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Ager D.,DSM Innovative Synthesis BV
Platinum Metals Review | Year: 2012

The fourth Novel Chiral Chemistries Japan (NCCJapan) Conference and Exhibition was held in Tokyo, Japan, from 15-16, March 2012. The first keynote was presented by Professor Masahiro Terada on enantioselective carboncarbon bond forming reactions catalyzed by chiral phosphonic acids, mainly derived from 3,3'-disubstituted 2,2'-bisnaphthols. The reactions discussed included hetero-Diels Alder reactions and condensations of vinyl ethers with azlactones to form β-alkoxy α-amido esters. The first day closed with the second keynote address from Professor Kiyoshi Tomioka where the first part of the lecture discussed additions of organometallic reagents to imines. The final keynote address closed the conference and was delivered by Professor Pher Anderson who informed that iridium-based catalysts could be used for the asymmetric hydrogenation of unfunctionalized alkenes. Source


Ager D.J.,DSM Innovative Synthesis BV | De Vries A.H.M.,Royal DSM | De Vries J.G.,Royal DSM
Chemical Society Reviews | Year: 2012

Asymmetric hydrogenations are increasingly being used to introduce stereogenic centres into products used in the life sciences industries. There are a number of potential pitfalls when moving from a laboratory reaction to a manufacturing process, not least of which is safety. Time-to-market pressure leads to short development times, which in the past could be a large barrier for the implementation of catalytic steps; now there are new ways to minimise this problem. The potential problems associated with impurities and other methods that can shut down the hydrogenation reactions are highlighted in this critical review (353 references). © 2012 The Royal Society of Chemistry. Source


Ager D.,DSM Innovative Synthesis BV
Platinum Metals Review | Year: 2012

Chemical catalysts can work well with a specific and well documented range of substrates, and in particular palladium finds wide use in essential reactions such as Heck coupling. The choice between a chemical and a biological catalyst depends on many factors. The background literature plays an important role, as does cost and speed to implement the process. A criterion used to decide what type of catalyst is used is that the process must include isolation of the product in acceptable yield and purity. If the product is very water soluble, isolation of the desired material can present a significant challenge. The criteria of cost and speed also contribute to the choice of catalyst system. In the early stages of development of a drug candidate, speed is of the essence but cost is still important. Both transition metal catalysts and biocatalysts might be required to produce an efficient process. Source


Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.3.3-03 | Award Amount: 7.40M | Year: 2012

BIOINTENSE is directed at addressing the challenges of low productivity and process intensity frequently hampering the implementation of bioprocesses in industry. For the future of the next generation of chemical processes in Europe it provides the opportunity not only to address intensification but also to enable this in a rapid manner. BIOINTENSE will make use of -technology to develop economically feasible intensified processes by integration of separation and process control, and to create tools to speed up the characterization and assessment of different process options and technologies and biocatalysts for increased process intensity. A strong focus lies in increasing the scale of biocatalytic and cascade reactions and to improve the fundamental factors that affect the economic feasibility. Both numbering up and scale-up methodologies will be tested. The BIOINTENSE consortium is ideally suited to address the challenges in KBBE.2012.3.3-03 and to meet the objectives, as it spans across disciplines, academia and industry: SMEs with a strong technology base in the areas of integrating separation in bioprocessing, biocatalyst development, immobilization, -reactor fabrication, and on-line monitoring will ensure top of the line industry focused research with a strong focus on scale-up and implementation. There is an urgent need for these challenges to be overcome to move towards a European Knowledge Based BioEconomy to exploit the environmental savings and economic potential if such bioprocesses were in place. Building on the recent advances in molecular biology, the time is now right to develop the necessary process engineering methodologies and implementation strategies to unlock the full potential of bioprocesses.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.68M | Year: 2013

The SusPhos training network will bring about a paradigm shift in the teaching of sustainable phosphorus chemistry, in the training of multidisciplinary-competent scientists, and in the publics view on chemistry to preserve the essential element phosphorus from depletion. SusPhos represents the first systematic investigation of the eco-friendly production, smart use, recycling and commercial exploitation of phosphorus-based processes and materials that use the precious element phosphorus in a sustainable manner. This approach should lead to fundamental insights into sustainable technologies and create an ideal platform for the training of young, ambitious researchers in a superb collaborative European setting. SusPhos will educate 14 broadly-oriented researchers at the interface of synthetic chemistry, catalysis, materials science, process chemistry, industrial phosphorus chemistry, and technology transfer. SusPhos intense training module combines the complementary strengths of nine academic and three industrial teams to promote intersectoral mobility of top-class multi-skilled researchers to enforce cross-fertilization of enhanced research synergies between the public and private European chemical sector. In its dual-mentor programme each of the ESRs and ERs will be supervised by one mentor from academia and one from industry to ensure an outstanding training in both sectors. The training programme uses highly innovative and timely methodologies to provide comprehensive multidisciplinary training of a new generation of young researchers capable of understanding and applying green chemistry to the conservation of phosphorus by environmentally benign conversions. Our SME Magpie Polymers and leading chemical companies Thermphos, Arkema and DSM will ensure rapid and effective technology transfer. As such the network will facilitate Europes continued global leadership on the sustainable use of phosphorus in an increasingly fierce competition for resources.

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