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Schmidt I.,Karl Winnacker Institute | Schewe H.,Karl Winnacker Institute | Gassel S.,Goethe University Frankfurt | Jin C.,Goethe University Frankfurt | And 4 more authors.
Applied Microbiology and Biotechnology | Year: 2011

The oxygenated β-carotene derivative astaxanthin exhibits outstanding colouring, antioxidative and health-promoting properties and is mainly found in the marine environment. To satisfy the growing demand for this ketocarotenoid in the feed, food and cosmetics industries, there are strong efforts to develop economically viable bioprocesses alternative to the current chemical synthesis. However, up to now, natural astaxanthin from Haematococcus pluvialis, Phaffia rhodozyma or Paracoccus carotinifaciens has not been cost competitive with chemically synthesized astaxanthin, thus only serving niche applications. This review illuminates recent advances made in elucidating astaxanthin biosynthesis in P. rhodozyma. It intensely focuses on strategies to increase astaxanthin titers in the heterobasidiomycetous yeast by genetic engineering of the astaxanthin pathway, random mutagenesis and optimization of fermentation processes. This review emphasizes the potential of P. rhodozyma for the biotechnological production of astaxanthin in comparison to other natural sources such as the microalga H. pluvialis, other fungi and transgenic plants and to chemical synthesis. © 2010 Springer-Verlag. Source


Jucker W.,DSM Nutritional Products AG
Chimia | Year: 2011

This short review intends to present some key facts on carotenoids in a popular scientific language on the occasion of the International Year of Chemistry. Carotenoids have a characteristic C40H56 structure and represent a market value of several hundred million Euros. Their chemical synthesis is still a demanding challenge for chemists. Health claims for several carotenoids are summarised and results of epidemiological studies are discussed. © Schweizerische Chemische Gesellschaft. Source


Takagi Y.,Division 5 Technology | Sugisawa T.,DSM Nutritional Products AG | Hoshino T.,Tamagawa University
Applied Microbiology and Biotechnology | Year: 2010

The fermentation process of 2-keto-L-gulonic acid (2KGA) from L-sorbose was developed using a two-stage continuous fermentation system. The mixed culture of Ketogulonicigenium vulgare DSM 4025 and Bacillus megaterium DSM 4026 produced 90 g/L of 2KGA from 120 g/L of L-sorbose at the dilution rate of 0.01 h -1 in a single-stage continuous fermentation process. But after the production period was beyond 150 h, the significant decrease of 2KGA productivity was observed. When the non-spore forming bacteria Xanthomonas maltophilia IFO 12692 was used instead of B. megaterium DSM 4026 as a partner strain for K. vulgare DSM 4025, the 2KGA productivity was significantly improved in a two-stage continuous culture mode, in which two fermentors of the same size and volume were connected in series. In this mode, with two sets of 3-L jar fermentors, the steady state could be continued to over 1,331.5 h at least, when the dilution rates were 0.0382 h-1 and 0.0380 hour-1, respectively, for the first and second fermentors. The overall productivity was calculated to be 2.15 g/L/h at 113.1 g/L and a molar conversion yield of 90.1%. In the up-scaling fermentation to 30-L jar fermentors, 118.5 g/L of 2KGA was produced when dilution rates in both stages were 0.0430 hour-1, and the overall productivity was calculated to be 2.55 g/L/h. © 2009 Springer-Verlag. Source


Patent
DSM Nutritional Products AG | Date: 2014-05-06

Disclosed are methods and compositions related to ONC-T18, D4-desaturases, D5 elongases, their isolation, characterization, production, identification, and use for fatty acid production, as well as organisms containing these compositions and organisms expressing them.


Patent
DSM Nutritional Products AG | Date: 2015-08-04

The present disclosure provides, inter alia,

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