Dubai, United Arab Emirates
Dubai, United Arab Emirates

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AbdullGaffar B.,Dubai Hospital
Southern Medical Journal | Year: 2010

Objectives: Gastrointestinal stromal tumor (GIST) is a relatively uncommon and predominantly sporadic tumor of the gastrointestinal tract (GIT). Infrequently, it can be associated with other neoplasms, notably GIT carcinomas and, rarely, extra-gastrointestinal tumors. Whether this concomitant occurrence is a causal association or a coincidence is not yet resolved, nor is its clinical importance determined. We attempted to investigate the frequency and spectrum of associations between non-incidental GISTs and extra-GIT tumors. Methods: A retrospective review study was carried out over 18 years of records. All confirmed cases of GISTs were retrieved from the pathology files of our institution. Each case was investigated for any synchronous or metachronous association with GIT or extra- GIT tumors. Results: Five (24%) out of 21 cases of GISTs were found to be either synchronously or metachronously associated with extra-gastrointestinal neoplasms in 55% of the women with GISTs. Males had no such association. Conclusion: The cause of the association between non-incidental GISTs and extra-GIT tumors is difficult to determine. In the majority of cases, this association is most likely a coincidental finding. Synchronous occurrence with certain tumors, however, may suggest a nonrandom causal association. We report a case series study of the possible association of GISTs with extra-GIT tumors in female patients. Like other studies, we suggest that patients - especially women - with GISTs should be clinically investigated and followed up for the possibility of coexisting GIT and extra-GIT neoplasms. Copyright © 2010 by The Southern Medical Association.


Dawood S.,Dubai Hospital
Expert Review of Molecular Diagnostics | Year: 2010

Once metastatic disease is documented, cure is no longer the goal and the disease is generally associated with poor outcomes, with the majority of patients dying of their disease rather than other causes. The last three decades have seen significant advances in the genomics, proteomics and molecular pathology of biomarkers in cancer, allowing for individualization of therapy that has significantly and positively impacted survival outcomes. Genetic signatures have been identified that can predict not only the future development of metastases, but also the development of specific sites of metastases. Protein biomarkers have been identified that are in use clinically for the monitoring of both disease progression and therapeutic efficacy. DNA- and RNA-based biomarkers have also been identified. This review will focus on some of the novel biomarkers that have been developed over the last decade. © 2010 Expert Reviews Ltd.


Dawood S.,Dubai Hospital | Cristofanilli M.,Fox Chase Cancer Center
Oncology | Year: 2011

Inflammatory breast cancer (IBC) is a rare and aggressive subtype of locally advanced breast cancer (LABC). Its diagnosis is primarily clinical; however, a pathological confirmation of invasive cancer is required. Historically, IBC was a uniformly fatal disease. A major advance in the last three decades has been the introduction of a multidisciplinary approach to the management of this aggressive disease, incorporating pre-operative chemotherapy, surgery, and radiation therapy; this approach has significantly improved survival. Our review focuses on the progress made in the field of IBC research over the last decade, with particular attention to advances in the areas of epidemiology, molecular biology, and clinical management.


Scaltriti M.,Massachusetts General Hospital | Scaltriti M.,Harvard University | Dawood S.,Dubai Hospital | Cortes J.,Vall dHebron Institute of Oncology VHIO
Clinical Cancer Research | Year: 2012

Many kinases and hormone receptors, important for cancer cell proliferation and survival, bind to and are dependent on the Hsp90 cycle for their folding and maturation. This provides the rationale for the development of small-molecule ATP competitors that, inhibiting Hsp90 function, lead to degradation of the "client" proteins. After continual efforts to improve the pharmacologic properties and the tolerability of these molecules, several Hsp90 inhibitors have exhibited activity in both preclinical models and in the clinical setting. As is the case with many other targeted agents, patient selection seems to be the major limitation to the success of these compounds. ERBB2-positive patients with breast cancer are exquisitely sensitive to Hsp90 inhibition. This is because ERBB2 is indispensable for growth and survival of this subtype of cancer, and at the same time ERBB2 is a client protein strictly dependent on Hsp90 for its maturation and stability. Extensive preclinical work identifying other ERBB-like client proteins will likely lead to the ability to enhance selection of appropriate patients for enrollment in more rational clinical trials. Hsp90 inhibition has also been reported to synergize with other therapeutic agents. Several ongoing studies testing different combinations of Hsp90 inhibitors with other targeted agents will confirm whether Hsp90 inhibition can potentiate the efficacy of targeted therapy and/or prevent the emergence of drug resistance. ©2012 AACR.


Abdullgaffar B.,Dubai Hospital
Cytopathology | Year: 2012

Objective: To study the trends of impact factor (IF) in four cytopathology journals. To investigate the factors that might influence IF in cytopathology literature and whether IF has any impact on cytopathology practice. Methods: The IFs of four cytopathology journals were searched from 2005 to 2009. The IFs and their relationships with the types and number of publications, publishers, the official societies, readership, the quality of their contents, the topics covered and the levels of evidence were compared. Results: Cancer Cytopathology (CC) had the highest IF. Acta Cytologica (AC) had the lowest IF, which appeared to be in decline. Cytopathology (C) and Diagnostic Cytopathology (DC) had a slow but steady increase in their IF. Components that might influence these differences could include the category and the society of the journal, targeted readers and certain types of publications. Publishers, the number of publications, the types of topics covered and the levels of evidence probably have no major effect on IF. Conclusions: IF has its own benefits and original applications. IF is a quantitative measure that does not reflect the levels of evidence in cytopathology journals. IF should not be abandoned because it might encourage competition between cytopathology journals, but it should not dictate their contents. © 2012 Blackwell Publishing Ltd.


Dawood S.,Dubai Hospital | Gonzalez-Angulo A.M.,University of Texas M. D. Anderson Cancer Center
Oncologist | Year: 2013

Metastasis to the central nervous system (CNS) is a devastating neurological complication of systemic cancer. Brain metastases from breast cancer have been documented to occur in approximately10%-16%of cases over the natural course of the disease with leptomeningeal metastases occurring in approximately2%- 5%of cases of breast cancer.CNSmetastases among women with breast cancer tend to occur among those whoare younger,havelarger tumors,andhaveamoreaggressive histological subtype such as the triple negative and HER2- positive subtypes. Treatment of CNS metastases involves various combinations of whole brain radiation therapy, surgery, stereotactic radiosurgery, and chemotherapy. We will discuss the progress made in the treatment and prevention of breast cancer-associated CNS metastases and will delve into the biological underpinnings of CNS metastases including evaluating the role of breast tumor subtype on the incidence, natural history, prognostic outcome, and impact of therapeutic efficacy. © AlphaMed Press 2013.


Dawood S.,Dubai Hospital
Oncology (Williston Park, N.Y.) | Year: 2011

Inflammatory breast cancer (IBC) is a rare and aggressive subtype of locally advanced breast cancer (LABC). Its diagnosis is primarily clinical; however, a pathological confirmation of invasive cancer is required. Historically, IBC was a uniformly fatal disease. A major advance in the last three decades has been the introduction of a multidisciplinary approach to the management of this aggressive disease, incorporating pre-operative chemotherapy, surgery, and radiation therapy; this approach has significantly improved survival. Our review focuses on the progress made in the field of IBC research over the last decade, with particular attention to advances in the areas of epidemiology, molecular biology, arid clinical management.


Abdullgaffar B.,Dubai Hospital
International Journal of Surgical Pathology | Year: 2010

Granulomatous appendicitis is a rare phenomenon. Idiopathic (primary) granulomatous appendicitis is very rare. It is a diagnosis by exclusion. There are many etiologies, both infectious and noninfectious, for secondary granulomatous appendicitis. Isolated appendiceal Crohn's disease (CD) is no longer an accepted explanation of idiopathic granulomatous appendicitis, but rather, it is thought to be part of more generalized gastrointestinal CD. Yersinia infection and CD constitute the main etiology of granulomatous appendicitis in the West. Infectious causes, mainly tuberculosis and parasitic infestations, are the main culprits in tropical and subtropical countries. This variation is probably a result of differences in the geographical distribution of these diseases. Recently, interval appendectomy has been suggested as an important cause of granulomatous appendicitis. The importance of interval appendectomy may vary according to the local practice of this procedure in each region. Other unusual causes may include sarcoidosis and foreign body reaction, mainly as a result of vegetable matter from feces. A review study of 3381 appendectomy specimens over a 4-year period showed only 13 cases (0.38%) of granulomatous appendicitis. Infectious and noninfectious causes were responsible for 62% and 38% of granulomatous appendicitis, respectively. Parasites alone were responsible for 38.5% of the cases. Interval appendectomy and CD each contributed 15% and 8%, respectively, of the total etiology. Granulomatous appendicitis was more common in young adult males.


Dawood S.,Dubai Hospital
Drugs | Year: 2010

The triple receptor-negative breast cancer (TNBC) subtype is characterized by the lack of expression of both hormone receptors as well as lack of over-expression andor lack of gene amplification of human epidermal growth factor receptor 2 (HER2). Approximately 1015 of breast carcinomas are known to be of the TNBC subtype, which constitutes approximately 80 of all 'basal-like tumours'. Risk factors for TNBC include young age at breast cancer diagnosis, young age at menarche, high parity, lack of breast feeding, high body mass index and African American ethnicity. The majority of BRCA1 tumours are TNBC. TNBC has a worse prognosis and tends to relapse early compared with other subtypes of breast cancer. Conversely, it displays increased chemosensitivity compared with other breast tumour subtypes. Several agents are currently being investigated as potential therapeutic agents for the treatment of women with TNBC including agents targeted against EGFR, anti-angiogenic agents, multityrosine kinase inhibitors and poly (ADP-ribose) polymerase (PARP) inhibitors. This review focuses on the epidemiology of TNBC, its pathological features, natural history and recurrence patterns as well as current and future management options. © 2010 Adis Data Information BV. All rights reserved.


Fakhratova M.,Dubai Hospital
Ophthalmic Genetics | Year: 2013

Purpose: To determine the cause of Leber congenital amaurosis (LCA) in a consanguineous Emirati family. Methods: The clinical diagnosis was made on the basis of medical history, ophthalmoscopy and standard ERG. The diagnosis was confirmed by molecular genetic analysis of known LCA genes by Next-Generation Sequencing (NGS). The latter was performed by Bioscientia Institut, Germany (as a clinical service for Latifa Hospital, Dubai). Results: The next generation sequencing of known LCA genes revealed a homozygous 1bp-insertion c.2608-2609insA in exon 16 of the RPGRIP1 gene. This mutation, which was confirmed by conventional Sanger sequencing, leads to a frameshift, resulting in a premature stop codon (p.Leu870TyrfsX7) and subsequently in a degradation of the m-RNA or in a truncation of the RPGRIP1 protein. The segregation analysis of the identified mutation was performed for the parental samples. Both parents carry the frameshift mutation in a heterozygous state. Conclusion: We report a novel RPGRIP1 mutation causing LCA in a consanguineous Emirati family. To the best of our knowledge, this alteration has not been described in the literature so far. © 2013 Informa Healthcare USA, Inc.

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