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Parsippany, NJ, United States

Engstrom M.,DSM Nutritional Products Inc.
Journal of animal science | Year: 2010

With appropriate management controls and statistical designs, on-farm trials are an increasingly valuable research tool. On-farm trials can speed up technology adoption, particularly with those studies requiring large numbers of animals. Useful designs include longitudinal (pen vs. pen) trials, in which pen is the experimental unit, and crossover or switchback designs, in which treatments are imposed on a schedule over 1 or more experimental groups. A paired-herd design has been used, in which herds are the experimental units in a crossover trial. Others have published similar studies, including a multisite crossover design that used 35 dairy farms to compare milk responses with a protein source by using individual cow records to evaluate differences in milk production. Recently, statistical process control (SPC) techniques have been used to evaluate management changes by using repeated measures on the farm. Although a drawback to SPC may be the lack of traditional statistics to test differences (i.e., the lack of a control group), standard run rules are used to demonstrate with statistical certainty that a process or variable has changed, or to characterize a seasonal change. With SPC, the inference is limited to the herd or group of animals being monitored. Meta-analysis techniques are powerful tools used to combine results from many similar trials in which the response of interest is either small (i.e., continuous variables) or of low frequency (i.e., discrete variables). Meta-analysis can be used to segment a database so as to validate and compare trial methods or to investigate publication bias. Additional design concerns for reproduction studies include the need for adequate numbers of observations and planning for the lag time between an experimental treatment and response measurement (e.g., confirmation of pregnancy).


Patent
DSM Nutritional Products Inc. | Date: 2013-03-04

A powder composition containing at least one fat-soluble vitamin dispersed in a matrix of a natural polysaccharide gum or a mixture of gums having an emulsifying capacity and/or a protein or a mixture of proteins having an emulsifying capacity. The fat-soluble vitamin in the powder compositions is in the form of droplets having an average diameter in the range of about 70 to about 200 nm. Tablets, beverages and beverage concentrates, foods, cosmetics and pharmaceuticals containing the powder composition can be made.


Patent
DSM Nutritional Products Inc. | Date: 2013-07-31

Disclosed are methods of improving the sensory and oxidative stability of oils (e.g., plant and animal oils) by combining an oil and an antioxidant composition comprising green tea extract and deodorizing the oil. Oils prepared by these methods are also disclosed.


Salem N.,DSM Nutritional Products Inc. | Kuratko C.N.,DSM Nutritional Products Inc.
Lipids in Health and Disease | Year: 2014

It has proven difficult to compare the bioavailability of krill oil (KO) vs. fish oil (FO) due to several of the characteristics of KO. These include the lower concentration of the active ingredients, eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n3), in KO as well as differences in their ratio relative to FO as well as the red color due to astaxanthin. In addition, the lipid classes in which EPA and DHA are found are quite different with KO containing phospholipid, di- and tri-glycerides as well as non-esterified fatty acid forms and with FO being primarily triglycerides. No human study has yet been performed that matches the dose of EPA and DHA in a randomized, controlled trial with measures of bloodstream EPA and DHA content. However, several claims have been made suggesting greater bioavailability of KO vs. FO. These have largely been based on a statistical argument where a somewhat lower dose of KO has been used to result in a similar bloodstream level of EPA and/or DHA or their total. However, the magnitude of the dosage differential is shown to be too small to be expected to result in differing blood levels of the long chain n-3 PUFAs. Some studies which have claimed to provide equal doses of KO and FO have actually used differing amounts of the two major n-3 fatty acid constituents. It is concluded that there is at present no evidence for greater bioavailability of KO vs. FO and that more carefully controlled human trials must be performed to establish their relative efficacies after chronic administration. © 2014 Salem and Kuratko.


Handa R.J.,University of Arizona | Weiser M.J.,DSM Nutritional Products Inc.
Frontiers in Neuroendocrinology | Year: 2014

The hypothalamo-pituitary-adrenal (HPA) axis represents a complex neuroendocrine feedback loop controlling the secretion of adrenal glucocorticoid hormones. Central to its function is the paraventricular nucleus of the hypothalamus (PVN) where neurons expressing corticotropin releasing factor reside. These HPA motor neurons are a primary site of integration leading to graded endocrine responses to physical and psychological stressors. An important regulatory factor that must be considered, prior to generating an appropriate response is the animal's reproductive status. Thus, PVN neurons express androgen and estrogen receptors and receive input from sites that also express these receptors. Consequently, changes in reproduction and gonadal steroid levels modulate the stress response and this underlies sex differences in HPA axis function. This review examines the make up of the HPA axis and hypothalamo-pituitary-gonadal (HPG) axis and the interactions between the two that should be considered when exploring normal and pathological responses to environmental stressors. © 2013 Elsevier Inc.

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