Dubai, United Arab Emirates

Dubai Medical College
Dubai, United Arab Emirates

Dubai Medical College for Girls is the first private college awarding degree of Medicine & Surgery in the United Arab Emirates. Wikipedia.

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Teo K.,Hamilton Health Sciences | Lear S.,Simon Fraser University | Lear S.,Providence Health Care | Islam S.,Hamilton Health Sciences | And 22 more authors.
JAMA - Journal of the American Medical Association | Year: 2013

Importance: Little is known about adoption of healthy lifestyle behaviors among individuals with a coronary heart disease (CHD) or stroke event in communities across a range of countries worldwide. Objective: To examine the prevalence of avoidance or cessation of smoking, eating a healthy diet, and undertaking regular physical activities by individuals with a CHD or stroke event. Design, Setting, and Participants: Prospective Urban Rural Epidemiology (PURE) was a large, prospective cohort study that used an epidemiological survey of 153 996 adults, aged 35 to 70 years, from 628 urban and rural communities in 3 high-income countries (HIC), 7 upper-middle-income countries (UMIC), 3 lower-middle-income countries (LMIC), and 4 low-income countries (LIC), who were enrolled between January 2003 and December 2009. Main Outcome Measures: Smoking status (current, former, never), level of exercise (low, ≤600 metabolic equivalent task [MET]-min/wk; moderate, 600-3000 MET-min/wk; high, ≥3000 MET-min/wk), and diet (classified by the Food Frequency Questionnaire and defined using the Alternative Healthy Eating Index). Results: Among 7519 individuals with self-reported CHD (past event: median, 5.0 [interquartile range {IQR}, 2.0-10.0] years ago) or stroke (past event: median, 4.0 [IQR, 2.0-8.0] years ago), 18.5% (95% CI, 17.6%-19.4%) continued to smoke; only 35.1% (95% CI, 29.6%-41.0%) undertook high levels of work- or leisure-related physical activity, and 39.0% (95% CI, 30.0%-48.7%) had healthy diets; 14.3% (95% CI, 11.7%-17.3%) did not undertake any of the 3 healthy lifestyle behaviors and 4.3% (95% CI, 3.1%-5.8%) had all 3. Overall, 52.5% (95% CI, 50.7%-54.3%) quit smoking (by income country classification: 74.9% [95% CI, 71.1%-78.6%] in HIC; 56.5% [95% CI, 53.4%-58.6%] in UMIC; 42.6% [95% CI, 39.6%-45.6%] in LMIC; and 38.1% [95% CI, 33.1%-43.2%] in LIC). Levels of physical activity increased with increasing country income but this trend was not statistically significant. The lowest prevalence of eating healthy diets was in LIC (25.8%; 95% CI, 13.0%-44.8%) compared with LMIC (43.2%; 95% CI, 30.0%-57.4%), UMIC (45.1%, 95% CI, 30.9%-60.1%), and HIC (43.4%, 95% CI, 21.0%-68.7%). Conclusion and Relevance: Among a sample of patients with a CHD or stroke event from countries with varying income levels, the prevalence of healthy lifestyle behaviors was low, with even lower levels in poorer countries. ©2013 American Medical Association. All rights reserved.

AbdRaboh N.R.,Dubai Medical College | AbdRaboh N.R.,Ain Shams University | Bayoumi F.A.,Dubai Medical College
Gene Reports | Year: 2016

Background Genetic factors have a considerable influence on the development and progress of malignancy. Matrix metallo-proteinases (MMPs) are a group of proteolytic enzymes which are proved to be involved in pathogenesis of breast cancer. Some functional single nucleotide polymorphisms (SNPs) affect the transcriptional activity of genes of MMPs. We aimed to investigate the possible association of 2 SNPs, C/T polymorphism of MMP9 gene, and 5A/6A polymorphism of MMP3 gene, with the occurrence and pathological criteria of breast cancer. Subjects and methods The present case control study included 59 breast cancer female patients, and 77 tumor free age matched control females. The SNPs were genotyped using polymerase chain reaction - restriction fragment length polymorphism assay. Results The results have shown higher frequency of T allele of C/T MMP9 and 5A of A5/A6 MMP3 in breast cancer patients as compared to control subjects with odd ratio (OR) of 1.8 (95% CI1.02–3.26) and 1.2 (0.71–1.89), respectively. Moreover, combined 5A and T alleles had a higher risk with OR of 2.3 (1.17–4.57). When the frequency of both alleles was analyzed in comparison to prognostic pathological parameters of the disease, there was a significant association of T allele of C/T MMP9 with advanced tumor size and histological grade with OR (95%CI) 2.5 (1.12–5.64) and 1.8 (0.78–4.17) respectively. Conclusion The results suggested that T allele of C/T MMP9 gene polymorphism is strongly linked to the incidence, growth and differentiation of breast cancer. © 2016

Mirshafiey A.,Tehran University of Medical Sciences | Simhag A.,Karolinska Institutet | El Rouby N.M.M.,Dubai Medical College | Azizi G.,Alborz University of Medical science | Azizi G.,Tehran University of Medical Sciences
International Journal of Dermatology | Year: 2015

T-helper 22 (Th22) cell is a new subset of CD4+ T cells that secrets interleukin (IL)-22 but not IL-17 or interferon-γ. Th22 is distinct from Th17 and other known CD4+ T-cell subsets with distinguished gene expression and function. Th22 subsets have chemokine receptors CCR6+ CCR4+ CCR10+ phenotype and aryl hydrocarbon receptor as the key transcription factor. This T-helper subset, by producing cytokines such as IL-22, IL-13, and tumor necrosis factor-α, is implicated in the pathogenesis of inflammatory skin disorder. This review discusses the role of Th22 and its cytokine IL-22 in the immunopathogenesis of inflammatory skin disorders such as psoriasis and atopic dermatitis. © 2015 The International Society of Dermatology.

Shehab N.G.,Cairo University | Abu-Gharbieh E.,Dubai Pharmacy College | Bayoumi F.A.,Dubai Medical College
BMC Complementary and Alternative Medicine | Year: 2015

Background: Flavonoids and other polyphenols play a protective role in liver diseases and possess a high antioxidant capacity. Objective: To compare and evaluate the antioxidant and hepatotoprotective activities of 4 deserts plants, Fagonia indica Burm. f., Calotropis procera R.Br., Zygophylum hamiense Schweinf. and Salsola imbricata Forssk. in correlation to their composition especially their phenolic content. Methods: The influence of extracting solvent on total phenolic and flavonoidal contents was assessed spectrophotometrically. The flavonoid and other polyphenolic components of the methanol extracts were analyzed by RP-HPLC. DPPH radical scavenging potential of the different extracts was estimated. The hepatoprotective and antioxidant activities of the extracts against CCl4-induced hepatotoxicity in mice were evaluated. Results: The flavonol quercitrin and rosmarinic acid were major in the F. indica, C. procera and S. imbricata samples, while rutin prevailed in that of Z. hamiense. The ethanolic and methanolic extracts showed noticeable DPPH radical-scavenging activity as compared to ascorbic acid. Assessment of liver enzymes revealed that oral administration of the extracts did not show any evidence of hepatotoxicity. Moreover, protection against CCl4-induced liver damage was evident upon administration of three plants extracts namely, F. indica, C. procera and S. imbricata. Conclusion: Overall, hepatotoxicity induced by CCl4 was effectively prevented by the three plants extracts through scavenging of free radicals and by boosting the antioxidant capacity of the liver. The protective effect of the plants could be attributed to their high quercitrin and rosmarinic acid contents. © 2015 Shehab et al.

Abu-Gharbieh E.,Dubai Pharmacy College | Bayoumi F.A.,Dubai Medical College | Ahmed N.G.,Dubai Pharmacy College
Mediators of Inflammation | Year: 2014

The aim of the study was to evaluate the potential protective effect of ozonized olive oil (OZO) in 2,4-dinitrobenzene sulphuric acid (DNBS) induced colitis in rats and to elucidate the role of some antioxidant defense system (superoxide dismutase "SOD," glutathione peroxidase "GSH-Px," and catalase "CAT") in these effects. The physicochemical parameters including viscosity, peroxide, and acid values of olive oil and OZO were evaluated. The animals were divided into several groups and the colitis was induced in the rats by intracolonic instillation of DNBS at dose of 15 mg/rat. Olive oil (OO) at dose of 6 mg/kg and OZO at doses of 3 and 6 mg/kg was administered orally for 7 days, starting the day before induction of colitis. Our results showed that macroscopic and microscopic damage scores were significantly reduced in a dose response manner in rats pretreated with OZO only. In contrast, CAT, GSH-Px, and SOD activities were significantly increased in the distal colon of inflamed animals pretreated with OZO with respect to control group dose dependently. Results demonstrate that OZO pretreatment exerts protective effects in DNBS induced colitis in rats and provide evidence that the protective effects of OZO are mediated by stimulation of some antioxidant enzymes. © 2014 Eman Abu-Gharbieh et al.

Abdraboh N.R.,Dubai Medical College | Ahmed N.,Dubai Pharmacy College
Research Journal of Medicinal Plant | Year: 2015

On the light of the antihyperglycemic effect of bark extract of S. campanulata (SC) that was detected by few previous studies, we aimed to investigate the glucose lowering effect of flowering branch and bark extracts of SC and its possible mechanistic background. The crude methanolic extracts of the bark and the flowering branch were tested for their anti-hyperglycemic effect in forty mice divided into 5 groups: group 1 received only 1% carboxymethyl cellulose (CMC) as negative control, all the other groups were subjected to alloxan induction of diabetes mellitus from which second group left without any treatment as positive control, the third and fourth groups were administrated the methanolic extracts of the flowering branch and bark respectively in dose of 500 mg kg-1. b.wt. and the fifth group received metformin in dose of 150 mg kg-1 b.wt. At the end of treatment period blood levels of glucose, insulin, triacylglycerols and cholesterol were estimated; in addition to the evaluation of muscle tissue concentration of insulin receptors. A significant reduction of blood glucose was noticed after 2 h of treatment with bark extract but not with flowering branch extract (p<0.05), moreover a significant rise in concentration of insulin receptors was found in bark extract and metformin treated groups as compared to control group (p<0.05). Consequently, we concluded that bark extract of S. campanulata may have a prospective antihyperglycemic therapeutic effect in diabetes; this influence could be through modifying the tissue expression of insulin receptors. © 2015 Academic Journals Inc.

Hussain K.,Rashid Hospital | Salah N.,Dubai Medical College | Hussain S.,United Arab Emirates University | Hussain S.,Dubai Medical College
Iranian Red Crescent Medical Journal | Year: 2012

Background: GST is a family of enzymes that are important in protection of the body against oxidative stress. Objectives: Investigate the association between GSTT1 and GSTM1 polymorr' ism and hypertension. Materials and Methods: GSTT1 and GSTM1 genotypes were detected by CR. The fragments were then analyzed by agarose gel electrophoresis. Results: There is no significant association between GSTT1 & GSTM1 polymorphism and hypertension (OR = 2.4, P > 0.05 and OR = 1.6, P> 0.05) Conclusions: GSTT1 & GSTM1 polymorphism can be considered a risk factor for hypertension.

Al Rukhaimi M.,Dubai Medical College
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia | Year: 2014

This review presents the views of an expert group of nephrologists from the Middle East along with an international expert on adaptation and implementation of the 2009 (KDIGO) guidelines for evaluation and manage-ment of mineral and bone disorders in chronic kidney disease (CKD-MBD) for practice in the Middle East countries. The members of the panel examined the KDIGO guidelines and formulated recommendations that can be implemented practically for the management of CKD-MBD in the Middle East. There was a broad agreement on most of the recommendations made by the KDIGO work-group. However, the panelists commented on specific areas and amplified certain concepts that might help the nephrologists in the Middle East. The final document was reviewed by all participants as well as by members of the Middle East task force implementation group for KDIGO guidelines. Their comments were incorporated. The guideline statements are presented along with detailed rationale and relevant discussion as well as limitations of the evidence. The panel recognized the need to upgrade the suggestion of KDIGO related to lateral abdominal radiograph and echocardiogram in patients with CKD stages 3-5D into a stronger recommendation. The panel underlined the risk of hyper-phosphatemia to CKD-MBD and the importance of prompt initiation or modification of therapy according to rising trends in para-thyroid hormone level. They recommended the use of non-calcium-based phosphate binders as the first-line therapy in CKD patients with signs of vascular calcification. The panel agreed that all aspects of the KDIGO recommendations concerning bone biopsy, evaluation and treatment of bone disease after kidney trans-plantation should be implemented as such.

Al Ojaimi E.H.,Dubai Medical College
Hormones | Year: 2014

Although Cushing's syndrome has been described in association with various neuroendocrine tumors producing ectopic adrenocorticotropin (ACTH), primary ovarian carcinoma rarely causes this syndrome. We hereby report the case of a 61-year-old woman presented with abdominal distension, facial swelling and skin pigmentation. Clinical and diagnostic evaluation revealed a right ovarian tumor with hypercortisolemia, high plasma ACTH, extremely high plasma ACTH precursors and lack of dexamethasone suppression. Removal of the tumor led to normalization of ACTH, ACTH precursors and cortisol levels. In addition, hypokalemia, hyperglycemia and elevated serum CA 125 were noted, which were also normalized after resection of the tumor. Histopathological examination indicated a primary ovarian carcinoma with a mixed pattern of differentiation. Immunohistochemistry showed immunoreactivity for chromogranin A, synaptophysin and ACTH. Hence, the diagnosis of Cushing's syndrome arising from an ovarian carcinoma secreting ectopic ACTH was made. The case was managed successfully, with subsequent good recovery and no evidence of recurrence at 4 years of follow-up.

Benomran F.,Dubai Medical College
Journal of Forensic and Legal Medicine | Year: 2010

Medical responsibility in the United Arab Emirates was formerly defined and governed according to Law 7 of 1975 for the practice of medical professions, which had been a part of civil law. The passing of Law 10 of 2008, namely the "Law on Medical Responsibility in UAE", enacted on 16th December 2008 created a new framework to deal with this issue. One of its provisions required medical practitioners to hold insurance policies, so that insurance companies pays damages to the plaintiff (patient) injured as a result of a physicians' negligence. This paper outlines the issue of medical responsibility and medical negligence. The author's translation of the new law into English is included so that its full text is available for the readers, especially expatriate doctors working in the UAE. Where appropriate, a brief comparison between the old law and new laws is also presented. The objective of this paper is to provide medical practitioners with basic information about the subject in general and to this legislation in particular. It is mandatory for doctors to realize inherent risks involved in the course of their practice. A basic knowledge of the law is required to avoid pitfalls and to safeguard oneself against errors arising from ignorance of the duties and rights of the professional person. © 2010 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

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