant decrease in the epididymal sperm motility was only observed in the high dose group. Morphological abnormalities were observed in sperms of treated animals. No distinct change in serum FSH, LH, and testosterone concentration was recorded. The histopathological findings supported to a high extent these results. The male contraceptive activity of Salsola imbricata could be ascribed to its phenolic components, especially quercitrin. © 2014 Naglaa Gamil Shehab and Eman Abu-Gharbieh.

Sarheed O.,Ras al-Khaimah Medical and Health Sciences University | Abdul Rasool B.K.,Dubai Pharmacy College
Open Biomedical Engineering Journal | Year: 2011

It has now been known for over a decade that low frequency ultrasound can be used to effectively enhance transdermal drug penetration - an approach termed sonophoresis. Mechanistically, acoustic cavitation results in the creation of defects in the stratum corneum that allow accelerated absorption of topically applied molecules. The aim of this study was to develop an optimised sonophoresis protocol for studying transdermal drug delivery in vitro. To this end, caffeine was selected as a model hydrophilic drug while porcine skin was used as a model barrier. Following acoustic validation, 20kHz ultrasound was applied for different durations (range: 5 s to 10 min) using three different modes (10%, 33% or 100% duty cycles) and two distinct sonication procedures (either before or concurrent with drug deposition). Each ultrasonic protocol was assessed in terms of its heating and caffeine flux-enhancing effects. It was found that the best regimen was a concurrent 5 min, pulsed (10% duty cycle) beam of SATA intensity 0.37 W/cm2. A key insight was that in the case of pulsed beams of 10% duty cycle, sonication concurrent with drug deposition was superior to sonication prior to drug deposition and potential mechanisms for this are discussed. © Sarheed and Abdul Rasool; Licensee Bentham Open.

Nessa F.,Dubai Pharmacy College | Ismail Z.,Universiti Sains Malaysia | Mohamed N.,Universiti Sains Malaysia
Pharmaceutical Biology | Year: 2010

Context: Blumea balsamifera DC (Compositae) leaves have been recommended for use as a folk medicinein the treatment of various diseases related to urolithiasis in southeast Asia. Phytochemical studies of thisplant revealed it contains four classes of flavonoids (e.g., flavonols, flavones, flavanones, and dihydroflavonolderivatives).Objective: In view of the broad pharmacological activity of flavonoids, this study was carried out to determinethe xanthine oxidase (XO) inhibitory and enzymatically produced superoxide radical scavenging activity ofdifferent organic extracts and that of the isolated flavonoids from B. balsamifera leaves.Materials and methods: The inhibitory activity of XO was assayed spectrophotometrically at 295 nm. Thesuperoxide radicals scavenging activity was assessed by NBT reduction method, spectrophotometrically at560 nm. A dose response curve was plotted for determining IC50 values.Results: The methanol extract (IC50 = 0.111 mg/mL) showed higher XO inhibitory activity than the chloroform(0.138 mg/mL) and pet-ether extracts (0.516 mg/mL). IC50 values of scavenging of superoxide radicals forextracts decreased in the order of: methanol (0.063 mg/mL) > chloroform (0.092 mg/mL) > pet-ether (0.321 mg/mL). The XO inhibitory activity of the isolated flavonoids and reference compounds tested decreased in theorder of: allopurinol > luteolin > quercetin > tamarixetin > 5,7,3',5'-tetrahydroxyflavanone > rhamnetin > luteolin-7-methyl ether > blumeatin > dihydroquercetin-4'-methyl ether > dihydroquercetin-7,4'-dimethylether > l-ascorbic acid.Discussion and conclusion: The results indicated that the flavone derivatives were more active than the flavonolderivatives. The flavanone derivatives were moderately active and the dihydroflavonol derivatives werethe least. The higher flavonoid content of extracts contributed to their higher XO inhibitory activity. © 2010 Informa Healthcare USA, Inc.

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